Initiating Pancreatic Enzyme Replacement Therapy (PERT) — Common Products — Clinical Pathway: All Settings

Clinical Pathway for Pancreatic Enzyme Replacement Therapy (PERT) in Children with or at Risk for Exocrine Pancreatic Insufficiency (EPI)

Common Products: FDA Approved Brands of Pancrelipase

Revised: April 2021

Enteric coated pancrelipase preparations

Creon, Pancrelipase

Product/Manufacturer Dosage Form/strength Lipase
USP Units		 Protease
USP Units		 Amylase
USP Units
Creon 3,000 3,000 9,500 15,000
Creon 6,000 6,000 19,000 30,000
Creon 12,000 12,000 38,000 60,000
Creon 24,000 24,000 76,000 120,000
Creon 36,000 36,000 114,000 180,000

Pancreaze, Pancrelipase

Product/Manufacturer Dosage Form/strength Lipase
USP Units		 Protease
USP Units		 Amylase
USP Units
MT2 2,600 6,200 10,850
MT4 4,200 14,200 24,600
MT10 10,500 35,500 61,500
MT16 16,800 56,800 98,400
MT20 21,000 54,700 83,900
MT37 37,000 97,300 149,900

Pertzye Pancrelipase, Bicarbonate Buffered

Product/Manufacturer Dosage Form/strength Lipase
USP Units		 Protease
USP Units		 Amylase
USP Units
Pertzye 4,000 4,000 14,375 15,125
Pertzye 8,000 8,000 28,750 30,250
Pertzye 16,000 16,000 57,500 60,500
Pertzye 24,000 24,000 86,250 90,750

Zenpep, Pancrelipase

Product/Manufacturer Dosage Form/strength Lipase
USP Units		 Protease
USP Units		 Amylase
USP Units
Zenpep 3000 3,000 10,000 14,000
Zenpep 5000 5,000 17,000 24,000
Zenpep 10,000 10,000 32,000 42,000
Zenpep 15,000 15,000 47,000 63,000
Zenpep 20,000 20,000 63,000 84,000
Zenpep 25,000 25,000 79,000 105,000
Zenpep 40,000 40,000 126,000 168,000
Zenpep 60,000 60,000 189,600 252,600

Non Enteric Coated Pancrelipase

Viokace Tablet

Product/Manufacturer Dosage Form/strength Lipase
USP Units		 Protease
USP Units		 Amylase
USP Units
Viokace 10,440 10,440 57,100 56,400
Viokace 20,880 20,880 112,500 113,400

RELiZORB

Lipase only cartridge for continuous enteral feeding