Hematopathology at Children’s Hospital of Philadelphia coordinates with various lab services for the diagnosis of disorders of hematopoietic cells, including leukemia, lymphoma, and other disorders of the blood and lymphoid systems. In many cases, the service triages patient samples, assigns appropriate portions to relevant laboratories, and integrates resulting findings to generate a unified and comprehensive diagnosis. Specimens can be sent to the hematopathology service using the Bone Marrow Submission Form, and will  be assigned to the appropriate laboratories. Alternatively, specimens can be submitted directly to the appropriate laboratories with the request for hematopathology diagnostic interpretation.

The hematopathology service collaborates closely with the following laboratories:

  • Anatomic Pathology: tissue biopsies and second opinion of glass slide sections, including paraffin immunohistochemical stains.
  • Hematology Laboratory: bone marrow aspirates cytochemical stains, body fluids, and peripheral blood, including cytochemical stains (NSE, MPO)
  • Immunology Laboratory: tissue biopsies, body fluids, bone marrow aspirate, and peripheral blood for flow cytometry for leukemia, lymphoma, ALPS (autoimmune lymphoproliferative disorder), and hereditary spherocytosis.
  • Division of Genomic Diagnostics: tissue biopsies and bone marrow aspirates for karyotype, SNP array, and NGS panels. Biopsy, aspirates, and unstained glass side tissue sections for FISH analysis.


Main Hospital, 5th Floor, Room 5NW27


Monday - Friday, 8 a.m. - 5 p.m.
No weekend, holiday or evening/night shift personnel are available.
A hematopathologist is on call  24 hours a day, 7 days a week for urgent specimens.

Shipping address

The Children’s Hospital of Philadelphia
Main Hospital, 5th Floor
Room 5NW27
3401 Civic Center Boulevard
Philadelphia PA 19104-4318