CHOP Researchers Uncover Molecular Basis of Antigen Processing for Cancer Target MR1
Published on in CHOP News
CHOP researchers have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target.
Pathology and Laboratory Medicine News and Updates
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CHOP Researchers Develop New Computational Tool to Interpret Clinical Significance of Cancer Mutations
Published on in CHOP News
CHOP researchers have developed new software called CancerVar, which helps researchers assess the clinical impacts of over 13 million somatic cancer mutations.
CHOP Brings Together Experts to Discuss Precision Medicine in Pediatric Cancer Care
Published on in CHOP News
More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.
Aberrant Splicing of CD22 in Acute Lymphoblastic Leukemia Underlies Resistance to Immunotherapy
Published on in CHOP News
Aberrant splicing leads to downregulation of CD22 in pediatric B-ALL, rendering malignant cells resistant to the effects of CD22-directed immunotherapies.
Study Rewrites Dogma of Adenovirus Infection and Double-stranded RNA
Published on in CHOP News
CHOP researchers have found no detectable levels of double-stranded RNA during adenovirus infection, upending previous assumptions about infection by the virus.
Two CHOP Researchers Receive NIH Funding for “High Risk, High Reward” Research
Published on in CHOP News
Their projects will focus on different aspects of gene expression, from developing new imaging tools to searching for causes of cancer.
Stephen R. Master, MD, PhD Begins Term as President of American Association for Clinical Chemistry
Published on in CHOP News
Dr. Stephen R. Master will serve as president of the American Association for Clinical Chemistry until July 2022.
CHOP Researchers Discover Unique Immune Response by Cells Critical to Lung Health
Published on in CHOP News
Type II alveolar cells, a major cell type infected by SARS-CoV-2, possess unique immunologic properties and appear to play a role in improving the outcome of respiratory viral infections.
CHOP Researchers Identify Protein that Restricts Herpes Simplex Virus Infection
Published on in CHOP News
Using a novel proteomics approach, CHOP researchers have identified a host protein that restricts herpes simplex virus 1 (HSV-1) infection.
Researchers Develop Sequencing Method to Detect RNA Modifications on Viral RNAs
Published on in CHOP News
CHOP researchers have developed a sequencing method to detect RNA modifications that regulate RNA splicing during adenovirus infection.