Kathrin Bernt Laboratory

The primary interest of the Bernt Laboratory lies in investigating the role of epigenetic gene regulation in normal hematopoietic stem cells, and extending these relevant findings to the study of leukemia. Epigenetic changes in cancer are of particular interest since, in contrast to DNA sequence alterations, they are potentially reversible.

Selected Publications

MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. J Clin Invest. 2016. doi:10.1172/JCI80825. 
Riedel SS, Haladyna J, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T* and Bernt KM*. 

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. T. Cell Rep. 2016 Feb 16. pii: S2211-1247(16)30057-2. doi: 10.1016/j.celrep.2016.01.064. [Epub ahead of print]PMID:26904942.
Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff

Histone profiles in cancer. Pharmacol Ther. 2015 Oct;154:87-109. doi: 10.1016/j.pharmthera.2015.07.004. Epub 2015 Jul 22. Review. PMID:26210403. 
Riedel SS, Neff T, Bernt KM.

Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia. Front Oncol. 2014 Mar 25;4:54.
Bernt KM, Hunger SP.