Allergy Publications

Recent publications from Allergy Program staff cover a wide spectrum of allergy research from condition-specific diagnosis and treatments, to the genetics behind certain allergy conditions, to new therapies and potential cures being explored at Children’s Hospital of Philadelphia. Below are some of our selected publications, separated by condition.

IgE-mediated food allergy publications

2021

Brown-Whitehorn TF, de Blay F, Spergel JM, Green TD, Peillon A, Sampson HA, Campbell DE. Sustained unresponsiveness to peanut after long-term peanut epicutaneous immunotherapy. J Allergy Clin Immunol Pract 9(1), 2021 Jan;9(1):524-525. PMID: 32835872. doi: 10.1016/j.jaip.2020.08.017. Epub 2020 Aug 22.

2020

Spergel ZC, Kennedy K, Alfaro MKC, Dorris SL, Capucilli P. What constitutes a severe food allergy reaction? Ann Allergy Asthma Immunol. 020; S1081-1206(20)30390-2.

Dupuis R, Kinsey EW, Spergel JM, Brown-Whitehorn T, Graves A, Samuelson K, Epstein C, Mollen C, Cannuscio CC. Food allergy management at school. J Sch Health. 2020 May;90(5):395-406. PMID: 32124441

Dribin TE, Sampson HA, Camargo CA Jr, Brousseau DC, Spergel JM, Neuman MI, Shaker M, Campbell RL, Michelson KA, Rudders SA, Assa'ad AH, Risma KA, Castells M, Schneider LC, Wang J, Lee J, Mistry RD, Vyles D, Vaughn LM, Schumacher DJ, Witry JK, Viswanathan S, Page EM, Schnadower D. Persistent, refractory, and biphasic anaphylaxis: a multidisciplinary Delphi study. J Allergy Clin Immunol. 2020 Nov; 146(5):1089-1096. doi: 10.1016/j.jaci.2020.08.015. Epub 2020 Aug 24.

Fleischer DM, Spergel JM, Kim EH, Campbell DE, Green TD, Bee KJ, Lambert R, Ocheltree T, Sampson HA. Evaluation of daily patch application duration for epicutaneous immunotherapy for peanut allergy. Allergy Asthma Proc. 2020 Jul 1;41(4):278-284. PMID: 32517847

Dahlsgaard KK, Lewis MO, Spergel JM. New issue of food allergy: Phobia of anaphylaxis in pediatric patients. J Allergy Clin Immunol. 2020 Oct;146(4):780-782. doi: 10.1016/j.jaci.2020.07.010. Epub 2020 Jul 23. PMID: 32710976

Fleischer DM, Shreffler WG, Campbell DE, Green TD, Anvari S, Assa'ad A, Bégin P, Beyer K, Bird JA, Brown-Whitehorn T, Byrne A, Chan ES, Cheema A, Chinthrajah S, Chong HJ, Davis CM, Ford LS, Gagnon R, Greenhawt M, Hourihane JO, Jones SM, Kim EH, Lange L, Lanser BJ, Leonard S, Mahler V, Maronna A, Nowak-Wegrzyn A, Oriel RC, O'Sullivan M, Petroni D, Pongracic JA, Prescott SL, Schneider LC, Smith P, Staab D, Sussman G, Wood R, Yang WH, Lambert R, Peillon A, Bois T, Sampson HA. Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results. J Allergy Clinical Immunol. 2020 Oct; 146(4):863-874. doi: 10.1016/j.jaci.2020.06.028. Epub 2020 Jul 10.

Dupuis R, Kinsey EW, Spergel JM, Brown-Whitehorn T, Graves A, Samuelson K, Epstein C, Mollen C, Cannuscio CC. Food Allergy Management at School. J Sch Health. 2020 May;90(5):395-406. doi: 10.1111/josh.12885. Epub 2020 Mar 2.

2019

Andorf S, Purington N, Kumar D, Long A, O'Laughlin KL, Sicherer S, Sampson H, Cianferoni A, Brown-Whitehorn TB, Petroni D, Makhija M, Robison RG, Lierl M, Logsdon S, Desai M, Galli SJ, Rael E, Assa'ad A, Chinthrajah S, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Nadeau K. A Phase 2 Randomized Controlled Multisite Study Using Omalizumab-facilitated Rapid Desensitization to Test Continued vs Discontinued Dosing in Multifood Allergic Individuals. EClinical Medicine. 2019 Jan 21; 7(1):27-38. doi: 10.1016/j.eclinm.2018.12.006. eCollection 2019 Jan.

Fleischer DM, Greenhawt M, Sussman G, Bégin P, Nowak-Wegrzyn A, Petroni D, Beyer K, Brown-Whitehorn T, Hebert J, Hourihane JO, Campbell DE, Leonard S, Chinthrajah RS, Pongracic JA, Jones SM, Lange L, Chong H, Green TD, Wood R, Cheema A, Prescott SL, Smith P, Yang W, Chan ES, Byrne A, Assa'ad A, Bird JA, Kim EH, Schneider L, Davis CM, Lanser BJ, Lambert R, Shreffler W. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 Mar 12; 321(10):945-955. Doi: 10.1001/jama.2019.1113.

Capucilli P, Kennedy K, Lee J, Grundmeier RW. & Spergel JM. Accidental versus new food reactions in a pediatric emergency department. J Allergy Clin Immunol.: In Practice 2019; 7(5): 1662-1664.

Capucilli P, Kennedy K., Kazatsky A., Cianferoni A. & Spergel, J.M. Fruit for thought: anaphylaxis to fruit pectin in foods. J Allergy Clin Immunol. Pract. 2019 Feb;7(2):719-720. doi: 10.1016/j.jaip.2018.11.047. Epub 2018 Dec 12.

Warren CM, Zaslavsky JM, Kan K, Spergel JM, Gupta RS. Epinephrine auto-injector carriage and use practices among US children, adolescents, and adults. Ann Allergy Asthma Immunol. 2018 Oct;121(4):479-491. doi: 10.1016/j.anai.2018.06.010. Epub 2018 Jun 21. PMID: 29936229.

Sindher S, Long AJ, Purington N, Chollet M, Slatkin S, Andorf S, Tupa D, Kumar D, Woch MA, O'Laughlin KL, Assaad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Nadeau KC, Chinthrajah RS. Analysis of a large, standardized food challenge data set to determine predictors of positive outcome across multiple allergens. Front Immunol. 2018 Nov 27;9:2689. doi: 10.3389/fimmu.2018.02689. eCollection 2018. PMID: 30538699; Central PMCID: PMC6277531.

Stranks AJ, Minnicozzi SC, Miller SJ, Burton OT, Logsdon SL, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Schneider LC, Oettgen HC. Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies. Ann Allergy Asthma Immunol.  2019 Feb;122(2):213-215. PMID: 30404033; Central PMCID: PMC6360101.

Capucilli P, Kennedy K, Kazatsky AM, Cianferoni A, Spergel JM. Fruit for thought: anaphylaxis to fruit pectin in foods. J Allergy Clin Immunol Pract. 2019 Feb;7(2):719-720. PMID: 30553053.

Capucilli P, Kennedy K, Lee J, Grundmeier RW, Spergel JM. Accidental versus new food allergy reactions in a pediatric emergency department. J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1662-1664. PMID: 30496829.

Shaker M, Yuan I, Kennedy KL, Capucilli P, Spergel JM. Idiopathic anaphylaxis and undiagnosed anorexia nervosa. Ann Allergy Asthma Immunol. 2019 Feb;122(2):215-217. PMID: 30352289.

Purington N, Chinthrajah RS, Long A, Sindher S, Andorf S, O'Laughlin K, Woch MA, Scheiber A, Assa'ad A, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Galli SJ, Desai M, Nadeau KC. Eliciting dose and safety outcomes from a large dataset of standardized multiple food challenges. Front Immunol. 2018 Sep 21;9:2057. PMID: 30298065; Central PMCID: PMC6160556.

PALISADE Group of Clinical Investigators, Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral immunotherapy for peanut allergy. N Engl J Med. 2018 Nov 22;379(21):1991-2001. PMID: 30449234.

Lewis MO, Brown-Whitehorn TF, Cianferoni A, Rooney C, Spergel JM. Peanut-allergic patient experiences after epicutaneous immunotherapy: peanut consumption and impact on QoL. Ann Allergy Asthma Immunol. 2019 Jul;123(1):101-103. PMID: 30978404.

Spergel JM, Elci OU, Muir AB, Liacouras CA, Wilkins BJ, Burke D, Lewis MO, Brown-Whitehorn T, Cianferoni A. Efficacy of epicutaneous immunotherapy in children with milk-induced eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2020 Feb;18(2):328-336.e. PMID: 31100455.

Andorf S, Purington N, Kumar D, Long A, O'Laughlin KL, Sicherer S, Sampson H,  Cianferoni A, Whitehorn TB, Petroni D, Makhija M, Robison RG, Lierl M, Logsdon S, Desai M, Galli SJ, Rael E, Assa'ad A, Chinthrajah S, Pongracic J, Spergel JM, Tam J, Tilles S, Wang J, Nadeau K. A Phase 2 randomized controlled multisite study using omalizumab-facilitated rapid desensitization to test continued vs discontinued dosing in multi-food allergic individuals. E Clinical Medicine. 2019 Jan 21;7:27-38. PMID: 31193674; Central PMCID: PMC6537534.

2018

Bird JA, Spergel JM, Jones SM, Rachid R, Assa'ad AH, Wang J, Leonard SA, Laubach SS, Kim EH, Vickery BP, Davis BP, Heimall J, Cianferoni A, MacGinnitie AJ, Crestani E, Burks AW; ARC001 Study Group. Efficacy and safety of AR101 in oral Immunotherapy for peanut allergy: Results of ARC001, a randomized, double-blind, placebo-controlled Phase 2 clinical trial. J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):476-485.e3. PMID:29092786

Lee J, Rodio B, Lavelle J, Lewis MO, English R, Hadley S, Molnar J, Jacobstein C, Cianferoni A, Spergel J, Zielinski L, Tsarouhas N, Brown-Whitehorn  T. Improving anaphylaxis care: The impact of a clinical pathway. Pediatrics. 2018 May;141(5). PMID: 29615480.

Shaker M, Stukus D, Chan ES, Fleischer DM, Spergel JM, Greenhawt M. To screen or not to screen: Comparing the health and economic benefits of early peanut introduction strategies in five countries. Allergy. 2018. Aug;73(8):1707-1714.  Epub 2018 May 24. PMID: 29601091

Warren CM, Zaslavsky JM, Kan K, Spergel JM, Gupta RS. Epinephrine auto-injector carriage and use practices among US children, adolescents, and adults. Ann Allergy Asthma Immunol. 2018 121(4):479-491. PMID: 29936229.

Shaker M, Stukus D, Chan ES, Fleischer DM, Spergel JM, Greenhawt M. To screen or not to screen: Comparing the health and economic benefits of early peanut introduction strategies in five countries. Allergy. 2018 Aug;73(8):1707-1714. doi: 10.1111/all.13446. Epub 2018 May 24. PMID:2960109

Capucilli P, Cianferoni A, Fiedler J, Gober L, Pawlowski N, Ram G, Saltzman R, Spergel JM, Heimall J. Differences in egg and milk food challenge outcomes based on tolerance to the baked form. Ann Allergy Asthma Immunol. 2018 Nov;121(5):580-587. doi: 10.1016/j.anai.2018.07.018. Epub 2018 Jul 21. PMID: 30036581.

Eosinophilic esophagitis (EoE) publications

2020

Spergel JM, Muir AB, Liacouras CA, Burke D, Lewis MO, Brown-Whitehorn T, Cianferoni A. Sustained milk consumption after 2 years post-milk epicutaneous immunotherapy for eosinophilic esophagitis. Allergy. 2020 Nov 17. doi: 10.1111/all.14659. Online ahead of print.

Spergel JM, Brown-Whitehorn T, Muir A, Liacouras CA. Medical algorithm: Diagnosis and treatment of eosinophilic esophagitis in children. Allergy. 2020 June;75(6):1522-1524. doi: 10.1111/all.14188. Epub 2020 Jan 31

Cianferoni A, Warren CM, Brown-Whitehorn T, Schultz-Matney F, Nowak-Wegrzyn A, Gupta RS. Eosinophilic esophagitis and allergic comorbidities in a US-population-based study. Allergy. 2020 June;75(6): 1466-1469. doi: 10.1111/all.14148. Epub 2020 Jan 9.

Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H. Persistent basal cell hyperplasia is associated with clinical and endoscopic findings in patients with histologically inactive eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2020 Jun;18(7):1475-1482.e. PMID: 31499251.

Shoda T, Wen T, Caldwell JM, Collins MH, Besse JA, Osswald GA, Abonia JP, Arva NC, Atkins D, Capocelli KE, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I,  Mukkada VA, Putnam PE, Sheridan RM, Spergel Ak R, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Molecular, endoscopic, histologic and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-site study. J Allergy Clin Immunol. 2020 Jan;145(1):255-269. PMID: 31738990.

Dunn JLM, Shoda T, Caldwell JM, Wen T, Aceves SS, Collins MH, Dellon ES, Falk GW, Leung J, Martin LJ, Menard-Katcher P, Rudman-Spergel A, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Rothenberg ME; CEGIR esophageal type 2 cytokine expression heterogeneity in eosinophilic esophagitis in a multi-site cohort. J Allergy Clin Immunol. 2020 145(6):1629-1640.e4. PMID: 32197970

Nakagawa H, Kasagi Y, Karakasheva TA, Hara T, Aaron B, Shimonosono M, Kijima T, Giroux V, Bailey D, Wilkins B, Abrams JA, Falk GW, Aceves SS, Spergel JM, Hamilton KE, Whelan KA, Muir AB. Modeling epithelial homeostasis and reactive epithelial changes in human and murine three-dimensional esophageal organoids. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e106. PMID: 32105412

Aceves S, Collins MH, Rothenberg ME, Furuta GT, Gonsalves N; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). J Allergy Clin Immunol. 2020 Jan;145(1):28-37. PMID: 31758958

Jensen ET, Aceves SS, Bonis PA, Bray K, Book W, Chehade M, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Katzka DA, Kyle S, Mack D, Kodroff E, Leung J, Mukkada VA, Scott M, Paliana A, Sable K, Spergel JM, Strobel MJ, Krischer J, Rothenberg ME, Abonia JP; and the CEGIR Investigator group. High patient disease burden in a cross-sectional, multicenter contact registry study of eosinophilic gastrointestinal diseases. J Pediatr Gastroenterol Nutr. 2020 Jun 11 PMID: 32541201

2019

Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract. Jul-Aug 2019;7(6):2059-2061. doi: 10.1016/j.jaip.2019.01.053. Epub 2019 Feb 11.

Spergel JM, Elci OU, Muir AB, Liacouras C, Benjamin J. Wilkins BJ, Burke D, Lewis MO, Brown-Whitehorn T, Antonella Cianferoni A. Efficacy of Epicutaneous Immunotherapy in Children with Milk-Induced Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2020 Feb; 18(2):328-336.e7. doi: 10.1016/j.cgh.2019.05.014. Epub 2019 May 14.

Cianferoni A, Shuker M, Brown-Whitehorn T, Hunter H, Venter C, Spergel JM. Food avoidance strategies in eosinophilic oesophagitis. Clin Exp Allergy. 2019 Mar; 49(3):269-284. doi: 10.1111/cea.13360

Ruffner M, Kennedy K, Cianferoni A. Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications. Expert Review of Clinical Immunology 2019; 15(1):83-95.

Leigh LY, Spergel JM. An in-depth characterization of a large cohort of adult patients with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2019 Jan;122(1):65-72.e1. PMID: 30223114.

Schoepfer AM, Hirano I, Coslovsky M, Roumet MC, Zwahlen M, Kuehni CE, Hafner  D, Alexander JA, Dellon ES, Gonsalves N, Leung J, Bussmann C, Collins MH, Newbury RO, Smyrk TC, Woosley JT, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Spergel JM, Falk GW, Meltzer BA, Comer GM, Straumann A, Safroneeva E; International EEsAI Study Group. Variation in endoscopic activity assessment and endoscopy score validation in adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2019 Jul; 17(8):1477-1488. PMID 30476587

Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic Esophagitis Is Late Manifestation of the Allergic March. J Allergy Clin Immunol Pract. 2018 Sep  - Oct;6(5):1528-1533. doi: 10.1016/j.jaip.2018.05.010. Epub 2018 Jun 25. PMID: 29954692; Central PMCID: PMC6131029. 10.1016/j.cgh.2018.11.032. [Epub ahead of print] PMID: 30476587.

Gupta SK, Falk GW, Aceves SS, Chehade M, Collins MH, Dellon ES, Gonsalves N, Hirano I, Mukkuda VA, Peterson KA, Spergel J, Yang GY, Furuta GT, Rothenberg ME;  Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the field of eosinophilic GI disorders through collaboration. Gastroenterology. 2019  Mar;156(4):838-842. doi: 10.1053/j.gastro.2018.10.057. Epub 2018 Nov 17. PMID: 30452923

Kasagi Y, Dods K, Wang JX, Chandramouleeswaran PM, Benitez AJ, Gambanga F, Kluger J, Ashorobi T, Gross J, Tobias JW, Klein-Szanto AJ, Spergel JM, Cianferoni A, Falk GW, Whelan KA, Nakagawa H, Muir AB. Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α. J Allergy Clin Immunol. 2019 Jul;144(1):171-182 PMID: 30578874; Central PMCID: PMC6586527.

Godwin B, Liacouras C, Mehta V, Eisenberg J, Agawu A, Brown-Whitehorn T, Ruffner MA, Verma R, Cianferoni A, Spergel JM, Muir AB. A review of tertiary referrals for management of pediatric esophageal eosinophilia. Front Pediatr. 2018 Jun 20;6:173. doi: 10.3389/fped.2018.00173. eCollection 2018. PMID:29974044; Central PMCID: PMC6019483

Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):2059-2061. PMID: 30763733.

Muir AB, Jensen ET, Wechsler JB, Menard-Katcher P, Falk GW, Aceves SS, Furuta GT, Dellon ES, Rothenberg ME, Spergel JM. Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2434-2436. PMID: 30922989.

Pesek RD, Reed CC, Muir AB, Fulkerson PC, Menard-Katcher C, Falk GW, Kuhl J,  Martin EK, Magier AZ, Ahmed F, Demarshall M, Gupta A, Gross J, Ashorobi T, Carpenter CL, Krischer JP, Gonsalves N, Spergel JM, Gupta SK, Furuta GT, Rothenberg ME, Dellon ES; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Increasing rates of diagnosis, substantial co-occurrence, and variable treatment patterns of eosinophilic gastritis, gastroenteritis, and colitis based on 10-year data across a multicenter consortium. Am J Gastroenterol. 2019 Jun;114(6):984-994. PMID: 31008735; Central PMCID: PMC6554065

Ruffner MA, Song L, Maurer K, Shi L, Carroll MC, Wang JX, Muir AB, Spergel JM, Sullivan KE. Toll-like receptor 2 stimulation augments esophageal barrier integrity. Allergy. Dec;74(12):2449-2460. PMID: 31267532.

Klinnert MD, Atkins D, Pan Z, Franciosi JP, Aceves SS, Spergel JM, Furuta GT.  Symptom burden and quality of life over time in pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2019 Dec;69(6):682-689. PMID: 31436703.

Pesek RD, Reed CC, Collins MH, Muir AB, Fulkerson PC, Menard-Katcher C, Falk GW, Kuhl J, Magier AZ, Ahmed FN, Demarshall M, Gupta A, Gross J, Ashorobi T, Carpenter CL, Krischer JP, Gonsalves N, Hirano I, Spergel JM, Gupta SK, Furuta GT, Rothenberg ME, Dellon ES; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Association between endoscopic and histologic findings in a multicenter retrospective cohort of patients with non-esophageal eosinophilic gastrointestinal disorders. Dig Dis Sci. 2019 Nov 26. PMID: 31773359

Muir AB, Brown-Whitehorn TF, Godwin B, Cianferoni A. Eosinophilic esophagitis:  early diagnosis is key. Clin Exp Gastroenterol. 2019 Aug 15; 12:391-399. doi: 10.2147/CEG.S175061. eCollection 2019.

Mehr S and Brown-Whitehorn T. What do allergists in practice need to know about non-IgE-mediated food allergies? Ann Allergy Asthma Immunol. 2019 June;122(6):589-59. doi: 10.1016/j.anai.2019.03.025. Epub 2019 Mar 30

2018

Cianferoni A, Ruffner MA, Guzek R, Guan S, Brown-Whitehorn T, Muir A, Spergel JM. Elevated expression of activated TH2 cells and milk-specific TH2 cells in milk-induced eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2018 Feb;120(2):177-183.e2. doi: 10.1016/j.anai.2017.11.006. Epub 2017 Dec 28.

Godwin B, Liacouras C, Mehta V, Eisenberg J, Agawu A, Brown-Whitehorn TF, Ruffner MA Verma R, Cianferoni A, Spergel JM, Muir AB: A Review of Tertiary Referrals for Management of Pediatric Esophageal Eosinophilia. Front Pediatr, June 2018. Notes: https://doi.org/10.3389/fped.2018.00173

Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March. J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1528-1533. doi: 10.1016/j.jaip.2018.05.010. Epub 2018 Jun 25.

Hill DA, Spergel JM. Epithelial acid imbalance in eosinophilic esophagitis. J Allergy Clin Immunol. 2018 Oct 10. pii: S0091-6749(18)31435-0. doi: 10.1016/j.jaci.2018.09.026. [Epub ahead of print] PMID: 30315831.

Muir A, Moore H, Spergel J. To treat or not to treat: The minimally symptomatic EoE patient. Ann Allergy Asthma Immunol. 2018 Oct 5. pii: S1081-1206(18)31291-2. doi: 10.1016/j.anai.2018.09.468. [Epub ahead of print] PMID: 30296478.

Petroni D, Spergel JM. Eosinophilic esophagitis and symptoms possibly related to eosinophilic esophagitis in oral immunotherapy. Ann Allergy Asthma Immunol. 2018 Mar;120(3):237-240.e4. doi: 10.1016/j.anai.2017.11.016. Epub 2018 Feb 1. PMID: 29397272.

Ruffner MA, Kennedy K, Cianferoni A. Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications. Expert Rev Clin Immunol. 2018 Nov 3:1-13. doi: 10.1080/1744666X.2019.1544893.

Ruffner MA, Spergel JM. Pediatric eosinophilic esophagitis: updates for the primary care setting. Curr Opin Pediatr. 2018 Sep 20. doi: 10.1097/MOP.0000000000000698. [Epub ahead of print] PMID: 3023937.

Cianferoni A, Ruffner MA, Guzek R, Guan S, Brown-Whitehorn T, Muir A, Spergel JM. Elevated expression of activated TH2 cells and milk-specific TH2 cells in milk-induced eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2018 Feb;120(2):177-183.e2. PMID: 29289462 PMC5875940

Cheng K, Gupta SK, Kantor S, Kuhl JT, Aceves SS, Bonis PA, Capocelli KE, Carpenter C, Chehade M, Collins MH, Dellon ES, Falk GW, Gopal-Srivastava R, Gonsalves N, Hirano I, King EC, Leung J, Krischer JP, Mukkada VA, Schoepfer A, Spergel JM, Straumann A, Yang GY, Furuta GT, Rothenberg ME. Creating a multi-center rare disease consortium -- the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Transl Sci Rare Dis. 2017 Dec 18;2(3-4):141-155. PMID: 29333363

Petroni D, Spergel JM. Eosinophilic esophagitis and symptoms possibly related to eosinophilic esophagitis in oral immunotherapy. Ann Allergy Asthma Immunol. 2018 120(3):237-240. PMID: 29397272

Fahey LM, Chandramouleeswaran PM, Guan S, Benitez AJ, Furuta GT, Aceves SS, Wang ML, Liacouras CA, Muir AB, Sleiman PM, Hakonarson H, Spergel JM, Cianferoni A. Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis. Clin Transl Gastroenterol. 2018 Mar 6;9(3):139. PMID: 29511165; Central PMCID: PMC5862152.

Kasagi Y, Chandramouleeswaran PM, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias JW, Hamilton KE, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H. The esophageal organoid system reveals functional interplay between notch and cytokines in reactive epithelial changes. Cell Mol Gastroenterol Hepatol. 2018 Jan 3;5(3):333-352. PMID: 29552622; Central PMCID: PMC5852293.

Shoda T, Wen T, Aceves SS, Abonia JP, Atkins D, Bonis PA, Caldwell JM, Capocelli KE, Carpenter CL, Collins MH, Dellon ES, Eby MD, Gonsalves N, Gupta SK, Falk GW, Hirano I, Menard-Katcher P, Kuhl JT, Krischer JP, Leung J, Mukkada VA, Spergel JM, Trimarchi MP, Yang GY, Zimmermann N, Furuta GT, Rothenberg ME;Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. Lancet Gastroenterol Hepatol. 2018 Jul;3(7):477-488. PMID: 29730081; Central PMCID: PMC5997568.

Fahey LM, Guzek R, Ruffner MA, Sullivan KE, Spergel J, Cianferoni A. EMSY is  increased and activates TSLP & CCL5 expression in eosinophilic esophagitis. Pediatr Allergy Immunol. 2018 Aug;29(5):565-568. PMID: 29663593

Hiremath G, Kodroff E, Strobel MJ, Scott M, Book W, Reidy C, Kyle S, Mack D,  Sable K, Abonia P, Spergel J, Gupta SK, Furuta TG, Rothenberg ME, Dellon ES. Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care. Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):483-493. PMID: 29615329; Central PMCID: PMC6167209

Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic esophagitis is a late manifestation of the allergic march. J Allergy Clin Immunol Pract. 2018 6(5):1528-1533. PMID: 29954692. Central PMCID: PMC6131029.

Ma C, van Rhijn BD, Jairath V, Nguyen TM, Parker CE, Aceves SS, Furuta GT, Gupta SK, Katzka DA, Safroneeva E, Schoepfer AM, Straumann A, Spergel JM, Pai RK, Feagan BG, Hirano I, Dellon ES, Bredenoord AJ. Heterogeneity in clinical, endoscopic, and histologic outcome measures and placebo response rates in clinical trials of eosinophilic esophagitis: A systematic review. Clin Gastroenterol Hepatol. 2018 Nov;16(11):1714-1729 Review. PMID: 29908360.

Aceves SS, King E, Collins MH, Yang GY, Capocelli KE, Abonia JP, Atkins D, Bonis PA, Carpenter CL, Dellon ES, Eby MD, Falk GW, Gonsalves N, Gupta SK, Hirano I, Kocher K, Krischer JP, Leung J, Lipscomb J, Menard-Katcher P, Mukkada VA, Pan Z, Spergel JM, Sun Q, Wershil BK, Rothenberg ME, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. J Allergy Clin Immunol. 2018 Jul;142(1):130-138. PMID: 29852258; Central PMCID: PMC6035777

Godwin B, Liacouras C, Mehta V, Eisenberg J, Agawu A, Brown-Whitehorn T, Ruffner MA, Verma R, Cianferoni A, Spergel JM, Muir AB. A review of tertiary referrals for management of pediatric esophageal eosinophilia. Front Pediatr. 2018 Jun 20;6:173. doi: 10.3389/fped.2018.00173. eCollection 2018. PMID: 29974044; Central PMCID: PMC6019483

Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract. 2019 Feb 11. pii: S2213-2198(19)30162-X. doi: 10.1016/j.jaip.2019.01.053. [Epub ahead of print] PMID: 30763733.

Muir AB, Jensen ET, Wechsler JB, Menard-Katcher P, Falk GW, Aceves SS, Furuta GT, Dellon ES, Rothenberg ME, Spergel JM. Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. J Allergy Clin Immunol Pract. 2019 Mar 25. pii: S2213-2198(19)30284-3. doi: 10.1016/j.jaip.2019.03.020.  [Epub ahead of print] PMID: 30922989.

Hiremath G, Kodroff E, Strobel MJ, Scott M, Book W, Reidy C, Kyle S, Mack D,  Sable K, Abonia P, Spergel J, Gupta SK, Furuta TG, Rothenberg ME, Dellon ES. Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care. Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):483-493. Epub 2018 Mar 31. PMID: 29615329; Central PMCID: PMC6167209

Fahey LM, Guzek R, Ruffner MA, Sullivan KE, Spergel J, Cianferoni A. EMSY is increased and activates TSLP & CCL5 expression in eosinophilic esophagitis. Pediatr Allergy Immunol. 2018 Aug;29(5):565-568. doi: 10.1111/pai.12907. Epub 2018 May 29. PMID: 29663593.

Shoda T, Wen T, Aceves SS, Abonia JP, Atkins D, Bonis PA, Caldwell JM, Capocelli KE, Carpenter CL, Collins MH, Dellon ES, Eby MD, Gonsalves N, Gupta SK, Falk GW, Hirano I, Menard-Katcher P, Kuhl JT, Krischer JP, Leung J, Mukkada VA, Spergel JM, Trimarchi MP, Yang GY, Zimmermann N, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. Lancet Gastroentero Hepatol. 2018 Jul;3(7):477-488. doi: 10.1016/S2468-1253(18)30096-7. Epub 2018 May. PMID: 29730081; d Central PMCID: PMC5997568.

Aceves SS, King E, Collins MH, Yang GY, Capocelli KE, Abonia JP, Atkins D, Bonis PA, Carpenter CL, Dellon ES, Eby MD, Falk GW, Gonsalves N, Gupta SK, Hirano I, Kocher K, Krischer JP, Leung J, Lipscomb J, Menard-Katcher P, Mukkada VA, Pan  Z, Spergel JM, Sun Q, Wershil BK, Rothenberg ME, Furuta GT; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. J Allergy Clin Immunol. 2018 Jul;142(1):130-138.e1. doi: 10.1016/j.jaci.2018.05.014. Epub 2018 May 29. PMID: 29852258; Central PMCID: PMC6035777.

Ma C, van Rhijn BD, Jairath V, Nguyen TM, Parker CE, Aceves SS, Furuta GT, Gupta SK, Katzka DA, Safroneeva E, Schoepfer AM, Straumann A, Spergel JM, Pai RK, Feagan BG, Hirano I, Dellon ES, Bredenoord AJ. Heterogeneity in clinical, endoscopic, and histologic outcome measures and placebo response rates in clinical trials of eosinophilic esophagitis: A systematic review. Clin Gastroenterol Hepatol. 2018 Nov;16(11):1714-1729.e3. doi: 10.1016/j.cgh.2018.06.005. Epub 2018 Jun 14. Review. PMID: 29908360.

Capucilli P, Cianferoni A, Grundmeier RW, Spergel JM. Comparison of comorbid diagnoses in children with and without eosinophilic esophagitis in a large population. Ann Allergy Asthma Immunol. 2018 Dec;121(6):711-716. PMID: 30194971.

Atopic dermatitis publications

2018

Kennedy K, Heimall J, Spergel JM. Advances in Atopic Dermatitis in 2017. J Allergy Clin Immunol. 2018 Oct 22. pii: S0091-6749(18)31480-5. doi: 10.1016/j.jaci.2018.10.012. [Epub ahead of print] PMID: 30359683.

Sauser J, Nutten S, de Groot N, Pecquet S, Simon D, Simon HU, Spergel JM, Koletzko S, Blanchard C.  Partially Hydrolyzed Whey Infant Formula: Literature Review on Effects on Growth and the Risk of Developing Atopic Dermatitis in Infants from the General Population. Int Arch Allergy Immunol. 2018 Jul 12:1-12. PMID: 30001534

FPIES publications

2021

Bird JA, Barni S, Brown-Whitehorn TF, du Toit G, Infante S, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome oral food challenge: Time for a change? Ann Allergy Asthma Immunol. 2021 May;126(5):506-515. doi: 10.1016/j.anai.2021.02.022. Epub 2021 Mar 1.

2020

Ruffner MA, Wang KY, Dudley JW, Cianferoni A, Grundmeier RW, Spergel JM, Brown-Whitehorn TF, Hill DA. Elevated Atopic Comorbidity in Patients with Food Protein-Induced Enterocolitis. J Allergy Clin Immunol Pract. 2020 Mar;8(3):1039-1046. PMID: 31759160

2019

Brown-Whitehorn T, Cianferoni A, editors. Food Protein Induced Enterocolitis (FPIES): Diagnosis and Management. Basel, Switzerland: Springer International Publishing; 2019.

Wang K, Lee J, Cianferoni A, Ruffner M, Dean A, Molleston J, Pawlowski N, Heimall J, Saltzman R, Ram G, Fiedler J, Gober L, Spergel J, Brown-Whitehorn T. Food protein-induced enterocolitis syndrome food challenges: experience from a large referral center. J Allergy Clin Immunol Pract. 2019;7(2):444-490.

Nowak-Wegrzyn A, Warren CM, Brown-Whitehorn T, Cianferoni A, Schultz-Matney F, Gupta RS. Food protein-induced enterocolitis syndrome in the US population-based study. J Allergy Clin Immunol. 2019 Oct;144(4):1128-1130. doi: 10.1016/j.jaci.2019.06.032. Epub 2019 Jul 6.

2018

Wang KY, Lee J, Cianferoni A, Ruffner MA, Dean A, Heimall J, et. al. Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. J Allergy Clin Immunol Pract. 2018 Sep 20. pii: S2213-2198(18)30585-3. doi: 10.1016/j.jaip.2018.09.009. [Epub ahead of print] PMID: 30243880.

Other allergy and immunology-focused publications

2021

Harrison SC, Tsilifis C, Slatter MA, Nademi Z, Worth A, Veys P, Ponsford MJ, Jolles S, Al-Herz W, Flood T, Cant AJ, Doffinger R, Barcenas-Morales G, Carpenter B, Hough R, Haraldsson Á, Heimall J, Grimbacher B, Abinun M, Gennery AR. Hematopoietic Stem Cell Transplantation Resolves the Immune Deficit Associated with STAT3-Dominant-Negative Hyper-IgE Syndrome.  J Clin Immunol. 2021 Feb 1. doi: 10.1007/s10875-021-00971-2. Online ahead of print. PMID: 33523338

2020

Weinreb SJ, Dodds KM, Burstein DS, Huang J, Rand EB, Mancilla E, Heimall JR, McBride MG, Paridon SM, Goldberg DJ, Rychik J. End-Organ Function and Exercise Performance in Patients With Fontan Circulation: What Characterizes the High Performers? J Am Heart Assoc. 2020 Dec 15;9(24):e016850. doi: 10.1161/JAHA.120.016850. Epub 2020 Dec 2. PMID: 33317366

Knight V, Heimall JR, Wright N, Dutmer CM, Boyce TG, Torgerson TR, Abraham RS. Follow-Up for an Abnormal Newborn Screen for Severe Combined Immunodeficiencies (NBS SCID): A Clinical Immunology Society (CIS) Survey of Current Practices. Int J Neonatal Screen. 2020 Jun 30;6(3):52. doi: 10.3390/ijns6030052. PMID: 33239578

Dorsey MJ, Wright NAM, Chaimowitz NS, Dávila Saldaña BJ, Miller H, Keller MD, Thakar MS, Shah AJ, Abu-Arja R, Andolina J, Aquino V, Barnum JL, Bednarski JJ, Bhatia M, Bonilla FA, Butte MJ, Bunin NJ, Chandra S, Chaudhury S, Chen K, Chong H, Cuvelier GDE, Dalal J, DeFelice ML, DeSantes KB, Forbes LR, Gillio A, Goldman F, Joshi AY, Kapoor N, Knutsen AP, Kobrynski L, Lieberman JA, Leiding JW, Oshrine B, Patel KP, Prockop S, Quigg TC, Quinones R, Schultz KR, Seroogy C, Shyr D, Siegel S, Smith AR, Torgerson TR, Vander Lugt MT, Yu LC, Cowan MJ, Buckley RH, Dvorak CC, Griffith LM, Haddad E, Kohn DB, Logan B, Notarangelo LD, Pai SY, Puck J, Pulsipher MA, Heimall J. Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers.  J Clin Immunol. 2020 Oct 2. doi: 10.1007/s10875-020-00865-9. Online ahead of print. PMID: 33006109

Sun D, Lee J, Heimall J, Jyonouchi S. Immunodeficiency in 22q11.2 duplication syndrome. J Allergy Clin Immunol Pract. 2020 Sep 16:S2213-2198(20)30951-X. doi: 10.1016/j.jaip.2020.09.005. Online ahead of print. PMID: 32949807

Sun D, Heimall J. Geographical distribution of allergy/immunology providers in the United States and association with median income. J Allergy Clin Immunol Pract. 2020 Sep;8(8):2802-2804. PMID: 32334079

Chan AY, Leiding JW, Liu X, Logan BR, Burroughs LM, Allenspach EJ, Skoda-Smith S, Uzel G, Notarangelo LD, Slatter M, Gennery AR, Smith AR, Pai SY, Jordan MB, Marsh RA, Cowan MJ, Dvorak CC, Craddock JA, Prockop SE, Chandrakasan S, Kapoor N, Buckley RH, Parikh S, Chellapandian D, Oshrine BR, Bednarski JJ, Cooper MA, Shenoy S, Davila Saldana BJ, Forbes LR, Martinez C, Haddad E, Shyr DC, Chen K, Sullivan KE, Heimall J, Wright N, Bhatia M, Cuvelier GDE, Goldman FD, Meyts I, Miller HK, Seidel MG, Vander Lugt MT, Bacchetta R, Weinacht KG, Andolina JR, Caywood E, Chong H, de la Morena MT, Aquino VM, Shereck E, Walter JE, Dorsey MJ, Seroogy CM, Griffith LM, Kohn DB, Puck JM, Pulsipher MA, Torgerson TR. Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey. Front Immunol. 2020 Feb 21;11:239. PMID: 32153572

Arnold DE, Maude SL, Callahan CA, DiNofia AM, Grupp SA, Heimall JR. Subcutaneous immunoglobulin replacement following CD19-specific chimeric antigen receptor T-cell therapy for B-cell acute lymphoblastic leukemia in pediatric patients. Pediatr Blood Cancer. 2020 Mar;67(3):e28092. doi: 10.1002/pbc.28092. Epub 2019 Dec 2. PMID: 31793170

Mansbach JM, Hasegawa K, Geller RJ, Espinola JA, Sullivan AF, Camargo CA Jr; MARC-35 Investigators. Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort. Pediatr Res. 2020 Feb;87(3):428-430. PMID: 31585458

2019

Heimall J. Genetic Testing to Diagnose Primary Immunodeficiency Disorders and to Identify Targeted Therapy. Immunol Allergy Clin North Am. 2019 Feb;39(1):129-140. doi: 10.1016/j.iac.2018.08.009. Review. PMID: 30466769

Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Aller Clini Immuno: In Practice 2019; 7(6): 2059-2061.

Bosticardo M, Yamazaki Y, Cowan J, Giardino G, Corsino C, Scalia G, Prencipe R, Ruffner M, Hill DA, Sakovich I, Yemialyanava I, Tam JS, Padem N, Elder ME, Sleasman JW, Perez E, Niebur H, Seroogy CM, Sharapova S, Gebbia J, Kleiner GI, Peake J, Abbott JK, Gelfand EW, Crestani E, Biggs C, Butte MJ, Hartog N, Hayward A, Chen K, Heimall J, Seeborg F, Bartnikas LM, Cooper MA, Pignata C, Bhandoola A, Notarangelo LD. Heterozygous FOXN1 variants cause low TRECs and severe T cell lymphopenia, revealing a crucial role of FOXN1 in supporting early thymopoiesis. Am J Hum Genet. 2019 Sep 5;105(3):549-561. PMID: 31447097

Le Coz C, Bengsch B, Khanna C, Trofa M, Ohtani T, Nolan BE, Henrickson SE, Lambert MP, Kim TO, Despotovic JM, Feldman S, Fadugba OO, Takach P, Ruffner M, Jyonouchi S, Heimall J, Sullivan KE, Wherry EJ, Romberg N. Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage. J Allergy Clin Immunol. 2019 Dec;144(6):1660-1673. PMID: 31445098

Marsh RA, Leiding JW, Logan BR, Griffith LM, Arnold DE, Haddad E, Falcone EL, Yin Z, Patel K, Arbuckle E, Bleesing JJ, Sullivan KE, Heimall J, Burroughs LM, Skoda-Smith S, Chandrakasan S, Yu LC, Oshrine BR, Cuvelier GDE, Thakar MS, Chen K, Teira P, Shenoy S, Phelan R, Forbes LR, Chellapandian D, Dávila Saldaña BJ, Shah AJ, Weinacht KG, Joshi A, Boulad F, Quigg TC, Dvorak CC, Grossman D, Torgerson T, Graham P, Prasad V, Knutsen A, Chong H, Miller H, de la Morena MT, DeSantes K, Cowan MJ, Notarangelo LD, Kohn DB, Stenger E, Pai SY, Routes JM, Puck JM, Kapoor N, Pulsipher MA, Malech HL, Parikh S, Kang EM; submitted on behalf of the Primary Immune Deficiency Treatment Consortium. Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT. J Clin Immunol. 2019 Oct;39(7):653-667. PMID: 31376032

Keller MD, Darko S, Lang H, Ransier A, Lazarski CA, Wang Y, Hanley PJ, Davila BJ, Heimall JR, Ambinder RF, Barrett AJ, Rooney CM, Heslop HE, Douek DC, Bollard CM. T-cell receptor sequencing demonstrates persistence of virus-specific T cells after antiviral immunotherapy. Br J Haematol. 2019 Oct;187(2):206-218. PMID: 31219185

Henrickson SE, Andre-Schmutz I, Lagresle-Peyrou C, Deardorff MA, Jyonouchi H, Neven B, Bunin N, Heimall JR. Hematopoietic Stem Cell Transplant for the Treatment of X-MAID. Front Pediatr. 2019 May 14;7:170 PMID: 31139601

Arnold DE, Seif AE, Jyonouchi S, Sullivan KE, Bunin NJ, Heimall JR. Allogeneic hematopoietic stem cell transplantation in adolescent patients with chronic granulomatous disease. J Allergy Clin Immunol Pract. 2019 Mar;7(3):1052-1054.e2. PMID: 30391552

Dvorak CC, Haddad E, Buckley RH, Cowan MJ, Logan B, Griffith LM, Kohn DB, Pai SY, Notarangelo L, Shearer W, Prockop S, Kapoor N, Heimall J, Chaudhury S, Shyr D, Chandra S, Cuvelier G, Moore T, Shenoy S, Goldman F, Smith AR, Sunkersett G, Vander Lugt M, Caywood E, Quigg T, Torgerson T, Chandrakasan S, Craddock J, Dávila Saldaña BJ, Gillio A, Shereck E, Aquino V, DeSantes K, Knutsen A, Thakar M, Yu L, Puck JM. The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018). J Allergy Clin Immunol. 2019 Jan;143(1):405-407. PMID: 30193840

Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel N, Sullivan KE, et. al. Autosomal dominant hyper IgE syndrome in the USIDNET registry. J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):996-1001. doi: 10.1016/j.jaip.2017.06.041. Epub 2017 Sep 19.

Haddad E, Logan BR, Griffith LM, Buckley RH, Parrott RE, Prockop SE, Small TN, Chaisson J, Dvorak CC, Murnane M, Kapoor N, Abdel-Azim H, Hanson IC, Martinez C, Bleesing JJH, Chandra S, Smith AR, Cavanaugh ME, Jyonouchi S, Sullivan KE, Burroughs L, Skoda-Smith S, Haight AE, Tumlin AG, Quigg TC, Taylor C, Dávila Saldaña BJ, Keller MD, Seroogy CM, Desantes KB, Petrovic A, Leiding JW, Shyr DC, Decaluwe H, Teira P, Gillio AP, Knutsen AP, Moore TB, Kletzel M, Craddock JA, Aquino V, Davis JH, Yu LC, Cuvelier GDE, Bednarski JJ, Goldman FD, Kang EM, Shereck E, Porteus MH, Connelly JA, Fleisher TA, Malech HL, Shearer WT, Szabolcs P, Thakar MS, Vander Lugt MT, Heimall J, Yin Z, Pulsipher MA, Pai SY, Kohn DB, Puck JM, Cowan MJ, O'Reilly RJ, Notarangelo LD. SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery. Blood. 2018 Oct 25;132(17):1737-1749. PMID: 30154114

Capucilli P, Cianferoni A, Fiedler J, Gober L, Pawlowski N, Ram G, Saltzman R, Spergel JM, Heimall J. Differences in egg and milk food challenge outcomes based on tolerance to the baked form. Ann Allergy Asthma Immunol. 2018 Nov;121(5):580-587. PMID: 30036581

Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu ML, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol. 2019 Jan;143(1):258-265. PMID: 29935219

Ruffner MA, Henrickson SE, Chilutti M, Grundmeier R, Spergel JM, Brown-Whitehorn TF. Improving allergy office scheduling increases patient follow  up and reduces asthma readmission after pediatric asthma hospitalization. Ann Allergy Asthma Immunol. 2018 Nov;121(5):561-567. PMID: 30170026; Central PMCID: PMC6236684.

2018

Henrickson SE, Manne S, Dolfi DV, Mansfield KD, Parkhouse K, Mistry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE, Wherry EJ. Genomic circuitry underlying immunological response to pediatric acute respiratory infection. Cell Rep. 2018 Jan 9;22(2):411-426. doi: 10.1016/j.celrep.2017.12.043.

Lawrence MG, Palacios-Kibler TV, Workman LJ, Schuyler AJ, Steinke JW, Sullivan KE, et. al. Low serum IgE is a sensitive and specific marker for common variable immunodeficiency (CVID). J Clin Immunol. 2018 Apr;38(3):225-233. doi: 10.1007/s10875-018-0476-0. Epub 2018 Feb 17.

Ruffner MA, Henrickson SE, Chilutti M, Grundmeier R, Spergel JM, Brown-Whitehorn TF. Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization. Ann Allergy Asthma Immunol. 2018 Aug 28. pii: S1081-1206(18)30705-1. [Epub ahead of print]

Heimall J, Logan BR, Cowan MJ, Notarangelo LD, Griffith LM, Puck JM, Kohn DB, Pulsipher MA, Parikh S, Martinez C, Kapoor N, O'Reilly R, Boyer M, Pai SY, Goldman F, Burroughs L, Chandra S, Kletzel M, Thakar M, Connelly J, Cuvelier G, Davila B, Shereck E, Knutsen A, Sullivan KE, DeSantes K, Gillio A, Haddad E, Petrovic A, Quigg T, Smith AR, Stenger E, Yin Z, Shearer WT, Fleisher T, Buckley RH, Dvorak CC. Immune Reconstitution and Survival of 100 SCID Patients Post Hematopoietic Cell Transplant: A PIDTC Natural History Study. Blood. 2017 Dec 21;130(25):2718-2727. PMID: 29021228

Dorjbal B, Stinson JR, Ma CA, Weinreich MA, Miraghazadeh B, Sullivan KE, et. al. Hypomorphic CARD11 mutations associated with diverse immunologic phenotypes with or without atopic disease. J Allergy Clin Immunol. 2018 Aug 28. pii: S0091-6749(18)31201-6. doi: 10.1016/j.jaci.2018.08.013. [Epub ahead of print]

Hasegawa K, Piedra PA, Bauer CS, Celedón JC, Mansbach JM, Spergel JM, Espinola JA, Camargo CA Jr; MARC-35 Investigators. Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study. Clin Exp Allergy. 2018 Aug;48(8):1063-1067.

Hasegawa K, Piedra PA, Bauer CS, Celedón JC, Mansbach JM, Spergel JM, Espinola JA, Camargo CA Jr; MARC-35 Investigators. Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study. Clin Exp Allergy. 2018 Aug;48(8):1063-1067. doi: 10.1111/cea.13166. Epub 2018 Jun 4. PMID: 29756403; Central PMCID:  PMC6105518.