Raquel Gur, MD, PhD

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Raquel Gur, MD, PhD, is a psychiatrist with the Youth Suicide Prevention, Intervention and Research Center at Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Gur is Professor of Psychiatry Neurology and Radiology at the University of Pennsylvania Perelman School of Medicine where she directs the Neuropsychiatry Section and the Schizophrenia Research Center and is Vice Chair of Research Development in the Department of Psychiatry. Her combined training in Psychology, Neurology and Psychiatry has provided the tools to pursue an academic career working with basic and clinical neuroscientists to advance the understanding of schizophrenia. In directing these research endeavors, she has interacted with scientists of diverse backgrounds, conducted collaborative interdisciplinary research, mentored junior faculty and trainees, and has come to know many patients and their families.  She is a member and has served in organizations including the Institute of Medicine of the National Academy of Sciences, the NIMH Council and the American Psychiatric Association task forces including the DSM-5 Psychosis work group. She is Past President of the Society of Biological Psychiatry and President Elect of the American College of Neuropsychopharmacology. NIMH has supported her research efforts and she has over 300 publications in peer-reviewed journals.

Education and Training

Medical School

MD - University of Pennsylvania, Philadelphia, PA

Additional Training

Post Doc in Clinical Psychology - University of Pennsylvania, Philadelphia, PA

Graduate Degree

PhD in Clinical and Developmental Psychology - Michigan State University, East Lansing, MI
MA in Psychology - Michigan State University, East Lansing, MI

Titles and Academic Titles

Attending Psychiatrist

The Karl and Linda Rickels Professor of Psychiatry, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2013

Gur RE, Kaltman D, Melhem ER, Ruparel K, Prabhakaran K, Riley M, Yodh E, Hakonarson H, Satterthwaite T, Gur RC. Incidental findings in youths volunteering for brain MRI research. AJNR Am J Neuroradiol. 2013 Oct;34(10):2021-5. doi: 10.3174/ajnr.A3525. Epub 2013 Jun 27.

Tang SX, Yi JJ, Calkins ME, Whinna DA, Kohler CG, Souders MC, McDonald-McGinn DM, Zackai EH, Emanuel BS, Gur RC, Gur RE. Psychiatric disorders in 22q11.2 deletion syndrome are prevalent but undertreated. Psychol Med. 2013 Sep 9:1-11. In press. PMID: 24016317

Satterthwaite TD, Elliott MA, Ruparel K, Loughead J, Prabhakaran K, Calkins ME, Hopson R, Jackson C, Keefe J, Riley M, Mentch FD, Sleiman P, Verma R, Davatzikos C, Hakonarson H, Gur RC, Gur RE. Neuroimaging of the Philadelphia Neurodevelopmental Cohort. Neuroimage. 2013 PMID: 23921101

2012

Satterthwaite TD, Elliott MA, Gerraty RT, Ruparel R, Loughead J, Calkins ME, Eickhoff SB, Hakonarson H, Gur RC, Gur RE, Wolf DH. An Improved Framework for Confound Regression and Filtering for Control of Motion Artifact in the Preprocessing of Resting-State Functional Connectivity Data. Neuroimage. 2012; 25:

Satterthwaite TD, Ruparel K, Loughead J, Elliott MA, Gerraty RT, Calkins ME, Hakonarson H, Gur RC, Gur RE, Wolf DH. Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youth. Neuroimage. 2012;61:723-729. PMID: 22484308

Satterthwaite TD, Wolf DH, Loughead J, Ruparel K, Elliott MA, Hakonarson H, Gur RC, Gur RE. Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youth. Neuroimage. 2012;60:623-632. PMID: 22233733

Wolf DH, Pinkham AE, Satterthwaite TD, Ruparel K, Elliott MA, Valdez J, Smith MA, Detre JA, Gur RC, Gur RE. Oral alprazolam acutely increases nucleus accumbens perfusion. Mol Psychiatry. 2012 in press. PMID: 23070072

Gur RC, Richard J, Calkins ME, Chiavacci R, Hansen JA, Bilker WB, Loughead J, Connolly JJ, Qiu H, Mentch FD, Abou-Sleiman PM, Hakonarson H, Gur RE. Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21. Neuropsychology. 2012; 26:251-265. PMID:22251308

2011

Carlson GC, Talbot K, Halene TB, Gandal MJ, Kazi HA, Schlosser L, Phung QH, Gur RE, Arnold SE, Siegel SJ. Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia. Proc Natl Acad Sci U S A. 2011; 108:E962-970. PMID: 21969553

Wolf DH, Gerraty R, Satterthwaite TD, Loughead J, Campellone T, Elliott MA, Turetsky BI, Gur RC, Gur RE. Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophrenia. Front Behav Neurosci. 2011;5:81. PMID:22355285

Wolf DH, Satterthwaite TD, Loughead J, Pinkham A, Overton E, Elliott MA, Dent GW, Smith MA, Gur RC, Gur RE. Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge. Psychopharmacology (Berl). 2011; 218:503-512. PMID: 21603892

2009

Gur RC, Ragland JD, Reivich M, Greenberg JH, Alavi A, Gur RE. Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default state. Cereb Cortex. 2009;19:375-382. PMID: 18534991

2007

Limbic Activation Associated with Misidentification of Fearful Faces and Flat Affect in Schizophrenia. Arch Gen Psychiatry. 2007; 64:1356-1366. PMID: 18056543

2006

Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, Gur RC.  Flat affect in schizophrenia: Relation to emotion processing and neurocognitive measures.Schizophrenia Bulletin.  2006, 32, 279-287.

2004

Gur RE, Kohler CG, Turetsky BI, Siegel SJ, Kanes SJ, Bilker WB, Brennan AR, Gur RC. A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia. Biol Psychiatry. 2004;55:512-517. PMID: 15023579

2002

Gur RE, McGrath C, Chan RM, Schroeder L, Turner T, Turetsky BI, Kohler C, Alsop D, Maldjian J, Ragland JD, Gur RC. An fMRI study of facial emotion processing in schizophrenia. Am J Psychiatry. 2002;159:1992-1999. PMID: 12450947

1998

Gur RE, Maany V, Mozley D, Swanson C, Bilker W, Gur RC. Subcortical MRI Volumes in Neuroleptic-Naive and Treated Patients With Schizophrenia. American J Psychiatry, 1998, 155, 1711-1717.

Gur RE, Cowell P, Turetsky BI, Gallacher F, Cannon T, Bilker W, Gur RC. A follow-up MRI study of schizophrenia: Relationship of neuroanatomic changes with clinical and neurobehavioral measures. Archives of General Psychiatry, 1998, 55, 145-152.

1995

Gur RE, Mozley PD, Resnick SM, Mozley LH, Shtasel DL, Gallacher F, Arnold SE, Karp JS, Alavi A, Reivich M, Gur RC. Resting cerebral glucose metabolism and clinical features of schizophrenia. Archives of General Psychiatry, 1995, 52, 657-667.

1994

Gur RE, Mozley PD, Shtasel DL, Cannon TD, Gallacher F, Turetsky BI, Grossman RI, Gur RC. Clinical subtypes of schizophrenia differ in brain and cerebrospinal fluid volume. American Journal of Psychiatry, 1994, 151, 343-350.

1991

Gur RE, Mozley PD, Resnick SM, Shtasel DL, Kohn MI, Zimmerman RA, Herman GT, Atlas SW, Grossman RI, Erwin RJ, Gur RC. Magnetic resonance imaging in schizophrenia: I. Volumetric analysis of brain and cerebrospinal fluid. Archives of General Psychiatry, 1991, 48, 407-412.

1987

Gur RE, Resnick SM, Alavi A, Gur RC, Caroff S, Dann R, Silver F, Saykin AJ, Chawluk JB, Kushner M, Reivich M. Regional brain function in schizophrenia: I. A positron emission tomography study. Archives of General Psychiatry, 1987, 44, 119-125.

Gur RE, Skolnick BE, Gur RC, Caroff S, Rieger W, Obrist WD, Younkin D, Reivich M. Brain function in psychiatric disorders: I. Regional cerebral blood flow in medicated schizophrenics. Archives of General Psychiatry, 1983, 40, 1250-1254.

1978

Gur RE. Left hemisphere dysfunction and left hemisphere over-activation in schizophrenia. Journal of Abnormal Psychology, 1978, 87, 226-238.

Awards and Honors

2013, President-Elect, American College of Neuropsychopharmacology
2012, National Alliance on Mental Illness (Pennsylvania Montgomery County) Brain Scientific Research Award
2011, American College of Physicians – William C. Menninger Memorial Award
2009, NARSAD - Lieber Prize for Outstanding Research in Schizophrenia
2007, President,  Society of Biological Psychiatry
IRG Member, Special Reviews Committee, National Institute of Mental Health (NIMH)
2007, American College of Psychiatrists Stanley Dean Award in Schizophrenia
2001, Institute of Medicine
2001, American Psychiatric Association Kempf Fund Award
2000, Fellow, American College of Neuropsychopharmacology
1999, NARSAD Distinguished Investigator Award
1997, William Osler Patient Oriented Research Award
1997, NAMI Exemplary Psychiatrist Award
1994, Member, American College of Neuropsychopharmacology
1989, NIMH Method to Extend Research In Time (MERIT) Award, MH42191