A thorough review of outcome measures that assess disease progression has not been established for any of the subcategories of Alexander disease. These results will be crucial to our understanding of disease presentation and progression. Providing this information about the pathophysiology will allow for effective development of clinical trials to test therapies and the future use of neuroprotective agents in children.

The purpose of this study is to find out how the brain learns to move in infants with and without brain injury. Some infants with brain injury later have cerebral palsy (CP), a condition that makes it hard for infants to learn how to move and control their balance, and others do not. Three groups of infants will participate- infants who had a brain injury and are at high risk for CP, infants who had a brain injury and are not at high risk for CP, and infants who are typically developing.