CHOP Researchers Reveal Molecular Mechanism Behind Pigment Production in Skin Cells
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CHOP researchers have shown that two kinases are essential in melanosome biogenesis, and that these kinases localize sequentially.
Pathology and Laboratory Medicine News and Updates
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CHOP Researchers Uncover Molecular Basis of Antigen Processing for Cancer Target MR1
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CHOP researchers have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target.
CHOP Researchers Develop New Computational Tool to Interpret Clinical Significance of Cancer Mutations
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CHOP researchers have developed new software called CancerVar, which helps researchers assess the clinical impacts of over 13 million somatic cancer mutations.
CHOP Brings Together Experts to Discuss Precision Medicine in Pediatric Cancer Care
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More than 250 experts gathered in Philadelphia and virtually to discuss the latest scientific advancements and breakthroughs in pediatric precision medicine oncology.
Aberrant Splicing of CD22 in Acute Lymphoblastic Leukemia Underlies Resistance to Immunotherapy
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Aberrant splicing leads to downregulation of CD22 in pediatric B-ALL, rendering malignant cells resistant to the effects of CD22-directed immunotherapies.
Study Rewrites Dogma of Adenovirus Infection and Double-stranded RNA
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CHOP researchers have found no detectable levels of double-stranded RNA during adenovirus infection, upending previous assumptions about infection by the virus.
CHOP Researchers Discover Unique Immune Response by Cells Critical to Lung Health
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Type II alveolar cells, a major cell type infected by SARS-CoV-2, possess unique immunologic properties and appear to play a role in improving the outcome of respiratory viral infections.
CHOP Researchers Identify Protein that Restricts Herpes Simplex Virus Infection
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Using a novel proteomics approach, CHOP researchers have identified a host protein that restricts herpes simplex virus 1 (HSV-1) infection.
Researchers Develop Sequencing Method to Detect RNA Modifications on Viral RNAs
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CHOP researchers have developed a sequencing method to detect RNA modifications that regulate RNA splicing during adenovirus infection.
CHOP Researchers Uncover Mechanism that Helps Adenovirus Replicate Efficiently in Host Cells
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In a study published in Nature Microbiology, CHOP researchers uncover a ubiquitination mechanism that helps adenovirus replicate efficiently in host cells.