Mpox — Indications for Vaccination — Clinical Pathway: Emergency Department, Outpatient Specialty Care and Primary Care

Mpox (Monkeypox) Clinical Pathway — Emergency Department, Outpatient Specialty Care and Primary Care

Indications for Vaccination

If a patient has been exposed to mpox, getting vaccinated may keep them from getting sick. Vaccination is most effective within four days of exposure but can help up to 14 days post-exposure.

Anyone at risk for coming into contact with mpox should be vaccinated. Individuals may self-identify as someone who may benefit from vaccination. In addition, anyone with known close contact (skin to skin) with someone with mpox in the last 14 days should be vaccinated immediately.

JYNNEOS Vaccine

≥ 18 yrs Subcutaneously or intradermally
< 18 yrs Subcutaneously
  • 2 doses given at least 4 wks apart
  • If 2nd dose is delayed do not restart series; give as soon as possible
  • If recovered from mpox do not vaccinate unless severely immunocompromised
  • Do not revaccinate if received a full 2nd dose series

Close contacts should be referred to patient’s county health department for vaccination. For close contacts under the age of 18 years old, should call 215-685-5488 for Philadelphia Department of Public Health vaccine hotline or 610-278-5117 for the Montgomery County Department of Public Health or their local county.

Philadelphia Department of Public Health — Mpox Updates  

Interim Clinical Considerations for Use of JYNNEOS and ACAM2000 Vaccines during the 2022 U.S. Mpox Outbreak