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Osteomyelitis — Conversion to Oral Antibiotic Therapy — Clinical Pathway: Emergency and Inpatient

Osteomyelitis Clinical Pathway — Emergency Department and Inpatient

Conversion to Oral Antibiotic Therapy

Osteomyelitis with Clinical Improvement within 48-72 Hours and No Pathogen Identified

Children with positive cultures should have antibiotics tailored based on reported susceptibilities. For children with diagnosis of osteomyelitis where no pathogen has been identified from blood, bone or other tissue, use the following guidance:

If initial empirical antibiotic treatment was: Transition child to following oral antibiotic:
Cefazolin, IV
  • Cephalexin, PO
    • 100 mg/kg/day in 3 divided doses
    • Max: 1,500 mg/dose
Clindamycin, IV
  • Clindamycin, PO
    • 14 mg/kg/dose 3 times daily
    • Max: 600 mg/dose
Vancomycin, IV Discuss with Infectious Diseases

Review the CHOP Formulary for complete drug information.

References

 

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