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Charles A. Stanley, MD

Emeritus Professor CE of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Charles A. Stanley, MD, is the medical director of the Congenital Hyperinsulinism Center at The Children's Hospital of Philadelphia and a professor emeritus of pediatrics at the Perelman School of Medicine at the University of Pennsylvania. He is a past-president of the Pediatric Endocrine Society (formerly named in honor of Lawson Wilkins) and currently serves on the Awards Committee.

Dr. Stanley is a world- renowned expert on disorders of insulin regulation in children. He has helped define the various types of hyperinsulinism (HI) and pioneered best practices for diagnosis and treatment of congenital HI.

Research into the genetic causes of HI (hypoglycemia caused by high levels of insulin in the blood) is an area Dr. Stanley is particularly passionate about. His laboratory is currently supported by a prestigious MERIT award from the NIH.

“Genetic diagnosis will enable physicians to determine with greater accuracy and speed which babies have the best chance of cure by surgical treatment,” he says.

Under Dr. Stanley’s mentorship, researchers were able to identify specific mutations in GLUD1, the gene that causes the hyperinsulinism/hyperammonemia (HI/HA) syndrome.

Under Dr. Stanley’s direction, CHOP’s HI program is one of few in the world that offers qualified patients a special positron emission tomography (PET) scan under research protocols. The 18F-DOPA PET scan helps the medical team distinguish between diffuse HI (spread throughout the pancreas) or focal HI (concentrated in one spot). For children with focal HI, the scan acts as a roadmap which allows the surgeon to remove only the affected part of the child’s pancreas and to cure the patient’s hyperinsulinism while minimizing the chance of diabetes.

Dr. Stanley has published numerous articles in journals such as The New England Journal of Medicine, Journal of Pediatrics, Diabetes, Journal of Clinical Endocrinology and Metabolism, and The Journal of Biological Chemisty. He was recently co-editor of Monogenic Hyperinsulinemic Hypoglycemia Disorders, volume 21 of “Frontiers in Diabetes.” Additionally, Dr. Stanley has served as an editorial board member, guest editor and reviewer for more than a dozen medical journals.

In conjunction with his published work, Dr. Stanley has also lectured extensively around the world about the causes and treatment of congenital hyperinsulinism and hypoglycemia (low blood sugar) in neonates and young children. He coordinated two international symposia where thought-leaders converged in Philadelphia to share their research and develop collaborations in the area of congenital hyperinsulinism and monogenic forms of diabetes.

Dr. Stanley earned his bachelor's degree in biochemical sciences from Harvard University, Cambridge, MA, and his medical degree from the University of Virginia School of Medicine, Charlottesville, VA. He completed his residency in pediatrics and a fellowship in metabolic diseases, both at The Children’s Hospital of Philadelphia, Philadelphia, PA.

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