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Hyperbilirubinemia/Jaundice — Nutrition, Hydration — Clinical Pathway: All Settings

Neonates with Hyperbilirubinemia/Jaundice Clinical Pathway

Nutrition, Hydration

Adequate nutrition increases enterohepatic circulation and promotes decreased TSB and avoids complications associated with dehydration.

Feeding Schedule
  • Encourage Frequent Feeding:
    • A minimum of at least 8 feeds in 24 hours is recommended
    • Infant can be off phototherapy for up to 30 minutes every 2-3 hours to feed
    • Use biliblanket during feeds
Breastfeeding
  • Protect/Support Breastfeeding Efforts:
    • The first week of breastfeeding is critical to milk production
    • Initiate breastfeeding within the first hour after birth, assess suckling adequacy
    • Initiate pumping with high-quality pump to enhance maternal milk production
    • Consult lactation consultant and involve unit-based breastfeeding resource nurse
    • Encourage supplementation with expressed milk, donor breast milk or formula as needed if not adequately hydrated and with a joint discussion with the parents.
  • Suboptimal Intake Hyperbilirubinemia:
    • Formerly known as breastfeeding jaundice
    • Attributed to suboptimal intake, peaks at 3-5 days
  • Breast Milk Jaundice Syndrome:
    • Prolonged elevated unconjugated hyperbilirubinemia that persists with adequate milk intake
    • Lasts up to 21 days
Intravenous Fluids
  • NG/OG Feeds:
    • Always consider NG/OG for enteral feeds as it increases enterohepatic circulation and helps excrete bilirubin
  • Consider IVF Fluids if:
    • Poor feeding, significant decrease in urine output
    • Concerning electrolytes
    • TSB level is within 2 points of exchange threshold
    • Concern for ongoing hemolysis
      • Hemolysis definition: Known DAT+ and retic count > 7%
  • IVF Guidance:
    • Single IV fluid bolus NS 10 mL/kg
    • Check BMP
    • Heparin-lock PIV
    • Do not start maintenance IVF
    • Encourage PO, consider NG/OG (6F) for continued enteral feeds after hydration
  • Care Escalation:
    • Consult Neonatology if any of the following:
      • TSB within 2 mg/dL of exchange threshold
      • TSB rate of rise > 0.5 mg/dL/hr
      • Evidence of hemolysis
      • Add CMP, CBC, reticulocyte count, DAT&S
      • NPO, IVFs

 

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