Researchers in the United Kingdom recently studied the impact of booster dosing on prevention of COVID-19 hospitalizations and deaths (Agrawal U, Bedston S, McCowan C, et al. Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. Lancet. 2022, Oct 15;400 (10360):1305-1320). Between December 2020 and February 2022, 16.2 million people completed their primary vaccine series and 13.8 million received a booster dose. About 59,000 of those who received their primary series and 26,000 of those who received a booster dose had severe outcomes. Those who remained at high risk of severe disease despite receiving a booster dose included:

  1. Older adults (> 80 years of age)
  2. Those with comorbidities (> 5) that put them at high risk of severe COVID-19
  3. Individuals receiving immunosuppressive therapy
  4. Those with chronic kidney disease.

These findings are consistent with those recently published by the CDC (Watkins LKF, Mitruka K, Dorough L, et al. Characteristics of reported deaths among fully vaccinated person with coronavirus disease 2019—United States, January – April 2021. Clin Infect Dis. 2022. Aug 24;75(1):e645-e652).

The authors concluded, “Older people, those with multimorbidity, and those with specific underlying health conditions remain at increased risk of COVID-19 hospitalisation and death after the initial vaccine booster and should, therefore, be prioritised for additional boosters, including novel optimized versions, and the increasing array of COVID-19 therapeutics.”

Materials in this section are updated as new information and vaccines become available. The Vaccine Education Center staff regularly reviews materials for accuracy.

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