Division of Gastroenterology, Hepatology and Nutrition Publications

Leaders in research and publications

View highlights of recent publications from the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia (CHOP).

Eosinophilic Disorders

Articles

Aceves SS, King E, Collins MH, Yang GY, Capocelli KE, Abonia JP, Atkins D, Bonis PA, Carpenter CL, Dellon ES, Eby MD, Falk GW, Gonsalves N, Gupta SK, Hirano I, Kocher K, Krischer JP, Leung J, Lipscomb J, Menard-Katcher P, Mukkada VA, Pan Z, Spergel JM, Sun Q, Wershil BK, Rothenberg ME, Furuta GT: Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. Journal of Allergy and Clinical Immunology 142(1): 130-138, Jul 2018 Notes: Assisted in patient recruitment and discussion of results

Dellon ES, Liacouras CA, Molina-Infante J, Furuta G T, Spergel M, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang G-Y, Hirano I, Bredenoord AJ: Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE conference. Gastroenterology Jul 2018

Muir Amanda B, Jensen Elizabeth T, Wechsler Joshua B, Menard-Katcher Paul, Falk Gary W, Aceves Seema S, Furuta Glenn T, Dellon Evan S, Rothenberg Mark E, Spergel Jonathan M: Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. The journal of allergy and clinical immunology. In practice Mar 2019.

Muir AB, Wang JX, Nakagawa H.: Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis. J of Gastroenterology 54(1): doi: 10.1007, Aug 2018 Notes: epub ahead of print.

Muir A, Moore H, Spergel J.: To treat or not to treat: The minimally symptomatic EoE patient. Ann Allergy Asthma Immunol 2018

Spergel Jonathan M, Elci Okan U, Muir Amanda B, Liacouras Chris A, Wilkins Benjamin J, Burke Deirdre, Lewis Megan O, Brown-Whitehorn Terri, Cianferoni Antonella: Efficacy of Epicutaneous Immunotherapy in Children with Milk-Induced Eosinophilic Esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association May 2019.

Pesek Robert D, Reed Craig C, Muir Amanda B, Fulkerson Patricia C, Menard-Katcher Calies, Falk Gary W, Kuhl Jonathan, Martin Ellen K, Magier Adam Z, Ahmed Faria, Demarshall Maureen, Gupta Ankur, Gross Jonathan, Ashorobi Tokunbo, Carpenter Christina L, Krischer Jeffrey P, Gonsalves Nirmala, Spergel Jonathan M, Gupta Sandeep K, Furuta Glenn T, Rothenberg Marc E, Dellon Evan S: Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium. The American journal of gastroenterology 114(6): 984-994, Jun 2019.

Shaverdashvili Khvaramze, Padlo Jennie, Weinblatt Daniel, Jia Yang, Jiang Wenpeng, Rao Divya, Laczkó Dorottya, Whelan Kelly A, Lynch John P, Muir Amanda B, Katz Jonathan P: KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. PloS one 14(4): e0215746, 2019.

Inflammatory Bowel Disease (IBD)

Articles

Ballengee Cortney R, Stidham Ryan W, Liu Chunyan, Kim Mi-Ok, Prince Jarod, Mondal Kajari, Baldassano Robert, Dubinsky Marla, Markowitz James, Leleiko Neal, Hyams Jeffrey, Denson Lee, Kugathasan Subra: Association Between Plasma Level of Collagen Type III alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Sep 2018.

Breton J, Kastl A, Hoffmann N, Rogers R, Grossman AB, Mamula P, Kelsen JR, Baldassano RN, Albenberg L: Efficacy of combination antibiotic therapy for refractory pediatric inflammatory bowel disease. Inflammatory Bowel Diseases Feb 2019 Notes: [Epub ahead of print]

Chenthan, Ballengee Cortney R, Liu Chunyan, Kim Mi-Ok, Baker Susan S, Baldassano Robert N, Cohen Stanley A, Crandall Wallace V, Denson Lee A, Dubinsky Marla C, Evans Jonathan, Gokhale Ranjana, Griffiths Anne, Guthery Stephen L, Oliva-Hemker Maria, Heyman Melvin B, Keljo David, Kellermayer Richard, Leleiko Neal S, Mack David R, Markowitz James F, Moulton Dedrick E, Noe Joshua D, Otley Anthony R, Patel Ashish S, Pfefferkorn Marian, Rabizadeh Shervin, Rosh Joel R, Snapper Scott, Walters Thomas D, Ziring David, Mondal Kajari, Kappelman Michael D, Hyams Jeffrey S, Kugathasan Subra: Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. Inflammatory bowel diseases Jan 2019.

Church Peter C, Kuint Ruth Cytter, Ledder Oren, Navas-López Victor M, Sladek Malgorzata, Brückner Annecarin, Baldassano Robert N, Weiss Batia, Yerushalmi Baruch, Saeed Shehzad A, Hyams Jeffrey, Otley Anthony, Griffiths Anne M, Turner Dan, Greer Mary-Louise C: Magnetic Resonance Enterography Cannot Replace Upper Endoscopy in Pediatric Crohn's Disease: An Imagekids Sub-study. Journal of pediatric gastroenterology and nutrition 67(1): 53-58, Jul 2018.

Conrad MA, Kelsen JR.: Genomic and Immunologic Drivers of Very Early-Onset Inflammatory Bowel Disease. Pediatr Dev Patho May 2019

Denson Lee A, Jurickova Ingrid, Karns Rebekah, Shaw Kelly A, Cutler David J, Okou David, Alexander Valencia C, Dodd Anne, Mondal Kajari, Aronow Bruce J, Haberman Yael, Linn Aaron, Price Adam, Bezold Ramona, Lake Kathleen, Jackson Kimberly, Walters Thomas D, Griffiths Anne, Baldassano Robert N, Noe Joshua D, Hyams Jeffrey S, Crandall Wallace V, Kirschner Barbara S, Heyman Melvin B, Snapper Scott, Guthery Stephen L, Dubinsky Marla C, Leleiko Neal S, Otley Anthony R, Xavier Ramnik J, Stevens Christine, Daly Mark J, Zwick Michael E, Kugathasan Subra: Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflammatory bowel diseases Aug 2018 Notes: doi: 10.1093/ibd/izy265 [Epub ahead of print]

Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY.: A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med April 2019

Grossman AB (reviewer/contributor): Pediatric Crohn's Disease. National Organization for Rare Disorders (https://rarediseases.org/rare-diseases/pediatric-crohns-disease ) 2019

Haberman Yael, Karns Rebekah, Dexheimer Phillip J, Schirmer Melanie, Somekh Judith, Jurickova Ingrid, Braun Tzipi, Novak Elizabeth, Bauman Laura, Collins Margaret H, Mo Angela, Rosen Michael J, Bonkowski Erin, Gotman Nathan, Marquis Alison, Nistel Mason, Rufo Paul A, Baker Susan S, Sauer Cary G, Markowitz James, Pfefferkorn Marian D, Rosh Joel R, Boyle Brendan M, Mack David R, Baldassano Robert N, Shah Sapana, Leleiko Neal S, Heyman Melvin B, Grifiths Anne M, Patel Ashish S, Noe Joshua D, Aronow Bruce J, Kugathasan Subra, Walters Thomas D, Gibson Greg, Thomas Sonia Davis, Mollen Kevin, Shen-Orr Shai, Huttenhower Curtis, Xavier Ramnik J, Hyams Jeffrey S, Denson Lee A: Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nature communications 10(1): 38, Jan 2019

Haberman Yael, Schirmer Melanie, Dexheimer Phillip J, Karns Rebekah, Braun Tzipi, Kim Mi-Ok, Walters Thomas D, Baldassano Robert N, Noe Joshua D, Rosh Joel, Markowitz James, Crandall Wallace V, Mack David R, Griffiths Anne M, Heyman Melvin B, Baker Susan S, Kellermayer Richard, Moulton Dedrick, Patel Ashish S, Gulati Ajay S, Steiner Steven J, LeLeiko Neal, Otley Anthony, Oliva-Hemker Maria, Ziring David, Kirschner Barbara S, Keljo David J, Guthery Stephen L, Cohen Stanley A, Snapper Scott, Evans Jonathan, Dubinsky Marla, Aronow Bruce, Hyams Jeffrey S, Kugathasan Subra, Huttenhower Curtis, Xavier Ramnik J, Denson Lee A: Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal immunology Dec 2018.

Hyams Jeffrey S, Davis Thomas Sonia, Gotman Nathan, Haberman Yael, Karns Rebekah, Schirmer Melanie, Mo Angela, Mack David R, Boyle Brendan, Griffiths Anne M, LeLeiko Neal S, Sauer Cary G, Keljo David J, Markowitz James, Baker Susan S, Rosh Joel, Baldassano Robert N, Patel Ashish, Pfefferkorn Marian, Otley Anthony, Heyman Melvin, Noe Joshua, Oliva-Hemker Maria, Rufo Paul A, Strople Jennifer, Ziring David, Guthery Stephen L, Sudel Boris, Benkov Keith, Wali Prateek, Moulton Dedrick, Evans Jonathan, Kappelman Michael D, Marquis M Alison, Sylvester Francisco A, Collins Margaret H, Venkateswaran Suresh, Dubinsky Marla, Tangpricha Vin, Spada Krista L, Saul Bradley, Wang Jessie, Serrano Jose, Hommel Kevin, Marigorta Urko M, Gibson Greg, Xavier Ramnik J, Kugathasan Subra, Walters Thomas, Denson Lee A: Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study. Lancet (London, England) Mar 2019.

Kelly Daniel, Kotliar Michael, Woo Vivienne, Jagannathan Sajjeev, Whitt Jordan, Moncivaiz Jessica, Aronow Bruce J, Dubinsky Marla C, Hyams Jeffrey S, Markowitz James F, Baldassano Robert N, Stephens Michael C, Walters Thomas D, Kugathasan Subra, Haberman Yael, Sundaram Nambirajan, Rosen Michael J, Helmrath Michael, Karns Rebekah, Barski Artem, Denson Lee A, Alenghat Theresa: Microbiota-sensitive epigenetic signature predicts inflammation in Crohn's disease. JCI insight 3(18), Sep 2018.

Kelsen JR, Russo P, Sullivan KE.: Early-Onset Inflammatory Bowel Disease. Immunol Allergy Clin North Am Feb 2019

Lekbua A, Ouahed J, O'Connell AE, Kahn SA, Goldsmith JD, Imamura T, Duncan CN, Kelsen JR, Worthey E, Snapper SB, Softic S.: Risk-factors Associated with Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. JPGN Feb 2019

Lindoso Livia, Mondal Kajari, Venkateswaran Suresh, Somineni Hari K, Ballengee Cortney, Walters Thomas D, Griffiths Anne, Noe Joshua D, Crandall Wallace, Snapper Scott, Rabizadeh Shervin, Rosh Joel R, LeLeiko Neal, Guthery Stephen, Mack David, Kellermayer Richard, Gulati Ajay S, Pfefferkorn Marian D, Moulton Dedrick E, Keljo David, Cohen Stanley, Oliva-Hemker Maria, Heyman Melvin B, Otley Anthony, Baker Susan S, Evans Jonathan S, Kirschner Barbara S, Patel Ashish S, Ziring David, Stephens Michael C, Baldassano Robert, Dubinsky Marla C, Markowitz James, Denson Lee A, Hyams Jeffrey, Kugathasan Subra, Ananthakrishnan Ashwin N: The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. The American journal of gastroenterology Sep 2018

Patel T, Conrad M, Kelsen JR: Common Threads in Pediatric Inflammatory Diseases: Insight Into Personalized Medicine. JAMA Pediatrics August 2018.

Priya Chatterji, Patrick A. Williams, Kelly A. Whelan, Fernando C. Samper, Sarah F. Andres, Lauren A. Simon, Louis R Parham, Rei Mizuno, Emma T. Lundsmith, David S.M. Lee, Shun Liang, H.R. Sagara Wijeratne; Stefanie Marti, Lillian Chau, Veronique Giroux, Benjamin J. Wilkins, Gary D. Wu, Premal Shah, Gian G. Tartaglia, and Kathryn E. Hamilton: Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1. EMBO Reports March 2019

Schirmer Melanie, Denson Lee, Vlamakis Hera, Franzosa Eric A, Thomas Sonia, Gotman Nathan M, Rufo Paul, Baker Susan S, Sauer Cary, Markowitz James, Pfefferkorn Marian, Oliva-Hemker Maria, Rosh Joel, Otley Anthony, Boyle Brendan, Mack David, Baldassano Robert, Keljo David, LeLeiko Neal, Heyman Melvin, Griffiths Anne, Patel Ashish S, Noe Joshua, Kugathasan Subra, Walters Thomas, Huttenhower Curtis, Hyams Jeffrey, Xavier Ramnik J: Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell host & microbe 24(4): 600-610.e4, Oct 2018

Somineni Hari K, Venkateswaran Suresh, Kilaru Varun, Marigorta Urko M, Mo Angela, Okou David T, Kellermayer Richard, Mondal Kajari, Cobb Dawayland, Walters Thomas D, Griffiths Anne, Noe Joshua D, Crandall Wallace V, Rosh Joel R, Mack David R, Heyman Melvin B, Baker Susan S, Stephens Michael C, Baldassano Robert N, Markowitz James F, Dubinsky Marla C, Cho Judy, Hyams Jeffrey S, Denson Lee A, Gibson Greg, Cutler David J, Conneely Karen N, Smith Alicia K, Kugathasan Subra: Blood-derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation. Gastroenterology Feb 2019.

Sullivan Ke, Conrad M, Kelsen JR: Very early-onset inflammatory bowel disease: an integrated approach. Curr Opin Allergy Clin Immuno 18, Dec 2018

Tokarz Rafal, Hyams Jeffrey S, Mack David R, Boyle Brendan, Griffiths Anne M, LeLeiko Neal S, Sauer Cary G, Shah Sapana, Markowitz James, Baker Susan S, Rosh Joel, Baldassano Robert N, Kugathasan Subra, Walters Thomas, Tagliafierro Teresa, Sameroff Stephen, Lee Bohyun, Che Xiaoyu, Oleynik Alexandra, Denson Lee A, Lipkin W Ian: Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Inflammatory bowel diseases May 2019.

Trusha Patel MD, Rawan Shraim BS, Kelly Maurer BA, Noor Dawany PhD, Claudio C. Giraudo PhD, Maire Conrad MD, Kathleen E. Sullivan MD, PhD and Judith R. Kelsen MD: Immunophenotyping of Very Early Onset Inflammatory Bowel Disease Patients: Population-Level Analysis  NASPGHAN 2018

Turner Dan, Griffiths Anne M, Wilson David, Mould Diane R, Baldassano Robert N, Russell Richard K, Dubinsky Marla, Heyman Melvin B, de Ridder Lissy, Hyams Jeffrey, Martin de Carpi Javier, Conklin Laurie, Faubion William A, Koletzko Sibylle, Bousvaros Athos, Ruemmele Frank M: Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary. Gut Apr 2019.

Wu Jing, Lubman David M, Kugathasan Subra, Denson Lee A, Hyams Jeffrey S, Dubinsky Marla C, Griffiths Anne M, Baldassano Robert N, Noe Joshua D, Rabizadeh Shervin, Gulati Ajay S, Rosh Joel R, Crandall Wallace V, Higgins Peter D R, Stidham Ryan W: Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease. The American journal of gastroenterology 114(5): 777-785, May 2019

Zhou Lei, Chu Coco, Teng Fei, Bessman Nicholas J, Goc Jeremy, Santosa Endi K, Putzel Gregory G, Kabata Hiroki, Kelsen Judith R, Baldassano Robert N, Shah Manish A, Sockolow Robbyn E, Vivier Eric, Eberl Gérard, Smith Kendall A, Sonnenberg Gregory F: Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature Apr 2019.

Books

Conrad M and Maxwell EC: Chapter 30: section on Intestinal Disorders. Nelson Pediatric Board Review - Certification and Recertification 2019

Liver

Articles

Agawu A, Wehrman A, Pogoriler J, Terry NA, Lin HC: A case report of a challenging diagnosis of biliary atresia in a patient receiving total parenteral nutrition. BMC Pediatrics 19(1): 72, 2019.

Alonso EM, Ye W, Hawthorne K, Venkat V, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider BL, Suchy FJ, Turmelle YP, Wang KS, Whitington PF, Sherker AH, Sokol RJ, Bezerra JA, Magee JC and the ChiLDReN Network: Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia:  The Multi-center START Trial. Journal of Pediatrics 202: 179-85, 2018

Berauer John-Paul, Mezina Anya I, Okou David T, Sabo Aniko, Muzny Donna M, Gibbs Richard A, Hegde Madhuri R, Chopra Pankaj, Cutler David J, Perlmutter David H, Bull Laura N, Thompson Richard J, Loomes Kathleen M, Spinner Nancy B, Rajagopalan Ramakrishnan, Guthery Stephen L, Moore Barry, Yandell Mark, Harpavat Sanjiv, Magee John C, Kamath Binita M, Molleston Jean P, Bezerra Jorge A, Murray Karen F, Alonso Estella M, Rosenthal Philip, Squires Robert H, Wang Kasper S, Finegold Milton J, Russo Pierre, Sherker Averell H, Sokol Ronald J, Karpen Saul J: Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome. Hepatology (Baltimore, Md.) Jan 2019

Biko David M, Smith Christopher L, Otero Hansel J, Saul David, White Ammie M, DeWitt Aaron, Glatz Andrew C, Piccoli David A, Mamula Petar, Rome Jonathan J, Dori Yoav: Intrahepatic dynamic contrast MR lymphangiography: initial experience with a new technique for the assessment of liver lymphatics. European radiology Mar 2019

Chen Y, Gilbert MA, Grochowski CM, McEldrew DA, Llewellyn J, Waisbourd-Zinman O, Hakonarson H, Bailey-Wilson JE, Russo P, Wells RG, Loomes KM, Spinner NB, Devoto M.: A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1. PLOS Genetics 14(8), August 2018

Erlichman J, Loomes K, Flick J: Biliary atresia. Best Practice http://bestpractice.bmj.com 2018.

Erlichman J, Loomes KM: Approach to Neonatal Cholestasis. Up to Date 2018

Loomes Kathleen M, Spino Cathie, Goodrich Nathan P, Hangartner Thomas N, Marker Amanda E, Heubi James E, Kamath Binita M, Shneider Benjamin L, Rosenthal Philip, Hertel Paula M, Karpen Saul J, Molleston Jean P, Murray Karen F, Schwarz Kathleen B, Squires Robert H, Teckman Jeffrey, Turmelle Yumirle P, Alonso Estella M, Sherker Averell H, Magee John C, Sokol Ronald J: Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology (Baltimore, Md.) 69(1): 245-257, Jan 2019

Mack Cara L, Spino Cathie, Alonso Estella M, Bezerra Jorge A, Moore Jeffrey, Goodhue Catherine, Ng Vicky L, Karpen Saul J, Venkat Veena, Loomes Kathleen M, Wang Kasper, Sherker Averell H, Magee John C, Sokol Ronald J: A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia. Journal of pediatric gastroenterology and nutrition 68(4): 495-501, Apr 2019.

Mitchell Ellen, Gilbert Melissa, Loomes Kathleen M: Alagille Syndrome. Clinics in liver disease 22(4): 625-641, 11 2018

Murray, K.F., Balistreri, W. F., Bansal, S., Whitworth, S.,  Evans, H.M., Gonzalez-Peralta, R.P., Wen, J., Massetto, B., Kersey, K., Shao, J.,  Garrison, K.L., Parhy, B., Brainard, D.M., Arnon, R., Gillis, L., Jonas, M.M., Lin, C.H., Narkewicz, M.R., Schwarz, K., Rosenthal, P.: Safety and Efficacy of Ledipasvir-Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6-11. Hepatology Aug 2018.

Narkewicz MR, Horslen S, Hardison RM, Shneider BL, Rodriguez-Baez N, Alonso EM, Ng VL, Leonis MA, Loomes KM, Rudnick DA, Rosenthal P, Romero R, Subbarao GC, Li R, Belle SH, Squires RH.: A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clinical Gastroenterology and Hepatology 2018

Shneider Benjamin L, Spino Cathie, Kamath Binita M, Magee John C, Bass Lee M, Setchell Kenneth D, Miethke Alexander, Molleston Jean P, Mack Cara L, Squires Robert H, Murray Karen F, Loomes Kathleen M, Rosenthal Philip, Karpen Saul J, Leung Daniel H, Guthery Stephen L, Thomas Danny, Sherker Averell H, Sokol Ronald J: Placebo-Controlled Randomized Trial of an Intestinal Bile Salt Transport Inhibitor for Pruritus in Alagille Syndrome. Hepatology communications 2(10): 1184-1198, Oct 2018

Books

Kamath BM and Loomes KM: Alagille Syndrome:  Pathogenesis and Clinical Management. Book. Springer, 2018.

Motility Disorders

Articles

Heuckeroth, RO: Even When You Know Everything, There Is Still More to Learn About Hirschsprung Disease. Gastroenterology 155(6): 1681-1684, December 2018

James P. White, Shanshan Xiong, Nicole P. Malvin, William Khoury-Hanold, Robert O. Heuckeroth, Thaddeus S. Stappenbeck and Michael S. Diamond: Intestinal Dysmotility Syndromes Following Systemic Infection by Flaviviruses. Cell November 2018

Sabine Schneider, Christina M. Wright, and Robert O. Heuckeroth: Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. Annual Reviews of Physiology Page:  doi: 10.1146/annurev-physiol-021317-121515.  October 2018

Silvia Huerta Lopez, Marina Avetisyan, Christina Wright, Karim Mesbah, Robert Kelly, Anne Moon, Robert O. Heuckeroth: Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit. Developmental Biology 444: Suppl 1:S337-S351.  October 2018 Notes: doi: 10.1016/j.ydbio.2018.09.017

Webster J, Lourie, E, Shaw, K, Huang, E: Implementation of a Constipation Action Plan in Primary Care Clinics to Decrease Referrals to Pediatric Gastroenterology: A Quality Improvement Initiative. Gastroenterology 155(1): e48-e49, 2018

Books

Webster, J, Godwin, B: Clinical Approach to Esophageal and Gastric Disorders. Nelson's Pediatric Board Review. Elsevier, 2018.

Nutrition (growth, development & malnutrition)

Articles

Cousminer DL, McCormack SE, Mitchell JA, Chesi A, Kindler JM, Kelly A, Voight BF, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Zemel BS, Grant SFA: Postmenopausal osteoporotic fracture-associated COLIA1 variant impacts bone accretion in girls. Bone Jan 2019

Eunsun Kim, Amanda Lisby, Connie Ma, Nathanael Lo, Ursula Ehmer, Katharina E. Hayer, Emma E. Furth, and Patrick Viatour: Promotion of growth factor signaling as a critical function of β-catenin during HCC progression. Nature Communications 2019 Notes: Acknowledged for microscopy expertise and imaging.

Kelly A, Shults J, Mostoufi-Moab S, McCormack SE, Stallings VA, Schall JI, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Winer KK, Leonard MB, Zemel BS: Pediatric Bone Mineral Accrual Z-Score Calculation Equations and Their Application in Childhood Disease. J Bone Miner Res. 34(1): 195-203, January 2019

McCormack SE, Kelly A, Mitchell JA, Cousminer DL, Chesi A, Kindler J, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer K, Grant SFA, Zemel BS: Accounting for skeletal maturation in the assessment of pediatric bone mineral density. Endocrine Society (ENDO), Annual Meeting, New Orleans, LA Mar 2019.

Mostoufi-Moab Sogol, Kelly Andrea, Mitchell Jonathan A, Baker Joshua, Zemel Babette S, Brodsky Jill, Long Jin, Leonard Mary B: Changes in pediatric DXA measures of musculoskeletal outcomes and correlation with quantitative CT following treatment of acute lymphoblastic leukemia. Bone 112: 128-135, Jul 2018.

Oyebimpe O. Adesina1, James G. Gurney, Guolian Kang, Martha Villavicencio, Jason R. Hodges, Wassim Chemaitilly, Sue C. Kaste, Babette S. Zemel, and Jane S. Hankins: Height-Corrected Low Bone Density in Sickle Cell Disease Associates with Severe Outcomes: SCCRIP Cohort Study Results. Blood Advances Mar 2019

Roy SM, Fields DA, Mitchell JA, Hawkes CP, Kelly A, Wu GD, DeRusso PA, Elovitz MA, Ford E, Drigo D, Zemel BS, McCormack SE: Body Mass Index is a Better Indicator of Body Composition than Weight-for-Length at Age 1 Month. The Journal of Pediatrics  204: 77-83, Jan 2019.

Sainath N, Schall J, Bertolaso C, McAnlis C, Stallings V.: Italian and North American dietary intake after ivacaftor treatment for cystic fibrosis gating mutations.  J Cyst Fibros 18(1): 135-143, January 2019

Books

Bass R, Goh V, Mascarenhas MR: Nutrition. The Philadelphia Guide:  Inpatient Pediatrics 3rd edition 2018

Maqbool, Elizabeth Prout Parks, Ala Shaikhkhalil, Jennifer Panganiban, Jonathan A. Mitchell, and Virginia A. Stallings: Nutritional Requirements. Kliegman et al: Nelson Textbook of Pediatrics. Elsevier, Chapter 55, Oct 2018

Panganiban J, Gilbaugh A, Tettey-Fio A, Mascarenhas MR: Integrative Medicine and Nutrition, Chapter 22. Pediatric Nutrition Handbook, 5th edition. Becker P and Konek S (eds.). Jones and Bartlett Learning, 2018

Pancreas

Articles

Ac A, Perito E, Pohl J, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery K, Fishman DS, Gariepy C, Giefer MJ, Gonska T, Heyman M, Himes R, Husain S, Maqbool A, Mascarenhas MR, McFerron B, Morinville V, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME: International Study Group of Pediatric Pancreatitis:  In Search for a Cure Cohort Study:  Design and Rationale for the INSPIRRE 2 Study from the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas - Official Journal of the American Pancreatic Association, Japan Pancreas Society, and the North American Neuroendocrine Tumor Society 47(10), November 2018

Lowe M, Husain S, Morinville V, Fishman D, Perito E, Freedman S, Gariepy C, pohl J, Giefer M, Abu-El-Haija M, Palermo J, Lin T. Nathan J, Liu Q, Mascarenhas M, Piccoli D, Shah U, Zimmerman M, Uc A: Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood:  Consensus from INSPPIRE. JPGN 67(2): 232-236, August 2018.

Sellers ZM, Dike C, Zhang KY, Giefer MJ, UcA, Abu-El-Haija M: A Unified Treatment Algorithm and Admission Order Set for Pediatric Acute Pancreatitis. J Pediatr Gastroenterol Nutr March 2019 Notes: doi: 10.1097/MPG.0000000000002341.

Books

Brownell J, McKnight-Nenci H, Thornton P, Maqbool A: Pancreatic Insufficiency and Complications of Surgery. Congenital Pediatric Hyperinsulinism. De Leon-Crutchlow D, Stanley C (eds.). Springer, Page: 131-141, 2019.


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