Rodney M. Camire, PhD

Rodney M. Camire, PhD

Rodney M. Camire, PhD, is an Associate Professor of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania, and a member of the Division of Hematology and Raymond G. Perelman Center for Cellular and Molecular Therapeutics at Children’s Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Rodney M. Camire is an Associate Professor of Pediatrics in the Perelman School of Medicine at The University of Pennsylvania and a member of the Division of Hematology at Children’s Hospital of Philadelphia. He is also a member of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics.

Rodney currently holds Children’s Hospital Endowed Chair in Hematology Research. His laboratory is interested in the molecular and cellular processes that contribute to and regulate blood coagulation and has over 15 years of experience studying the biochemistry of clotting factors. His laboratory has developed several novel clotting factors which are in preclinical/clinical development for the treatment of hemophilia and bleeding and he holds over 15 patents. In addition to translational work, his laboratory is interested in questions related to the enzymology, biochemistry and molecular genetics of enzyme complexes of blood coagulation with an emphasis on factors X, V, FIX and VIII. 

He has been funded from the NIH since 2003 and has published over 60 primary and review articles related to blood coagulation. Dr. Camire is as an Associate Editor for the Journal of Thrombosis and Haemostasis and is active with a variety of organizations sitting on the board of directors of the North American Society on Thrombosis and Hemostasis and Thrombosis and Hemostasis Societies of North America. He received his B.A. from Saint Anselm College and his PhD in biochemistry from The University of Vermont.

Education and Training

Fellowship

Post-doctoral Fellow in Pediatrics/Hematology - University of Pennsylvania, Philadephia, PA
Post-doctoral Fellow in Biochemistry - University of Vermont, Burlington, VT

Graduate Degree

PhD in Biochemistry - University of Vermont, Burlington, VT

Titles and Academic Titles

Associate Professor, Department of Pediatrics

Member, Children's Hospital of Philadelphia Research Institute

Endowed Chair in Pediatric Hematology

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2016

Thalji, N.K., Ivanciu, L., Davidson, R., Gimotty, P.A., Krishnaswamy, S., and Camire, R.M: A rapid pro-hemostatic approach to overcome direct oral anticoagulants. Nat. Med. 22(8): 924-932, 2016.

Siner, J.I., Samelson-Jones, B.J., Crudele, J.M., French, R.A., Lee, B.J., Zhou, S., Merricks, E., Raymer, R., Nichols, T.C., Camire, R.M., and Arruda, V.R: Circumventing burin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models. JCI Insight. 2016 Oct 6;1(16):e89371.

Nguyen, G.N., George, L.A., Siner, J.I., Davidson, R.J., Zander, C.B., Zheng, X.L., Arruda, V.R., Camire, R.M., and Sabatino, S.E: Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A. J Thromb Haemost. 2016 Oct 17. doi: 10.1111/jth.13543. [Epub ahead of print]

2015

Sehgal, A. , Barros, S., Ivanciu, L., Cooley, B., Qin, J., Racie, T., Hettinger J., Carioto, M., Jiang, Y., Brodsky, J., Prabhala, H., Zhang, X., Attarwala, H., Hutabarat, R., Foster, D., Milstein, S., Charisse, K., Kuchimanchi, S., Maier, M.A., Nechev, L., Sorensen, B., Simon, A.R., Dargaud, Y., Negrier, C., Camire, R.M., and Akinc, A: An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia. Nat. Med. 21(5): 492-497, 2015.

Liang, H., Kerschen, E.J., Basu, S., Hernandez, I., Zogg, M., Jia, S., Hessner, M.J., Toso, R., Rezaie, A., Fernandez J.A., Camire, R.M., Ruf, W., Griffin, J.H., and Weiler, H: Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood 126(21): 2415-2423, 2015.

Hui, D.J., Edmonson S.C., Podsakoff G.M., Pien G.C., Ivanciu L., Camire R.M., Ertl H., Mingozzi F., High K.A., and Basner-Tschakarjan E: AAV capsid CD8+ T-cell epitopes are highly conserved across AAV serotypes. Mol. There. Methods Clin. Dev. 2: 15029, 2015.

George, L.A., Thalji, N.K., Raffini, L.J., Gimotty, P.A. and Camire, R.M: Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen-like FXa(I16L). J. Thromb. Haemost. 13(9): 1694-1698, 2015.

Baroni, M., Pavani, G., Pinotti, M., Branchini, A., Bernardi, F., and Camire, R.M: Asymmetric processing of mutant factor X Arg386Cys reveals differences between intrinsic and extrinsic pathway activation. Biochim. Biophys. Acta. 1854(10 Pt A): 1351-1356, 2015.

2014

Vadivel, K., Ponnuraj, S., Kumar, Y., Zaiss, A.K., Bunce, M.W., Camire, R.M., Wu, L., Evseenko, D., Herschman, H.R., Bajaj, M.S., and Bajaj, S.P: Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J. Biol. Chem. 289(45): 31647-31661, 2014.

Greene, T.K., Zhai, L., Razzo, B.M., Vo, K., Sabatino, D., Camire, R.M., Arruda, V.R., and Poncz, M: Apoptotic effects of platelet factor VIII on megakaryopoiesis: implications for a modified human FVIII for platelet-based gene therapy. J. Thromb. Haemost. 12(12): 2102-2112, 2014.

Abstracts

2015

Wood, J.P., Baumann Kreuziger, L., Camire, R.M., and Mast, A.E: TFPIα Has Reduced Ability to Inhibit FV Leiden. Blood 126(23): 423, 2015.

Weiler, H., Liang, H., Kerschen, E.J., Rezaie, A., Fernandez, J.A.,  Camire, R.M., Ruf, W., Griffin, J.H., and Toso, T: Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C. Blood 126(23): 216, 2015.

Verhoef, D., Camire, R.M., Reitsma, P.H., and Bos, M.H.A: The C-domains of pseudonaja textilis venom factor V contribute to cofactor stability but are dispensable for lipid-independent prothrombinase function. J. Thromb. Haemost. 13(2): 314, 2015.

Thalji, N., Krishnaswamy, S., and Camire, R.M: Direct factor Xa inhibitors paradoxically prolong the half life of active factor Xa in plasma. J. Thromb. Haemost 13(2): 902, 2015.

Siner, J.I., Samelson-Jones, B., Crudele, J.M., Zhou, S., Merricks, E., Nichols, T., Camire, R.M., and Arruda, V.R: Enhanced factor VIII gene therapy for hemophilia a dogs with a novel Furin-evading factor VIII variant. J. Thromb. Haemost. 13(2): 43, 2015.

Samuelson-Jones, B., Finn, J.D., Camire, R.M., and Arruda, V.R: Investigations into anticoagulant resistance and enhanced activation as putative molecular mechanisms of the hyperactivity of factor IX Padua. J. Thromb. Haemost. 13(2): 320, 2015.

Reglinska-Matveyev, N., Crawley, J.T., Camire, R.M., Lane, D.A., and Ahnstrom, J: FV enhances protein S cofactor function for TFPI in the inhibition of FXa. J. Thromb. Haemost. 13(2): 54, 2015.

Lyde Jr., R.B., Zhai, L., Vo, K., Jadwiga Jarocha, D., Sullivan, S., Arruda, V.R., Camire, R.M., French, D., and Poncz, M: You have access Towards the Care of Hemophilia a Patients Using Induced Pluripotent Stem Cell (iPSC)-Derived Megakaryocytes (iMks) Expressing Coagulation Factor (F) VIII. Blood 126(23): 2266, 2015.

Livaja-Koshiar, R., Camire, R.M., Ho, M., and Dahlback, B: East texas FV-Short/TFPI interaction in inhibition of FXa- and TF-initiated thrombin generation. J. Thromb. Haemost. 13(2): 54, 2015.

Kumar, S., Stayrook, S., Camire, R.M., and Krishnaswamy, S: The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox. Blood 126(23): 121, 2015.

Kumar, S., Stayrook, S., Camire, R.M., and Krishnaswamy, S: The X-Ray Structure of a Variant of Human Factor V Provides Structural Insights into the Procofactor Activation Paradox. Blood 126(23): 121, 2015.

Greene, L.A., Thalji, N.K., Bradford, H., Krishnaswamy, S., and Camire, R.M: Prothrombin Membrane Binding and Gla-Dependent Function Are Not Required for Effective Hemostasis In Vivo. Blood 126(23): 124, 2015.

Greene, L.A,, Thalji, N.K., and Camire, R.M: Zymogen-like FXA variant as novel warfarin reversal strategy: pre-clinical evaluation and mechanism of action. J. Thromb. Haemost. 13(2): 491, 2015.

Camire, R.M: Factor V and TFPI Interactions. J. Thromb. Haemost. 13(2): 53, 2015.

2014

Wood, J.P., Baumann Kreuziger, L.M., Camire, R.M., Desai, U.R., and Mast, A.E: Relieving Inhibition of Prothrombinase By TFPIα: a Procoagulant Activity of Unfractionated, Low Molecular Weight, and Nonanticoagulant Heparins. Blood 124(21): 1478, 2014.

Toso, R., Bunce, M.W., Camire, R.M: The C-Terminus Basic Region of TFPIα Dynamically Regulates FV(a) Function: Evaluation of FV-Short. Blood 124(21): 578, 2014.

Thalji, N.K., Ivanciu, L., Jasuja, R., Patel-Hett, S., Fruebis, J., Pittman, D., and Camire, R.M: Zymogen-like FXa Is a Potent Bypassing Agent for Reversal of Direct FXa Inhibitors in Vivo. Blood 124(21): 582, 2014.

Siner, J.I., Crudele, J.M., Connolly, C.T., Zhou, S., Merricks, E.P.,  Nichols, T.C., Camire, R.M., Arruda, V.R: Unexpected Role of PACE/Furin Cleavage Site in FVIII Biology: Implications for Hemophilia a Therapy. Blood 124(21): 105, 2014.

Reema, J., Patel-Hett, S., Camire, R.M., Fruebis, J. and Pittman, D: A Zymogen-like Factor Xa Improves Hemostasis in a Murine Bleeding Model. Blood 124(21): 1476, 2014.

Nguyen, G.N., Siner, J.I., Davidson, R.J., Arruda, V.R., Camire, R.M.,  Sabatino, D.E: Human Factor VIII Variants with Diminished PACE-Furin Cleavage Exhibit Increased Biological Activity and Therapeutic Efficacy. Blood 124(21): 104, 2014.

Kumar, S., Stayrook, S., Huntington, J.A.,  Camire, R.M., and Krishnaswamy, S: New Structural Insights into High Affinity Membrane Binding By Coagulation Factor V/Va. Blood 124(21): 4216, 2014.

Greene, L.A., Thalji, N.K., Raffini, L.J., and Camire, R.M: Zymogen-like FXa Variant As a Short-Acting Warfarin Reversal Agent: Pre-Clinical Evaluation and Mechanism of Action. Blood 124(21): 4262, 2014.

Books

Chapters

2012

Camire, R.M. and Margaritis, P: Genetics of Coagulation. Hemostasis and Thrombosis:  Basic Principles & Clinical Practice, 6th Edition. Marder, V.J., Aird, W.C., Bennett, J.S., Schulman, S. and White, G.C. (eds.). Lippincott Williams & Wilkins, Philadelphia, PA. Chapter 10: 146-162, 2012.

2006

Camire, R.M. and Pollak, E.S: Genetics of Coagulation  Hemostasis and Thrombosis:  Basic Principles & Clinical Practice, 5th Edition. Colman, R.W., Marder, V.J., Clowes, A.W., George, J.N., and Goldhaber, S.Z.  (eds.). Lippincott Williams & Wilkins, Philadelphia, PA.  Chapter 4: 59-89, 2006.

2003

Camire, R.M., Larson, P.J., High, K.A: Molecular Genetics of Blood Coagulation. Thrombosis and Hemorrhage, 3rd Edition. Loscalzo, J. and Schafer, A.I. (eds.). Lippincott Williams and Wilkins, Philadelphia, PA. Chapter 2: 22-34, 2003.

Posters and Presentations

Lectures by Invitation

2016

Camire RM. "Rethinking Events in the Hemostatic Process" Plenary Session 2016 World Federation of Hemophilia World Congress; 2016 Jul; Orlando, FL. 

Camire RM. "Rediscovering Factor V:  Mechanisms Regulating FV Activation and Function" 2016 Gordon Research Conference in Hemostasis, Stowe, VT.

Camire RM. "Anticoagulation-induced Bleeding-Therapeutic Strategies" 8th Symposium on Hemostasis-Translational and Basic Science Discoveries; 2016 May; Chapel Hill, NC.

Camire RM. "Novel Protein Strategies for Hemophilia Treatment" XXXVI World Congress of the International Society of Hematology; 2016 Apr; Glasgow, Scotland.

Camire RM. "Novel Procoagulant Approaches to Treat Bleeding" Louisiana State University, Department of Biochemistry;2016 Mar; New Orleans, LA.

2015

Camire RM. "Mechanisms Regulating FV Activation and Function"  Novo Nordisk Workshop on TFPI/Protein S/Factor V; 2015 Nov; Favrholm, Denmark.

Camire RM. "Hemostasis and Novel Hemophilia Therapeutics"  Keynote Speaker, Hematology Association of Ireland; 2015 Oct; Galway, Ireland.

Camire RM.  "Activation Complex Formation"  NHLBI Working Group on the Mechanisms of Inhibitor Development in Hemophilia; 2015 Jun; Washington, DC.

Camire RM. "New Insights into Coagulation Factor V and TFPI Interactions"  Abstract Symposia, XXV Congress of The International Society of Thrombosis and Haemostasis; 2015 Jun; Toronto, Canada.

Camire RM. "Re-Engineering Factor Xa to Treat Bleeding"  The University of Ferrara; 2015 May; Ferrara, Italy.

Camire RM.  "Bioengineering FVIII Function" Pfizer Research; 2015 Apr; Collegeville, PA.

2014

Camire RM. "Zymogen-like FXa as an approach to bleeding disorders"  National Hemophilia Foundation 12th Workshop on Novel Technologies and Gene Transfer for Hemophilia; 2014 Oct; Washington, DC.

Camire RM. "Re-engineering FXa to Treat Bleeding"  Regulation of Coagulation Session, Thrombosis & Hemostasis Summit 2014; 2014 Apr; Chicago, IL.

Camire RM. "New Insights into Factor V:  Biology and Regulation"  NovoNordisk; 2014 Mar; Copenhagen, Denmark.

Awards and Honors

2014, The Children's Hospital of Philadelphia Endowed Chair in Hematology Research, CHOP
2012, Martin Villar Hemostasis Award (1st Prize), Grifols
2009, Copernicus Visiting Scientist-IUSS-Ferrara 1391, University of Ferrara
2009, Alumni Academic Achievement Award, Saint Anslem College
2005, Young Investigator Award, XXth Congress of the International Society on Thrombosis and Haemostasis
2005, Early Career Investigator Award, The Bayer Hemophilia Awards Program, Bayer Corporation
2003, American Heart Association (Penn/Del) Research Award, President's Reception
2001, Young Investigator Award, XVIIIth Congress of the International Society on Thrombosis and Haemostasis
2001, Young Investigator Award, 43rd Annual Meeting of the American Society of Hematology
2000, Ruth L. Kirschstein National Research Service Award, NIH
2000, Young Investigator Award, 42nd Annual Meeting of the American Society of Hematology
2000, Best Poster Presentation by a Postdoctoral Fellow, Cardiovascular Biology Retreat, University of Pennsylvania
1999, Young Investigator Award, XVIIth Congress of the International Society on Thrombosis and Haemostasis
1997, Young Investigator Award, 39th Annual Meeting of the American Society of Hematology
1997, Graduate Research Forum (2nd Prize), University of Vermont
1997,  Young Investigator Award, XVIth Congress of the International Society on Thrombosis and Haemostasis
1996,  Graduate Research Forum (1st Prize), University of Vermont
1995,  Young Investigator Award, 37th Annual Meeting of the American Society of Hematology
1995, Graduate Research Forum (1st Prize), University of Vermont
1994, Biology Department Award, Saint Anselm College
1994, Magna cum laude, Saint Anselm College

Editorial and Academic Positions

Editorial Positions

2014-present, Reviewer, Reviews on Recent Clinical Trials
2013-present, Reviewer, Translational Research
2013-present, Reviewer, Nature Medicine
2013-present, Associate Editor, Journal of Thrombosis and Haemostasis
2012-present, Reviewer, Journal of Cellular and Molecular Medicine
2011-present, Reviewer, Haemophilia
2010-present, Reviewer, The Journal of Biological Chemistry
2010-present, Editorial Board, ISRN Hematology
2009-present, Reviewer, FEBS Letters
2008-present, Reviewer, Thrombosis and Haemostasis
2007-present, Reviewer, Protein Peptide Letters
2007-present, Reviewer, Haematologica
2007-present, Reviewer, The Journal of Clinical Investigation
2006-present, Reviewer, Biochemistry
2006-present, Reviewer, Thrombosis Research
2005-present, Reviewer, American Journal of Hematology
2004-present, Reviewer, Blood Coagulation and Fibrinolysis
2003-present, Reviewer, Journal of Thrombosis and Haemostasis
2003-present, Reviewer, Blood

Academic and Institutional Committees

2016-present, Member, Space Committee, CHOP Research Institute
2014-present, Advisory Committee, Hematology Clinical Research Training Program, UPENN
2014-present, Member, Institutional Intellectual Property Advisory Committee (IIPAC), CHOP

Leadership and Memberships

Memberships in Professional Organizations and Honorary Societies

International

2013-2016, Thrombosis and Hemostasis Societies of North America 
- 2013-2016, Board of Directors

National

2014-2017, The American Society of Hematology, Scientific Committee on Hemostasis 
- 2016, Vice Chair
- 2017, Chair

2001-present, The American Society of Hematology

1994-present, Delta Epsilon Sigma