Program for Integrated Immunodeficiency and Cellular Therapy (PIICT) News

A collaborative team of researchers from Children’s Hospital of Philadelphia (CHOP) found that hematopoietic stem cell transplantation is a highly effective method for treating patients with monogenic inflammatory bowel disease (IBD), a more severe form of the illness usually affecting younger patients.

CHOP researchers have shown that IgA acts as a “tuner” that regulates the number of microbes the body sees every day, restraining a systemic immune response.

Using a model developed at CHOP, researchers find high cost of treatment most likely to prevent premature death in patients with agammaglobulinemia undermines its benefits.