Rodney M. Camire, PhD

Rodney M. Camire, PhD

Rodney M. Camire, PhD, is a Professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania and a member of the Division of Hematology and Raymond G. Perelman Center for Cellular and Molecular Therapeutics at Children’s Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Rodney M. Camire is a Professor of Pediatrics in the Perelman School of Medicine at The University of Pennsylvania and a member of the Division of Hematology at Children’s Hospital of Philadelphia. He is also a member of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics.

Rodney currently holds Children’s Hospital Endowed Chair in Hematology Research. His laboratory is interested in the molecular and cellular processes that contribute to and regulate blood coagulation and has over 15 years of experience studying the biochemistry of clotting factors. His laboratory has developed several novel clotting factors which are in preclinical/clinical development for the treatment of hemophilia and bleeding and he holds over 15 patents. In addition to translational work, his laboratory is interested in questions related to the enzymology, biochemistry and molecular genetics of enzyme complexes of blood coagulation with an emphasis on factors X, V, FIX and VIII. 

He has been funded from the NIH since 2003 and has published over 60 primary and review articles related to blood coagulation. Dr. Camire is as an Associate Editor for the Journal of Thrombosis and Haemostasis and is active with a variety of organizations sitting on the board of directors of the North American Society on Thrombosis and Hemostasis and Thrombosis and Hemostasis Societies of North America. He received his B.A. from Saint Anselm College and his PhD in biochemistry from The University of Vermont.

Education and Training

Fellowship

Post-doctoral Fellow in Pediatrics/Hematology - University of Pennsylvania, Philadephia, PA

Post-doctoral Fellow in Biochemistry - University of Vermont, Burlington, VT

Graduate Degree

PhD in Biochemistry - University of Vermont, Burlington, VT

Titles and Academic Titles

Professor, Department of Pediatrics

Member, Children's Hospital of Philadelphia Research Institute

Endowed Chair in Pediatric Hematology

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2018

Jarocha, D., Vo, K.K., Lyde, R.B., Hayes, V., Camire, R.M., and Poncz, M: Enhancing functional platelet release in vivo from in vitro-grown megakaryocytic using small molecule inhibitors. Blood Advances 2(6): 597-606, 2018.

Gunaratne, R., Kumar, S., Frederiksen, J.W., Stayrook, S., Lohrmann, J.L., Perry, K., Bompiani, K.M., Chabada, C.V., Thalji, N.K., Ho, M.D., Arepally, G., Camire, R.M., Krishnaswamy, K., and Sullenger, B.A: Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass. Nat. Biotechnol. In Press, 2018.

2017

Vadivel, K., Kumar, Y., Bunce, M.W., Camire, R.M., Bajaj, M.S., and Bajaj, S.P: Interaction of factor V B-domain acidic region with its basic region and TFPI/TFPI2:  Structural insights from molecular modeling studies. International Biology Review 1(1): 1-12, 2017.

Sim, X., Jarocha, D., Hayes, V., Haney, H.A., Marks, M.S., Camire, R.M., French, D.L., Poncz, M., and Gadue, P: Identifying and enriching the platelet-producing human stem cell-derived megakaryocytic using factor V uptake. Blood 130: 192-204, 2017 Notes: Commentary on paper/Cover page of journal.

Santamaria, S., Reglinska-Matveyev, N., Gierula, M., Camire, R.M., Crawley, J.T.B., Lane, D.A., and Ahnstrom, J: Factor V anticoagulant cofactor activity that targets the early phase of coagulation. J. Biol. Chem. 292: 9335-9344, 2017.

Polderdijk, S.G.I., Adams, T.E., Ivanciu, L., Camire, R.M., Baglin, T.P., and Huntington, J.A: Design and characterization of an APC-specific serpin for the treatment of hemophilia. Blood 129(1): 105-113, 2017.

Nguyen, G.N., George, L.A., Siner, J.I., Davidson, R.J., Zander, C.B., Zheng, X.L., Arruda, V.R., Camire, R.M., and Sabatino, S.E: Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. J. Thromb. Haemost. 15(1): 110-121, 2017.

Lee, E. J., Dykas, D. J., Leavitt, A. D., Camire, R. M., Ebberink, E., de Frutos, P. G., Gnanasambandan, K., Gu, S.X., Huntington, J.A., Lentz, S.R., Mertens, K., Parish, C.R., Rezaie, A.R., Sayeski, P.P., Cromwell, C., Bar, N., Halene, S., Neparidze, N., Parker, T.L., Burns, A.J., Dumont, A., Yao, X., Lyad Ochao Chaar, C., Connors, J.M., Bale, A.E., and Lee, A.I: Whole-exome sequencing in evaluation of patients with venous thromboembolism.  Blood Advances 1(16): 1224-1237, 2017.

2016

Thalji, N.K., Ivanciu, L., Davidson, R., Gimotty, P.A., Krishnaswamy, S., and Camire, R.M: A rapid pro-hemostatic approach to overcome direct oral anticoagulants. Nat. Med. 22(8): 924-932, 2016.

Siner, J.I., Samelson-Jones, B.J., Crudele, J.M., French, R.A., Lee, B.J., Zhou, S., Merricks, E., Raymer, R., Nichols, T.C., Camire, R.M., and Arruda, V.R: Circumventing burin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models. JCI Insight. 2016 Oct 6;1(16):e89371.

Nguyen, G.N., George, L.A., Siner, J.I., Davidson, R.J., Zander, C.B., Zheng, X.L., Arruda, V.R., Camire, R.M., and Sabatino, S.E: Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. J Thromb Haemost. 2016 Oct 17. doi: 10.1111/jth.13543. [Epub ahead of print]

2015

Sehgal, A. , Barros, S., Ivanciu, L., Cooley, B., Qin, J., Racie, T., Hettinger J., Carioto, M., Jiang, Y., Brodsky, J., Prabhala, H., Zhang, X., Attarwala, H., Hutabarat, R., Foster, D., Milstein, S., Charisse, K., Kuchimanchi, S., Maier, M.A., Nechev, L., Sorensen, B., Simon, A.R., Dargaud, Y., Negrier, C., Camire, R.M., and Akinc, A: An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nat. Med. 21(5): 492-497, 2015.

Liang, H., Kerschen, E.J., Basu, S., Hernandez, I., Zogg, M., Jia, S., Hessner, M.J., Toso, R., Rezaie, A., Fernandez J.A., Camire, R.M., Ruf, W., Griffin, J.H., and Weiler, H: Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood 126(21): 2415-2423, 2015.

Hui, D.J., Edmonson S.C., Podsakoff G.M., Pien G.C., Ivanciu L., Camire R.M., Ertl H., Mingozzi F., High K.A., and Basner-Tschakarjan E: AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes. Mol. There. Methods Clin. Dev. 2: 15029, 2015.

George, L.A., Thalji, N.K., Raffini, L.J., Gimotty, P.A. and Camire, R.M: Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L). J. Thromb. Haemost. 13(9): 1694-1698, 2015.

Baroni, M., Pavani, G., Pinotti, M., Branchini, A., Bernardi, F., and Camire, R.M: Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation. Biochim. Biophys. Acta. 1854(10 Pt A): 1351-1356, 2015.

2014

Vadivel, K., Ponnuraj, S., Kumar, Y., Zaiss, A.K., Bunce, M.W., Camire, R.M., Wu, L., Evseenko, D., Herschman, H.R., Bajaj, M.S., and Bajaj, S.P: Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J. Biol. Chem. 289(45): 31647-31661, 2014.

Greene, T.K., Zhai, L., Razzo, B.M., Vo, K., Sabatino, D., Camire, R.M., Arruda, V.R., and Poncz, M: Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. J. Thromb. Haemost. 12(12): 2102-2112, 2014.

Abstracts

2017

Verhoef, D., Nicolaes, G.A.F., Schrijver, R., Camire, R.M., Reitsma, P.H., and Bos, M.H.A: Human-snake chimeras of cofactor V reveal allostery between the A- and C- domains. J. Thromb. Haemost. 1: 7, 2017 Notes: Abstract symposia oral presentation given by collaborator.

Samson-Jones, B.J., French, R.A., Martin, N.B., Nichols, T.C., Camire, R.M., and Arruda, V.R: Immunogenicity and efficacy of FIX-Padua in distinct canine models of severe hemophilia B following AAV gene therapy to skeletal muscle or liver. J. Thromb. Haemost. 1: 145, 2017 Notes: Oral presentation given by collaborator.

Poderdijk, S., Adams, T., Ivanciu, L., Camire, R., Baglin, T., and Huntington, J: An engineered serpin for the treatment of hemophilia. J. Thromb. Haemost. 1: 141, 2017 Notes: Oral presentation given by collaborator.

Petrillo, T. and Camire, R.M: New insights into FV-short function and interaction with TFPIα. J. Thromb. Haemost. 1: 357, 2017 Notes: Poster presentation given by postdoctoral fellow.

Lyde, R., Ahn, H., Vo, K., Jarocha, D., Zhai, L., Sullivan, S., Arruda, V., Sabatino, D., Camire, R., French, D., and Poncz, M: Prophylactic platelet Factor (F)VIII infusions established from induced pluripotent stem cell (iPSC)-derived megakaryocytic in hemophilia A. J. Thromb. Haemost. 1: 176, 2017 Notes: Oral presentation given by collaborator.

Ivanciu, L., Arruda, V.R. and Camire, R.M: Altering FIX zymogenicity extends procoagulant function and improves hemostatic function in murine hemophilia B. J. Thromb. Haemost. 1: 378, 2017 Notes: Post presentation given by postdoctoral fellow.

George, L., Giermasz, A., Sullivan, S., Ducore, J., Rasko, J., Samelson-Jones, B., McGuinn, C., Teitel, J., Galvao, A., Camire, R., Luk, A., Wright, F., Wachtel, K., Carr, M., Anguela, X., and High, K: SPK-9001: Aden-associated virus mediated gene transfer for hemophilia B achieved durable endogenous prophylaxis at levels of activity sufficient to achieve significant mean reduction in annual bleeding and infusions rates in preliminary data from an on-going phase 1/2a trial. J. Thromb. Haemost. 1: 143, 2017 Notes: Oral presentation given by collaborator.

Dahlback, B., Guo, L.J., Livaja-Koshiar, R., Tran, S., and Camire, R.M: Factor V-short and protein S as synergistic TFPIα cofactors. J. Thromb. Haemost. 1: 10, 2017 Notes: Abstract symposia oral presentation given by collaborator.

Ayombil, F., Petrillo, T., and Camire, R.M: TFPIα protects FV- short from rapid inactivation by activated protein C. J. Thromb. Haemost. 1: 9, 2017 Notes: Abstract Symposia oral presentation given by postdoctoral fellow.

2016

Samelson-Jones, B.J., Finn, J.D., Camire, R.M., and Arruda, V.R: New Hyperactive Factor IX Variants Bioengineered Based upon Biochemical Studies of Factor IX Padua. Blood 128: 1384, 2016 Notes: Poster presentation given by a collaborator at the 58th Annual Meeting of the American Society of Hematology, San Diego, CA.

Lyde Jr., R.B., Ahn, H., Vo, K.K., Jadwiga Jarocha, D., Zhai, L., Sullivan, S.K., Arruda, V.R., Sabatino, D.E., Camire, R.M., French D. and Poncz, M: Infusion of Coagulation Factor VIII-Containing Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Shows Potential As Hemophilia a Treatment. Blood 128: 2559, 2016 Notes: Poster presentation given by a collaborator at the 58th Annual Meeting of the American Society of Hematology, San Diego, CA.

Kumar, S., Deng, W., Stayrook, S., Li,R.,Camire, R.M., and Krishnaswamy, S: Structural Basis for the Procofactor to Cofactor Transition in Human Factor V. Blood 128: 253, 2016 Notes: Oral presentation given by a collaborator at the 58th Annual Meeting of the American Society of Hematology, San Diego, CA.

Gunaratne, R., Frederiksen, J., Thalji, N.K., Ho, M.D., Arepally, G.M., Camire R.M., and Sullenger, B.A: RNA Aptamer Against FXa Synergizes with FXa Catalytic Site Inhibitors to Effectively and Reversibly Anticoagulate Blood in an Ex Vivo Oxygenator Circuit. Blood 128: 3823, 2016 Notes: Poster presentation given by a collaborator at the 58th Annual Meeting of the American Society of Hematology, San Diego, CA.

Books

Chapters

2012

Camire, R.M. and Margaritis, P: Genetics of Coagulation. Hemostasis and Thrombosis:  Basic Principles & Clinical Practice, 6th Edition. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S. and White, G.C. (eds.). Lippincott Williams & Wilkins, Philadelphia, PA. Chapter 10: 146-162, 2012.

2006

Camire, R.M. and Pollak, E.S: Genetics of Coagulation  Hemostasis and Thrombosis:  Basic Principles & Clinical Practice, 5th Edition. Colman, R.W., Marder, V.J., Clowes, A.W., George, J.N., and Goldhaber, S.Z.  (eds.). Lippincott Williams & Wilkins, Philadelphia, PA.  Chapter 4: 59-89, 2006.

2003

Camire, R.M., Larson, P.J., High, K.A: Molecular Genetics of Blood Coagulation. Thrombosis and Hemorrhage, 3rd Edition. Loscalzo, J. and Schafer, A.I. (eds.). Lippincott Williams and Wilkins, Philadelphia, PA. Chapter 2: 22-34, 2003.

Posters and Presentations

Lectures by Invitation

2018

Camire RM. "Alternative Approaches to Hemophilia Treatment", Pfizer Satellite Symposium, World Federation of Hemophilia, Glasgow, Scotland. May, 2018.

Camire RM. Modifiers of the Bleeding Phenotype in Hemophilia", Eastern Pennsylvania NHF Chapter, Philadelphia, PA.. May, 2018.

Camire RM. "Regulation of Coagulation Factor V:  New Mechanistic Insights and Clinical Consequences", McMaster University, Hamilton, Ontario Canada. Apr, 2018.

2017

Camire RM. "Bioengineered Factor Xa as a Therapeutic Strategy to Treat Bleeding" Earl W. Davie Symposium, The Centre for Blood Research, The University of British Columbia, Vancouver, BC, Canada. Nov, 2017.

Camire RM. "Zymogen Transition of Clotting Factors"  State of the Art Session, XXVI Congress of The International Society of Thrombosis and Haemostasis, Berlin, Germany. Jul, 2017.

2016

Camire RM. "New Regulatory Aspects of Coagulation Factor V-Biochemical and Clinical Consequences", Emory University, Atlanta, GA. Nov, 2016.

Camire RM. "Rethinking Events in the Hemostatic Process" Plenary Session 2016 World Federation of Hemophilia World Congress; 2016 Jul; Orlando, FL. 

Camire RM. "Rediscovering Factor V:  Mechanisms Regulating FV Activation and Function" 2016 Gordon Research Conference in Hemostasis, Stowe, VT.

Camire RM. "Anticoagulation-induced Bleeding-Therapeutic Strategies" 8th Symposium on Hemostasis-Translational and Basic Science Discoveries; 2016 May; Chapel Hill, NC.

Camire RM. "Novel Protein Strategies for Hemophilia Treatment" XXXVI World Congress of the International Society of Hematology; 2016 Apr; Glasgow, Scotland.

Camire RM. "Novel Procoagulant Approaches to Treat Bleeding" Louisiana State University, Department of Biochemistry;2016 Mar; New Orleans, LA.

2015

Camire RM. "Mechanisms Regulating FV Activation and Function"  Novo Nordisk Workshop on TFPI/Protein S/Factor V; 2015 Nov; Favrholm, Denmark.

Camire RM. "Hemostasis and Novel Hemophilia Therapeutics"  Keynote Speaker, Hematology Association of Ireland; 2015 Oct; Galway, Ireland.

Camire RM.  "Activation Complex Formation"  NHLBI Working Group on the Mechanisms of Inhibitor Development in Hemophilia; 2015 Jun; Washington, DC.

Camire RM. "New Insights into Coagulation Factor V and TFPI Interactions"  Abstract Symposia, XXV Congress of The International Society of Thrombosis and Haemostasis; 2015 Jun; Toronto, Canada.

Camire RM. "Re-Engineering Factor Xa to Treat Bleeding"  The University of Ferrara; 2015 May; Ferrara, Italy.

Camire RM.  "Bioengineering FVIII Function" Pfizer Research; 2015 Apr; Collegeville, PA.

Awards and Honors

2017, 18th ISTH Biennial Award for Contributions to Hemostasis (BACH)-Investigator Recognition Award, International Society of Thrombosis and Hemostasis.

2016, F1000 Prime Faculty Member

2014, The Children's Hospital of Philadelphia Endowed Chair in Hematology Research, CHOP

2012, Martin Villar Hemostasis Award (1st Prize), Grifols

2009, Copernicus Visiting Scientist-IUSS-Ferrara 1391, University of Ferrara

2009, Alumni Academic Achievement Award, Saint Anslem College

2005, Young Investigator Award, XXth Congress of the International Society on Thrombosis and Haemostasis

2005, Early Career Investigator Award, The Bayer Hemophilia Awards Program, Bayer Corporation

2003, American Heart Association (Penn/Del) Research Award, President's Reception

2001, Young Investigator Award, XVIIIth Congress of the International Society on Thrombosis and Haemostasis

2001, Young Investigator Award, 43rd Annual Meeting of the American Society of Hematology

2000, Ruth L. Kirschstein National Research Service Award, NIH

2000, Young Investigator Award, 42nd Annual Meeting of the American Society of Hematology

2000, Best Poster Presentation by a Postdoctoral Fellow, Cardiovascular Biology Retreat, University of Pennsylvania

1999, Young Investigator Award, XVIIth Congress of the International Society on Thrombosis and Haemostasis

1997, Young Investigator Award, 39th Annual Meeting of the American Society of Hematology

1997, Graduate Research Forum (2nd Prize), University of Vermont

1997,  Young Investigator Award, XVIth Congress of the International Society on Thrombosis and Haemostasis

1996,  Graduate Research Forum (1st Prize), University of Vermont

1995,  Young Investigator Award, 37th Annual Meeting of the American Society of Hematology

1995, Graduate Research Forum (1st Prize), University of Vermont

1994, Biology Department Award, Saint Anselm College

1994, Magna cum laude, Saint Anselm College

Editorial and Academic Positions

Editorial Positions

2017-present, Reviewer, The Proceedings of the National Academy of Sciences
2014-present, Reviewer, Reviews on Recent Clinical Trials
2013-present, Reviewer, Translational Research
2013-present, Reviewer, Nature Medicine
2013-present, Associate Editor, Journal of Thrombosis and Haemostasis
2012-present, Reviewer, Journal of Cellular and Molecular Medicine
2011-present, Reviewer, Haemophilia
2010-present, Reviewer, The Journal of Biological Chemistry
2010-present, Editorial Board, ISRN Hematology
2009-present, Reviewer, FEBS Letters
2008-present, Reviewer, Thrombosis and Haemostasis
2007-present, Reviewer, Protein Peptide Letters
2007-present, Reviewer, Haematologica
2007-present, Reviewer, The Journal of Clinical Investigation
2006-present, Reviewer, Biochemistry
2006-present, Reviewer, Thrombosis Research
2005-present, Reviewer, American Journal of Hematology
2004-present, Reviewer, Blood Coagulation and Fibrinolysis
2003-present, Reviewer, Journal of Thrombosis and Haemostasis
2003-present, Reviewer, Blood

Academic and Institutional Committees

2018-present, Research Trainee Advisory Committee, CHOPp
2016-present, Space Committee, CHOP Research Institute
2014-present, Advisory Committee, Hematology Clinical Research Training Program, UPENN
2014-present, Institutional Intellectual Property Advisory Committee (IIPAC), CHOP

Leadership and Memberships

Memberships in Professional Organizations and Honorary Societies

International

2017-present, Pfizer Global ASPIRE Hemophilia Grant Review Panel

2013-present, North American Society of Thrombosis and Hemostasis
- 2016-present, Chair of Board
- 2013-present, Board of Directors

2006-present, International Society of Thrombosis and Hemostasis
- 2011-2017, Scientific Advisory Board

National

2014-2017, The American Society of Hematology, Scientific Committee on Hemostasis
- 2016, Vice Chair- 2017, Chair

2006-present, American Heart Association
- 2015-2018, ATVB Scientific Sessions Programming Committee

2001-present, The American Society of Hematology

1998-present, American Association for the Advancement of Science

1994-present, Delta Epsilon Sigma