CHOP Researchers Develop Versatile and Low-Cost Technology for Targeted Long-read RNA Sequencing
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CHOP researchers have developed a versatile and low-cost technology for targeted sequencing of full-length RNA molecules.
Pathology and Laboratory Medicine News and Updates
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CHOP Researchers Reveal How NSAIDs Worsen C. difficile Infections
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CHOP researchers have shown that NSAIDs disrupt epithelial cells in the colon and sensitize them to C. difficile toxins by perturbing cell mitochondria.
CHOP Researchers Develop Stable, Scalable Universal MHC Molecules
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CHOP researchers have engineered stable, universal MHC-I molecules that can be produced rapidly at scale, allowing researchers to develop vaccines and immunotherapies more quickly.
New Computational Tool Identifies Novel Targets for Cancer Immunotherapy
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CHOP and UCLA researchers have created a tool that can discover tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.
CHOP Researchers Reveal Complex Assembly Process Involved in DNA Virus Replication
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CHOP researchers have shown that adenovirus proteins use a process called phase separation to coordinate production of viral progeny, which could have broad implications.
CHOP-led Study Shows that Antibiotic-Resistant Microbes in the Gut Make C. difficile More Infectious
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CHOP researchers have found that Enterococcus – an antibiotic-resistant, opportunistic pathogen – works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive.
CHOP Researchers Reveal Molecular Mechanism Behind Pigment Production in Skin Cells
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CHOP researchers have shown that two kinases are essential in melanosome biogenesis, and that these kinases localize sequentially.
CHOP Researchers Uncover Molecular Basis of Antigen Processing for Cancer Target MR1
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CHOP researchers have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target.
CHOP Researchers Develop New Computational Tool to Interpret Clinical Significance of Cancer Mutations
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CHOP researchers have developed new software called CancerVar, which helps researchers assess the clinical impacts of over 13 million somatic cancer mutations.
CHOP Brings Together Experts to Discuss Precision Medicine in Pediatric Cancer Care
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More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.