The purpose of this study is to compare the genes of African American children and adults who have inflammatory bowel disease (IBD) with the genes of those who do not have IBD. Genes are pieces of hereditary material found in human cells. How an individual's genes cause intestinal inflammation in IBD is still being tested and not much is known about the association between genes and IBD in individuals with African ancestry. We hope to understand which genes cause IBD and if certain genes can help doctors personalize treatment for patients with IBD. For more information please contact IBDResearch@email.chop.edu.

The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for.

The purpose of this study is to learn more about a new device that measures stomach and bowel myoelectric (electricity produced by muscles) activity in children and young adults using body surface gastric mapping (BSGM). The BSGM device is FDA approved for use in individuals aged 12 and older.

We are looking to partner with patients who have a confirmed diagnosis of a Motility Disorder and/or Functional Gastrointestinal Disorder (FGID) or patients who are having motility tests/procedures performed for clinical care. We are also looking for healthy controls without any history of inflammatory disease or pyloric disorders. All study participants must be 8 - 25 years of age and have a body mass index (BMI) of less than 35.

Participation is completely voluntary, and subjects may withdraw at any time without affecting their care. Participants may receive compensation for their time.

CAPTURE Inflammatory Bowel Disease (IBD) is a multi-center, longitudinal study designed with the goal of advancing precision medicine in pediatric IBD. Participants in CAPTURE IBD will continue to receive their usual care at the Children's Hospital of Philadelphia. The study team will ask participants to give blood, stool, and tissue samples at the same time as scheduled IBD clinical visits, endoscopy, or bowel surgery visits. Additionally, participants will be asked to complete electronic surveys at scheduled clinic visits, including any scheduled endoscopy or bowel surgery visits. The study will use the biospecimens and health data as a research resource that can help scientists to answer questions like:

• Can we help guide the selection of the most effective IBD therapies for pediatric and young adult populations?
• Can we help identify new treatments for pediatric patients who are not responding to current available therapies?
• Can we advance our understanding of who are the best candidates for surgery in pediatric Crohn's disease and the best treatment approaches after surgery?

CAPTURE IBD will enroll 3,000 patients, ages 4-21 years old, who have an established or suspected diagnosis of IBD at 12 sites across the United States.

Children's Hospital of Philadelphia (CHOP) is inviting healthy individuals ages 0-21 to become part of a unique opportunity to help other kids heal: the CHOP Pediatric Fecal Microbiota Transplant (FMT) Stool Bank. This unique program is the first of its kind in the United States and offers screened stool donations from healthy children that may be used to provide life-changing treatment for children suffering from serious gut infections like recurrent C. difficile - an illness that can cause significant symptoms and complications. Contributing to this program could make a direct difference in providing safe and effective treatment options for serious gut infections in children.