Amish C. Shah, MD, PhD

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Amish C. Shah, MD, PhD, is a neuro-oncologist and Director of the Neuro-Oncology Fellowship Program at Children's Hospital of Philadelphia.

Areas of Expertise: Pediatric brain and spine tumors, Neurofibromatosis type 1, Neurofibromatosis type 2, Neurofibromatosis-related malignancies, Retinoblastoma, Ocular/eye tumors, Histiocytic tumors primarily in the CNS (Juvenile Xanthogranuloma, Langerhans Cell Histiocytosis, etc.)
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD/PhD, Medical Scientist Training Program - University of Alabama School of Medicine, Birmingham, AL


Pediatrics (Integrated Research Pathway) - The Children’s Hospital of Philadelphia, Philadelphia, PA


Pediatric Neuro-Oncology - The Children’s Hospital of Philadelphia, Philadelphia, PA

Pediatric Oncology/Hematology - The Children’s Hospital of Philadelphia, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Director, Neuro-Oncology Fellowship Program

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Areas of Focus

Research Topics




Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC. Selumetinib in Children with Inoperable Plexiform Neurofibromas. N Engl J Med. 2020 Apr 9;382(15):1430-1442. doi: 10.1056/NEJMoa1912735. Epub 2020 Mar 18. PMID: 32187457


Vogel J, Grewal A, O'Reilly S, Lustig R, Kurtz G, Minturn JE, Shah AC, Waanders AJ, Belasco JB, Cole KA, Fisher MJ, Phillips PC, Balamuth NJ, Storm PB, Hill-Kayser CE. Risk of brainstem necrosis in pediatric patients with central nervous system malignancies after pencil beam scanning proton therapy. Acta Oncol. 2019 Dec;58(12):1752-1756. doi: 10.1080/0284186X.2019.1659996. Epub 2019 Sep 12. PMID: 31512931


Mahdi J, Shah AC, Sato A, Morris SM, McKinstry RC, Listernick R, Packer RJ, Fisher MJ, Gutmann DH. A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1. Neurology. 2017 Apr 18;88(16):1584-1589. doi: 10.1212/WNL.0000000000003881. Epub 2017 Mar 22. PMID: 28330960


Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang T, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatr Blood Cancer. 2016 Jan;63(1):21-6. doi: 10.1002/pbc.25697. Epub 2015 Jul 31. PMID: 26235452.

Awards and Honors

2012-2014, T32, Grant: 5T32CA009615-23, PI: John Maris; Post-doctoral appointment
2004-2007, Ruth L. Kirschstein National Research Service Award, NIH: 1 F31 NS050924-01
2006, Oral Presentation Research Award, International Herpesvirus Workshop, Seattle, WA
2005, AAAS Science Award
2004, Outstanding Cancer Research, Medical Student Research, UASOM
1999, Graduated Summa Cum Laude - University of Georgia, Athens, GA