Blood Bank and Transfusion Medicine Division

The Division of Blood Bank and Transfusion Medicine at Children’s Hospital of Philadelphia consists of a Blood Bank and Transfusion Service, Apheresis Unit, Cell and Gene Therapy Laboratory, Tissue Bank, and Surgical Satellite Facilities. 

We receive blood products from the American Red Cross and sponsor 4 blood drives a year at our Main Hospital as well as two other campus locations, CHOP North and Wanamaker Building. We also provide an Autologous and/or Directed Donor Collection Service through our blood supplier, The American Red Cross.  We perform over 25,000 transfusions a year including leukoreduced red blood cells and platelets, fresh frozen plasma, cryoprecipitate, granulocytes, and fresh whole blood. 

Our diverse patient populations consists of hematology and oncology patients including a large comprehensive sickle cell program as well as surgical patients including a large cardiothoracic and craniofacial patient population.  The Transfusion Service is active in participating in research in the area of blood utilization, freshness of blood, and sickle cell patient alloimmunization. The Apheresis Unit performs over 900 procedures a year focused primarily on red blood cell exchange, and also providing plasma exchange and hematopoietic progenitor cell (HPC) and T cell collections, and extracorporeal photopheresis.  

The Cell and Gene Therapy Laboratory supports an active transplant service by processing, storage, and manipulation of stem cells as well as participating in translational research, such as the CART-19 therapies and gene therapy protocols for hemoglobinopathies, progressing research in this area forward. The Division works closely with the OR to support an active tissue transplant service and to provide tissue and blood products at our surgical satellite facilities.

Directed Donations

Directed donation brochure

  • Directed donor red cell products are collected at the American Red Cross, not at Children’s Hospital of Philadelphia.
  • Each prospective donor must have an orange directed donor tag for each product donated.
  • The physician determines the blood product needed, the number needed, the date of need and the number of donors to send, and completes a directed donor tag for each donor, and gives them to the parent or patient. The Blood Bank cannot hand out directed donor tags directly to family members or to donors.
  • The parent or patient gives the tags to their selected donors.
  • The donor presents the tag at the donor center.
  • The Blood Bank has no information about directed donations until a product is actually received at the Blood Bank.


Main Hospital, 5NE35


24 hours/day, 7 days/week