Vaccine History: Vaccine Availability Timeline

These dates represent when vaccines first became available. Please note that if you are unsure about having received a vaccine, this table can only tell you whether the vaccine was available, but cannot confirm whether you personally had the vaccine since not everyone in the population was immunized.

Routinely recommended vaccines

1914 – Pertussis vaccine

1926 – Diphtheria vaccine

1938 – Tetanus vaccine

1945 – Inactivated influenza vaccine - trivalent (shot; not routinely recommended)

1948 – Diphtheria, tetanus, and pertussis vaccines combined to form DTP

1955 – Inactivated polio vaccine (shot)

1960 – Live polio vaccine (oral)

1963 – Measles vaccine

1967 – Mumps vaccine

1969- Rubella vaccine

1971 – Measles, mumps and rubella vaccines combined to form MMR

1981 – Hepatitis B vaccine

1985 – Hib vaccine

1992 – DTaP vaccine

1995 – Varicella vaccine

1995-1996 – Hepatitis A vaccine

1998 – Rotavirus vaccine (Rotashield®)(removed from market 1999)

2000 – Pneumococcal conjugate vaccine

2003 – Intranasal influenza vaccine — trivalent (no longer recommended for use in 2016)

2005 – Meningococcal conjugate vaccine for adolescents

2005 – Tdap vaccine for adolescents

2006 – HPV vaccine for adolescent girls

2006 – Rotavirus vaccine (RotaTeq®)

2006 – Shingles vaccine (60 yrs & older)

2008 – Rotavirus vaccine (RotaRix®)

2009 – HPV vaccine for adolescent boys

2013 – Inactivated and intranasal influenza vaccine — quadrivalent (the intranasal version was no longer recommended for use in 2016)

2014 – Meningococcal B vaccine licensed

Vaccines not routinely recommended

1798 – Smallpox vaccine (discontinued use for general population in US 1972)

1885 – First rabies vaccines

1896 – Typhoid fever vaccine

1927 – Tuberculosis vaccine (BCG)

1930s – Japanese Encephalitis (JE) vaccine

1935 – Yellow fever vaccine

1954 – Anthrax vaccine

1965 – Currently used anthrax vaccine

1986 – Currently used JE vaccine

1997 – Currently used rabies vaccines

1999-2002 - Lyme disease vaccine (no longer available)

Reviewed by Paul A. Offit, MD on June 28, 2016

Materials in this section are updated as new information and vaccines become available. The Vaccine Education Center staff regularly reviews materials for accuracy.

You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. You should not use it to replace any relationship with a physician or other qualified healthcare professional. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel.