CHOP Researchers Discover Key Metabolic Process Responsible for Rapid Immune Responses
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A metabolite called NAD encourages immune cells to divide more quickly and could be used to improve efficacy of cell-based therapies.
Pathology and Laboratory Medicine News and Updates
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Researchers Identify Three Genes Associated with Neurodevelopmental Disorders
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All three genes had variants affecting splicing and resulted in symptoms like developmental delays, intellectual disability, hypotonia, seizures and autism.
CHOP Researchers Show “Cryptic” Viral Peptide Drives Large Part of Immune Response in Influenza A Virus Infection
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A new study by researchers at CHOP and Penn has identified an important role for a non-classical MHC molecule that engages with a cryptic viral peptide derived from influenza A virus.
New Computational Tool Tracks Transfer of Mitochondria from T Cells to Cancer Cells
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CHOP researchers have developed a computational tool to determine which cells in patient tumor samples receive mitochondria from T cells.
CHOP Researchers Develop Versatile and Low-Cost Technology for Targeted Long-read RNA Sequencing
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CHOP researchers have developed a versatile and low-cost technology for targeted sequencing of full-length RNA molecules.
CHOP Researchers Reveal How NSAIDs Worsen C. difficile Infections
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CHOP researchers have shown that NSAIDs disrupt epithelial cells in the colon and sensitize them to C. difficile toxins by perturbing cell mitochondria.
CHOP Researchers Develop Stable, Scalable Universal MHC Molecules
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CHOP researchers have engineered stable, universal MHC-I molecules that can be produced rapidly at scale, allowing researchers to develop vaccines and immunotherapies more quickly.
New Computational Tool Identifies Novel Targets for Cancer Immunotherapy
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CHOP and UCLA researchers have created a tool that can discover tumor antigens derived from alternative RNA splicing, expanding the pool of cancer immunotherapy targets.
CHOP Researchers Reveal Complex Assembly Process Involved in DNA Virus Replication
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CHOP researchers have shown that adenovirus proteins use a process called phase separation to coordinate production of viral progeny, which could have broad implications.
CHOP-led Study Shows that Antibiotic-Resistant Microbes in the Gut Make C. difficile More Infectious
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CHOP researchers have found that Enterococcus – an antibiotic-resistant, opportunistic pathogen – works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive.