Areas of Expertise:
Leukemia as a complication of anticancer treatment, Leukemia in infants, Molecular pathogenesis of childhood leukemia
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)
Education and Training
MD - Boston University School of Medicine, Boston, MA
Pediatrics - Children's Hospital of Pittsburgh, PA
Pediatrics - Children's Hospital of Pittsburgh, PA
Medical Staff Fellow - National Cancer Institute, Pediatric Branch, NIH, Bethesda, MD
Biotechnology Fellow - Pediatric Branch, National Cancer Institute, Bethesda, MD
Titles and Academic Titles
Joshua Kahan Endowed Chair in Pediatric Leukemia
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Areas of Focus
- Evaluation of the Antiviral Agent Ribavirin as a Treatment for Acute Lymphoblastic Leukemia (ALL) in Infants
- The Role of Topoisomerase (TOP2) Cleavage in Leukemia-Causing Chromosomal Translocations
Laboratories & Research Programs
Urtishak KA, Robinson BW, Rappaport EF, Sarezky MD, Biegel JA, Nichols KE, Wilmoth DM, Wang LS, Stern JW, Felix CA. Unique Familial MLL(KMT2A)-Rearranged Precursor B-Cell Infant Acute Lymphoblastic Leukemia in Non-twin Siblings. Pediatr Blood Cancer. 2016 Jul;63(7):1175-80. doi: 10.1002/pbc.25957. Epub 2016 Mar 21. PMID: 26999444.
Peng M, Ostrovsky J, Kwon Y, Polvak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser D, Argon Y, Falk M. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Hum Mol Genet [Epub 2015 Jun 3. doi: 10.1093/hmg/ddv207] Accession number 26041819
Dreyer, Z.E., Hilden, J.M., Jones, T., Devidas, M., Winick, N.J., Willman, C.L., Harvey, R.C., Chen, I.-M., Behm, F.G., Pullen J., Wood, B.L., Carroll A.J., Heerema, N.A., Felix, C.A., Robinson, B., Reaman G.H., Salzer,W.L., Hunger, S.P., Carroll, W.L., Camitta, B.M. Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3). Pediatr Blood Cancer. 62(3) 419-426,2015 [Epub Nov 2014. doi: 10.1002/pbc.25322]
Barker DE, Dragnani TA, Dunnick JK, Felix CA, Ferguson LR, Joel SP, von Kries R, van Leeuwen FE, Little J, Olin S, Olsen JH, Poirier MC, Shearer MJ, Slikker Jr, W, Sullivan FM, Tursov V, Walker VE. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 76. Lyon: IARC Press, 2000.
O'Sullivan MJ, Felix CA, Fletcher JA. Chapter 45. Cytogenetic and Molecular Pathology of Pediatric Cancer. In: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG, editors. Oncology of Infancy and Childhood. 8th ed. Philadelphia: Saunders Elsevier; 2015.
Felix CA. Therapy-Related Leukemias. In: Pui, CH, editor. Childhood Leukemias. 3rd Ed. Cambridge (UK): Cambridge University Press; 2012. p. 723-771.
Brown PA, Felix CA. Molecularly Targeted Therapy for Infant ALL. In: Arceci RJ, Houghton PJ, editors. Molecularly Targeted Therapy for Childhood Cancer. New York (NY): Springer Science; 2010. p. 31-58.
O'Sullivan MJ, Fletcher JA, Felix CA. Chapter 5. Cytogenetic and Molecular Pathology of Pediatric Cancer. In: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG, editors. Oncology of Infancy and Childhood. 7th ed. Philadelphia (PA): Saunders Elsevier; 2009. p. 99-174.
Felix CA. Chapter 29. Secondary Myelodysplasia/Acute Myeloid Leukemia. In: Young NS, Gerson SL, High KA, editors. Clinical Hematology. 1st ed. Philadelphia (PA): Elsevier; 2006. p. 374-389.
Felix CA. Chapter 31. Therapy-Related Leukemias. In: Pui CH, editor. Childhood Leukemias. 2nd ed. Cambridge (UK): Cambridge University Press; 2006. p. 774-804.
Iannone R, Pulsipher M, Slayton W, Felix CA. A review of hematopoietic stem cell transplantation for infant acute lymphoblastic leukemia with MLL gene rearrangement. (Minireview) In: Cotter FE, editor. BloodMed. Oxford (UK): Blackwell Publishing; 2004. http://www.bloodmed.com
Felix CA. Chemotherapy-related second cancers. In: Neugut AI, Meadows AT, Robinson E, editors. Multiple Primary Cancers: Incidence, Etiology, Diagnosis and Prevention. Baltimore (MD): Williams & Wilkins; 1999. p. 137-164.
Kirsch IR, Aplan PD, Begley CG, Bertness V, Felix CA, Lipkowitz S, Nakahara K, Nussmeier M, Reynolds L, Seibel N, Stern MH, Tchorz K. Abnormal antigen receptor formation in normal, ataxia-telangiectasia, and malignant lymphocytes. In: The Molecular Basis of Immune Diseases, Miami Biotechnology Winter Symposia. IRL Press/Oxford University Press; 1990. p. 22-24, 1990.
Felix CA, Korsmeyer SJ. Immunology and molecular biology of lymphomas. In: Roth J, Ruckerderschel J, Weisenburger T, editors. Thoracic Oncology. Orlando (FL): W.B. Saunders;1998. p. 403-447.
Graninger W, Wright JJ, Felix CA, Korsmeyer SJ. Characterization of acute leukemia using lineage associated molecular probes. In: Stass SA, editor. The Acute Leukemias: Biologic, Diagnostic, and Therapeutic Determinants. New York (NY): Marcel Decker, Inc.; 1987. p. 299-325.
Kirsch IR, Bertness V, Denny C, Felix CA, Seibel N, Hollis GF. Gene rearrangements in B and T-cells. In: Gale RP, Rai K, editors. Chronic Lymphocytic Leukemia: Recent Progress, Future Directions. New York (NY): Alan R. Liss, Inc.; 1987. p. 1-10.
Korsmeyer SJ, Bakhshi A, Wright JJ, Graninger WC, Felix CA, Seto M. Molecular markers of clonality, lineage, differentiation, and translocation in B-cell neoplasms. In: Ferrarini M, editor. The Molecular Basis of B-Lymphocyte Differentiation and Function. New York (NY): Plenum Press; 1986. p. 131-139.
Posters and Presentations
Urtishak, K.A., Wang, L.-S., Teachey, D.T., Tasian, S.K., Barrett, J.S., Chen, I-M.L., Atlas, S.R., Harvey, R.C., Heerema, N.A., Carroll, A.J., Hunger, S.P., Willman, C.L., Felix, C.A. PI3K/AKT/mTOR Signaling is a Significant Druggable Pathway in Infant Acute Lymphoblastic Leukemia (ALL). Proc 55th Annual Meeting American Society of Hematology, 2013. (Presented by K. Urtishak)
“Dysregulated Gene Expression and Molecular Targeting of Infant ALL”, ACC Hematologic Malignancies Program / Normal & Malignant Hematopoiesis RAG Joint Retreat, Philadelphia, PA, September 2014.
“Pharmacologic Targeting of Cell Death and Signaling Alterations in Infant ALL,” CHOP Research Institute 2013 Scientific Symposium: Collaboration Fueling Discovery; in Plenary Session II: Mito Cell, the Search for a Signal Answer, Philadelphia, PA, May 2013.
“Flow Cytometric Assays in Therapeutic Targeting of Infant ALL,” PennFlow 2013: Measuring the Life and Death of a Cell, Philadelphia, PA, April 2013.
Awards and Honors
2012, Joshua Kahan Endowed Chair in Pediatric Leukemia
2007, America's Top Doctors For Cancer
2006, Eagles Fly for Leukemia Award for Excellence in Treatment of Pediatric Cancer Patients
2006, Association of American Physicians (Elected Member)
2005-2006, 2009-2012, Philadelphia Magazine Top Doctors
2003, Society for Pediatric Research (Elected Member)
2001, Stohlman Scholar Award, Leukemia & Lymphoma Society
2000, Honorary Master of Arts Degree, University of Pennsylvania
2000, Eastern Pennsylvania Chapter Leukemia & Lymphoma Society Distinguished Leadership Award
1999, Klaus and Mary Hummeler Endowed Research Prize, The Children's Hospital of Philadelphia
1999, Eastern Pennsylvania Chapter Leukemia Society of America Distinguished Leadership Award
1992, American Society of Clinical Oncology Young Investigator Award
1991, American Association for Cancer Research Travel Award
1990, American Society of Pediatric Hematology-Oncology Young Investigator Award
1988, American Society of Hematology Travel Award
1987, American Society of Clinical Oncology Young Investigator in Training Travel Award
1977, Alpha Sigma Nu
1977, Alpha Epsilon Delta
1976, Phi Beta Kappa-junior year induction
1977, Graduated summa cum laude - Boston College, Chestnut Hill, MA
1973-1977, Boston College Honors Program
Editorial and Academic Positions
2013-present, Blood, editorial board
2004-2014, Pediatric Blood & Cancer, editorial board
Ad Hoc Reviewer
American Journal of Hematology
American Journal of Human Genetics
British Journal of Cancer
British Journal of Haematology
Cancer Genetics and Cytogenetics
Clinical Cancer Research
Clinical and Diagnostic Laboratory Immunology
Genes, Chromosomes and Cancer
International Journal of Pediatric Hematology/Oncology
Journal of Clinical Investigation
Journal of Clinical Oncology
Journal of the National Cancer Institute
Journal of Pediatrics
New England Journal of Medicine
Pediatric Blood & Cancer
Proceedings of the National Academy of Sciences
The American Journal of Human Genetics
The Journal of Pediatric Hematology-Oncology
European Journal of Hematology
Academic and Institutional Committees
2011-2014, Hearings List for the Faculty Grievance Commission
2004-present, Research Affinity Group (RAG) Council, Joseph Stokes, Jr. Research Institute
2003-present, Normal and Malignant Hematopoiesis Research Affinity Group Leader
1999-present, University of Pennsylvania School of Medicine Combined Degree Admissions/Advisory Committee
1998, Founding Member, Center for Cancer Pharmacology, University of Pennsylvania Cancer Center
Leadership and Memberships
Memberships in Professional Organizations
2006-present, Association of American Physicians
2003-present, Society for Pediatric Research
2000-present, Children’s Oncology Group
1999-present, American Association for the Advancement of Science
1994-present, American Society of Hematology
1992-present, American Society of Clinical Oncology
1991-present, American Association for Cancer Research
1988-present, American Society of Pediatric Hematology-Oncology
Patient Experience Ratings
About the Patient Experience Rating System
The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
We are committed to true transparency. However, to ensure the comments are fair and correctly attributed, we review each one before posting to the website. We exclude entire comments that disclose patient's protected health information, are off-topic, or include other confidential or inappropriate content. Comments will appear on provider bios only if providers have a minimum number of comments.
Comments are shared internally for education purposes to ensure that we are doing our very best for the patients and families for whom we are privileged to care.
The comments are submitted by patients and families and reflect their views and opinions. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.