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Preseptal or Orbital Cellulitis Clinical Pathway, All Settings – Transition from IV to PO Antibiotics for Children with Adequate Response to Treatment

Preseptal or Orbital Cellulitis Clinical Pathway — All Settings

Transition from IV to PO Antibiotics for Children with Adequate Response to Treatment

Recommendations in the table below apply to children with preseptal or orbital cellulitis.

Antibiotics should be streamlined based on positive culture results when available.

Initial IV Antibiotic Transition to the Following PO Antibiotics
Cefazolin
  • Cephalexin, PO
    • 60 mg/kg/day divided three times daily
      Max: 3,000 mg/day
Clindamycin
  • Clindamycin, PO
    • 10 mg/kg/dose three times daily
      Max: 600 mg/dose
Ampicillin-Sulbactam
  • Amoxicillin-Clavulanic Acid
    • 90 mg/kg/day divided twice daily
      Max: 4,000 mg/day using ES (suspension) or XR (tablet) formulation
Ampicillin-Sulbactam and Vancomycin Discuss with ID
Vancomycin, Ceftriaxone and Metronidazole Discuss with ID

 

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