Carolyn A. Felix, MD

Papers

2016

Urtishak KA, Robinson BW, Rappaport EF, Sarezky MD, Biegel JA, Nichols KE, Wilmoth DM, Wang LS, Stern JW, Felix CA. Unique Familial MLL(KMT2A)-Rearranged Precursor B-Cell Infant Acute Lymphoblastic Leukemia in Non-twin Siblings. Pediatr Blood Cancer. 2016 Jul;63(7):1175-80. doi: 10.1002/pbc.25957. Epub 2016 Mar 21. PMID: 26999444.

2015

Peng M, Ostrovsky J, Kwon Y, Polvak E, Licata J, Tsukikawa M, Marty E, Thomas J, Felix CA, Xiao R, Zhang Z, Gasser D, Argon Y, Falk M. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Hum Mol Genet [Epub 2015 Jun 3. doi: 10.1093/hmg/ddv207] Accession number 26041819

2014

Dreyer, Z.E., Hilden, J.M., Jones, T., Devidas, M., Winick, N.J., Willman, C.L., Harvey, R.C., Chen, I.-M., Behm, F.G., Pullen J., Wood, B.L., Carroll A.J., Heerema, N.A., Felix, C.A., Robinson, B., Reaman G.H., Salzer,W.L., Hunger, S.P., Carroll, W.L., Camitta, B.M. Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3). Pediatr Blood Cancer. 62(3) 419-426,2015 [Epub Nov 2014. doi: 10.1002/pbc.25322]

Books

Barker DE, Dragnani TA, Dunnick JK, Felix CA, Ferguson LR, Joel SP, von Kries R, van Leeuwen FE, Little J, Olin S, Olsen JH, Poirier MC, Shearer MJ, Slikker Jr, W, Sullivan FM, Tursov V, Walker VE. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 76. Lyon: IARC Press, 2000.

Chapters

2015

O'Sullivan MJ, Felix CA, Fletcher JA. Chapter 45. Cytogenetic and Molecular Pathology of Pediatric Cancer. In: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG, editors. Oncology of Infancy and Childhood. 8th ed. Philadelphia: Saunders Elsevier; 2015.

2012

Felix CA. Therapy-Related Leukemias. In: Pui, CH, editor. Childhood Leukemias. 3rd Ed.  Cambridge (UK): Cambridge University Press; 2012. p. 723-771.

2010

Brown PA, Felix CA. Molecularly Targeted Therapy for Infant ALL. In: Arceci RJ, Houghton PJ, editors. Molecularly Targeted Therapy for Childhood Cancer. New York (NY): Springer Science; 2010. p. 31-58.

2009

O'Sullivan MJ, Fletcher JA, Felix CA. Chapter 5. Cytogenetic and Molecular Pathology of Pediatric Cancer. In: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG, editors. Oncology of Infancy and Childhood. 7th ed. Philadelphia (PA): Saunders Elsevier; 2009. p. 99-174.

2006

Felix CA. Chapter 29. Secondary Myelodysplasia/Acute Myeloid Leukemia. In: Young NS, Gerson SL, High KA, editors. Clinical Hematology. 1st ed. Philadelphia (PA): Elsevier; 2006. p. 374-389.

Felix CA. Chapter 31. Therapy-Related Leukemias. In: Pui CH, editor. Childhood Leukemias. 2nd ed. Cambridge (UK): Cambridge University Press; 2006. p. 774-804.

2004

Iannone R, Pulsipher M, Slayton W, Felix CA. A review of hematopoietic stem cell transplantation for infant acute lymphoblastic leukemia with MLL gene rearrangement. (Minireview) In: Cotter FE, editor. BloodMed. Oxford (UK): Blackwell Publishing; 2004. http://www.bloodmed.com

1999

Felix CA. Chemotherapy-related second cancers. In: Neugut AI, Meadows AT, Robinson E, editors. Multiple Primary Cancers: Incidence, Etiology, Diagnosis and Prevention. Baltimore (MD): Williams & Wilkins; 1999. p. 137-164.

1990

Kirsch IR, Aplan PD, Begley CG, Bertness V, Felix CA, Lipkowitz S, Nakahara K, Nussmeier M, Reynolds L, Seibel N, Stern MH, Tchorz K. Abnormal antigen receptor formation in normal, ataxia-telangiectasia, and malignant lymphocytes. In: The Molecular Basis of Immune Diseases, Miami Biotechnology Winter Symposia. IRL Press/Oxford University Press; 1990. p. 22-24, 1990.

1988

Felix CA, Korsmeyer SJ. Immunology and molecular biology of lymphomas. In: Roth J, Ruckerderschel J, Weisenburger T, editors. Thoracic Oncology. Orlando (FL): W.B. Saunders;1998. p. 403-447.

1987

Graninger W, Wright JJ, Felix CA, Korsmeyer SJ. Characterization of acute leukemia using lineage associated molecular probes. In: Stass SA, editor. The Acute Leukemias: Biologic, Diagnostic, and Therapeutic Determinants. New York (NY): Marcel Decker, Inc.; 1987. p. 299-325.

Kirsch IR, Bertness V, Denny C, Felix CA, Seibel N, Hollis GF. Gene rearrangements in B and T-cells. In: Gale RP, Rai K, editors. Chronic Lymphocytic Leukemia: Recent Progress, Future Directions. New York (NY): Alan R. Liss, Inc.; 1987. p. 1-10.

1986

Korsmeyer SJ, Bakhshi A, Wright JJ, Graninger WC, Felix CA, Seto M. Molecular markers of clonality, lineage, differentiation, and translocation in B-cell neoplasms. In: Ferrarini M, editor. The Molecular Basis of B-Lymphocyte Differentiation and Function. New York (NY): Plenum Press; 1986. p. 131-139.

Posters and Presentations

2013

Urtishak, K.A., Wang, L.-S., Teachey, D.T., Tasian, S.K., Barrett, J.S., Chen, I-M.L., Atlas, S.R., Harvey, R.C., Heerema, N.A., Carroll, A.J., Hunger, S.P., Willman, C.L., Felix, C.A. PI3K/AKT/mTOR Signaling is a Significant Druggable Pathway in Infant Acute Lymphoblastic Leukemia (ALL). Proc 55th Annual Meeting American Society of Hematology, 2013. (Presented by K. Urtishak)

Invited Lectures

2014

“Dysregulated Gene Expression and Molecular Targeting of Infant ALL”, ACC Hematologic Malignancies Program / Normal & Malignant Hematopoiesis RAG Joint Retreat, Philadelphia, PA, September 2014.

2013

“Pharmacologic Targeting of Cell Death and Signaling Alterations in Infant ALL,” CHOP Research Institute 2013 Scientific Symposium: Collaboration Fueling Discovery; in Plenary Session II: Mito Cell, the Search for a Signal Answer, Philadelphia, PA, May 2013.

“Flow Cytometric Assays in Therapeutic Targeting of Infant ALL,” PennFlow 2013: Measuring the Life and Death of a Cell, Philadelphia, PA, April 2013.