Division of Gastroenterology, Hepatology and Nutrition Publications

Leaders in research and publications

View highlights of recent publications from the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia (CHOP).

COVID-19

Articles

Keating BJ, Mukhtar EH, Elftmann ED, Eweje FR, Gao H, Ibrahim LI, Kathawate RG, Lee AC, Li EH, Moore KA, Nair N, Chaluvadi V, Reason J, Zanoni F, Honkala AT, Al-Ali AK, Abdullah Alrubaish F, Ahmad Al-Mozaini M, Al-Muhanna FA, Al-Romaih K, Goldfarb SB, Kellogg R, Kiryluk K, Kizilbash SJ, Kohut TJ, Kumar J, O'Connor MJ, Rand EB, Redfield RR, Rolnik B, Rossano J, Sanchez PG, Alavi A, Bahmani A, Bogu GK, Brooks AW, Metwally AA, Mishra T, Marks SD, Montgomery RA, Fishman JA, Amaral S, Jacobson PA, Wang M, Snyder MP. Early detection of SARS-CoV-2 and other infections in solid organ transplant recipients and household members using wearable devices. Transpl Int. 2021 Jun;34(6):1019-1031. doi: 10.1111/tri.13860. Epub 2021 May 5. PMID: 33735480; PMCID: PMC8250335.

Eosinophilic Disorders

Articles

Aceves S, Collins MH, Rothenberg ME, Furuta GT, Gonsalves N; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). J Allergy Clin Immunol. 2020 Jan;145(1):28-37. doi: 10.1016/j.jaci.2019.11.012. Epub 2019 Nov 20. PMID: 31758958; PMCID: PMC6981250.

Benitez AJ, Tanes C, Mattei L, Hofstaedter CE, Kim DK, Gross J, Ruffner MA, Albenberg L, Spergel J, Bittinger K, Muir AB. Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis. Allergy. 2021 May;76(5):1549-1552. doi: 10.1111/all.14602. Epub 2020 Oct 19. PMID: 32990947; PMCID: PMC8130179.

Chiang AWT, Duong LD, Shoda T, Nhu QM, Ruffner M, Hara T, Aaron B, Joplin E, Manresa MC, Abonia JP, Dellon ES, Hirano I, Gonsalves N, Gupta SK, Furuta GT, Rothenberg ME, Lewis NE, Muir AB, Aceves SS; CEGIR Investigator Group. Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. J Pediatr Gastroenterol Nutr. 2021 May 1;72(5):718-722. doi: 10.1097/MPG.0000000000003032. PMID: 33394891; PMCID: PMC8048378.

Godwin B, Wilkins B, Muir AB. EoE disease monitoring: Where we are and where we are going. Ann Allergy Asthma Immunol. 2020 Mar;124(3):240-247. doi: 10.1016/j.anai.2019.12.004. Epub 2019 Dec 9. PMID: 31830586; PMCID: PMC7059875.

Klein J, Wilkins BJ, Verma R, Muir AB. Collagenous Gastritis Masquerading as Eosinophilic Gastritis. ACG Case Rep J. 2021 Feb 22;8(2):e00527. doi: 10.14309/crj.0000000000000527. PMID: 33634200; PMCID: PMC7901789.

Miller TL, Desai AD, Garrison MM, Lee D, Muir A, Lion KC. Drivers of Variation in Diagnosis and Management of Eosinophilic Esophagitis: A Survey of Pediatric Gastroenterologists. Dig Dis Sci. 2021 May 11. doi: 10.1007/s10620-021-07039-6. Epub ahead of print. PMID: 33974186.

Pesek RD, Reed CC, Collins MH, Muir AB, Fulkerson PC, Menard-Katcher C, Falk GW, Kuhl J, Magier AZ, Ahmed FN, Demarshall M, Gupta A, Gross J, Ashorobi T, Carpenter CL, Krischer JP, Gonsalves N, Hirano I, Spergel JM, Gupta SK, Furuta GT, Rothenberg ME, Dellon ES; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders. Dig Dis Sci. 2020 Jul;65(7):2024-2035. doi: 10.1007/s10620-019-05961-4. Epub 2019 Nov 26. PMID: 31773359; PMCID: PMC7315780.

Sabet C, Klion AD, Bailey D, Jensen E, Chehade M, Abonia JP, Rothenberg ME, Furuta GT, Muir AB; CEGIR Investigator Group. Do rural health disparities affect prevalence data in pediatric eosinophilic esophagitis? J Allergy Clin Immunol Pract. 2021 Jun;9(6):2549-2551. doi: 10.1016/j.jaip.2021.03.027. PMID: 34112494.

Spergel JM, Brown-Whitehorn TA, Muir A, Liacouras CA. Medical algorithm: Diagnosis and treatment of eosinophilic esophagitis in children. Allergy. 2020 Jun;75(6):1522-1524. doi: 10.1111/all.14188. Epub 2020 Jan 31. PMID: 31953959; PMCID: PMC8040021.

Spergel JM, Muir AB, Liacouras CA, Burke D, Lewis MO, Brown-Whitehorn T, Cianferoni A. Sustained milk consumption after 2 years post-milk epicutaneous immunotherapy for eosinophilic esophagitis. Allergy. 2021 May;76(5):1573-1576. doi: 10.1111/all.14659. Epub 2020 Nov 28. PMID: 33202086.

Spergel JM, Brown-Whitehorn TA, Muir A, Liacouras CA. Medical algorithm: Diagnosis and treatment of eosinophilic esophagitis in children. Allergy. 2020 Jun;75(6):1522-1524. doi: 10.1111/all.14188. Epub 2020 Jan 31. PMID: 31953959.

Spergel JM, Elci OU, Muir AB, Liacouras CA, Wilkins BJ, Burke D, Lewis MO, Brown-Whitehorn T, Cianferoni A. Efficacy of Epicutaneous Immunotherapy in Children With Milk-Induced Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2020 Feb;18(2):328-336.e7. doi: 10.1016/j.cgh.2019.05.014. Epub 2019 May 14. PMID: 31100455.

Godwin B, Wilkins B, Muir AB. EoE disease monitoring: Where we are and where we are going. Ann Allergy Asthma Immunol. 2020 Mar;124(3):240-247. doi: 10.1016/j.anai.2019.12.004. Epub 2019 Dec 9. PMID: 31830586; PMCID: PMC7059875.

Nakagawa H, Kasagi Y, Karakasheva TA, Hara T, Aaron B, Shimonosono M, Kijima T, Giroux V, Bailey D, Wilkins B, Abrams JA, Falk GW, Aceves SS, Spergel JM, Hamilton KE, Whelan KA, Muir AB. Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three-Dimensional Esophageal Organoids. Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e106. doi: 10.1002/cpsc.106. PMID: 32105412; PMCID: PMC7288850.

Muir AB, Whelan KA, Dougherty MK, Aaron B, Navarre B, Aceves SS, Dellon ES, Jensen ET. The potential for malignancy from atopic disorders and allergic inflammation: A systematic review and meta-analysis. Clin Exp Allergy. 2020 Feb;50(2):147-159. doi: 10.1111/cea.13537. Epub 2019 Dec 20. PMID: 31743536; PMCID: PMC6994341.

Muir AB, Brown-Whitehorn T, Godwin B, Cianferoni A. Eosinophilic esophagitis: early diagnosis is the key. Clin Exp Gastroenterol. 2019 Aug 15;12:391-399. doi: 10.2147/CEG.S175061. PMID: 31616174; PMCID: PMC6699505.

Muir AB, Jensen ET, Wechsler JB, Menard-Katcher P, Falk GW, Aceves SS, Furuta GT, Dellon ES, Rothenberg ME, Spergel JM. Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. J Allergy Clin Immunol Pract. 2019 Sep-Oct;7(7):2434-2436. doi: 10.1016/j.jaip.2019.03.020. Epub 2019 Mar 25. PMID: 30922989.

Ruffner MA, Song L, Maurer K, Shi L, Carroll MC, Wang JX, Muir AB, Spergel JM, Sullivan KE. Toll-like receptor 2 stimulation augments esophageal barrier integrity. Allergy. 2019 Dec;74(12):2449-2460. doi: 10.1111/all.13968. Epub 2019 Jul 25. PMID: 31267532; PMCID: PMC7083217.

Whelan KA, Godwin BC, Wilkins B, Elci OU, Benitez A, DeMarshall M, Sharma M, Gross J, Klein-Szanto AJ, Liacouras CA, Dellon ES, Spergel JM, Falk GW, Muir AB, Nakagawa H. Persistent Basal Cell Hyperplasia Is Associated With Clinical and Endoscopic Findings in Patients With Histologically Inactive Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2020 Jun;18(7):1475-1482.e1. doi: 10.1016/j.cgh.2019.08.055. Epub 2019 Sep 6. PMID: 31499251; PMCID: PMC7058491.

Aceves SS, King E, Collins MH, Yang GY, Capocelli KE, Abonia JP, Atkins D, Bonis PA, Carpenter CL, Dellon ES, Eby MD, Falk GW, Gonsalves N, Gupta SK, Hirano I, Kocher K, Krischer JP, Leung J, Lipscomb J, Menard-Katcher P, Mukkada VA, Pan Z, Spergel JM, Sun Q, Wershil BK, Rothenberg ME, Furuta GT: Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. Journal of Allergy and Clinical Immunology 142(1): 130-138, Jul 2018 Notes: Assisted in patient recruitment and discussion of results

Dellon ES, Liacouras CA, Molina-Infante J, Furuta G T, Spergel M, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang G-Y, Hirano I, Bredenoord AJ: Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE conference. Gastroenterology Jul 2018

Muir Amanda B, Jensen Elizabeth T, Wechsler Joshua B, Menard-Katcher Paul, Falk Gary W, Aceves Seema S, Furuta Glenn T, Dellon Evan S, Rothenberg Mark E, Spergel Jonathan M: Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. The journal of allergy and clinical immunology. In practice Mar 2019.

Muir AB, Wang JX, Nakagawa H.: Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis. J of Gastroenterology 54(1): doi: 10.1007, Aug 2018 Notes: epub ahead of print.

Muir A, Moore H, Spergel J.: To treat or not to treat: The minimally symptomatic EoE patient. Ann Allergy Asthma Immunol 2018

Spergel Jonathan M, Elci Okan U, Muir Amanda B, Liacouras Chris A, Wilkins Benjamin J, Burke Deirdre, Lewis Megan O, Brown-Whitehorn Terri, Cianferoni Antonella: Efficacy of Epicutaneous Immunotherapy in Children with Milk-Induced Eosinophilic Esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association May 2019.

Pesek Robert D, Reed Craig C, Muir Amanda B, Fulkerson Patricia C, Menard-Katcher Calies, Falk Gary W, Kuhl Jonathan, Martin Ellen K, Magier Adam Z, Ahmed Faria, Demarshall Maureen, Gupta Ankur, Gross Jonathan, Ashorobi Tokunbo, Carpenter Christina L, Krischer Jeffrey P, Gonsalves Nirmala, Spergel Jonathan M, Gupta Sandeep K, Furuta Glenn T, Rothenberg Marc E, Dellon Evan S: Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium. The American journal of gastroenterology 114(6): 984-994, Jun 2019.

Shaverdashvili Khvaramze, Padlo Jennie, Weinblatt Daniel, Jia Yang, Jiang Wenpeng, Rao Divya, Laczkó Dorottya, Whelan Kelly A, Lynch John P, Muir Amanda B, Katz Jonathan P: KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. PloS one 14(4): e0215746, 2019.

Inflammatory Bowel Disease (IBD)

Articles

Breton J, Kastl A, Conrad MA, Baldassano RN. Positioning Biologic Therapies in the Management of Pediatric Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2020 Aug;16(8):400-414. PMID: 34035746; PMCID: PMC8132662.

Breton J, Witmer CM, Zhang Y, Downing M, Stevenson J, McDermott J, Siddique SM, Grossman AB. Utilization of an Electronic Medical Record-integrated Dashboard Improves Identification and Treatment of Anemia and Iron Deficiency in Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020 Nov 9:izaa288. doi: 10.1093/ibd/izaa288. Epub ahead of print. PMID: 33165613.

Buckley LH, Xiao R, Perman MJ, Grossman AB, Weiss PF. Psoriasis Associated With Tumor Necrosis Factor Inhibitors in Children With Inflammatory Diseases. Arthritis Care Res (Hoboken). 2021 Feb;73(2):215-220. doi: 10.1002/acr.24100. Epub 2021 Jan 3. Erratum in: Arthritis Care Res (Hoboken). 2021 May;73(5):764. PMID: 31646743; PMCID: PMC8176628.

Bushman FD, Conrad M, Ren Y, Zhao C, Gu C, Petucci C, Kim MS, Abbas A, Downes KJ, Devas N, Mattei LM, Breton J, Kelsen J, Marakos S, Galgano A, Kachelries K, Erlichman J, Hart JL, Moraskie M, Kim D, Zhang H, Hofstaedter CE, Wu GD, Lewis JD, Zackular JP, Li H, Bittinger K, Baldassano R. Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease. Cell Host Microbe. 2020 Sep 9;28(3):422-433.e7. doi: 10.1016/j.chom.2020.07.020. Epub 2020 Aug 20. PMID: 32822584.

Conrad MA, Kelsen JR. Editorial to Temporal Gut Microbial Changes Predict Recurrent Clostridium difficile Infection in Patients With and Without Ulcerative Colitis. Inflamm Bowel Dis. 2020 Oct 23;26(11):1759-1760. doi: 10.1093/ibd/izz336. PMID: 31968096; PMCID: PMC8243268.

Dou Y, Maurer K, Conrad M, Patel T, Shraim R, Sullivan KE, Kelsen J. Mucosal Invariant T cells are Diminished in Very Early-Onset Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2021 Jun 7. doi: 10.1097/MPG.0000000000003189. Epub ahead of print. PMID: 34117197.

Goyal A, Zheng Y, Albenberg LG, Stoner NL, Hart L, Alkhouri R, Hampson K, Ali S, Cho-Dorado M, Goyal RK, Grossman A. Anemia in Children With Inflammatory Bowel Disease: A Position Paper by the IBD Committee of the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2020 Oct;71(4):563-582. doi: 10.1097/MPG.0000000000002885. PMID: 32947565.

Haberman Y, Minar P, Karns R, Dexheimer PJ, Ghandikota S, Tegge S, Shapiro D, Shuler B, Venkateswaran S, Braun T, Ta A, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Dotson JL, Mack DR, Kellermayer R, Griffiths AM, Heyman MB, Baker SS, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Gokhale R, Kim S, Guthery SL, Cohen SA, Snapper S, Aronow BJ, Stephens M, Gibson G, Dillman JR, Dubinsky M, Hyams JS, Kugathasan S, Jegga AG, Denson LA. Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease. J Crohns Colitis. 2020 Aug 8;15(2):273–86. doi: 10.1093/ecco-jcc/jjaa166. Epub ahead of print. PMID: 32770196; PMCID: PMC7904088.

Havele SA, Clark AK, Oboite M, Conrad MA, Perman MJ, Rubin AI, Treat JR. Bowel-associated dermatosis-arthritis syndrome in a child with very early onset inflammatory bowel disease. Pediatr Dermatol. 2021 May;38(3):697-698. doi: 10.1111/pde.14544. Epub 2021 Mar 21. PMID: 33749007.

Hung HH, Lee HC, Yeung CY, Wang NL, Tang TY, Winter HS, Kelsen JR, Jiang CB. Importance of early detection of infantile inflammatory bowel disease with defective IL-10 pathway: A case report. Medicine (Baltimore). 2021 May 28;100(21):e25868. doi: 10.1097/MD.0000000000025868. PMID: 34032699; PMCID: PMC8154448.

Hyams JS, Brimacombe M, Haberman Y, Walters T, Gibson G, Mo A, Mack D, Griffiths A, Boyle B, LeLeiko N, Markowitz J, Rosh J, Patel A, Shah S, Baldassano R, Pfefferkorn M, Sauer C, Dailey J, Venkateswaran S, Kugathasan S, Denson LA. Clinical and Host Biological Factors Predict Colectomy Risk in Children Newly Diagnosed With Ulcerative Colitis. Inflamm Bowel Dis. 2021 Apr 27:izab061. doi: 10.1093/ibd/izab061. Epub ahead of print. PMID: 33904583.

Kelsen JR, Dawany N, Conrad MA, Karakasheva TA, Maurer K, Wei JM, Uman S, Dent MH, Behera R, Bryant LM, Ma X, Moreira L, Chatterji P, Shraim R, Merz A, Mizuno R, Simon LA, Muir AB, Giraudo C, Behrens EM, Whelan KA, Devoto M, Russo PA, Andres SF, Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Inflamm Bowel Dis. 2021 Jan 19;27(2):256-267. doi: 10.1093/ibd/izaa145. PMID: 32556182; PMCID: PMC7813751.

Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group. A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn's Disease. Gastroenterology. 2021 May 27:S0016-5085(21)03069-9. doi: 10.1053/j.gastro.2021.05.047. Epub ahead of print. PMID: 34052278.

Liang G, Conrad MA, Kelsen JR, Kessler LR, Breton J, Albenberg LG, Marakos S, Galgano A, Devas N, Erlichman J, Zhang H, Mattei L, Bittinger K, Baldassano RN, Bushman FD. Dynamics of the Stool Virome in Very Early-Onset Inflammatory Bowel Disease. J Crohns Colitis. 2020 Nov 7;14(11):1600-1610. doi: 10.1093/ecco-jcc/jjaa094. PMID: 32406906; PMCID: PMC7648169.

Mack DR, Saul B, Boyle B, Griffiths A, Sauer C, Markowitz J, LeLeiko N, Keljo D, Rosh JR, Baker SS, Steiner S, Heyman MB, Patel AS, Baldassano R, Noe J, Rufo P, Kugathasan S, Walters T, Marquis A, Thomas SM, Denson L, Hyams J; PROTECT STUDY GROUP. Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children. J Pediatr Gastroenterol Nutr. 2020 Sep;71(3):354-360. doi: 10.1097/MPG.0000000000002797. PMID: 32520830.

Marcovitch L, Focht G, Horesh A, Shosberger A, Hyams J, Bousvaros A, Hale AE, Baldassano R, Otley A, Mack DR, Kappelman MD, Griffiths AM, Turner D. Agreement on Symptoms Between Children With Ulcerative Colitis and Their Caregivers: Towards Developing the TUMMY-UC. J Pediatr Gastroenterol Nutr. 2021 Mar 4. doi: 10.1097/MPG.0000000000003120. Epub ahead of print. PMID: 33720091.

Mitchel EB, Paul A, El-Ali A, Cheng PC, Albenberg LG. Drug-induced Lung Disease Associated With Ustekinumab in a Pediatric Patient With Crohn Disease. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):e143-e145. doi: 10.1097/MPG.0000000000002783. PMID: 33093382.

Mitchel EB, Rosenbaum S, Gaeta C, Huang J, Raffini LJ, Baldassano RN, Denburg MR, Albenberg L. Venous Thromboembolism in Pediatric Inflammatory Bowel Disease: A Case-Control Study. J Pediatr Gastroenterol Nutr. 2021 May 1;72(5):742-747. doi: 10.1097/MPG.0000000000003078. PMID: 33605670.

Moore H, Dubes L, Fusillo S, Baldassano R, Stein R. Tofacitinib Therapy in Children and Young Adults with Pediatric-Onset Medically-Refractory Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2021 Jun 1. doi: 10.1097/MPG.0000000000003190. Epub ahead of print. PMID: 34091545.

Moore H, Wechsler J, Frost C, Whiteside E, Baldassano R, Markowitz J, Muir AB. Comorbid Diagnosis of Eosinophilic Esophagitis and Inflammatory Bowel Disease in the Pediatric Population. J Pediatr Gastroenterol Nutr. 2021 Mar 1;72(3):398-403. doi: 10.1097/MPG.0000000000003002. PMID: 33230079.

Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton K, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Yeboa KA, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz B, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelhardt KR, Cant AJ, Hambleton S, Barclay A, Toth-Petroczy A, Vuzman D, Carmichael N, Bodea C, Cassa CA, Devoto M, Maas RL, Behrens EM, Giraudo CG, Snapper SB. Variants in STXBP3 Are Associated With Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Apr 23:jjab077. doi: 10.1093/ecco-jcc/jjab077. Epub ahead of print. PMID: 33891011.

Palchaudhuri S, Albenberg L, Lewis JD. Diet Recommendations for Hospitalized Patients With Inflammatory Bowel Disease: Better Options Than Nil Per Os. Crohns Colitis 360. 2020 Oct;2(4):otaa059. doi: 10.1093/crocol/otaa059. Epub 2020 Jul 17. PMID: 33954288; PMCID: PMC8096188.

Roy Paladhi U, Harb AH, Daniel SG, Dawwas GK, Schnellinger EM, Wollack C, Aberra FN, Bewtra M, Green JA, Klaproth JA, Lichtenstein GR, Saxena A, Berera S, Buchner A, Mehta SJ, Osterman MT, Rashid F, Tomov V, Caldera F, Sumona S, Mahadevan U, Roy A, Nessel L, Wu GD, Bittinger K, Lewis JD. The Impact of Introducing Patient-Reported Inflammatory Bowel Disease Symptoms via Electronic Survey on Clinic Visit Length, Patient and Provider Satisfaction, and the Environment Microbiome. Inflamm Bowel Dis. 2021 Apr 15;27(5):746-750. doi: 10.1093/ibd/izaa356. PMID: 33452800.

Smith SA, Ogawa SA, Chau L, Whelan KA, Hamilton KE, Chen J, Tan L, Chen EZ, Keilbaugh S, Fogt F, Bewtra M, Braun J, Xavier RJ, Clish CB, Slaff B, Weljie AM, Bushman FD, Lewis JD, Li H, Master SR, Bennett MJ, Nakagawa H, Wu GD. Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines. J Clin Invest. 2021 Jan 4;131(1):e133371. doi: 10.1172/JCI133371. PMID: 33141762; PMCID: PMC7773399.

Somineni HK, Nagpal S, Venkateswaran S, Cutler DJ, Okou DT, Haritunians T, Simpson CL, Begum F, Datta LW, Quiros AJ, Seminerio J, Mengesha E, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Iskandar H, Dryden GW, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kuemmerle JF, Lazarev M, Li E, Mannon P, Moulton DE, Newberry RD, Patel AS, Pekow J, Saeed SA, Valentine JF, Wang MH, McCauley JL, Abreu MT, Jester T, Molle-Rios Z, Palle S, Scherl EJ, Kwon J, Rioux JD, Duerr RH, Silverberg MS, Zwick ME, Stevens C, Daly MJ, Cho JH, Gibson G, McGovern DPB, Brant SR, Kugathasan S. Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. Am J Hum Genet. 2021 Mar 4;108(3):431-445. doi: 10.1016/j.ajhg.2021.02.001. Epub 2021 Feb 17. PMID: 33600772; PMCID: PMC8008495.

Ta AD, Ollberding NJ, Karns R, Haberman Y, Alazraki AL, Hercules D, Baldassano R, Markowitz J, Heyman MB, Kim S, Kirschner B, Shapiro JM, Noe J, Oliva-Hemker M, Otley A, Pfefferkorn M, Kellermayer R, Snapper S, Rabizadeh S, Xavier R, Dubinsky M, Hyams J, Kugathasan S, Jegga AG, Dillman JR, Denson LA. Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease. Inflamm Bowel Dis. 2021 Jan 16:izaa339. doi: 10.1093/ibd/izaa339. Epub ahead of print. PMID: 33452801.

Turner D, Bishai J, Reshef L, Abitbol G, Focht G, Marcus D, Ledder O, Lev-Tzion R, Orlanski-Meyer E, Yerushalmi B, Aloi M, Griffiths AM, Albenberg L, Kolho KL, Assa A, Cohen S, Gophna U, Vlamakis H, Lurz E, Levine A. Antibiotic Cocktail for Pediatric Acute Severe Colitis and the Microbiome: The PRASCO Randomized Controlled Trial. Inflamm Bowel Dis. 2020 Oct 23;26(11):1733-1742. doi: 10.1093/ibd/izz298. PMID: 31833543.

Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MI, Garay JAR, Lee SH, Guttman DS, Griffiths A, Moayyedi P, Panaccione R, Huynh H, Steinhart HA, Aumais G, Dieleman LA, Turner D; CCC IBD GEM Project research team, Paterson AD, Croitoru K. Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn's disease subjects. BMC Med Genet. 2020 Oct 15;21(1):204. doi: 10.1186/s12881-020-01115-w. PMID: 33059653; PMCID: PMC7566148.

Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD; Crohn’s and Colitis Canada Genetic Environmental Microbial Project Research Consortium; CCC GEM Project recruitment site directors include Maria Abreu, Croitoru K. Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease. Gastroenterology. 2020 Dec;159(6):2092-2100.e5. doi: 10.1053/j.gastro.2020.08.005. Epub 2020 Aug 10. PMID: 32791132.

Tokarz R, Hyams JS, Mack DR, Boyle B, Griffiths AM, LeLeiko NS, Sauer CG, Shah S, Markowitz J, Baker SS, Rosh J, Baldassano RN, Kugathasan S, Walters T, Tagliafierro T, Sameroff S, Lee B, Che X, Oleynik A, 3Denson LA, Lipkin WI. Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Inflamm Bowel Dis. 2019 Sep 18;25(10):1656-1662. doi: 10.1093/ibd/izz099. PMID: 31112614; PMCID: PMC7108593.

Conrad MA, Kelsen JR. Genomic and Immunologic Drivers of Very Early-Onset Inflammatory Bowel Disease. Pediatr Dev Pathol. 2019 May-Jun;22(3):183-193. doi: 10.1177/1093526619834807. Epub 2019 Mar 6. PMID: 30841788; PMCID: PMC6942488.

Albenberg L, Brensinger CM, Wu Q, Gilroy E, Kappelman MD, Sandler RS, Lewis JD. A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares. Gastroenterology. 2019 Jul;157(1):128-136.e5. doi: 10.1053/j.gastro.2019.03.015. Epub 2019 Mar 11. PMID: 30872105; PMCID: PMC6726378.

Turner D, Griffiths AM, Wilson D, Mould DR, Baldassano RN, Russell RK, Dubinsky M, Heyman MB, de Ridder L, Hyams J, Martin de Carpi J, Conklin L, Faubion WA, Koletzko S, Bousvaros A, Ruemmele FM. Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary. Gut. 2020 Jan;69(1):32-41. doi: 10.1136/gutjnl-2018-317987. Epub 2019 Apr 12. PMID: 30979718.

Ballengee CR, Stidham RW, Liu C, Kim MO, Prince J, Mondal K, Baldassano R, Dubinsky M, Markowitz J, Leleiko N, Hyams J, Denson L, Kugathasan S. Association Between Plasma Level of Collagen Type III Alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease. Clin Gastroenterol Hepatol. 2019 Aug;17(9):1799-1806. doi: 10.1016/j.cgh.2018.09.008. Epub 2018 Sep 10. PMID: 30213581; PMCID: PMC6531351.

Conrad MA, Kelsen JR. Editorial to Temporal Gut Microbial Changes Predict Recurrent Clostridium difficile Infection in Patients With and Without Ulcerative Colitis. Inflamm Bowel Dis. 2020 Jan 22:izz336. doi: 10.1093/ibd/izz336. Epub ahead of print. PMID: 31968096.

Kelsen JR, Sullivan KE, Rabizadeh S, Singh N, Snapper S, Elkadri A, Grossman AB. NASPGHAN Position Paper on The Evaluation and Management for Patients with Very Early-Onset Inflammatory Bowel Disease (VEO-IBD). J Pediatr Gastroenterol Nutr. 2019 Dec 30. doi: 10.1097/MPG.0000000000002567. Epub ahead of print. PMID: 31899730.

Mitchel EB, Paul A, El-Ali A, Cheng PY, Albenberg LG. Drug Induced Lung Disease Associated with Ustekinumab in a Pediatric Patient with Crohn's Disease. J Pediatr Gastroenterol Nutr. 2020 May 12. doi: 10.1097/MPG.0000000000002783. Epub ahead of print. PMID: 32404766.

Breton J, Kastl A, Hoffmann N, Rogers R, Grossman AB, Mamula P, Kelsen JR, Baldassano RN, Albenberg L. Efficacy of Combination Antibiotic Therapy for Refractory Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019 Aug 20;25(9):1586-1593. doi: 10.1093/ibd/izz006. PMID: 30715364; PMCID: PMC6939824.

Buckley LH, Xiao R, Perman MJ, Grossman AB, Weiss PF. Psoriasis Associated with Tumor Necrosis Factor-Alpha Inhibitors in Children with Inflammatory Diseases. Arthritis Care Res (Hoboken). 2019 Oct 23. doi: 10.1002/acr.24100. Epub ahead of print. PMID: 31646743.

Conrad MA, Kelsen JR. The Treatment of Pediatric Inflammatory Bowel Disease with Biologic Therapies. Curr Gastroenterol Rep. 2020 Jun 15;22(8):36. doi: 10.1007/s11894-020-00773-3. PMID: 32542562.

El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BGP, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR. Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2020 Apr 29:S1542-3565(20)30600-5. doi: 10.1016/j.cgh.2020.04.055. Epub ahead of print. PMID: 32360820.

Forrest CB, Forrest KD, Clegg JL, de la Motte A, Amaral S, Grossman AB, Furth SL. Establishing the content validity of PROMIS Pediatric pain interference, fatigue, sleep disturbance, and sleep-related impairment measures in children with chronic kidney disease and Crohn's disease. J Patient Rep Outcomes. 2020 Feb 12;4(1):11. doi: 10.1186/s41687-020-0178-2. PMID: 32052205; PMCID: PMC7016154.

Kelsen JR, Dawany N, Conrad MA, Karakasheva TA, Maurer K, Wei JM, Uman S, Dent MH, Behera R, Bryant LM, Ma X, Moreira L, Chatterji P, Shraim R, Merz A, Mizuno R, Simon LA, Muir AB, Giraudo C, Behrens EM, Whelan KA, Devoto M, Russo PA, Andres SF, Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Inflamm Bowel Dis. 2020 Jun 19:izaa145. doi: 10.1093/ibd/izaa145. Epub ahead of print. PMID: 32556182.

Kelsen JR, Sullivan KE, Rabizadeh S, Singh N, Snapper S, Elkadri A, Grossman AB. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Evaluation and Management for Patients With Very Early-onset Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2020 Mar;70(3):389-403. doi: 10.1097/MPG.0000000000002567. PMID: 32079889.

Lekbua A, Ouahed J, O'Connell AE, Kahn SA, Goldsmith JD, Imamura T, Duncan CN, Kelsen JR, Worthey E, Snapper SB, Softic S. Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2019 Jul;69(1):e13-e18. doi: 10.1097/MPG.0000000000002297. PMID: 31232887; PMCID: PMC6607918.

Liang G, Conrad MA, Kelsen JR, Kessler LR, Breton J, Albenberg LG, Marakos S, Galgano A, Devas N, Erlichman J, Zhang H, Mattei L, Bittinger K, Baldassano RN, Bushman FD. The dynamics of the stool virome in very early onset inflammatory bowel disease. J Crohns Colitis. 2020 May 14:jjaa094. doi: 10.1093/ecco-jcc/jjaa094. Epub ahead of print. PMID: 32406906.

Lichtenstein GR, Shahabi A, Seabury SA, Lakdawalla DN, Espinosa OD, Green S, Brauer M, Baldassano RN. Lifetime Economic Burden of Crohn's Disease and Ulcerative Colitis by Age at Diagnosis. Clin Gastroenterol Hepatol. 2020 Apr;18(4):889-897.e10. doi: 10.1016/j.cgh.2019.07.022. Epub 2019 Jul 18. PMID: 31326606.

Mack DR, Saul B, Boyle B, Griffiths A, Sauer C, Markowitz J, LeLeiko N, Keljo D, Rosh JR, Baker SS, Steiner S, Heyman MB, Patel AS, Baldassano R, Noe J, Rufo P, Kugathasan S, Walters T, Marquis A, Thomas SM, Denson L, Hyams J; PROTECT STUDY GROUP. Analysis of Using the Total White Blood Cell Count to Define Severe New Onset Ulcerative Colitis in Children. J Pediatr Gastroenterol Nutr. 2020 Jun 9. doi: 10.1097/MPG.0000000000002797. Epub ahead of print. PMID: 32520830.

Mitchel E, Diamond T, Albenberg L. Venous Thrombosis in Pediatric Inflammatory Bowel Disease. J Pediatr. 2020 Jan;216:213-217. doi: 10.1016/j.jpeds.2019.09.034. Epub 2019 Oct 11. PMID: 31610937.

Moore H, Dolce P, Devas N, Baldassano R, Martinelli M. Post-induction infliximab trough levels and disease activity in the clinical evolution of pediatric ulcerative colitis. United European Gastroenterol J. 2020 May;8(4):425-435. doi: 10.1177/2050640620912877. Epub 2020 Mar 12. PMID: 32213038; PMCID: PMC7226697.

Turner D, Bishai J, Reshef L, Abitbol G, Focht G, Marcus D, Ledder O, Lev-Tzion R, Orlanski-Meyer E, Yerushalmi B, Aloi M, Griffiths AM, Albenberg L, Kolho KL, Assa A, Cohen S, Gophna U, Vlamakis H, Lurz E, Levine A. Antibiotic Cocktail for Pediatric Acute Severe Colitis and the Microbiome: The PRASCO Randomized Controlled Trial. Inflamm Bowel Dis. 2019 Dec 13:izz298. doi: 10.1093/ibd/izz298. Epub ahead of print. PMID: 31833543.

Ballengee Cortney R, Stidham Ryan W, Liu Chunyan, Kim Mi-Ok, Prince Jarod, Mondal Kajari, Baldassano Robert, Dubinsky Marla, Markowitz James, Leleiko Neal, Hyams Jeffrey, Denson Lee, Kugathasan Subra: Association Between Plasma Level of Collagen Type III alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Sep 2018.

Breton J, Kastl A, Hoffmann N, Rogers R, Grossman AB, Mamula P, Kelsen JR, Baldassano RN, Albenberg L: Efficacy of combination antibiotic therapy for refractory pediatric inflammatory bowel disease. Inflammatory Bowel Diseases Feb 2019 Notes: [Epub ahead of print]

Chenthan, Ballengee Cortney R, Liu Chunyan, Kim Mi-Ok, Baker Susan S, Baldassano Robert N, Cohen Stanley A, Crandall Wallace V, Denson Lee A, Dubinsky Marla C, Evans Jonathan, Gokhale Ranjana, Griffiths Anne, Guthery Stephen L, Oliva-Hemker Maria, Heyman Melvin B, Keljo David, Kellermayer Richard, Leleiko Neal S, Mack David R, Markowitz James F, Moulton Dedrick E, Noe Joshua D, Otley Anthony R, Patel Ashish S, Pfefferkorn Marian, Rabizadeh Shervin, Rosh Joel R, Snapper Scott, Walters Thomas D, Ziring David, Mondal Kajari, Kappelman Michael D, Hyams Jeffrey S, Kugathasan Subra: Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. Inflammatory bowel diseases Jan 2019.

Church Peter C, Kuint Ruth Cytter, Ledder Oren, Navas-López Victor M, Sladek Malgorzata, Brückner Annecarin, Baldassano Robert N, Weiss Batia, Yerushalmi Baruch, Saeed Shehzad A, Hyams Jeffrey, Otley Anthony, Griffiths Anne M, Turner Dan, Greer Mary-Louise C: Magnetic Resonance Enterography Cannot Replace Upper Endoscopy in Pediatric Crohn's Disease: An ImageKids Sub-study. Journal of pediatric gastroenterology and nutrition 67(1): 53-58, Jul 2018.

Conrad MA, Kelsen JR.: Genomic and Immunologic Drivers of Very Early-Onset Inflammatory Bowel Disease. Pediatr Dev Patho May 2019

Denson Lee A, Jurickova Ingrid, Karns Rebekah, Shaw Kelly A, Cutler David J, Okou David, Alexander Valencia C, Dodd Anne, Mondal Kajari, Aronow Bruce J, Haberman Yael, Linn Aaron, Price Adam, Bezold Ramona, Lake Kathleen, Jackson Kimberly, Walters Thomas D, Griffiths Anne, Baldassano Robert N, Noe Joshua D, Hyams Jeffrey S, Crandall Wallace V, Kirschner Barbara S, Heyman Melvin B, Snapper Scott, Guthery Stephen L, Dubinsky Marla C, Leleiko Neal S, Otley Anthony R, Xavier Ramnik J, Stevens Christine, Daly Mark J, Zwick Michael E, Kugathasan Subra: Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflammatory bowel diseases Aug 2018 Notes: doi: 10.1093/ibd/izy265 [Epub ahead of print]

Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY.: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med April 2019

Grossman AB (reviewer/contributor): Pediatric Crohn's Disease. National Organization for Rare Disorders (https://rarediseases.org/rare-diseases/pediatric-crohns-disease ) 2019

Haberman Yael, Karns Rebekah, Dexheimer Phillip J, Schirmer Melanie, Somekh Judith, Jurickova Ingrid, Braun Tzipi, Novak Elizabeth, Bauman Laura, Collins Margaret H, Mo Angela, Rosen Michael J, Bonkowski Erin, Gotman Nathan, Marquis Alison, Nistel Mason, Rufo Paul A, Baker Susan S, Sauer Cary G, Markowitz James, Pfefferkorn Marian D, Rosh Joel R, Boyle Brendan M, Mack David R, Baldassano Robert N, Shah Sapana, Leleiko Neal S, Heyman Melvin B, Grifiths Anne M, Patel Ashish S, Noe Joshua D, Aronow Bruce J, Kugathasan Subra, Walters Thomas D, Gibson Greg, Thomas Sonia Davis, Mollen Kevin, Shen-Orr Shai, Huttenhower Curtis, Xavier Ramnik J, Hyams Jeffrey S, Denson Lee A: Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nature communications 10(1): 38, Jan 2019

Haberman Yael, Schirmer Melanie, Dexheimer Phillip J, Karns Rebekah, Braun Tzipi, Kim Mi-Ok, Walters Thomas D, Baldassano Robert N, Noe Joshua D, Rosh Joel, Markowitz James, Crandall Wallace V, Mack David R, Griffiths Anne M, Heyman Melvin B, Baker Susan S, Kellermayer Richard, Moulton Dedrick, Patel Ashish S, Gulati Ajay S, Steiner Steven J, LeLeiko Neal, Otley Anthony, Oliva-Hemker Maria, Ziring David, Kirschner Barbara S, Keljo David J, Guthery Stephen L, Cohen Stanley A, Snapper Scott, Evans Jonathan, Dubinsky Marla, Aronow Bruce, Hyams Jeffrey S, Kugathasan Subra, Huttenhower Curtis, Xavier Ramnik J, Denson Lee A: Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal immunology Dec 2018.

Hyams Jeffrey S, Davis Thomas Sonia, Gotman Nathan, Haberman Yael, Karns Rebekah, Schirmer Melanie, Mo Angela, Mack David R, Boyle Brendan, Griffiths Anne M, LeLeiko Neal S, Sauer Cary G, Keljo David J, Markowitz James, Baker Susan S, Rosh Joel, Baldassano Robert N, Patel Ashish, Pfefferkorn Marian, Otley Anthony, Heyman Melvin, Noe Joshua, Oliva-Hemker Maria, Rufo Paul A, Strople Jennifer, Ziring David, Guthery Stephen L, Sudel Boris, Benkov Keith, Wali Prateek, Moulton Dedrick, Evans Jonathan, Kappelman Michael D, Marquis M Alison, Sylvester Francisco A, Collins Margaret H, Venkateswaran Suresh, Dubinsky Marla, Tangpricha Vin, Spada Krista L, Saul Bradley, Wang Jessie, Serrano Jose, Hommel Kevin, Marigorta Urko M, Gibson Greg, Xavier Ramnik J, Kugathasan Subra, Walters Thomas, Denson Lee A: Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study. Lancet (London, England) Mar 2019.

Kelly Daniel, Kotliar Michael, Woo Vivienne, Jagannathan Sajjeev, Whitt Jordan, Moncivaiz Jessica, Aronow Bruce J, Dubinsky Marla C, Hyams Jeffrey S, Markowitz James F, Baldassano Robert N, Stephens Michael C, Walters Thomas D, Kugathasan Subra, Haberman Yael, Sundaram Nambirajan, Rosen Michael J, Helmrath Michael, Karns Rebekah, Barski Artem, Denson Lee A, Alenghat Theresa: Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight 3(18), Sep 2018.

Kelsen JR, Russo P, Sullivan KE.: Early-Onset Inflammatory Bowel Disease. Immunol Allergy Clin North Am Feb 2019

Lekbua A, Ouahed J, O'Connell AE, Kahn SA, Goldsmith JD, Imamura T, Duncan CN, Kelsen JR, Worthey E, Snapper SB, Softic S.: Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. JPGN Feb 2019

Lindoso Livia, Mondal Kajari, Venkateswaran Suresh, Somineni Hari K, Ballengee Cortney, Walters Thomas D, Griffiths Anne, Noe Joshua D, Crandall Wallace, Snapper Scott, Rabizadeh Shervin, Rosh Joel R, LeLeiko Neal, Guthery Stephen, Mack David, Kellermayer Richard, Gulati Ajay S, Pfefferkorn Marian D, Moulton Dedrick E, Keljo David, Cohen Stanley, Oliva-Hemker Maria, Heyman Melvin B, Otley Anthony, Baker Susan S, Evans Jonathan S, Kirschner Barbara S, Patel Ashish S, Ziring David, Stephens Michael C, Baldassano Robert, Dubinsky Marla C, Markowitz James, Denson Lee A, Hyams Jeffrey, Kugathasan Subra, Ananthakrishnan Ashwin N: The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. The American journal of gastroenterology Sep 2018

Patel T, Conrad M, Kelsen JR: Common Threads in Pediatric Inflammatory Diseases: Insight Into Personalized Medicine. JAMA Pediatrics August 2018.

Priya Chatterji, Patrick A. Williams, Kelly A. Whelan, Fernando C. Samper, Sarah F. Andres, Lauren A. Simon, Louis R Parham, Rei Mizuno, Emma T. Lundsmith, David S.M. Lee, Shun Liang, H.R. Sagara Wijeratne; Stefanie Marti, Lillian Chau, Veronique Giroux, Benjamin J. Wilkins, Gary D. Wu, Premal Shah, Gian G. Tartaglia, and Kathryn E. Hamilton: Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1. EMBO Reports March 2019

Schirmer Melanie, Denson Lee, Vlamakis Hera, Franzosa Eric A, Thomas Sonia, Gotman Nathan M, Rufo Paul, Baker Susan S, Sauer Cary, Markowitz James, Pfefferkorn Marian, Oliva-Hemker Maria, Rosh Joel, Otley Anthony, Boyle Brendan, Mack David, Baldassano Robert, Keljo David, LeLeiko Neal, Heyman Melvin, Griffiths Anne, Patel Ashish S, Noe Joshua, Kugathasan Subra, Walters Thomas, Huttenhower Curtis, Hyams Jeffrey, Xavier Ramnik J: Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell host & microbe 24(4): 600-610.e4, Oct 2018

Somineni Hari K, Venkateswaran Suresh, Kilaru Varun, Marigorta Urko M, Mo Angela, Okou David T, Kellermayer Richard, Mondal Kajari, Cobb Dawayland, Walters Thomas D, Griffiths Anne, Noe Joshua D, Crandall Wallace V, Rosh Joel R, Mack David R, Heyman Melvin B, Baker Susan S, Stephens Michael C, Baldassano Robert N, Markowitz James F, Dubinsky Marla C, Cho Judy, Hyams Jeffrey S, Denson Lee A, Gibson Greg, Cutler David J, Conneely Karen N, Smith Alicia K, Kugathasan Subra: Blood-derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Gastroenterology Feb 2019.

Sullivan Ke, Conrad M, Kelsen JR: Very early-onset inflammatory bowel disease: an integrated approach. Curr Opin Allergy Clin Immuno 18, Dec 2018

Tokarz Rafal, Hyams Jeffrey S, Mack David R, Boyle Brendan, Griffiths Anne M, LeLeiko Neal S, Sauer Cary G, Shah Sapana, Markowitz James, Baker Susan S, Rosh Joel, Baldassano Robert N, Kugathasan Subra, Walters Thomas, Tagliafierro Teresa, Sameroff Stephen, Lee Bohyun, Che Xiaoyu, Oleynik Alexandra, Denson Lee A, Lipkin W Ian: Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Inflammatory bowel diseases May 2019.

Trusha Patel MD, Rawan Shraim BS, Kelly Maurer BA, Noor Dawany PhD, Claudio C. Giraudo PhD, Maire Conrad MD, Kathleen E. Sullivan MD, PhD and Judith R. Kelsen MD: Immunophenotyping of Very Early Onset Inflammatory Bowel Disease Patients: Population-Level Analysis  NASPGHAN 2018

Turner Dan, Griffiths Anne M, Wilson David, Mould Diane R, Baldassano Robert N, Russell Richard K, Dubinsky Marla, Heyman Melvin B, de Ridder Lissy, Hyams Jeffrey, Martin de Carpi Javier, Conklin Laurie, Faubion William A, Koletzko Sibylle, Bousvaros Athos, Ruemmele Frank M: Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary. Gut Apr 2019.

Wu Jing, Lubman David M, Kugathasan Subra, Denson Lee A, Hyams Jeffrey S, Dubinsky Marla C, Griffiths Anne M, Baldassano Robert N, Noe Joshua D, Rabizadeh Shervin, Gulati Ajay S, Rosh Joel R, Crandall Wallace V, Higgins Peter D R, Stidham Ryan W: Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease. The American journal of gastroenterology 114(5): 777-785, May 2019

Zhou Lei, Chu Coco, Teng Fei, Bessman Nicholas J, Goc Jeremy, Santosa Endi K, Putzel Gregory G, Kabata Hiroki, Kelsen Judith R, Baldassano Robert N, Shah Manish A, Sockolow Robbyn E, Vivier Eric, Eberl Gérard, Smith Kendall A, Sonnenberg Gregory F: Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature Apr 2019.

Books

Conrad M and Maxwell EC: Chapter 30: section on Intestinal Disorders. Nelson Pediatric Board Review - Certification and Recertification 2019

Liver

Articles

Bittermann T, Abt PL, Olthoff KM, Kaur N, Heimbach JK, Emamaullee J. Impact of Advanced Renal Dysfunction on Posttransplant Outcomes After Living Donor Liver Transplantation in the United States. Transplantation. 2021 Mar 2. doi: 10.1097/TP.0000000000003728. Epub ahead of print. PMID: 33660658.

Bittermann T, Dwinnells K, Chadha S, Wolf MS, Olthoff KM, Serper M. Low Health Literacy Is Associated With Frailty and Reduced Likelihood of Liver Transplant Listing: A Prospective Cohort Study. Liver Transpl. 2020 Nov;26(11):1409-1421. doi: 10.1002/lt.25830. Epub 2020 Oct 7. PMID: 32567232.

Chapin CA, Melin-Aldana H, Kreiger PA, Burn T, Neighbors K, Taylor SA, Ostilla L, Wechsler JB, Horslen SP, Leonis MA, Loomes KM, Behrens EM, Squires RH, Alonso EM; Pediatric Acute Liver Failure Study Group. Activated CD8 T-cell Hepatitis in Children With Indeterminate Acute Liver Failure: Results From a Multicenter Cohort. J Pediatr Gastroenterol Nutr. 2020 Dec;71(6):713-719. doi: 10.1097/MPG.0000000000002893. PMID: 32796431.

Chapin CA, Melin-Aldana H, Kreiger PA, Burn T, Neighbors K, Taylor SA, Ostilla L, Wechsler JB, Horslen SP, Leonis MA, Loomes KM, Behrens EM, Squires RH, Alonso EM; Pediatric Acute Liver Failure Study Group. Activated CD8 T-cell Hepatitis in Children With Indeterminate Acute Liver Failure: Results From a Multicenter Cohort. J Pediatr Gastroenterol Nutr. 2020 Dec;71(6):713-719. doi: 10.1097/MPG.0000000000002893. PMID: 32796431.

Clarkston K, Lee J, Donoghue S, Peters H, Eiroa H, Shah AA, Loomes K, Wen J, Oliver M, Hardikar W, Prada CE, Asai A. Acute liver dysfunction with delayed peak of serum aminotransferase levels as a presentation of ornithine transcarbamylase deficiency in females. Am J Med Genet A. 2021 Mar;185(3):909-915. doi: 10.1002/ajmg.a.62031. Epub 2020 Dec 24. PMID: 33369132; PMCID: PMC7974766.

Deneau MR, Mack C, Mogul D, Perito ER, Valentino PL, Amir AZ, DiGuglielmo M, Draijer LG, El-Matary W, Furuya KN, Gupta N, Hochberg JT, Horslen S, Jensen MK, Jonas MM, Kerkar N, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mohammad S, Ovchinsky N, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Vitola B, Zizzo A, Guthery SL. Oral Vancomycin, Ursodeoxycholic Acid, or No Therapy for Pediatric Primary Sclerosing Cholangitis: A Matched Analysis. Hepatology. 2021 Mar;73(3):1061-1073. doi: 10.1002/hep.31560. PMID: 32946600.

Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, Tavares Fagundes ED, El-Matary W, Ferrari F, Furuya KN, Gupta N, Hochberg JT, Homan M, Horslen S, Iorio R, Jensen MK, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammad S, Mohan P, Moroz S, Ovchinsky N, Palle S, Papadopoulou A, Rao G, Rodrigues Ferreira A, Sathya P, Schwarz KB, Shah U, Shteyer E, Singh R, Smolka V, Soufi N, Tanaka A, Varier R, Vitola B, Woynarowski M, Zerofsky M, Zizzo A, Guthery SL. The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children. Hepatology. 2021 Mar;73(3):1074-1087. doi: 10.1002/hep.31393. Epub 2020 Dec 19. PMID: 32464706.

Ekpanyapong S, Philips N, Loza BL, Abt P, Furth EE, Tondon R, Khungar V, Olthoff K, Shaked A, Hoteit MA, Reddy KR. Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience. J Clin Exp Hepatol. 2020 Jul-Aug;10(4):304-315. doi: 10.1016/j.jceh.2019.11.003. Epub 2019 Nov 22. PMID: 32655233; PMCID: PMC7335705.

El-Matary W, Guthery SL, Amir AZ, DiGuglielmo M, Draijer LG, Furuya KN, Gupta N, Hochberg JT, Horslen S, Kerkar N, Koot BGP, Laborda TJ, Loomes KM, Mack C, Martinez M, Miethke A, Miloh T, Mogul D, Mohammed S, Moroz S, Ovchinsky N, Perito ER, Rao G, Ricciuto A, Sathya P, Schwarz KB, Shah U, Singh R, Soufi N, Valentino PL, Zizzo A, Deneau MR. Colorectal Dysplasia and Cancer in Pediatric-Onset Ulcerative Colitis Associated With Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. 2021 May;19(5):1067-1070.e2. doi: 10.1016/j.cgh.2020.04.055. Epub 2020 Apr 29. PMID: 32360820.

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Zhao X, Lorent K, Escobar-Zarate D, Rajagopalan R, Loomes KM, Gillespie K, Mesaros C, Estrada MA, Blair I, Winkler JD, Spinner NB, Devoto M, Pack M. Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia. Gastroenterology. 2020 Jun 4:S0016-5085(20)34754-5. doi: 10.1053/j.gastro.2020.05.080. Epub ahead of print. PMID: 32505743.

Mendenhall SD, Sawyer JD, West BL, Neumeister MW, Shaked A, Levin LS. Pediatric vascularized composite allotransplantation: What is the landscape for obtaining appropriate donors in the United States? Pediatr Transplant. 2019 Aug;23(5):e13466. doi: 10.1111/petr.13466. Epub 2019 May 12. PMID: 31081211.

Agawu A, Wehrman A, Pogoriler J, Terry NA, Lin HC: A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition. BMC Pediatrics 19(1): 72, 2019.

Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Whitington PF, Sherker AH, Sokol RJ, Bezerra JA, Magee JC and the ChiLDReN Network: Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia:  The Multi-center START Trial. Journal of Pediatrics 202: 179-85, 2018

Berauer John-Paul, Mezina Anya I, Okou David T, Sabo Aniko, Muzny Donna M, Gibbs Richard A, Hegde Madhuri R, Chopra Pankaj, Cutler David J, Perlmutter David H, Bull Laura N, Thompson Richard J, Loomes Kathleen M, Spinner Nancy B, Rajagopalan Ramakrishnan, Guthery Stephen L, Moore Barry, Yandell Mark, Harpavat Sanjiv, Magee John C, Kamath Binita M, Molleston Jean P, Bezerra Jorge A, Murray Karen F, Alonso Estella M, Rosenthal Philip, Squires Robert H, Wang Kasper S, Finegold Milton J, Russo Pierre, Sherker Averell H, Sokol Ronald J, Karpen Saul J: Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome. Hepatology (Baltimore, Md.) Jan 2019

Biko David M, Smith Christopher L, Otero Hansel J, Saul David, White Ammie M, DeWitt Aaron, Glatz Andrew C, Piccoli David A, Mamula Petar, Rome Jonathan J, Dori Yoav: Intrahepatic dynamic contrast MR lymphangiography: initial experience with a new technique for the assessment of liver lymphatics. European radiology Mar 2019

Chen Y, Gilbert MA, Grochowski CM, McEldrew DA, Llewellyn J, Waisbourd-Zinman O, Hakonarson H, Bailey-Wilson JE, Russo P, Wells RG, Loomes KM, Spinner NB, Devoto M.: A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1. PLOS Genetics 14(8), August 2018

Erlichman J, Loomes K, Flick J: Biliary atresia. Best Practice http://bestpractice.bmj.com 2018.

Erlichman J, Loomes KM: Approach to Neonatal Cholestasis. Up to Date 2018

Loomes Kathleen M, Spino Cathie, Goodrich Nathan P, Hangartner Thomas N, Marker Amanda E, Heubi James E, Kamath Binita M, Shneider Benjamin L, Rosenthal Philip, Hertel Paula M, Karpen Saul J, Molleston Jean P, Murray Karen F, Schwarz Kathleen B, Squires Robert H, Teckman Jeffrey, Turmelle Yumirle P, Alonso Estella M, Sherker Averell H, Magee John C, Sokol Ronald J: Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology (Baltimore, Md.) 69(1): 245-257, Jan 2019

Mack Cara L, Spino Cathie, Alonso Estella M, Bezerra Jorge A, Moore Jeffrey, Goodhue Catherine, Ng Vicky L, Karpen Saul J, Venkat Veena, Loomes Kathleen M, Wang Kasper, Sherker Averell H, Magee John C, Sokol Ronald J: A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia. Journal of pediatric gastroenterology and nutrition 68(4): 495-501, Apr 2019.

Mitchell Ellen, Gilbert Melissa, Loomes Kathleen M: Alagille Syndrome. Clinics in liver disease 22(4): 625-641, 11 2018

Murray, K.F., Balistreri, W. F., Bansal, S., Whitworth, S.,  Evans, H.M., Gonzalez-Peralta, R.P., Wen, J., Massetto, B., Kersey, K., Shao, J.,  Garrison, K.L., Parhy, B., Brainard, D.M., Arnon, R., Gillis, L., Jonas, M.M., Lin, C.H., Narkewicz, M.R., Schwarz, K., Rosenthal, P.: Safety and Efficacy of Ledipasvir-Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6-11. Hepatology Aug 2018.

Narkewicz MR, Horslen S, Hardison RM, Shneider BL, Rodriguez-Baez N, Alonso EM, Ng VL, Leonis MA, Loomes KM, Rudnick DA, Rosenthal P, Romero R, Subbarao GC, Li R, Belle SH, Squires RH.: A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clinical Gastroenterology and Hepatology 2018

Shneider Benjamin L, Spino Cathie, Kamath Binita M, Magee John C, Bass Lee M, Setchell Kenneth D, Miethke Alexander, Molleston Jean P, Mack Cara L, Squires Robert H, Murray Karen F, Loomes Kathleen M, Rosenthal Philip, Karpen Saul J, Leung Daniel H, Guthery Stephen L, Thomas Danny, Sherker Averell H, Sokol Ronald J: Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. Hepatology communications 2(10): 1184-1198, Oct 2018

Books

Kamath BM and Loomes KM: Alagille Syndrome:  Pathogenesis and Clinical Management. Book. Springer, 2018.

Motility Disorders

Articles

Ambartsumyan L, Khlevner J, Nurko S, Rosen R, Kaul A, Pandolfino JE, Ratcliffe E, Yacob D, Li BUK, Punati J, Sood M, Rao SSC, Levitt MA, Cocjin JT, Rodriguez L, Flores A, Rosen JM, Belkind-Gerson J, Saps M, Garza JM, Fortunato JE, Schroedl RL, Keefer LA, Friedlander J, Heuckeroth RO, Rao M, El-Chammas K, Vaz K, Chumpitazi BP, Sanghavi R, Matta SKR, Danialifar T, Di Lorenzo C, Darbari A. Proceedings of the 2018 Advances In Motility and In NeuroGastroenterology: AIMING for the Future Single Topic Symposium. J Pediatr Gastroenterol Nutr. 2020 Aug;71(2):e59-e67. doi: 10.1097/MPG.0000000000002720. PMID: 32287151.

Benitez AJ, Budhu S, Burger C, Turco R, Ballester L, Shah A, Lynch K, Fiorino K, Menard-Katcher C, Muir AB, Mamula P. Use of the functional luminal imaging probe in pediatrics: A comparison study of patients with achalasia before and after endoscopic dilation and non-achalasia controls. Neurogastroenterol Motil. 2021 Apr 19:e14133. doi: 10.1111/nmo.14133. Epub ahead of print. PMID: 33871917.

Gao T, Wright-Jin EC, Sengupta R, Anderson JB, Heuckeroth RO. Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system. JCI Insight. 2021 May 24;6(10):e145854. doi: 10.1172/jci.insight.145854. PMID: 33848271; PMCID: PMC8262371.

Hashmi SK, Barka V, Yang C, Schneider S, Svitkina TM, Heuckeroth RO. Pseudo-obstruction-inducing ACTG2R257C alters actin organization and function. JCI Insight. 2020 Aug 20;5(16):e140604. doi: 10.1172/jci.insight.140604. PMID: 32814715; PMCID: PMC7455133.

Hashmi SK, Ceron RH, Heuckeroth RO. Visceral myopathy: clinical syndromes, genetics, pathophysiology, and fall of the cytoskeleton. Am J Physiol Gastrointest Liver Physiol. 2021 Jun 1;320(6):G919-G935. doi: 10.1152/ajpgi.00066.2021. Epub 2021 Mar 17. PMID: 33729000.

Heuckeroth RO. Nerves Make the Bowel Happy, Even When the Enteric Nervous System Is Missing! Cell Mol Gastroenterol Hepatol. 2021 Jun 1:S2352-345X(21)00101-6. doi: 10.1016/j.jcmgh.2021.05.012. Epub ahead of print. PMID: 34087230.

Heuckeroth RO. Newly Identified Enteric Nervous System Precursors in the Mesentery Make One Skip, But Not For Joy! Cell Mol Gastroenterol Hepatol. 2021;12(1):378-379. doi: 10.1016/j.jcmgh.2021.03.010. Epub 2021 Apr 12. PMID: 33857486.

Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Jun 15:e14199. doi: 10.1111/nmo.14199. Epub ahead of print. PMID: 34132458.

Smith-Edwards KM, Edwards BS, Wright CM, Schneider S, Meerschaert KA, Ejoh LL, Najjar SA, Howard MJ, Albers KM, Heuckeroth RO, Davis BM. Sympathetic Input to Multiple Cell Types in Mouse and Human Colon Produces Region-Specific Responses. Gastroenterology. 2021 Mar;160(4):1208-1223.e4. doi: 10.1053/j.gastro.2020.09.030. Epub 2020 Sep 24. PMID: 32980343; PMCID: PMC7956113.

Soret R, Schneider S, Bernas G, Christophers B, Souchkova O, Charrier B, Righini-Grunder F, Aspirot A, Landry M, Kembel SW, Faure C, Heuckeroth RO, Pilon N. Glial Cell-Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease. Gastroenterology. 2020 Nov;159(5):1824-1838.e17. doi: 10.1053/j.gastro.2020.07.018. Epub 2020 Jul 17. PMID: 32687927.

Wright CM, Schneider S, Smith-Edwards KM, Mafra F, Leembruggen AJL, Gonzalez MV, Kothakapa DR, Anderson JB, Maguire BA, Gao T, Missall TA, Howard MJ, Bornstein JC, Davis BM, Heuckeroth RO. scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3. Cell Mol Gastroenterol Hepatol. 2021;11(5):1548-1592.e1. doi: 10.1016/j.jcmgh.2020.12.014. Epub 2021 Jan 11. PMID: 33444816; PMCID: PMC8099699.

Kovacic K, Kapavarapu PK, Sood MR, Li BUK, Nugent M, Simpson P, Miranda A. Nausea exacerbates symptom burden, quality of life, and functioning in adolescents with functional abdominal pain disorders. Neurogastroenterol Motil. 2019 Jul;31(7):e13595. doi: 10.1111/nmo.13595. Epub 2019 Apr 7. PMID: 30957319.

Ambartsumyan L, Khlevner J, Nurko S, Rosen R, Kaul A, Pandolfino JE, Ratcliffe E, Yacob D, Li BUK, Punati J, Sood M, Rao SSC, Levitt MA, Cocjin JT, Rodriguez L, Flores A, Rosen JM, Belkind-Gerson J, Saps M, Garza JM, Fortunato J, Schroedl RL, Keefer LA, Friedlander J, Heuckeroth RO, Rao M, El-Chammas K, Vaz K, Chumpitazi BP, Sanghavi R, Matta SKR, Danialifar T, Di Lorenzo C, Darbari A. Proceedings of the 2018 Advances in Motility and in Neurogastroenterology: AIMING for the Future Single Topic Symposium. J Pediatr Gastroenterol Nutr. 2020 Apr 13. doi: 10.1097/MPG.0000000000002720. Epub ahead of print. PMID: 32287151.

Baumgarten HD, Wright CM, Rossidis AC, Lawrence KM, Kim AG, Mejaddam AY, McGovern PE, Orr MN, Coons BE, Butt Z, Li H, Hwang G, Radu A, Brown LJ, Rubenstein RC, Peranteau WH, Davey M, Heuckeroth RO, Flake AW. The EXTrauterine Environment for Neonatal Development Supports Normal Intestinal Maturation and Development. Cell Mol Gastroenterol Hepatol. 2020 May 28:S2352-345X(20)30076-X. doi: 10.1016/j.jcmgh.2020.05.006. Epub ahead of print. PMID: 32474164.

Gilbert MA, Schultz-Rogers L, Rajagopalan R, Grochowski CM, Wilkins BJ, Biswas S, Conlin LK, Fiorino KN, Dhamija R, Pack MA, Klee EW, Piccoli DA, Spinner NB. Protein-elongating mutations in MYH11 are implicated in a dominantly inherited smooth muscle dysmotility syndrome with severe esophageal, gastric, and intestinal disease. Hum Mutat. 2020 May;41(5):973-982. doi: 10.1002/humu.23986. Epub 2020 Feb 6. PMID: 31944481. 

Graham KD, López SH, Sengupta R, Shenoy A, Schneider S, Wright CM, Feldman M, Furth E, Valdivieso F, Lemke A, Wilkins BJ, Naji A, Doolin EJ, Howard MJ, Heuckeroth RO. Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning. Gastroenterology. 2020 Jun;158(8):2221-2235.e5. doi: 10.1053/j.gastro.2020.02.035. Epub 2020 Feb 27. PMID: 32113825.

Kastl AJ Jr, Terry NA, Wu GD, Albenberg LG. The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions. Cell Mol Gastroenterol Hepatol. 2020;9(1):33-45. doi: 10.1016/j.jcmgh.2019.07.006. Epub 2019 Jul 22. PMID: 31344510; PMCID: PMC6881639.

Shah AA, Kastl A, Godwin B, Mamula P, Fiorino KN. Obscure Gastrointestinal Bleeding Secondary to Diffuse Gastric Heterotopia in the Proximal Jejunum. J Pediatr Gastroenterol Nutr. 2019 Sep;69(3):e88. doi: 10.1097/MPG.0000000000002240. PMID: 31436673.

Wright CM, Garifallou JP, Schneider S, Mentch HL, Kothakapa DR, Maguire BA, Heuckeroth RO. Dlx1/2 mice have abnormal enteric nervous system function. JCI Insight. 2020 Feb 27;5(4):e131494. doi: 10.1172/jci.insight.131494. PMID: 32017713; PMCID: PMC7101142.

Heuckeroth, RO: Even When You Know Everything, There Is Still More to Learn About Hirschsprung Disease. Gastroenterology 155(6): 1681-1684, December 2018

James P. White, Shanshan Xiong, Nicole P. Malvin, William Khoury-Hanold, Robert O. Heuckeroth, Thaddeus S. Stappenbeck and Michael S. Diamond: Intestinal Dysmotility Syndromes Following Systemic Infection by Flaviviruses. Cell November 2018

Sabine Schneider, Christina M. Wright, and Robert O. Heuckeroth: Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. Annual Reviews of Physiology Page:  doi: 10.1146/annurev-physiol-021317-121515.  October 2018

Silvia Huerta Lopez, Marina Avetisyan, Christina Wright, Karim Mesbah, Robert Kelly, Anne Moon, Robert O. Heuckeroth: Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit. Developmental Biology 444: Suppl 1:S337-S351.  October 2018 Notes: doi: 10.1016/j.ydbio.2018.09.017

Webster J, Lourie, E, Shaw, K, Huang, E: Implementation of a Constipation Action Plan in Primary Care Clinics to Decrease Referrals to Pediatric Gastroenterology: A Quality Improvement Initiative. Gastroenterology 155(1): e48-e49, 2018

Books

Webster, J, Godwin, B: Clinical Approach to Esophageal and Gastric Disorders. Nelson's Pediatric Board Review. Elsevier, 2018.

Nutrition (growth, development & malnutrition)

Articles

Aerts L, Terry NA, Sainath NN, Torres C, Martín MG, Ramos-Molina B, Creemers JW. Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea. Genes (Basel). 2021 May 10;12(5):710. doi: 10.3390/genes12050710. PMID: 34068683; PMCID: PMC8151971.

Avitabile CM, Saavedra S, Sivakumar N, Goldmuntz E, Paridon SM, Zemel BS. Marked skeletal muscle deficits are associated with 6-minute walk distance in paediatric pulmonary hypertension. Cardiol Young. 2021 Feb 11:1-8. doi: 10.1017/S1047951121000342. Epub ahead of print. PMID: 33568240.

Bashaw H, Brownell JN, Schall JI, Stallings VA. Measures of Dietary Fat and Energy Absorption in Healthy Adults. Pancreas. 2020 Jul;49(6):845-854. doi: 10.1097/MPA.0000000000001587. PMID: 32590620.

Baumgarten HD, Wright CM, Rossidis AC, Lawrence KM, Kim AG, Mejaddam AY, McGovern PE, Orr MN, Coons BE, Butt Z, Li H, Hwang G, Radu A, Brown LJ, Rubenstein RC, Peranteau WH, Davey M, Heuckeroth RO, Flake AW. The EXTrauterine Environment for Neonatal Development Supports Normal Intestinal Maturation and Development. Cell Mol Gastroenterol Hepatol. 2020;10(3):623-637. doi: 10.1016/j.jcmgh.2020.05.006. Epub 2020 May 28. PMID: 32474164; PMCID: PMC7408362.

Chin HB, Baird DD, Kaplan SL, Darge K, Adgent MA, Ford EG, Rogan WJ, Stallings VA, Umbach DM. Characterization of ovarian development in girls from birth to 9 months. Paediatr Perinat Epidemiol. 2021 Jan;35(1):75-82. doi: 10.1111/ppe.12673. Epub 2020 Apr 13. PMID: 32285479; PMCID: PMC7554126.

Chin HB, Kelly A, Adgent MA, Patchel SA, James K, Vesper HW, Botelho JC, Chandler DW, Zemel BS, Schall JI, Ford EG, Darge K, Stallings VA, Baird DD, Rogan WJ, Umbach DM. Reproductive hormone concentrations and associated anatomical responses: does soy formula affect minipuberty in boys? J Clin Endocrinol Metab. 2021 May 20:dgab354. doi: 10.1210/clinem/dgab354. Epub ahead of print. PMID: 34013335.

Cousminer DL, Wagley Y, Pippin JA, Elhakeem A, Way GP, Pahl MC, McCormack SE, Chesi A, Mitchell JA, Kindler JM, Baird D, Hartley A, Howe L, Kalkwarf HJ, Lappe JM, Lu S, Leonard ME, Johnson ME, Hakonarson H, Gilsanz V, Shepherd JA, Oberfield SE, Greene CS, Kelly A, Lawlor DA, Voight BF, Wells AD, Zemel BS, Hankenson KD, Grant SFA. Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual. Genome Biol. 2021 Jan 4;22(1):1. doi: 10.1186/s13059-020-02207-9. PMID: 33397451; PMCID: PMC7780623.

Gould PW, Zemel BS, Taratuta EG, Baker JF. Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning. J Rheumatol. 2021 Apr;48(4):504-512. doi: 10.3899/jrheum.200673. Epub 2020 Nov 1. PMID: 33132219; PMCID: PMC8087721.

Graff M, Justice AE, Young KL, Marouli E, Zhang X, Fine RS, Lim E, Buchanan V, Rand K, Feitosa MF, Wojczynski MK, Yanek LR, Shao Y, Rohde R, Adeyemo AA, Aldrich MC, Allison MA, Ambrosone CB, Ambs S, Amos C, Arnett DK, Atwood L, Bandera EV, Bartz T, Becker DM, Berndt SI, Bernstein L, Bielak LF, Blot WJ, Bottinger EP, Bowden DW, Bradfield JP, Brody JA, Broeckel U, Burke G, Cade BE, Cai Q, Caporaso N, Carlson C, Carpten J, Casey G, Chanock SJ, Chen G, Chen M, Chen YI, Chen WM, Chesi A, Chiang CWK, Chu L, Coetzee GA, Conti DV, Cooper RS, Cushman M, Demerath E, Deming SL, Dimitrov L, Ding J, Diver WR, Duan Q, Evans MK, Falusi AG, Faul JD, Fornage M, Fox C, Freedman BI, Garcia M, Gillanders EM, Goodman P, Gottesman O, Grant SFA, Guo X, Hakonarson H, Haritunians T, Harris TB, Harris CC, Henderson BE, Hennis A, Hernandez DG, Hirschhorn JN, McNeill LH, Howard TD, Howard B, Hsing AW, Hsu YH, Hu JJ, Huff CD, Huo D, Ingles SA, Irvin MR, John EM, Johnson KC, Jordan JM, Kabagambe EK, Kang SJ, Kardia SL, Keating BJ, Kittles RA, Klein EA, Kolb S, Kolonel LN, Kooperberg C, Kuller L, Kutlar A, Lange L, Langefeld CD, Le Marchand L, Leonard H, Lettre G, Levin AM, Li Y, Li J, Liu Y, Liu Y, Liu S, Lohman K, Lotay V, Lu Y, Maixner W, Manson JE, McKnight B, Meng Y, Monda KL, Monroe K, Moore JH, Mosley TH, Mudgal P, Murphy AB, Nadukuru R, Nalls MA, Nathanson KL, Nayak U, N'Diaye A, Nemesure B, Neslund-Dudas C, Neuhouser ML, Nyante S, Ochs-Balcom H, Ogundiran TO, Ogunniyi A, Ojengbede O, Okut H, Olopade OI, Olshan A, Padhukasahasram B, Palmer J, Palmer CD, Palmer ND, Papanicolaou G, Patel SR, Pettaway CA, Peyser PA, Press MF, Rao DC, Rasmussen-Torvik LJ, Redline S, Reiner AP, Rhie SK, Rodriguez-Gil JL, Rotimi CN, Rotter JI, Ruiz-Narvaez EA, Rybicki BA, Salako B, Sale MM, Sanderson M, Schadt E, Schreiner PJ, Schurmann C, Schwartz AG, Shriner DA, Signorello LB, Singleton AB, Siscovick DS, Smith JA, Smith S, Speliotes E, Spitz M, Stanford JL, Stevens VL, Stram A, Strom SS, Sucheston L, Sun YV, Tajuddin SM, Taylor H, Taylor K, Tayo BO, Thun MJ, Tucker MA, Vaidya D, Van Den Berg DJ, Vedantam S, Vitolins M, Wang Z, Ware EB, Wassertheil-Smoller S, Weir DR, Wiencke JK, Williams SM, Williams LK, Wilson JG, Witte JS, Wrensch M, Wu X, Yao J, Zakai N, Zanetti K, Zemel BS, Zhao W, Zhao JH, Zheng W, Zhi D, Zhou J, Zhu X, Ziegler RG, Zmuda J, Zonderman AB, Psaty BM, Borecki IB, Cupples LA, Liu CT, Haiman CA, Loos R, Ng MCY, North KE. Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry. Am J Hum Genet. 2021 Apr 1;108(4):564-582. doi: 10.1016/j.ajhg.2021.02.011. Epub 2021 Mar 12. PMID: 33713608; PMCID: PMC8059339.

Guo M, Zemel BS, Hawkes CP, Long J, Kelly A, Leonard MB, Jaramillo D, Mostoufi-Moab S. Sarcopenia and preserved bone mineral density in paediatric survivors of high-risk neuroblastoma with growth failure. J Cachexia Sarcopenia Muscle. 2021 Jun 29. doi: 10.1002/jcsm.12734. Epub ahead of print. PMID: 34184837.

Hawkes CP, Mostoufi-Moab S, McCormack SE, Grimberg A, Zemel BS. Leg length and sitting height reference data and charts for children in the United States. Data Brief. 2020 Aug 5;32:106131. doi: 10.1016/j.dib.2020.106131. PMID: 32904356; PMCID: PMC7452688.

Kindler JM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, Winer KK, Zemel BS. Pediatric Reference Ranges for Ultradistal Radius Bone Density: Results from the Bone Mineral Density in Childhood Study. J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3529–39. doi: 10.1210/clinem/dgaa380. PMID: 32561914; PMCID: PMC7465545.

Kindler JM, Kelly A, Khoury PR, Levitt Katz LE, Urbina EM, Zemel BS. Bone Mass and Density in Youth With Type 2 Diabetes, Obesity, and Healthy Weight. Diabetes Care. 2020 Oct;43(10):2544-2552. doi: 10.2337/dc19-2164. Epub 2020 Aug 10. PMID: 32778556; PMCID: PMC7510020.

Li Y, Feng D, Esangbedo IC, Zhao Y, Han L, Zhu Y, Fu J, Li G, Wang D, Wang Y, Li M, Gao S, Willi SM. Insulin resistance, beta-cell function, adipokine profiles and cardiometabolic risk factors among Chinese youth with isolated impaired fasting glucose versus impaired glucose tolerance: the BCAMS study. BMJ Open Diabetes Res Care. 2020 Feb;8(1):e000724. doi: 10.1136/bmjdrc-2019-000724. PMID: 32049638; PMCID: PMC7039594.

Lisanti AJ, Savoca M, Gaynor JW, Mascarenhas MR, Ravishankar C, Sullivan E, Pieciak K, Costarino A, Chen J, Kennedy A, Olsen R, Min J, Mondal A, Huang J, Irving SY. Standardized Feeding Approach Mitigates Weight Loss in Infants with Congenital Heart Disease. J Pediatr. 2021 Apr;231:124-130.e1. doi: 10.1016/j.jpeds.2020.12.047. Epub 2020 Dec 23. PMID: 33359473; PMCID: PMC8005454.

Mancilla EE, Zielonka B, Roizen JD, Dodds KM, Rand EB, Heimall JR, Chen F, Wu C, Goldberg DJ, Rychik J. Growth in Children with a Fontan Circulation. J Pediatr. 2021 Aug;235:149-155.e2. doi: 10.1016/j.jpeds.2021.04.019. Epub 2021 Apr 19. PMID: 33887332.

Mayne SL, Morales KH, Williamson AA, Grant SFA, Fiks AG, Basner M, Dinges DF, Zemel BS, Mitchell JA. Associations of the residential built environment with adolescent sleep outcomes. Sleep. 2021 Jun 11;44(6):zsaa276. doi: 10.1093/sleep/zsaa276. PMID: 33507268; PMCID: PMC8193550.

Mennella JA, Reiter A, Brewer B, Pohlig RT, Stallings VA, Trabulsi JC. Early Weight Gain Forecasts Accelerated Eruption of Deciduous Teeth and Later Overweight Status during the First Year. J Pediatr. 2020 Oct;225:174-181.e2. doi: 10.1016/j.jpeds.2020.06.019. Epub 2020 Jun 15. PMID: 32553836; PMCID: PMC7529945.

Mitchell JA, Morales KH, Williamson AA, Huffnagle N, Eck C, Jawahar A, Juste L, Fiks AG, Zemel BS, Dinges DF. Engineering a Mobile Platform to Promote Sleep in the Pediatric Primary Care Setting. medRxiv [Preprint]. 2020 Nov 7:2020.11.06.20223719. doi: 10.1101/2020.11.06.20223719. Update in: Sleep Adv. 2021 Apr 15;2(1):zpab006. PMID: 33173886; PMCID: PMC7654877.

Mitchell JA, Morales KH, Williamson AA, Huffnagle N, Eck C, Jawahar A, Juste L, Fiks AG, Zemel BS, Dinges DF. Engineering a mobile platform to promote sleep in the pediatric primary care setting. Sleep Adv. 2021 Apr 15;2(1):zpab006. doi: 10.1093/sleepadvances/zpab006. PMID: 33981997; PMCID: PMC8101485.

Shah R, Alshaikh B, Schall JI, Kelly A, Ford E, Zemel BS, Umbach DM, Adgent M, Stallings VA. Endocrine-sensitive physical endpoints in newborns: ranges and predictors. Pediatr Res. 2021 Feb;89(3):660-666. doi: 10.1038/s41390-020-0950-2. Epub 2020 May 12. PMID: 32396926; PMCID: PMC7657971.

Stallings VA, Tindall AM, Mascarenhas MR, Maqbool A, Schall JI. Correction: Improved residual fat malabsorption and growth in children with cystic fibrosis treated with a novel oral structured lipid supplement: A randomized controlled trial. PLoS One. 2020 Sep 17;15(9):e0239642. doi: 10.1371/journal.pone.0239642. Erratum for: PLoS One. 2020 May 8;15(5):e0232685. PMID: 32941528; PMCID: PMC7498082.

Tindall AM, Schall JI, Seme B, Ratshaa B, Tolle M, Nnyepi MS, Mazhani L, Rutstein RM, Steenhoff AP, Stallings VA. Vitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana. PLoS One. 2020 Aug 13;15(8):e0236510. doi: 10.1371/journal.pone.0236510. PMID: 32790765; PMCID: PMC7425960.

Trabulsi JC, Smethers AD, Eosso JR, Papas MA, Stallings VA, Mennella JA. Impact of early rapid weight gain on odds for overweight at one year differs between breastfed and formula-fed infants. Pediatr Obes. 2020 Oct;15(10):e12688. doi: 10.1111/ijpo.12688. Epub 2020 Jul 23. PMID: 32705816; PMCID: PMC7773222.

Vaikunth SS, Leonard MB, Whitehead KK, Goldberg DJ, Rychik J, Zemel BS, Avitabile CM. Deficits in the Functional Muscle-Bone Unit in Youth With Fontan Physiology. J Pediatr. 2021 Jun 29:S0022-3476(21)00650-8. doi: 10.1016/j.jpeds.2021.06.068. Epub ahead of print. PMID: 34214589.

Yau MS, Kuipers AL, Price R, Nicolas A, Tajuddin SM, Handelman SK, Arbeeva L, Chesi A, Hsu YH, Liu CT, Karasik D, Zemel BS, Grant SF, Jordan JM, Jackson RD, Evans MK, Harris TB, Zmuda JM, Kiel DP. A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations. J Bone Miner Res. 2021 Mar;36(3):469-479. doi: 10.1002/jbmr.4220. Epub 2020 Dec 18. PMID: 33249669.

Zemel BS, Wasserman H, Kelly A, Fan B, Shepherd J, Lappe J, Gilsanz V, Oberfield S, Winer KK, Kalkwarf HJ. Intermachine differences in DXA measurements vary by skeletal site, and impact the assessment of low bone density in children. Bone. 2020 Dec;141:115581. doi: 10.1016/j.bone.2020.115581. Epub 2020 Aug 11. PMID: 32795677; PMCID: PMC7680379.

Hjorth MF, Astrup A, Zohar Y, Urban LE, Sayer RD, Patterson BW, Herring SJ, Klein S, Zemel BS, Foster GD, Wyatt HR, Hill JO. Personalized nutrition: pretreatment glucose metabolism determines individual long-term weight loss responsiveness in individuals with obesity on low-carbohydrate versus low-fat diet. Int J Obes (Lond). 2019 Oct;43(10):2037-2044. doi: 10.1038/s41366-018-0298-4. Epub 2018 Dec 19. PMID: 30568260; PMCID: PMC6584064.

Mitchell JA, Williamson A, Fiks AG. Targeting Sleep Duration and Timing for Prevention of Adolescent Obesity. JAMA Pediatr. 2019 Sep 16:10.1001/jamapediatrics.2019.3080. doi: 10.1001/jamapediatrics.2019.3080. Epub ahead of print. PMID: 31524928; PMCID: PMC7219655. 

Hjorth MF, Astrup A, Zohar Y, Urban LE, Sayer RD, Patterson BW, Herring SJ, Klein S, Zemel BS, Foster GD, Wyatt HR, Hill JO. Personalized nutrition: pretreatment glucose metabolism determines individual long-term weight loss responsiveness in individuals with obesity on low-carbohydrate versus low-fat diet. Int J Obes (Lond). 2019 Oct;43(10):2037-2044. doi: 10.1038/s41366-018-0298-4. Epub 2018 Dec 19. PMID: 30568260; PMCID: PMC6584064.          

Leonard MB, Wehrli FW, Ziolkowski SL, Billig E, Long J, Nickolas TL, Magland JF, Nihtianova S, Zemel BS, Herskovitz R, Rajapakse CS. A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease. Bone. 2019 Oct;127:271-279. doi: 10.1016/j.bone.2019.05.022. Epub 2019 May 31. PMID: 31158505.

Kelly A, Magge SN, Walega R, Cochrane C, Pipan ME, Zemel BS, Cohen MS, Gidding SS, Townsend R. Cross-Sectional Study of Arterial Stiffness in Adolescents with Down Syndrome. J Pediatr. 2019 Sep;212:79-86.e1. doi: 10.1016/j.jpeds.2019.04.059. Epub 2019 Jun 11. PMID: 31201031; PMCID: PMC6754250.

Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET, Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin MR, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VWV; Early Growth Genetics Consortium, Grant SFA. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Hum Mol Genet. 2019 Oct 1;28(19):3327-3338. doi: 10.1093/hmg/ddz161. PMID: 31504550; PMCID: PMC6859434.

Brownell JN, Bashaw H, Stallings VA. Growth and Nutrition in Cystic Fibrosis. Semin Respir Crit Care Med. 2019 Dec;40(6):775-791. doi: 10.1055/s-0039-1696726. Epub 2019 Oct 28. PMID: 31659726.

Dougherty KA, Schall JI, Bertolaso C, Smith-Whitley K, Stallings VA. Vitamin D Supplementation Improves Health-Related Quality of Life and Physical Performance in Children with Sickle Cell Disease and in Healthy Children. J Pediatr Health Care. 2020 Jun 5:S0891-5245(20)30120-6. doi: 10.1016/j.pedhc.2020.04.007. Epub ahead of print. PMID: 32507538.

Hawkes CP, Mostoufi-Moab S, McCormack SE, Grimberg A, Zemel BS. Sitting Height to Standing Height Ratio Reference Charts for Children in the United States. J Pediatr. 2020 Jun 21:S0022-3476(20)30754-X. doi: 10.1016/j.jpeds.2020.06.051. Epub ahead of print. PMID: 32579888.

Hou R, Cole SA, Graff M, Haack K, Laston S, Comuzzie AG, Mehta NR, Ryan K, Cousminer DL, Zemel BS, Grant SFA, Mitchell BD, Shypailo RJ, Gourlay ML, North KE, Butte NF, Voruganti VS. Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children. Bone. 2020 Mar;132:115175. doi: 10.1016/j.bone.2019.115175. Epub 2019 Nov 29. PMID: 31790847; PMCID: PMC7120871.

Kindler JM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, Winer KK, Zemel BS. Pediatric Reference Ranges for Ultradistal Radius Bone Density: Results from the Bone Mineral Density in Childhood Study. J Clin Endocrinol Metab. 2020 Jun 19:dgaa380. doi: 10.1210/clinem/dgaa380. Epub ahead of print. PMID: 32561914.

Kohut T, Robbins J, Panganiban J. Update on childhood/adolescent obesity and its sequela. Curr Opin Pediatr. 2019 Oct;31(5):645-653. doi: 10.1097/MOP.0000000000000786. PMID: 31145127.

Magge SN, Zemel BS, Pipan ME, Gidding SS, Kelly A. Cardiometabolic Risk and Body Composition in Youth With Down Syndrome. Pediatrics. 2019 Aug;144(2):e20190137. doi: 10.1542/peds.2019-0137. Epub 2019 Jul 17. PMID: 31315916; PMCID: PMC6855833. . 

Mennella JA, Reiter A, Brewer B, Pohlig RT, Stallings VA, Trabulsi JC. Early Weight Gain Forecasts Accelerated Eruption of Deciduous Teeth and Later Overweight Status during the First Year. J Pediatr. 2020 Jun 15:S0022-3476(20)30720-4. doi: 10.1016/j.jpeds.2020.06.019. Epub ahead of print. PMID: 32553836.

Parks EP, Finnerty DD, Panganiban J, Frasso R, Bishop-Gilyard C, Tewksbury CM, Williams NN, Dumon KR, Cordero G, Hill DL, Sarwer DB. Perspectives of adolescents with severe obesity on social Media in Preparation for weight-loss surgery: a qualitative study. BMC Pediatr. 2020 Mar 2;20(1):96. doi: 10.1186/s12887-020-1992-7. PMID: 32122314; PMCID: PMC7050129.

Weber DR, Gordon RJ, Kelley JC, Leonard MB, Willi SM, Hatch-Stein J, Kelly A, Kosacci O, Kucheruk O, Kaafarani M, Zemel BS. Poor Glycemic Control Is Associated With Impaired Bone Accrual in the Year Following a Diagnosis of Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Oct 1;104(10):4511-4520. doi: 10.1210/jc.2019-00035. PMID: 31034056; PMCID: PMC6736051.

Brownell JN, Schall JI, Mcanlis CR, Smith-Whitley K, Norris CF, Stallings VA. Effect of High-dose Vitamin A Supplementation in Children With Sickle Cell Disease: A Randomized, Double-blind, Dose-finding Pilot Study. J Pediatr Hematol Oncol. 2020 Mar;42(2):83-91. doi: 10.1097/MPH.0000000000001673. PMID: 31764511. 

Liang G, Zhao C, Zhang H, Mattei L, Sherrill-Mix S, Bittinger K, Kessler LR, Wu GD, Baldassano RN, DeRusso P, Ford E, Elovitz MA, Kelly MS, Patel MZ, Mazhani T, Gerber JS, Kelly A, Zemel BS, Bushman FD. The stepwise assembly of the neonatal virome is modulated by breastfeeding. Nature. 2020 May;581(7809):470-474. doi: 10.1038/s41586-020-2192-1. Epub 2020 Apr 15. PMID: 32461640; PMCID: PMC7263352.

Mitchell JA, Morales KH, Williamson AA, Huffnagle N, Ludwick A, Grant SFA, Dinges DF, Zemel BA. Changes in Sleep Duration and Timing During the Middle-to-High School Transition. J Adolesc Health. 2020 Jun 20:S1054-139X(20)30211-1. doi: 10.1016/j.jadohealth.2020.04.024. Epub ahead of print. PMID: 32576483. 

Patterson F, Mitchell JA, Dominick G, Lozano AJ, Huang L, Hanlon AL. Does meeting physical activity recommendations ameliorate association between television viewing with cardiovascular disease risk? A cross-sectional, population-based analysis. BMJ Open. 2020 Jun 11;10(6):e036507. doi: 10.1136/bmjopen-2019-036507. PMID: 32532775; PMCID: PMC7295402.

Stallings VA, Tindall AM, Mascarenhas MR, Maqbool A, Schall JI. Improved residual fat malabsorption and growth in children with cystic fibrosis treated with a novel oral structured lipid supplement: A randomized controlled trial. PLoS One. 2020 May 8;15(5):e0232685. doi: 10.1371/journal.pone.023265.  PMID: 32384122; PMCID: PMC7209323.

Cousminer DL, McCormack SE, Mitchell JA, Chesi A, Kindler JM, Kelly A, Voight BF, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Zemel BS, Grant SFA: Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls. Bone Jan 2019

Eunsun Kim, Amanda Lisby, Connie Ma, Nathanael Lo, Ursula Ehmer, Katharina E. Hayer, Emma E. Furth, and Patrick Viatour: Promotion of growth factor signaling as a critical function of β-catenin during HCC progression. Nature Communications 2019 Notes: Acknowledged for microscopy expertise and imaging.

Kelly A, Shults J, Mostoufi-Moab S, McCormack SE, Stallings VA, Schall JI, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Winer KK, Leonard MB, Zemel BS: Pediatric Bone Mineral Accrual Z-Score Calculation Equations and Their Application in Childhood Disease. J Bone Miner Res. 34(1): 195-203, January 2019

McCormack SE, Kelly A, Mitchell JA, Cousminer DL, Chesi A, Kindler J, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer K, Grant SFA, Zemel BS: Accounting for skeletal maturation in the assessment of pediatric bone mineral density. Endocrine Society (ENDO), Annual Meeting, New Orleans, LA Mar 2019.

Mostoufi-Moab Sogol, Kelly Andrea, Mitchell Jonathan A, Baker Joshua, Zemel Babette S, Brodsky Jill, Long Jin, Leonard Mary B: Changes in pediatric DXA measures of musculoskeletal outcomes and correlation with quantitative CT following treatment of acute lymphoblastic leukemia. Bone 112: 128-135, Jul 2018.

Oyebimpe O. Adesina1, James G. Gurney, Guolian Kang, Martha Villavicencio, Jason R. Hodges, Wassim Chemaitilly, Sue C. Kaste, Babette S. Zemel, and Jane S. Hankins: Height-Corrected Low Bone Density in Sickle Cell Disease Associates with Severe Outcomes: SCCRIP Cohort Study Results. Blood Advances Mar 2019

Roy SM, Fields DA, Mitchell JA, Hawkes CP, Kelly A, Wu GD, DeRusso PA, Elovitz MA, Ford E, Drigo D, Zemel BS, McCormack SE: Body Mass Index is a Better Indicator of Body Composition than Weight-for-Length at Age 1 Month. The Journal of Pediatrics  204: 77-83, Jan 2019.

Sainath N, Schall J, Bertolaso C, McAnlis C, Stallings V.: Italian and North American dietary intake after ivacaftor treatment for cystic fibrosis gating mutations.  J Cyst Fibros 18(1): 135-143, January 2019

Books

Bass R, Goh V, Mascarenhas MR: Nutrition. The Philadelphia Guide:  Inpatient Pediatrics 3rd edition 2018

Maqbool, Elizabeth Prout Parks, Ala Shaikhkhalil, Jennifer Panganiban, Jonathan A. Mitchell, and Virginia A. Stallings: Nutritional Requirements. Kliegman et al: Nelson Textbook of Pediatrics. Elsevier, Chapter 55, Oct 2018

Panganiban J, Gilbaugh A, Tettey-Fio A, Mascarenhas MR: Integrative Medicine and Nutrition, Chapter 22. Pediatric Nutrition Handbook, 5th edition. Becker P and Konek S (eds.). Jones and Bartlett Learning, 2018

Pancreas

Articles

Brownell JN, Haupt M, Orlova E, Schall JI, Stallings VA. Genetic Variants, Fat Malabsorption, and Ancestral Background in a Small Chronic Pancreatitis Cohort. Pancreas. 2020 Sep;49(8):e76-e78. doi: 10.1097/MPA.0000000000001623. PMID: 32833953; PMCID: PMC7450390.

Brownell JN, Haupt M, Orlova E, Schall JI, Stallings VA. Genetic Variants, Fat Malabsorption, and Ancestral Background in a Small Chronic Pancreatitis Cohort. Pancreas. 2020 Sep;49(8):e76-e78. doi: 10.1097/MPA.0000000000001623. PMID: 32833953; PMCID: PMC7450390.

Dike CR, Zimmerman B, Zheng Y, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Pohl J, Perito ER, Ooi CY, Nathan JD, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Husain SZ, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Fishman DS, Bellin M, Barth B, Abu-El-Haija M, Lowe ME, Uc A. Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From the INSPPIRE Study. J Pediatr Gastroenterol Nutr. 2020 Jul;71(1):112-118. doi: 10.1097/MPG.0000000000002661. PMID: 32079978; PMCID: PMC7305964.

Freeman AJ, Maqbool A, Bellin MD, Goldschneider KR, Grover AS, Hartzell C, Piester TL, Szabo F, Kiernan BD, Khalaf R, Kumar R, Rios M, Husain SZ, Morinville VD, Abu-El-Haija M. Medical Management of Chronic Pancreatitis in Children: A Position Paper by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2021 Feb 1;72(2):324-340. doi: 10.1097/MPG.0000000000003001. PMID: 33230082; PMCID: PMC8054312.

Gariepy CE, Ooi CY, Maqbool A, Ellery KM. Demographics and risk factors for pediatric recurrent acute pancreatitis. Curr Opin Gastroenterol. 2021 Jun 11. doi: 10.1097/MOG.0000000000000764. Epub ahead of print. PMID: 34120130.

Patel N, Sellers ZM, Grover A, Liu QY, Maqbool A, Morinville VD, Abu-El-Haija M, Husain SZ. Endoscopic Pancreatic Function Testing (ePFT) in Children: A Position Paper From the NASPGHAN Pancreas Committee. J Pediatr Gastroenterol Nutr. 2021 Jan 1;72(1):144-150. doi: 10.1097/MPG.0000000000002931. PMID: 32910088.

Stevens JP, Brownell JN, Freeman AJ, Bashaw H. COVID-19-associated Multisystem Inflammatory Syndrome in Children Presenting as Acute Pancreatitis. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):669-671. doi: 10.1097/MPG.0000000000002860. PMID: 33093376.

Vajravelu ME, Lee JJ, Mitteer L, Zemel BS, Bittinger K, De León DD. Gut Microbiome Profile After Pancreatectomy in Infants With Congenital Hyperinsulinism. Pancreas. 2021 Jan 1;50(1):89-92. doi: 10.1097/MPA.0000000000001708. PMID: 33370028; PMCID: PMC7783597.

Palermo TM, Murray C, Aalfs H, Abu-El-Haija M, Barth B, Bellin MD, Ellery K, Fishman DS, Gariepy CE, Giefer MJ, Goday P, Gonska T, Heyman MB, Husain SZ, Lin TK, Liu QY, Mascarenhas MR, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Schwarzenberg SJ, Sellers ZM, Serrano J, Shah U, Troendle D, Zheng Y, Yuan Y, Lowe M, Uc A; Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer. Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC). Contemp Clin Trials. 2020 Jan;88:105898. doi: 10.1016/j.cct.2019.105898. Epub 2019 Nov 19. PMID: 31756383; PMCID: PMC6952537.

Perito ER, Palermo TM, Pohl JF, Mascarenhas M, Abu-El-Haija M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer M, Gonska T, Heyman MB, Himes RW, Husain SZ, Lin T, Liu Q, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Rhee S, Schwarzenberg SJ, Shah U, Troendle DM, Werlin S, Wilschanski M, Zheng Y, Zimmerman MB, Lowe M, Uc A. Factors Associated With Frequent Opioid Use in Children With Acute Recurrent and Chronic Pancreatitis. J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):106-114. doi: 10.1097/MPG.0000000000002502. PMID: 31567889; PMCID: PMC6934913.

Abu-El-Haija M, Lowe M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Lin TK, Liu Q, Mascarenhas MR, Maqbool A, McFerron B, Morinville V, Nathan J, Ooi CY, Perito E, Pohl JF, Schwarzenberg SJ, Shah U, Troendle D, Werlin S, Wilschanski M, Zimmerman B, Uc A. Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium. Pancreatology. 2020 Jun;20(4):781-784. doi: 10.1016/j.pan.2020.04.001. Epub 2020 Apr 9. PMID: 32332002.

Bellin MD, Lowe M, Zimmerman MB, Wilschanski M, Werlin S, Troendle DM, Shah U, Schwarzenberg SJ, Pohl JF, Perito E, Ooi CY, Nathan JD, Morinville VD, McFerron BA, Mascarenhas MR, Maqbool A, Liu Q, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Barth B, Abu-El-Haija M, Uc A. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort. J Pediatr Gastroenterol Nutr. 2019 Nov;69(5):599-606. doi: 10.1097/MPG.0000000000002482. PMID: 31651815; PMCID: PMC6834233.

Brownell JN, Schall JI, Stallings VA. Pancreatic Function in Chronic Pancreatitis: A Cohort Study Comparing 3 Methods of Detecting Fat Malabsorption and the Impact of Short-term Pancreatic Enzyme Replacement Therapy. Pancreas. 2019 Sep;48(8):1068-1078. doi: 10.1097/MPA.0000000000001381. PMID: 31404029; PMCID: PMC7243202.

Liu QY, Abu-El-Haija M, Husain SZ, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Lin TK, Maqbool A, Mascarenhas M, McFerron BA, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A. Risk Factors for Rapid Progression From Acute Recurrent to Chronic Pancreatitis in Children: Report From INSPPIRE. J Pediatr Gastroenterol Nutr. 2019 Aug;69(2):206-211. doi: 10.1097/MPG.0000000000002405. PMID: 31136562; PMCID: PMC6699635.

Ac A, Perito E, Pohl J, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery K, Fishman DS, Gariepy C, Giefer MJ, Gonska T, Heyman M, Himes R, Husain S, Maqbool A, Mascarenhas MR, McFerron B, Morinville V, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME: International Study Group of Pediatric Pancreatitis:  In Search for a Cure Cohort Study:  Design and Rationale for the INSPIRRE 2 Study from the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas - Official Journal of the American Pancreatic Association, Japan Pancreas Society, and the North American Neuroendocrine Tumor Society 47(10), November 2018

Lowe M, Husain S, Morinville V, Fishman D, Perito E, Freedman S, Gariepy C, Pohl J, Giefer M, Abu-El-Haija M, Palermo J, Lin T. Nathan J, Liu Q, Mascarenhas M, Piccoli D, Shah U, Zimmerman M, Uc A: Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood:  Consensus from INSPPIRE. JPGN 67(2): 232-236, August 2018.

Sellers ZM, Dike C, Zhang KY, Giefer MJ, Uc A, Abu-El-Haija M: A Unified Treatment Algorithm and Admission Order Set for Pediatric Acute Pancreatitis. J Pediatr Gastroenterol Nutr March 2019 Notes: doi: 10.1097/MPG.0000000000002341.

Books

Brownell J, McKnight-Menci H, Thornton P, Maqbool A: Pancreatic Insufficiency and Complications of Surgery. Congenital Pediatric Hyperinsulinism. De Leon-Crutchlow D, Stanley C (eds.). Springer, Page: 131-141, 2019.


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