Carolyn A. Felix, MD

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Carolyn A. Felix, MD, is an attending physician at the Cancer Center at Children's Hospital of Philadelphia, with an expertise in treating leukemia in children.

Areas of Expertise: Leukemia as a complication of anticancer treatment, Leukemia in infants, Molecular pathogenesis of childhood leukemia
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Boston University School of Medicine, Boston, MA


Pediatrics - Children's Hospital of Pittsburgh, PA


Pediatrics - Children's Hospital of Pittsburgh, PA


Medical Staff Fellow - National Cancer Institute, Pediatric Branch, NIH, Bethesda, MD
Biotechnology Fellow - Pediatric Branch, National Cancer Institute, Bethesda, MD

Board Certification

Hematology – American Board of Internal Medicine
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Areas of Focus

Laboratories & Research Programs

Research Topics




Robinson BW, Kairalla JA, Devidas M, Carroll AJ, Harvey RC, Heerema NA, Willman CL, Ball AR, Woods EC, Ballantyne NC, Urtishak KA, Behm FG, Reaman GH, Hilden JM, Camitta BM, Winick NJ, Pullen J, Carroll WL, Hunger SP, Dreyer ZE, Felix CA. KMT2A partner genes in infant acute lymphoblastic leukemia have prognostic significance and correlate with age, white blood cell count, sex, and central nervous system involvement: a Children's Oncology Group P9407 trial study. Haematologica. 2023 Mar 2. Epub 2023/03/03. doi:10.3324/haematol.2022.281552. PMID 36861410.


Felix, CA, Slater, DJ, Davenport, JW, Yu, X, Gregory, BD, Li, MM, Rappaport, EF, Cheung, NV. KMT2A-MAML2 Rearrangement Emerged and Regressed During Neuroblastoma Therapy without Leukemia after 12.8-Year Follow-Up. Pediatr Blood Cancer. Jan 2022; 69(1): e29344.

Germano, G, Porazzi, P, Felix, CA. Leukemia-Associated Transcription Factor Mllt3 Is Important for Primitive Erythroid Development in Zebrafish Embryogenesis. Dev Dyn  (Apr 16 2022).


Chen, C, Yu, W, Alikarami, F, Qiu, Q, Chen, CH, Flournoy, J, Gao, P, Uzun, Y, Fang, L, Davenport, JW, Hu, Y, Zhu, Q, Wang, K, Libbrecht, C, Felmeister, A, Rozich, I, Ding, YY, Hunger, SP, Felix, CA, Wu, H, Brown, PA, Guest, EM, Barrett, DM, Bernt, KM, Tan, K. Single-cell multiomics reveals increased plasticity, resistant populations and stem-cell-like blasts in KMT2A-rearranged leukemia. Blood. 2021 Dec 5. pii: 482898. doi: 10.1182/blood.2021013442. PMID: 34864916


Urtishak KA, Wang LS, Culjkovic-Kraljacic B, Davenport JW, Porazzi P, Vincent TL, Teachey DT, Tasian SK, Moore JS, Seif AE, Jin S, Barrett JS, Robinson BW, Chen IL, Harvey RC, Carroll MP, Carroll AJ, Heerema NA, Devidas M, Dreyer ZE, Hilden JM, Hunger SP, Willman CL, Borden KLB, Felix CA. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38(13):2241-2262.Epub 2018 Nov 26. PMID: 30478448.


Yu, X., Davenport, J.W., Urtishak, K.A. Carillo, M.L., Gosai, S.J., Kolaris, C.P., Byl, J.A.W., Rappaport, E.F., Osheroff, N., Gregory, B.D.*, Felix, C.A.* (*Co-corresponding). Genome-Wide TOP2A DNA Cleavage is Biased Towards Translocated and Highly Transcribed Loci. Genome Res. 27 (7) 1238-1249; 2017; Accession Number 28385713; doi 10.1101/gr.211615.116; PMC5495075.


Urtishak, K. A., Robinson, B. W., Rappaport, E. F., Sarezky, M. D., Biegel, J. A., Nichols, K. E., Wilmoth, D. M., Wang, L. S., Stern, J. W., Felix, C. A.  Unique Familial MLL(KMT2A)-Rearranged Precursor B Cell Infant Acute Lymphoblastic Leukemia (ALL) in Non-twin Siblings. Pediatr Blood Cancer [Epub 2016 March 21. doi: 10.1002/pbc.25957] Accession Number 26999444.

Awards and Honors

2012, Joshua Kahan Endowed Chair in Pediatric Leukemia

2007, America's Top Doctors For Cancer

2006, Eagles Fly for Leukemia Award for Excellence in Treatment of Pediatric Cancer Patients

2006, Association of American Physicians (Elected Member)

2005-2006, 2009-2012, Philadelphia Magazine Top Doctors

2003, Society for Pediatric Research (Elected Member)

2001, Stohlman Scholar Award, Leukemia & Lymphoma Society

2000, Honorary Master of Arts Degree, University of Pennsylvania

2000, Eastern Pennsylvania Chapter Leukemia & Lymphoma Society Distinguished Leadership Award

1999, Klaus and Mary Hummeler Endowed Research Prize, The Children's Hospital of Philadelphia

1999, Eastern Pennsylvania Chapter Leukemia Society of America Distinguished Leadership Award

1992, American Society of Clinical Oncology Young Investigator Award

1991, American Association for Cancer Research Travel Award

1990, American Society of Pediatric Hematology-Oncology Young Investigator Award

1988, American Society of Hematology Travel Award

1987, American Society of Clinical Oncology Young Investigator in Training Travel Award

1977, Alpha Sigma Nu

1977, Alpha Epsilon Delta

1976, Phi Beta Kappa-junior year induction

1977, Graduated summa cum laude - Boston College, Chestnut Hill, MA

1973-1977, Boston College Honors Program

Editorial and Academic Positions

Editorial Positions

2013-present, Blood, editorial board

2004-2014, Pediatric Blood & Cancer, editorial board

Ad Hoc Reviewer for Journals

American Journal of Hematology

American Journal of Human Genetics



British Journal of Cancer

British Journal of Haematology


Cancer Genetics and Cytogenetics

Cancer Letters

Cancer Research

Clinical Cancer Research

Clinical and Diagnostic Laboratory Immunology

Genes, Chromosomes and Cancer

International Journal of Pediatric Hematology/Oncology

Journal of Clinical Investigation

Journal of Clinical Oncology

Journal of the National Cancer Institute

Journal of Pediatrics


Molecular Diagnosis

New England Journal of  Medicine


Pediatric Blood & Cancer

Proceedings of the National Academy of Sciences

The American Journal of Human Genetics

The Journal of Pediatric Hematology-Oncology

European Journal of Hematology 

Ad Hoc Reviewer for Grants

Leukemia & Lymphoma Society, Academic Clinical Trials Program Peer Review Committee

Academic and Institutional Committees

2011-2014, Hearings List for the Faculty Grievance Commission

2004-present, Research Affinity Group (RAG) Council, Joseph Stokes, Jr. Research Institute

2003-present, Normal and Malignant Hematopoiesis Research Affinity Group Leader

1999-present, University of Pennsylvania School of Medicine Combined Degree Admissions/Advisory Committee

1998, Founding Member, Center for Cancer Pharmacology, University of Pennsylvania Cancer Center

Leadership and Memberships

Memberships in Professional Organizations

2006-present, Association of American Physicians

2003-present, Society for Pediatric Research

2000-present, Children’s Oncology Group

1999-present, American Association for the Advancement of Science

1994-present, American Society of Hematology

1992-present, American Society of Clinical Oncology

1991-present, American Association for Cancer Research

1988-present, American Society of Pediatric Hematology-Oncology

Major Teaching and Clinical Responsibilities at the University of Pennsylvania

2022, External Examiner for PhD Thesis Committee of Grace Egan, MD, FRCP, Laboratory of Aaron D. Schimmer, MD, PhD, FRCPC, The Hospital for Sick Children and Princess Margaret Cancer Centre, University of Toronto