Craig Bassing Laboratory
Led by Craig Bassing, PhD, researchers in the Craig Bassing Laboratory are studying the contributions of mutations in cellular DNA repair machinery and normal lymphocyte development to oncogenic mechanisms in childhood lymphomas and leukemias. The primary long-term goal of the work in this lab is to design, develop and test novel treatments for pediatric cancers that are more effective and less toxic than current clinical therapies.
Somatic inactivation of ATM in hematopoietic cells predisposes mice to cyclin D3 dependent T cell acute lymphoblastic leukemia. Cell Cycle 2015;14(3):388-98.
Ehlic LA, Yang-Iott K, DeMicco A, Bassing CH.
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to enforce Tcrb and Igh allelic exclusion. J Immunol. 2014 Sep 15;193(6):2881-90.
Steinel NC, Fisher M, Yang-Iott KS, Bassing CH.
The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development. J Immunol. 2014 Oct 15;193(8):4032-42.
Rupp LJ, Brady BL, Carpenter AC, De Obaldia ME, Bhandoola A, Bosselut R, Muljo SA, Bassing CH.