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Sepsis, N/IICU — Management of Refractory Shock — Clinical Pathway: ICU and Inpatient

Suspected Sepsis Clinical Pathway — N/IICU

Management of Refractory Shock

Definition Treatment and Management
Shock persists despite escalation of two vasopressors
  • Discuss with N/IICU ECMO resource attending
  • Consider initiation of additional vasopressor agents (e.g., dobutamine, epinephrine, norepinephrine, milrinone, vasopressin) or hydrocortisone if not already started
  • Consider other etiology causing or contributing to refractory shock:
    • Pneumothorax
    • Pericardial effusion or cardiac tamponade
    • Ventricular dysfunction
    • Intravascular fluid status
    • Electrolyte abnormalities (sodium, potassium, ionized calcium values)
  • Consider obtaining CXR, ECHO, electrolytes and blood gas if not previously obtained
  • Consider PICU or CICU consult

 

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