The Jill and Mark Fishman Center for Lymphatic Disorders Publications

Lymphatic imaging

Dori Y, Keller MS, Fogel MA, Rome JJ, Whitehead KK, Harris MA, Itkin M. MRI of lymphatic abnormalities after functional single-ventricle palliation surgeryAJR Am J Roentgenol. 2014 Aug;203(2):426-31. PMID: 24848564

Dori Y, Zviman MM, Itkin M. Dynamic contrast-enhanced MR lymphangiography: feasibility study in swineRadiology. 2014 Nov;273(2):410-6. PMID: 24988434

Itkin MG, McCormack FX, Dori Y.: Diagnosis and treatment of lymphatic plastic bronchitis in adults using advanced lymphatic imaging and percutaneous embolization. Annals of the American Thoracic Society 13(10): 1689-1696, Oct 2016.

Biko DM, Johnstone JA, Dori Y, Victoria T, Oliver ER, Itkin M.: Recognition of Neonatal Lymphatic Flow Disorder: Fetal MR Findings and Postnatal MR Lymphangiogram Correlation Acad Radiol 18(2): 30106-5, March 2018.

Jobes DR, Brown LA, Dori Y, Itkin M, Nicolson SC.: Lymphatic imaging and intervention in a pediatric population: Anesthetic considerations Paediatr Anaesth 28(6): 507-512, June 2018.

Biko DM, Smith CL, Otero HJ, Saul D, White AM, DeWitt A, Glatz AC, Piccoli DA, Mamula P, Rome JJ, Dori Y. Intrahepatic dynamic contrast MR lymphangiography: initial experience with a new technique for the assessment of liver lymphatics. Eur Radiol. 2019 Oct;29(10):5190-5196. doi: 10.1007/s00330-019-06112-z. Epub 2019 Mar 18. PMID: 30887210.

Biko DM, Reisen B, Otero HJ, Ravishankar C, Victoria T, Glatz AC, Rome JJ, Dori Y. Imaging of central lymphatic abnormalities in Noonan syndromePediatr Radiol. 2019 May;49(5):586-592. PMID: 30613845

Biko DM, DeWitt AG, Pinto EM, Morrison RE, Johnstone JA, Griffis H, O'Byrne ML, Fogel MA, Harris MA, Partington SL, Whitehead KK, Saul D, Goldberg DJ, Rychik J, Glatz AC, Gillespie MJ, Rome JJ, Dori Y. MRI Evaluation of Lymphatic Abnormalities in the Neck and Thorax after Fontan Surgery: Relationship with OutcomeRadiology. 2019 Jun;291(3):774-780. PMID: 30938628

Biko DM, Dori Y, Savoca M, Krishnamurthy G, Smith CL, Laje P, Rome JJ, Escobar F. Pediatric pulmonary lymphatic flow Disorders: Diagnosis and management. Pediatr Respir Rev. 2020 Nov;36:2-7. doi: 10.1016/j.prrv.2019.11.002. Epub 2019 Nov 29. PMID: 31884062.

Mejia EJ, Otero HJ, Smith CL, Shipman M, Liu M, Pinto E, DeWitt A, Rome JJ, Dori Y, Biko DM.: Use of Contrast-Enhanced Ultrasound to Determine Thoracic Duct Patency. J Vasc Interv Radiol 31(10): 1670-1674, October 2020.

Dori Y, Smith CL, DeWitt AG, Srinivasan A, Krishnamurthy G, Escobar FA, Biko DM. Intramesenteric dynamic contrast pediatric MR lymphangiography: initial experience and comparison with intranodal and intrahepatic MR lymphangiography. Eur Radiol. 2020 Oct;30(10):5777-5784. doi: 10.1007/s00330-020-06949-9. Epub 2020 May 27. PMID: 32462442.

Smith CL, Liu M, Saravanan M, Dewitt AG, Biko DM, Pinto EM, Escobar FA, Krishnamurthy G, Brownell JN, Mamula P, Glatz AC, Gillespie MJ, O'Byrne ML, Ravishankar C, Rome JJ, Dori Y. Liver lymphatic anatomy and role in systemic lymphatic disease. Eur Radiol. 2022 Jan;32(1):112-121. doi: 10.1007/s00330-021-08098-z. Epub 2021 Jun 24. PMID: 34165621.

Ramirez-Suarez KI, Tierradentro-Garcia LO, Smith CL, Krishnamurthy G, Escobar FA, Otero HJ, Rapp JB, Dori Y, Biko DM. Dynamic contrast-enhanced magnetic resonance lymphangiography. Pediatr Radiol. 2022 Feb;52(2):285-294. doi: 10.1007/s00247-021-05051-6. Epub 2021 Apr 8. PMID: 33830292.

Lemley BA, Biko DM, Dewitt AG, Glatz AC, Goldberg DJ, Saravanan M, O'Byrne ML, Pinto E, Ravishankar C, Rome JJ, Smith CL, Dori Y: Intrahepatic Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography: Potential Imaging Signature for Protein-Losing Enteropathy in Congenital Heart Disease  J Am Heart Assoc 5(10): e021542, October 2021.

Brownell JN, Biko DM, Mamula P, Krishnamurthy G, Escobar F, Srinivasan A, Laje P, Piccoli DA, Pinto E, Smith CL, Dori Y: Dynamic Contrast Magnetic Resonance Lymphangiography Localizes Lymphatic Leak to the Duodenum in Protein-losing Enteropathy. Journal of Pediatric Gastroenterology and Nutrition 74(1): 38-45, January 2022.

Tierradentro-Garcia LO, Smith CL, Ramirez-Suarez KI, Krishnamurthy G, Escobar FA, Otero HJ, Rapp JB, Dori Y, Biko D: Dynamic Contrast-Enhanced magnetic resonance lymphangiography. Pediatric Radiology 52(2): 285-294, February 2022.

Yekeler E, Krishnamurthy G, Smith CL, Escobar FA, Pinto E, Rapp JB, Otero HJ, White AM, Dori Y, Biko DM: Dynamic contrast-enhanced MR lymphangiography: feasibility of using ferumoxytol in patients with chronic kidney disease European Radiology 32(4): 2564-2571, April 2022.

Ramirez-Suarez KI, Tierradentro-Garcia LO, Stern JA, Dori Y, Escobar FA, Otero HJ, Rapp JB, Smith CL, Krishnamurthy G, Biko DM: State-of-the-art imaging for lymphatic evaluation in children. Pediatric Radiology August 2022.

Simon M, Dori Y, Smith CL, Biko DM, Surrey LF, Adams DM, Krishnamurthy G, Rapp JB. Alternative Evaluation of the Right Axillary Lymphatic Pathway by Using Dynamic Contrast-enhanced MR Lymphangiography. Radiol Cardiothorac Imaging. 2022 Oct 27; 4(5):e220035. doi: 10.1148/ryct.220035. PMID: 36339058; PMCID: PMC9627229

Plastic bronchitis

Avitabile CM, Goldberg DJ, Dodds K, Dori Y, Ravishankar C, Rychik J: A multifaceted approach to the management of plastic bronchitis after cavopulmonary palliation. Ann Thorac Surg 98(2): 634-640, Aug 2014.

Dori Y, Keller MS, Rychik J, Itkin M. Successful treatment of plastic bronchitis by selective lymphatic embolization in a Fontan patientPediatrics. 2014 Aug;134(2):e590-5. PMID: 25002668

Itkin MG, McCormack FX, Dori Y.: Diagnosis and treatment of lymphatic plastic bronchitis in adults using advanced lymphatic imaging and percutaneous embolization. Annals of the American Thoracic Society 13(10): 1689-1696, Oct 2016.

Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, Goldberg DJ, Goldfarb S, Rychik J, Itkin M. Percutaneous Lymphatic Embolization of Abnormal Pulmonary Lymphatic Flow as Treatment of Plastic Bronchitis in Patients With Congenital Heart DiseaseCirculation. 2016 Mar 22;133(12):1160-70. PMID: 26864093

Geanacopoulos AT, Savla JJ, Pogoriler J, Piccione J, Phinizy P, DeWitt AG, Blinder JJ, Pinto E, Itkin M, Dori Y, Goldfarb SB.: Bronchoscopic and histologic findings during lymphatic intervention for plastic bronchitis. Pediatr Pulmonol 53(11): 1574-1581, Nov 2018.

Protein losing enteropathy

Kylat RI, Witte MH, Barber BJ, Dori Y, Ghishan FK: Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization. Pediatr Gastroenterol Hepatol Nutr 22(6): 594-600, November 2019.

Rychik J, Dodds KM, Goldberg D, Glatz AC, Fogel M, Rossano J, Chen J, Pinto E, Ravishankar C, Rand E, Rome JJ, Dori Y: Protein Losing Enteropathy After Fontan Operation: Glimpses of Clarity Through the Lifting Fog. World J Pediatr Congenit Heart Surg 11(1): 92-96, January 2020.

Brownell JN, Biko DM, Mamula P, Krishnamurthy G, Escobar F, Srinivasan A, Laje P, Piccoli DA, Pinto E, Smith CL, Dori Y: Dynamic Contrast Magnetic Resonance Lymphangiography Localizes Lymphatic Leak to the Duodenum in Protein-losing Enteropathy. Journal of Pediatric Gastroenterology and Nutrition 74(1): 38-45, January 2022.

Lymphatics and congenital heart disease

Dori Y, Keller MS, Fogel MA, Rome JJ, Whitehead KK, Harris MA, Itkin M. MRI of lymphatic abnormalities after functional single-ventricle palliation surgeryAJR Am J Roentgenol. 2014 Aug;203(2):426-31. PMID: 24848564

Avitabile CM, Goldberg DJ, Dodds K, Dori Y, Ravishankar C, Rychik J: A multifaceted approach to the management of plastic bronchitis after cavopulmonary palliation. Ann Thorac Surg 98(2): 634-640, Aug 2014.

Dori Y, Keller MS, Rychik J, Itkin M. Successful treatment of plastic bronchitis by selective lymphatic embolization in a Fontan patientPediatrics. 2014 Aug;134(2):e590-5. PMID: 25002668

Dori Y, Keller MS, Rome JJ, Gillespie MJ, Glatz AC, Dodds K, Goldberg DJ, Goldfarb S, Rychik J, Itkin M. Percutaneous Lymphatic Embolization of Abnormal Pulmonary Lymphatic Flow as Treatment of Plastic Bronchitis in Patients With Congenital Heart DiseaseCirculation. 2016 Mar 22;133(12):1160-70. PMID: 26864093

Savla JJ, Itkin M, Rossano JW, Dori Y. Post-Operative Chylothorax in Patients With Congenital Heart Disease. J Am Coll Cardiol. 2017 May 16;69(19):2410-2422. doi: 10.1016/j.jacc.2017.03.021. PMID: 28494978.

Kylat RI, Witte MH, Barber BJ, Dori Y, Ghishan FK: Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization. Pediatr Gastroenterol Hepatol Nutr 22(6): 594-600, November 2019.

Biko DM, DeWitt AG, Pinto EM, Morrison RE, Johnstone JA, Griffis H, O'Byrne ML, Fogel MA, Harris MA, Partington SL, Whitehead KK, Saul D, Goldberg DJ, Rychik J, Glatz AC, Gillespie MJ, Rome JJ, Dori Y. MRI Evaluation of Lymphatic Abnormalities in the Neck and Thorax after Fontan Surgery: Relationship with OutcomeRadiology. 2019 Jun;291(3):774-780. PMID: 30938628

Rychik J, Dodds KM, Goldberg D, Glatz AC, Fogel M, Rossano J, Chen J, Pinto E, Ravishankar C, Rand E, Rome JJ, Dori Y: Protein Losing Enteropathy After Fontan Operation: Glimpses of Clarity Through the Lifting Fog. World J Pediatr Congenit Heart Surg 11(1): 92-96, January 2020.

Ghosh RM, Griffis HM, Glatz AC, Rome JJ, Smith CL, Gillespie MJ, Whitehead KK, O'Byrne ML, Biko DM, Ravishankar C, Dewitt AG, Dori Y: Prevalence and Cause of Early Fontan Complications: Does the Lymphatic Circulation Play a Role? J Am Heart Assoc 9(7): e015318, April 2020.

Tomasulo C.E., Chen J.M., Smith C.L., Maeda K., Rome J.J., Dori Y. Lymphatic Disorders and Management in Patients With Congenital Heart Disease. 2021. Annals of Thoracic Surgery. 10.1016/j.athoracsur.2020.10.058. PMID: 33373590

Vaiyani D., Saravanan M., Dori Y., Pinto E., Gillespie M.J., Rome J.J., Goldberg D.J., Smith C.L., O’Byrne M.L., DeWitt A.G., Ravishankar C. Post-operative Chylothorax in Patients with Repaired Transposition of the Great Arteries. 2021. Pediatric Cardiology. 10.1007/s00246-021-02774-z. PMID: 34841467

Kylat RI, Witte MH, Barber BJ, Dori Y, Ghishan FK: Resolution of Protein-Losing Enteropathy after Congenital Heart Disease Repair by Selective Lymphatic Embolization. Pediatr Gastroenterol Hepatol Nutr 22(6): 594-600, November 2019.

Biko DM, DeWitt AG, Pinto EM, Morrison RE, Johnstone JA, Griffis H, O'Byrne ML, Fogel MA, Harris MA, Partington SL, Whitehead KK, Saul D, Goldberg DJ, Rychik J, Glatz AC, Gillespie MJ, Rome JJ, Dori Y. MRI Evaluation of Lymphatic Abnormalities in the Neck and Thorax after Fontan Surgery: Relationship with Outcome. Radiology. 2019 Jun;291(3):774-780. PMID: 30938628

Rychik J, Dodds KM, Goldberg D, Glatz AC, Fogel M, Rossano J, Chen J, Pinto E, Ravishankar C, Rand E, Rome JJ, Dori Y: Protein Losing Enteropathy After Fontan Operation: Glimpses of Clarity Through the Lifting Fog. World J Pediatr Congenit Heart Surg 11(1): 92-96, January 2020.

Ghosh RM, Griffis HM, Glatz AC, Rome JJ, Smith CL, Gillespie MJ, Whitehead KK, O'Byrne ML, Biko DM, Ravishankar C, Dewitt AG, Dori Y: Prevalence and Cause of Early Fontan Complications: Does the Lymphatic Circulation Play a Role? J Am Heart Assoc 9(7): e015318, April 2020.

Tomasulo C.E., Chen J.M., Smith C.L., Maeda K., Rome J.J., Dori Y. Lymphatic Disorders and Management in Patients With Congenital Heart Disease. 2021. Annals of Thoracic Surgery. 10.1016/j.athoracsur.2020.10.058. PMID: 33373590

Vaiyani D., Saravanan M., Dori Y., Pinto E., Gillespie M.J., Rome J.J., Goldberg D.J., Smith C.L., O’Byrne M.L., DeWitt A.G., Ravishankar C. Post-operative Chylothorax in Patients with Repaired Transposition of the Great Arteries. 2021. Pediatric Cardiology. 10.1007/s00246-021-02774-z. PMID: 34841467

Ramirez-Suarez KI, Tierradentro-García LO, Biko DM, Otero HJ, White AM, Dori Y, Smith CL, Vatsky S, Rapp JB: Lymphatic anomalies in congenital heart disease. Pediatric Radiology 2022

Smith CL, Dori Y, O'Byrne ML, Glatz AC, Gillespie MJ, Rome JJ: Transcatheter Thoracic Duct Decompression for Multicompartment Lymphatic Failure After Fontan Palliation. Circulation Cardiovascular Interventions 2022 Notes: Epub 2022 Jun 16.

Savla JJ, Kelly B, Krogh E, Smith CL, Krishnamurthy G, Glatz AC, DeWitt AG, Pinto EM, Ravishankar C, Gillespie MJ, O'Byrne ML, Escobar FA, Rome JJ, Hjortdal V, Dori Y. Occlusion Pressure of the Thoracic Duct in Fontan Patients With Lymphatic Failure: Does Dilatation Challenge Contractility? World J Pediatr Congenit Heart Surg. 2022 Nov; 13(6):737-744. doi: 10.1177/21501351221119394. PMID: 36300263

Chylothorax

Savla JJ, Itkin M, Rossano JW, Dori Y. Post-Operative Chylothorax in Patients With Congenital Heart Disease. J Am Coll Cardiol. 2017 May 16;69(19):2410-2422. doi: 10.1016/j.jacc.2017.03.021. PMID: 28494978.

Weissler JM, Cho EH, Koltz PF, Carney MJ, Itkin M, Laje P, Levin LS, Dori Y, Kanchwala SK, Kovach SJ. Lymphovenous Anastomosis for the Treatment of Chylothorax in Infants: A Novel Microsurgical Approach to a Devastating ProblemPlast Reconstr Surg. 2018 Jun;141(6):1502-1507. PMID: 29794709

Vaiyani D., Saravanan M., Dori Y., Pinto E., Gillespie M.J., Rome J.J., Goldberg D.J., Smith C.L., O’Byrne M.L., DeWitt A.G., Ravishankar C. Post-operative Chylothorax in Patients with Repaired Transposition of the Great Arteries. 2021. Pediatric Cardiology. 10.1007/s00246-021-02774-z. PMID: 34841467

Neonatal

Biko DM, Johnstone JA, Dori Y, Victoria T, Oliver ER, Itkin M.: Recognition of Neonatal Lymphatic Flow Disorder: Fetal MR Findings and Postnatal MR Lymphangiogram Correlation Acad Radiol 18(2): 30106-5, March 2018.

Weissler JM, Cho EH, Koltz PF, Carney MJ, Itkin M, Laje P, Levin LS, Dori Y, Kanchwala SK, Kovach SJ. Lymphovenous Anastomosis for the Treatment of Chylothorax in Infants: A Novel Microsurgical Approach to a Devastating ProblemPlast Reconstr Surg. 2018 Jun;141(6):1502-1507. PMID: 29794709

Reisen B, Kovach SJ, Levin LS, Pinto E, Nadolski GJ, Itkin M, Dori Y, Laje P. Thoracic duct-to-vein anastomosis for the management of thoracic duct outflow obstruction in newborns and infants: a CASE series. J Pediatr Surg. 2020 Feb;55(2):234-239. doi: 10.1016/j.jpedsurg.2019.10.029. Epub 2019 Nov 1. PMID: 31708212.

Pinto E, Dori Y, Smith C, DeWitt A, Williams C, Griffis H, Escobar F, Biko DM, Krishnamurthy G, Rome J, Glatz AC, Liu M, Ravishankar C, Zhang H, Taha D. Neonatal lymphatic flow disorders: impact of lymphatic imaging and interventions on outcomes. J Perinatol. 2021 Mar;41(3):494-501. doi: 10.1038/s41372-020-00771-3. Epub 2020 Sep 2. PMID: 32879418.

Khan S, Smith CL, Pinto EM, Taha DK, Gibbs KA, Rosenblatt SA, Dori Y. Effect of positive  pressure ventilation on lymphatic flow in pediatric patients. J Perinatol. 2022 Nov 25. doi: 10.1038/s41372-022-01563-7. Epub ahead of print. PMID: 36434049

Genetic disorders

Li D, Wenger TL, Seiler C, March ME, Gutierrez-Uzquiza A, Kao C, Bhoj E, Tian L, Rosenbach M, Liu Y, Robinson N, Behr M, Chiavacci R, Hou C, Wang T, Bakay M, Pellegrino da Silva R, Perkins JA, Sleiman P, Levine MA, Hicks PJ, Itkin M, Dori Y, Hakonarson H.: Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly. Hum Mol Genet 27(18): 3233-3245, September 2018.

Biko DM, Reisen B, Otero HJ, Ravishankar C, Victoria T, Glatz AC, Rome JJ, Dori Y. Imaging of central lymphatic abnormalities in Noonan syndromePediatr Radiol. 2019 May;49(5):586-592. PMID: 30613845

Li D, March ME, Gutierrez-Uzquiza A, Kao C, Seiler C, Pinto E, Matsuoka LS, Battig MR, Bhoj EJ, Wenger TL, Tian L, Robinson N, Wang T, Liu Y, Weinstein BM, Swift M, Jung HM, Kaminski CN, Chiavacci R, Perkins JA, Levine MA, Sleiman PMA, Hicks PJ, Strausbaugh JT, Belasco JB, Dori Y, Hakonarson H. ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitorNat Med. 2019 Jul;25(7):1116-1122. PMID: 31263281

Foster JB, Li D, March ME, Sheppard SE, Adams DM, Hakonarson H, Dori Y. Kaposiform lymphangiomatosis effectively treated with MEK inhibition. EMBO Mol Med. 2020 Oct 7;12(10):e12324. doi: 10.15252/emmm.202012324. Epub 2020 Sep 7. PMID: 32894644; PMCID: PMC7539180.

Dori Y, Smith C, Pinto E, Snyder K, March ME, Hakonarson H, Belasco J. Severe Lymphatic Disorder Resolved With MEK Inhibition in a Patient With Noonan Syndrome and SOS1 Mutation. Pediatrics. 2020 Dec;146(6):e20200167. doi: 10.1542/peds.2020-0167. PMID: 33219052.

Li D., Sheppard S.E., Peroutka C., Barnes C., Reid J.R., Smith C.L., Dori Y., Hakonarson H. Expanded phenotypic spectrum of JAG1-associated diseases: Central conducting lymphatic anomaly with a pathogenic variant in JAG1. 2021. Clinical Genetics, 99(5): 742-743. 10.1111/cge.13915. PMID: 33433009

Surgical procedures

Weissler JM, Cho EH, Koltz PF, Carney MJ, Itkin M, Laje P, Levin LS, Dori Y, Kanchwala SK, Kovach SJ. Lymphovenous Anastomosis for the Treatment of Chylothorax in Infants: A Novel Microsurgical Approach to a Devastating ProblemPlast Reconstr Surg. 2018 Jun;141(6):1502-1507. PMID: 29794709

Reisen B, Kovach SJ, Levin LS, Pinto E, Nadolski GJ, Itkin M, Dori Y, Laje P. Thoracic duct-to-vein anastomosis for the management of thoracic duct outflow obstruction in newborns and infants: a CASE series. J Pediatr Surg. 2020 Feb;55(2):234-239. doi: 10.1016/j.jpedsurg.2019.10.029. Epub 2019 Nov 1. PMID: 31708212.