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CHOP researchers have identified variants of a chaperone molecule that optimizes the binding and presentation of foreign antigens across the human population.
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CHOP researchers have found that Enterococcus – an antibiotic-resistant, opportunistic pathogen – works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive.
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CHOP researchers have shown that two kinases are essential in melanosome biogenesis, and that these kinases localize sequentially.
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CHOP researchers have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target.
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CHOP researchers have developed new software called CancerVar, which helps researchers assess the clinical impacts of over 13 million somatic cancer mutations.
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More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.
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Aberrant splicing leads to downregulation of CD22 in pediatric B-ALL, rendering malignant cells resistant to the effects of CD22-directed immunotherapies.
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CHOP researchers have found no detectable levels of double-stranded RNA during adenovirus infection, upending previous assumptions about infection by the virus.
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Their projects will focus on different aspects of gene expression, from developing new imaging tools to searching for causes of cancer.
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Dr. Stephen R. Master will serve as president of the American Association for Clinical Chemistry until July 2022.