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G. Scott Worthen, MD

Physician-Scientist in Neonatology

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Awards

1994, American Society for Clinical Investigation
1986, RJR-Nabisco Research Scholar
1983, American Heart Association Clinician-Scientist

Editorial and Academic Positions

Academic and institutional committees

2009-present, IACUC, The Children's Hospital of Philadelphia
2013-present, Executive committee Center for Lung Biology, University of Pennsylvania

Leadership

Memberships in professional organizations

International societies

International Endotoxin Society

National societies

American College of Chest Physicians
American Thoracic Society
Western Society for Clinical Investigation
American Thoracic Society

  • Member, Program Committee for Allergy, Immunology, and Inflammation Section

NIH review panels

1991-1998, Founding Member, Lung Biology and Pathology Review Panel

Original Papers

2012

Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 71(1):107-114, Jan 2012. PMC3610412

Mei J, Liu Y, Dai N, Hoffmann C, Hudock KM, Zhang P, Guttentag SH, Kolls JK, Oliver PM, Buslunan FD, Worthen GS. Cxcr2 and Cxcl5 regulate the IL-17/G-CSFaxis and neutrophil homeostasis in mice. J. Clin Invest. 122(3):974-986, Mar 2012. PMC3287232

Ramon H.E., Beal A., Liu Y, Worthen G.S., and P. M. Oliver. The E3 ubiquitin ligase adaptor Ndfip 1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines. J ImmunoI. 188(8):4023-4031, Apr 2012. PMC3713491

Balamayooran G, Batra S, Cai S, Mei J, Worthen GS, Penn AL, Jeyaseelan S. Role of CXCL5 in leukocyte recruitment to the lungs during secondhand smoke exposure. 2012 Am J Resp Cell Mol BioI. 47(1):104-111, Ju12012. PMC3402800

Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Homg W, Fridlender Bayuh R, Worthen GS, Albelda SM. Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils. PLoS One. http://www.ncbi.nlm.nih.gov/pubmedI22348096 7(2):e31524, 2012. PMC3279406

Hudock KM, Liu Y, Mei J, Marino RC, Hale JE, Dai N, Worthen GS. Delayed resolution of lung inflammation in Il-1rn-/- mice reflects elevated IL-17/G-CSF expression. Am J Respir Cell Mol BioI. 47:436-444, Oct 2012. PMC3488622 

2011

Liu Y, Mei J. Gonzales L, Yang G, Dai N, Wang P, et al. IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol. 2011 Mar 1;186(5):3197-205. Epub Jan 31. Cited in PubMed; PMID 21282514. Read the abstract

2010

Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS. Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest. 2010 Nov 1;120(11):3917-22. doi: 10.1172/JC143326. Epub 2010 Oct 25. Cited in PubMed; PMID 20972336. Read the article

Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, et al. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010 Jul 23;3(1):106-17. Cited in PubMed; PMID 20643340. Read the abstract

2009

Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell. 2009 Sep 8;16(3):183-94. Cited in PubMed; PMID 19732719. Read the article 

Cai S, Zemans RL, Young SK, Worthen GS, Jeyaseelan S. Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2009 Jun;40(6):701-9. Epub 2008 Nov 6. Read the article

Zemans RL, Briones N, Young SK, Malcolm KC, Refaeli Y, Downey GP, et al. A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction. J Immunol Methods. 1009 Jan 30;340(2):102-15. Epub 2008 Nov 14. Cited in PubMed; PMID 19010330. Read the article

 

 

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