Ingredients in Hepatitis B Vaccines
This table shows the ingredients in hepatitis B vaccines currently available for use in the U.S.
Find out more about hepatitis B and the vaccines that protect against it.
| Vaccine name* | Antigen | Adjuvant | Stabilizers | Preservatives | Residual byproducts |
|---|---|---|---|---|---|
| Engerix-B | Surface protein from hepatitis B virus | Aluminum hydroxide | Sodium chloride, Disodium phosphate dihydrate, Sodium dihydrogen phosphate dihydrate | None | Proteins from cells used to grow virus (yeast cells) |
| Heplisav-B | Surface protein from hepatitis B virus | CpG | Sodium chloride, Dibasic dodecahydrate sodium phosphate, Monobasic dihydrate sodium phosphate, Polysorbate 80 | None | Proteins and DNA from cells used to grow virus (yeast cells), Deoxycholate |
| Recombivax | Surface protein from hepatitis B virus | Amorphous aluminum hydroxyphosphate sulfate | None | None | Proteins from cells used to grow virus (yeast cells), Formaldehyde |
*Information from package insert dated: no date (Engerix-B); 9/2024 (Heplisav-B); 2/2018 (Recombivax)
This table shows ingredients in hepatitis B vaccines no longer available in the U.S. as of 2025.
| Vaccine name | Antigen | Adjuvant | Stabilizers | Preservatives | Residual byproducts |
|---|---|---|---|---|---|
| PreHevbrio* | Surface protein from hepatitis B virus (3 versions of the protein) | Aluminum hydroxide | Sodium chloride, Potassium chloride, Disodium hydrogen phosphate dodecahydrate, Potassium dihydrogen phosphate anhydrous | None | Proteins and DNA from cells used to grow virus (Chinese hamster ovary cells), Bovine serum albumin, Formaldehyde |
| *Date discontinued: November 15, 2024 Reason: Company went out of business; no vaccine safety or effectiveness concerns. More information: Manufacturer press release; FDA information | |||||
Reviewed by Paul A. Offit, MD, on May 8, 2025