The Clinical Immunology Laboratory at Children’s Hospital of Philadelphia (CHOP) offers a broad selection of standard and unique clinical assays performed by highly trained technologists. The lab offers many comprehensive, high-quality laboratory tests in immunology, oncology, hematology, rheumatology and gastroenterology. Our laboratory has a specific focus and expertise in pediatric immunodeficiencies as well as leukemia and lymphoma, where we offer specialized testing and interpretation. 

The lab uses flow cytometry for immunophenotyping studies to: 

• Characterize leukemias and lymphomas
• Enumerate T, B, and natural killer cells – along with their subsets – to diagnose severe combined immunodeficiencies (SCID) and combined immunodeficiencies
• Measure oxidative burst of phagocytes for the diagnosis of chronic granulomatous disease (CGD)
• Screen for leukocyte adhesion deficiency (LAD)
• Screen for autoimmune lymphoproliferative syndrome (ALPS)
• Aid in the diagnosis of hereditary spherocytosis (HS).
• Aid in the diagnosis of hemophagocytic lymphohistiocytosis (HLH)
• Lymphocyte function can be assessed by mitogen, antigen-stimulated lymphocyte cultures, and functional NK-cell assay 

Lymphocyte function can be assessed by mitogen- or antigen-stimulated lymphocyte cultures. 

We offer measurement of immunoglobulin levels and assessment of antibody responses to specific vaccine antigens. Specific antibody markers for autoimmune disorders and allergy testing are also available. 

Our goal is to work closely with our clinical and research colleagues to provide cutting-edge laboratory tests to expedite and aid in diagnostic patient care. 

Location

Abramson Research Center, Room 714H 

Hours

Monday – Friday, 7:30 a.m. – 5 p.m. 
No weekend or holiday hours. 

Please note: Specimens for lymphocyte cultures (mitogen, tetanus, candida, PHA-only, and newborn immunodeficiency panel), DHR assays, and hereditary spherocytosis (HS – EMA binding) assays must arrive in the lab before 11 a.m. on Fridays or the day before a holiday. 

Are you a provider shipping a sample to us?

ATTN: Clinical Immunology Laboratory | STAT LAB SPECIMEN 
Children’s Hospital of Philadelphia 
Abramson Research Center, 7th Floor 
Room 714H 
3615 Civic Center Blvd. 
Philadelphia, PA 19104 

All shipment tracking information must be sent to SpecimenTracking@CHOP.edu. 

Forms

• Clinical Immunology Requisition Form