Sarah K. Tasian, MD

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Sarah K. Tasian, MD, is Chief of the Hematologic Malignancies Program at Children’s Hospital of Philadelphia.

Areas of Expertise: Acute myelogenous leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Targeted cancer therapies, Immunotherapy, Clinical trials
Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Sarah K. Tasian, MD is a pediatric oncologist and physician-scientist at the Children’s Hospital of Philadelphia and University of Pennsylvania School of Medicine who is interested in development of molecularly-targeted therapeutics for children with high-risk leukemias. She is a graduate of the University of Notre Dame (BS, BA) and Baylor College of Medicine (MD), and she trained in Pediatrics at Seattle Children’s Hospital and in Pediatric Hematology-Oncology at University of California, San Francisco (UCSF). She specialises in the clinical care of children with hematologic malignancies and is an internationally-recognized expert in pediatric ALL and AML. Her bench-to-bedside and bedside-back-to-bench translational laboratory research program focuses upon testing of kinase inhibitors and chimeric antigen receptor (CAR) T cell immunotherapies in genetic subsets of childhood ALL and AML. Dr Tasian has leadership roles in the Children’s Oncology Group (COG) ALL and Myeloid Diseases committees and Leukemia Lymphoma Society PedAL/EuPAL consortium, is the COG Developmental Therapeutics committee Vice-Chair of Biology for Hematologic Malignancies, and leads or co-leads several national or international early phase clinical trials testing precision medicine therapies in children with high-risk leukemias.

Dr. Tasian believes in comprehensive, compassionate care of her patients and their families, recognizing that a diagnosis of childhood cancer and its associated intensive therapies are life-changing experiences that impact the entire family.

Dr. Tasian's profile on the Perelman School of Medicine at the University of Pennsylvania website.

Education and Training

Medical School

MD - Baylor College of Medicine, Houston, TX

Residency

Pediatrics - Seattle Children’s Hospital and University of Washington, Seattle, WA

Fellowship

Pediatric Hematology-Oncology - University of California, San Francisco (UCSF), San Francisco, CA

Additional Training

National Institutes of Health-Howard Hughes Medical Institute Research Scholars Program - National Cancer Institute/Pediatric Oncology Branch, Bethesda, MD (Tumor Immunology)

Board Certification

Pediatric Hematology-Oncology
Pediatrics

Titles and Academic Titles

Chief, Hematologic Malignancies Program

Attending Physician, Division of Oncology

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Areas of Focus

Laboratories & Research Programs

Research Topics

Publications

Papers

2021

Pikman Y, Tasian SK, Sulis ML, Stevenson K, Blonquist TM, Apsel Winger B, Cooper TM, Pauly M, Maloney KW, Burke MJ, Brown PA, Gossai N, McNeer JL, Shukla NN, Cole PD, Kahn JM, Chen J, Barth MJ, Magee JA, Gennarini L, Adhav AA, Clinton CM, Ocasio-Martinez N, Gotti G, Li Y, Lin S, Imamovic A, Tognon CE, Patel T, Faust HL, Contreras CF, Cremer A, Cortopassi WA, Garrido Ruiz D, Jacobson MP, Dharia NV, Su A, Robichaud AL, Saur Conway A, Tarlock K, Stieglitz E, Place AE, Puissant A, Hunger SP, Kim AS, Lindeman NI, Gore L, Janeway KA, Silverman LB, Tyner JW, Harris MH, Loh ML, Stegmaier K. Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium. Cancer Discov. 2021, online ahead of print. PMID 33563661

Si SJ, Tasian SK, Bassiri H, Fisher BT, Atalla J, Patel R, Romberg N, Lambert MP, Paessler M, Behrens EJ, Teachey DT, Sullivan KE. Diagnostic Challenges in Pediatric Hemophagocytic Lymphohistiocytosis.  J Clin Immunol. 2021, online ahead of print. PMID 33761058

Duault C, Kumar A, Taghi Khani A, Lee SJ, Yang L, Huang M, Hurtz C, Manning B, Ghoda LY, McDonald T, Lacayo NJ, Sakamoto KM, Carroll MP, Tasian SK, Marcucci G, Yu J, Caligiuri MA, Maecker HT, Swaminathan S. Activated Natural Killer Cells Predict Poor Clinical Prognosis in High-risk B- and T- cell Acute Lymphoblastic Leukemia. Blood. 2021, online ahead of print. PMID 34077953

Ding YY, Kim H, Madden K, Loftus JP, Chen GM, Hottman DA, Zhang R, Xu J, Hu Y, Tasian SK*, Tan K.* Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia. Clinical Cancer Research. 2021, in press. (*co-senior authors)

Niswander LM, Loftus JP, Lainey E, Cayé-Eude A, Pondrom M, Hottman DA, Iacobucci I, Mullighan CG, Jain NG, Konopleva M, Cavé H, Baruchel A, Rohrlich PS*, Tasian SK*. Therapeutic Potential of Ruxolitinib and Ponatinib in Patients with EPOR-Rearranged Ph-like ALL. Haematologica. 2021, in press. (*co-senior authors)

Schulz L, Torres-Diz M, Cortés-López M, Hayer KE, Asnani M, Tasian SK, Barash Y, Sotillo E, Zarnack K, König J, Thomas-Tikhonenko A. Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts. Genome Biology. 2021, in press. PMID 34183059.

Tasian SK, Silverman LB, Whitlock JA, Sposto R, Loftus JP, Schafer ES, Schultz KR, Hutchinson RJ, Gaynon PS, Orgel E, Bateman CM, Cooper TM, Laetsch TW, Sulis ML, Chi Y-Y, Malvar J, Wayne AS, Rheingold SR. Temsirolimus Combined with Cyclophosphamide and Etoposide for Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia: a Therapeutic Advances in Childhood Leukemia Consortium Trial (TACL 2014-001) 2021, submitted.

Qin H, Yang L, Chukinas JA, Shah NN, Tarun S, Pouzolles M, Chien CD Niswander LM, Welch AR, Taylor NA, Tasian SK*, Fry TJ*. Systematic Preclinical Evaluation of CD33-Directed Chimeric Antigen Receptor T Cell Immunotherapy for Acute Myeloid Leukemia Defines Optimized Construct Design. 2021, submitted. (*co-senior authors)

2020

Liou Am Van Arnam J, Pillai V, Seif AE, Tasian SK, Phillips CA. Transient atypical monocytosis aftere a/b Tt-cell-depleted haploidentical hematopoietic stem cell transplantation. Pediatr Blood Cancer. 67(4): e21893, 2020. PMID 31867817

Hurtz C, Wertheim GB, Loftus JP, Blumenthal D, Lehman A, Li Y, Manning B, Cummins KD, Burkhardt JK, Perl AE, Caroll M, Tasian SK. Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia. J Clin Invest. 130(7): 3637-3653, 2020. PMID 32191635

Loftus JP, Yahiaoui A, Brown PA, Wang M, Shauf A, Tannheimer S, Tasian SK. Combinatorial Efficacy of Entospletinib and Chemotherapy in Patient-Derived Xenograft Models of Infant ALL. Haematologica. 106(4):1067-1078, 2020. PMID 32313848

Vadakeklolathu J, Minden MD, Hood T, Church SE, Reeder S, Altmann H, Sullivan AM, Viboch E, Patel T, Ibramimova N, Warren SE, Arruda A, Liang Y, Schmitz M, Cesano A, Valk PJM, Löwenberg B, Pockley AG, Bornhäuser M, Tasian SK, Rettig MP, Davidson-Moncada J, DiPersio JF, Rutella S. Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia. Sci Transl Med. 12(546): eaaz0463, 2020. PMID 32493790

He B, Gao P, Ding YY, Chen C-H, Chen G, Chen C, Kim H, Tasian SK, Hunger SP, Tan K. Diverse Non-Coding Mutations Contribute to Deregulation of Cis-Regulatory Landscape in Pediatric Cancers. Science Advances. 6(30): eaba3064, 2020. PMID 32832663

Pearson ADJ, Zwaan CM, Kolb EA, Karres D, Guillot J, Kim SY, Marshall L, Tasian SK, Smith M, Cooper T, Adamson PC, Barry E, Benettaib B, Binlich F, Borgman A, Brivio E, Capdeville R, Delgado D, Faller DV, Fogelstrand L, Goodman Fraenkel P, Hasle H, Heenen D, Kaspers G, Kieran M, Klusmann J-H, Lesa G, Ligas F, Mappa S, Mohamed H, Moore A, Morris J, Nottage K, Reinhardt D, Scobie N, Simko S, Winkler T, Norge K, Reaman G, Vassal G. Paediatric Strategy Forum for Medicinal Product Development for Acute Myeloid Leukaemia In Children and Adolescents: ACCELERATE in Collaboration with the European Medicines Agency with Participation of the Food and Drug Administration. Eur J Cancer. 136: 116-129, 2020. PMID 32688206

Contreras CF, Higham CS, Behnert A, Kim K, Stieglitz E, Tasian SK. Clinical Utilization of Blinatumomab and Inotuzumab Immunotherapy in Children with Relapsed or Refractory B-Acute Lymphoblastic Leukemia. Pediatr Blood Cancer. 24: e28718, online ahead of print, 2020. PMID 33098744

Hecht A, Meyer JA, Behnert A, Wong E, Chehab F, Olshen A, Hechmer A, Aftandilian C, Bhat R, Choi SW, Chonat S, Farrar JE, Fluchel M, Frangoul H, Han JH, Kolb EA, Kuo DJ, MacMillan ML, Maese L, Maloney KW, Narendran A, Oshrine B, Schultz KR, Sulis ML, Van Mater D, Tasian SK, Hofmann WK, Loh ML, Stieglitz E. Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia. Haematologica. Online ahead of print, 2020. PMID 33375775

2019

Tasian SK, Casas JA, Posocco D, Gandre-Babbe S, Gagne AL, Liang G, Loh ML, Weiss MJ, French DL, Chou ST. Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells. Leukemia. 33(1): 181-190, 2019. PMID: 2988490

Gagne AL, Maguire JA, Gandre-Babbe S, Chou ST, Tasian SK, Loh ML, Weiss MJ, Gadue P, French DL. Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL. Stem Cell Res. 31: 157-160, 2018. PMID: 30096712

Black KL, Naqvi AS, Asnani M, Hayer KE, Yang SY, Gillespie E, Bagashev A, Pillai V, Tasian SK, Gazzara MR, Carroll M, Taylor D, Lynch KW, Barash Y, Thomas-Tikhonenko A. Aberrant splicing in B-cell acute lymphoblastic leukemia. Nucleic Acids Res. 46(21): 11357-11369, 2018. PMID: 30357359

Urtishak KA, Wang LS, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen IL, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden KLB, Felix CA. Oncogene. 38(13): 2241-2262, 2019. PMID 30478448

Wagner S, Vadakeklolathu J, Tasian SK, Altmann H, Bornhäuser M, Pockley AG, Ball GR, Rutella S. A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study. Blood Adv. 3(8): 1330-1346, 2019. PMID 31015209

Surrey LF, MacFarland SP, Chang F, Cao K, Rathi KS, Akgumus GT, Gallo D, Lin F, Gleason A, Raman P, Aplenc R, Bagatell R, Minturn J, Mosse Y, Santi M, Tasian SK, Waanders AJ, Sarmady M, Maris JM, Hunger SP, Li MM. Clinical utility of custom-designed NGS panel testing in pediatric tumors. Genome Med. 11(1):32, 2019. PMID 3113306833.

Chang F, Lin F, Cao K, Surrey LF, Aplenc R, Bagatell R, Resnick AC, Santi M, Storm PB, Tasian SK, Waanders AJ, Hunger SP, Li MM. Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. J Mol Diagn. 21(5): 873-883, 2019. PMID 3125579

2018

Zhang Q, Shi C, Han L, Jain N, Roberts KG, Ma H, Cai T, Cavazos A, Tabe Y, Jacamo R, Mu H, Zhao Y, Wang J, Wu SC, Cao F, Zeng Z, Zhou J, Mi Y, Jabbour EJ, Levine R, Tasian SK, Mullighan CG, Weinstock DM, Fruman DA, Konopleva M. Inhibition of mTORC1/C2 Signaling Improves Anti-Leukemia Efficacy of JAK/STAT Blockade in CRLF2-Rearranged and/ or JAK-Driven Philadelphia Chromosome-Like Acute B-Cell Lymphoblastic Leukemia. Oncotarget. 9: 8027-8041, 2018.  PMID: 29487712

Gotesman M, Vo TTT, Herzog LO, Tea T, Mallya S, Tasian SK, Konopleva M, Fruman DA.  mTOR Inhibition Enhances Efficacy of Dasatinib in ABL-rearranged Ph-like B-ALL. Oncotarget. 9: 6562-6571, 2018. PMID: 29464092

Ding YY, Stern JW, Jubelirer TF, Wertheim GB, Li F, Chang F, Gu Z, Mullighan CG, Li Y, Harvey RC, Chen I-M, Willman CL, Hunger SP, Li MM, Tasian SK. Clinical Efficacy of Ruxolitinib and Chemotherapy in a Child with Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia with GOLGA5-JAK2 Fusion and Induction Failure. Haematologica. 103(9):e427-e431, 2018. PMID: 29773603

Abstracts

2020

Bagashev A, Ross S, Fry TJ*, Tasian SK*. Co-Targeting of the Thymic Stromal Lymphopoietin Receptor to Decrease Immunotherapeutic Resistance in CRLF2-Rearranged Ph-like ALL. 2020. (accepted abstract at 12th Biennial Childhood Leukemia & Lymphoma Symposium; Valencia, Spain – meeting canceled due to viral pandemic. *co-senior authors)

Zhao X, Li MM, Schubert J, Wu J, Lin F, Wertheim GB, Surrey L, Luo M, Zhong Y, Wu C, Cao K, Aplenc R, Bagatell R, Mosse YP, Olson TS, Santi M, Tasian SK, Storm P, Maris JM, Hunger S. Clinical Significance of Serial Tumor Next Generation Sequencing (NGS) in 155 Pediatric Cancer Patients. J Clin Oncol. Abstract #306513, 2020. (Poster presentation at ASCO annual meeting given by collaborator; virtual meeting due to viral pandemic)

Rheingold SR, Silverman LB, Whitlock JA, Sposto R, Schafer ES, Schultz KR, Hutchinson RJ, Gaynon PG, Bateman C, Cooper TM, Laetsch TW, Sulis ML, Wayne AL, Tasian SK. Temsirolimus combined with etoposide and cyclophosphamide for relapsed/refractory acute lymphoblastic leukemia: Therapeutic advances in Childhood Leukemia Consortium (TACL 2014-001) trial. J Clin Oncol. Abstract #312377, 2020. (Oral presentation at ASCO annual meeting given by collaborator; virtual meeting due to viral pandemic)

Tasian SK, Dai Y, Devidas M, Roberts KG, Harvey RC, Chen I-M, Carroll AJ, Heerema NA, Reshmi SC, Gastier-Foster JM, Borowitz MJ, Wood BL, Mullighan CG, Willman CL, Maloney KW, Larsen EC, Angiolillo AL, Schore RJ, Burke MJ, Salter WL, Winick NJ, Carroll WL, Hunger SP, Raetz EA, Rabin KR, Loh ML. Outcomes of Patients with CRLF2-Overexpressing Acute Lymphoblastic Leukemia without Down Syndrome: a Report from the Children’s Oncology Group. Blood. Abstract #1095, 2020. (Oral poster presentation at ASH annual meeting – meeting held virtually due to viral pandemic)

Rabin KR, Devidas M, Chen Z, Dai Y, Tasian SK, Hitzler JK, Roberts KG, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Mullighan CG, Harvey RC, Chen I-M, Willman CL, Reshmi SC, Gastier-Foster JM, Maloney KW, Larsen EC, Schore RJ, Burke MJ, Salter WL, Winick NJ, Carroll WL, Raetz EA, Angiolillo AL, Loh ML,Hunger SP. Outcomes of Patients with Down Syndrome and CRLF2-Overexpressing Acute Lymphoblastic Leukemia (ALL): A Report from the Children’s Oncology Group (COG). Blood. Abstract #1094, 2020. (Oral poster presentation at ASH annual meeting given by collaborator – meeting held virtually due to viral pandemic)

Hurtz C, Wertheim GB, Bhansali R, Lee SJ, Kumar A, Lehman A, Jeschke GR, Crispino J, Besson T, Shi J, Swaminathan S, Tasian SK*, Carroll M*. DYRK1A Is Required to Alleviate Replication Stress in KMT2A-Rearranged Acute Lymphoblastic Leukemia. Blood. Abstract #1095, 2020. (Oral presentation at ASH annual meeting given by collaborator – meeting held virtually due to viral pandemic; *co-senior authors)

2019

Niswander LN, Chien CD, Bagashev A, Chukinas AJ, Leach L, Graff Z, Tasian SK*, Fry TJ*. Multi-Modal Targeting of FLT3R Signaling with Chimeric Antigen Receptor T Cell Immunotherapy and Tyrosine Kinase Inhibition in High-Risk Pediatric Leukemias. 2019. (Poster presentation at NCI PI-DDN annual meeting; Rockville, MD; *co-senior authors)

Bagashev A, Ross S, Fry TJ*, Tasian SK*. Co-Targeting of the Thymic Stromal Lymphopoietin Receptor to Decrease Immunotherapeutic Resistance in CRLF2-Rearranged Ph-like ALL. 2019. (Poster presentation at NCI PI-DDN annual meeting; Rockville, MD; *co-senior authors)

Lamble AJ, Eidenschink Brodersen L, Alonzo TA, Wing J, Gerbing RB, Pardo L, Sung L, Tasian SK, Cooper TM, Kolb EA, Aplenc R, Loken MR, Meshinchi S. Correlation of CD123 Expression Level with Disease Characteristics and Outcomes in Pediatric Acute Myeloid Leukemia: A Report from the Children’s Oncology Group. Abstract #459, 2019. (Oral presentation at ASH annual meeting; Orlando, Florida)

Vadakekolathu J, Minden MD, Hood T, Church SE, Reeder S,Altmann H, Sullivan AH, Viboch EJ, Patel T, Ibrahimova N, Warren SE, Arruda A, Schmitz M, Liang Y, Cesano A, Pockley AG, Vlak P, Löwenberg B, Bornhäuser M, Tasian SK, Rettig MP, Davidson-Moncada JK, DiPersio JF, Rutella S. Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia. Abstract #460, 2019. (Oral presentation at ASH annual meeting; Orlando, Florida)

Hurtz C, Wertheim G, Loftus JP, Blumenthal D, Lehman A, Li Y, Manning B, Cummins KD, Burkhardt JK, Perl AE, Carroll M, Tasian SK. Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Ph-like ALL. Abstract #757, 2019. (Oral presentation at ASH annual meeting; Orlando, Florida; ASH abstract achievement award for mentee)

Hurtz C, Wertheim G, Bhansali RDS, Lehman A, Jeschke G, Crispino JD, Besson T, Tasian SK*, Carroll M*. DYRK1A is Regulated by Oncogenic KMT2A and Required for Survival of KMT2A-Rearranged Acute Lymphoblastic Leukemia. Abstract #2742, 2019. (Poster presentation at ASH annual meeting; Orlando, Florida. *co-senior authors)

Pufall MA, Fang M, Bradley RK, Guo-Liang C, Lanier R, Tasian SK. Glucocorticoids Regulate the Splicing Factor MBNL1, a Potential Control Point for B-Cell Specification. Abstract #2478, 2019. (Poster presentation at ASH annual meeting; Orlando, Florida.)

Zimmerman JAO, Fang M, Modi A, Dupuy A, Tasian SK, Pufall MA. PI3K Inhibition Enhances Sensitivity of Primary High-Risk Childhood B-Cell Acute Lymphoblastic Leukemia Cells to Glucocorticoid Chemotherapy. Abstract #2572, 2019. (Poster presentation at ASH annual meeting; Orlando, Florida.)

 

Books

Chapters

2021

Tasian SK. Are we ABL to do better for children with BCR-ABL1-like acute lymphocytic leukaemia? Lancet Haematol. 2021 Jan;8(1):e6-e8. PMID 33357484

Tran TH and Tasian SK. Management of Ph-like ALL. Pathogenesis and Treatment of Acute Leukemia, edited by Harinder Gill. Basel, Switzerland; Springer Nature Publishing, in press, 2021.

Tasian SK. Immunotherapy and TKIs: Precision Agonism or Antagonism for Ph+ ALL. The Hematologist. 18(2). 2021.

SE Conneely and Tasian SK. Take Your ‘Asparagus Medicine,’ Kids! The Hematologist. 2021.

Pommert L and Tasian SK. Chemotherapy Drug Shortages in Pediatric Oncology: A Global Public Health Crisis Threatening Our Children. The Hematologist. 2021.

Lamble AJ and Tasian SK. Bacon-Wrapped Chemo: Can LiposomalCytarabine/Daunomycin Improve Outcomes for Children with Newly-Diagnosed AML Versus Conventional Therapy? The Hematologist. 2021.

2020

Harvey RC and Tasian SK. Clinical Testing for Philadelphia Chromosome-like Acute Lymphoblastic Leukemia. Blood Adv. 4(1): 218-228, 2020. PMID 31935290

Bonifant CL and Tasian SK. The Future of Immunotherapy for Childhood Leukemia. Curr Opin Pediatr. 32(1): 13-25, 2020. PMID 31851053

Curran EK and Tasian SK. Ph-like ALL: Diagnosis and Management. Hematologic Malignancies: Acute Leukemias. (editors Faderl/Kantarjian/Estey) Springer Publishing, 2020, in press.

Tran TH and Tasian SK. Treatment of Ph-like ALL. Acute Lymphoblastic Leukemia: Translational Science and Clinical Management for Children and Adults from the Bench to the Bedside, edited by Mark M Litzow and Elizabeth A Raetz. Basel, Switzerland; Springer Nature Publishing, in press, 2020.

Tasian SK and Peters C. Targeted therapy or transplantation for paediatric ABL-class Ph-like acute lymphocytic leukaemia? Lancet Haematol. 2020 Dec;7(12):e858-e859. PMID 33242441

2019

Lamble AJ and Tasian SK. Opportunities for Immunotherapy in Childhood AML. Blood Adv. 3(22): 3750-3758, 2019.  PMID 31770440

Lamble AJ and Tasian SK. Opportunities for Immunotherapy in Childhood AML. Hematology Am Soc Hemtol Educ Program. 2019(1): 218-225. PMID 31808843

Awards and Honors

2021, CHOP Pediatric Residency Faculty Honor Roll Teaching Award

2020, CHOP Pediatric Hematology/Oncology Fellow Teaching Award

2018, American Society of Clinical Investigation (ASCI) Young Investigator

2015, Best of ASH Annual Meeting recognition for oral presentation

2014, Best poster presentation, International Society of Paediatric Oncology annual conference

2013-2014, Canuso Foundation Innovation Award

2013-2014, ALSF Scholar in Developmental Therapeutics

2012-2014, Alex’s Lemonade Stand Foundation Young Investigator Award

2011-2012, American Society of Clinical Oncology Young Investigator Award

2010, American Society of Clinical Oncology Trainee Travel Award

2010, American Society of Hematology Travel Award

2009-2014, National Institutes of Health Loan Repayment Program (NIH-LRP)

2009, UCSF Pediatric Fellow Teaching Award

2002-2004, Alpha Omega Alpha, cum laude 

2001-2002, HHMI-NIH Research Scholars Program fellowship

1999, Outstanding Senior Student in Notre Dame Honors Program

1999, Honors Program, Phi Beta Kappa, summa cum laude

1999, USA Today Academic All-American

1995-1999, University of Notre Dame Honors Program

1995, National Merit Finalist

1995, University of Notre Dame Early Action Scholar

1995, Graduated Salutatorian and Summa Cum Laude - Saint Agnes Academy, Houston, TX

Editorial and Academic Positions

Editorial Positions

2014-present, Frontiers in Oncology, review editor

Ad hoc reviewer

2015 – present, Pediatric Blood and Cancer 

2015-present, PLOS One  

​2015-present, British Journal of Clinical Pharmacology

2014-present, British Journal of Hematology

2014-present, American Journal of Hematology

2014-present, Blood

2014-present, British Medical Journal

2012-present, Leukemia

2012-present, Haematologica

Review editor

2014-present, American Journal of Hematology

Academic and Institutional Committees

2012-present, Pediatric Hematology-Oncology Fellowship, committee interviewer

2011-present, Pediatric Protocol Review Committee

2011-present, Hematologic Malignancies Steering Committee

Leadership and Memberships

Memberships in professional organizations

International

2016 - present, Member, International BFM Study Group (iBFM)

2016 - present, Member, European Hematology Association (EHA)

2014-present, International Society of Paediatric Oncology/Société Internationale D’Oncologie Pédiatrique  (SIOP)

2008-present, Children’s Oncology Group

2015-present, AALL1521 Study Chair

2014-present, ALL Disease Committee Member

2014-present, AALL1331 Study Committee Member

2013-present, Ph-like ALL Working Group Member

2013-present, AML New Agents Committee Member

2013-present, Myeloid Disease Committee Member

2011-present, ADVL1011 Study Committee Member

National

2010-present, American Society of Clinical Oncology

2009-present, American Society of Pediatric Hematology-Oncology

2007-present, American Society of Hematology