Jonathan A. Mitchell, PhD

Jonathan A. Mitchell, PhD

Jonathan A. Mitchell, PhD, is a Physician Instructor in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Postdoctoral Fellow of Epidemiology - Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA

Undergraduate Degree

BSc (Hons) in Physiology - University of Glasgow, Glasgow, Scotland

Graduate Degree

PhD in Exercise Science - University of South Carolina, Columbia, SC
MsC in Human Nutrition - University of Glasgow, Glasgow, Scotland

Titles and Academic Titles

Physician Instructor

Research Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Publications

Papers

2017

Mitchell JA, Dowda M, Pate RR, Kordas K, Froberg K, Sardinha LA, Kolle E, Page A, on behalf of the International Children's Accelerometry Database (ICAD) Collaborators: Physical Activity, Sedentary Behavior and Childhood Obesity: a Quantile Regression Analysis. Medicine and Science in Sports and Exercise. Med Sci Sports Exerc. 2017 Mar;49(3):466-473. doi: 10.1249/MSS.0000000000001129.

Kerr J, Marinac CR, Ellis K, Godbole S, Hipp JA, Glanz K, Mitchell JA, Laden F, James P, Berrigan D: Comparison of accelerometry methods for estimating physical activity. Med Sci Sports Exerc. 2017 Mar;49(3):617-624. doi: 10.1249/MSS.0000000000001124.

James P, Hart JE, Hipp JA, Mitchell JA, Kerr J, Hurvitz PM, Glanz K, Laden F. GPS-based exposure to greenness and walkability and accelerometry-based physical activity. Cancer Epidemiol Biomarkers Prev. 2017 Feb 14. pii: cebp.0925.2016. doi: 10.1158/1055-9965.EPI-16-0925. [Epub ahead of print].

Cancer Epidemiol Biomarkers Prev. 2017 Feb 14. pii: cebp.0925.2016. doi: 10.1158/1055-9965.EPI-16-0925. [Epub ahead of print].

Chesi A, Mitchell JA, Kalkwarf HJ, Bradfield JP, Lappe J, Cousminer DL, Roy SM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA, Kelly A, Zemel B, Grant SFA.: A Genome-Wide Association Study Identifies Two Sex-specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites. J Bone Miner Res. 2017 Feb 9. doi: 10.1002/jbmr.3097. [Epub ahead of print].

2016

Mitchell JA, Godbole S, Moran K, Murray K, James P, Laden F, Hipp JA, Kerr J, Glanz K: No evidence of reciprocal associations between daily sleep and physical activity. Medicine and Science in Sports and Exercise 48(10): 1950-6, Sept 2016.

Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe J, Gilsanz V, Oberfield SE, Shepherd J, Kelly A, Zemel BS, Grant SFA: Rare EN1 variants and pediatric bone mass.  Journal of Bone and Mineral Research 31(8): 1513-7, Aug 2016.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe J, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SFA, Zemel BS: Physical activity benefits the skeleton of children genetically predisposed to lower bone density in adulthood. Journal of Bone and Mineral Research  31(8): 1504-12, Aug 2016.

Roy SA, Spivack J, Faith M, Chesi A, Mitchell JA, Kelly A, Grant SFA, McCormack SE, Zemel BS: Infant BMI or Weight-for-Length and Obesity Risk in Early Childhood. Pediatrics 137(5): pii e20153492, May 2016.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS: Genetic risk scores implicated in adult bone fragility associate with pediatric bone density. Journal of Bone and Mineral Research 31(4), April 2016 Notes: doi: 10.1002/jbmr.2744.

Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe J, Gilsanz V, Oberfield SE, Shepherd J, Kelly A, Zemel BS, Grant SFA: Rare EN1 variants and pediatric bone mass.  Journal of Bone and Mineral Research Mar 2016.

Roy SA, Spivack J, Faith M, Chesi A, Mitchell JA, Kelly A, Grant SFA, McCormack SE, Zemel BS: Infant BMI or Weight-for-Length and Obesity Risk in Early Childhood. Pediatrics Feb 2016.

2015

Zeigler-Johnson C, Morales KH, Glanz K, Spangler E, Mitchell J, Rebbeck TR: Individual- and neighborhood-level education influences the effect of obesity on prostate cancer treatment failure after prostatectomy. Cancer Causes Control 26(9): 1329-1337, Sep 2015.

Mitchell JA, Chesi A, Elci O, McCormack S, Kalkwarf H, Lappe J, Gilsanz V, Oberfield S, Shepherd J, Kelly A, Zemel B, Grant SFA: Genetics of bone mass in childhood and adolescence: effects of sex and maturation interactions. Journal of Bone and Mineral Research 30(9): 1676-1683, Sep 2015.

Chesi A, Mitchell JA, Kalkwarf HJ, Bradfield JP, Lappe JM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA,, Kelly A, Zemel BS, Grant SFA: A trans-ethnic genome-wide association study identifies gender specific loci influencing pediatric aBMD and BMC at the distal radius. Human Molecular Genetics 24(17): 5053-5059, Sep 2015.

Roy SA, Chesi A, Mentch F, Xiao R. Chiavacci R, Mitchell JA, Kelly A, Hakonarson H, Grant SFA, Zemel BS, McCormack SE: Body Mass Index (BMI) trajectories in infancy differ by population ancestry and may presage disparities in early childhood obesity. Journal of Clinical Endocrinology and Metabolism 100(4): 1551-1560, Apr 2015.

2014

Mitchell JA, Bottai M, Park Y, Marshall SJ, Moore SC, Matthews CE: A prospective study of sedentary behavior and changes in the body mass index distribution. Medicine and Science in Sports and Exercise 46(12): 2244-52, Dec 2014.

Abstracts

2017

Mitchell JA, Cousminer DL, Chesi A, Elci O, McCormack SE, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SFA, Zemel BS: High And Low Impact Physical Activity Substitution and Pediatric Bone Density. American College of Sports Medicine (ACSM) Annual Meeting, Denver, CO. Jun 2017.

Huffnagle N, Demarco L, Gantz C, Hodge K, Nelson E, Mitchell JA : Recruiting Healthy Subjects in the Clinical Setting: The Sleep and Growth Study. CHOP Research Institute Poster Day, Philadelphia, PA. Feb 2017.

2016

Marinac C, Quante M, Mariani S, Weng J, Redline S, Cespedes Feliciano E, Hipp JA, Mitchell J, James P: Associations Between Timing of Meals, Physical Activity, Light Exposure, and Sleep with Body Mass Index in Free-Living Adults. Fourth Annual Celebration of Junior Investigators in Cancer Research, Dana-Farber / Harvard Cancer Center and Harvard TREC Center, Boston, MA. Nov 2016.

Cousminer DL, Mitchell JA, Chesi A, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Voight BF, Oberfield SE, Shepherd JA, Kelly A, McCormack SE, Zemel BS, Grant SFA : Individual Variants and Genetic Risk Score for Puberty Timing Associate with Pediatric Bone Mineral Density. American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Atlanta, GA Sept 2016.

Cousminer DL, Mitchell JA, Chesi A, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Voight BF, Oberfield SE, Shepherd JA, Kelly A, McCormack SE, Zemel BS, Grant SFA : Heritability of Bone Mineral Density and Content in Childhood and Adolescence. American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Atlanta, GA Sept 2016.

Cousminer DL, Mitchell JA, Chesi A, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Voight BF, Oberfield SE, Shepherd JA, Kelly A, McCormack SE, Zemel BS, Grant SFA: Individual Variants and Genetic Risk Score for Puberty Timing Associate with Pediatric Bone Mineral Density. ASBMR Symposium on Bone-omics: Translating Genomic Discoveries into Clinical Applications Sept 2016.

Chesi A, Mitchell JA, Kalkwarf HJ, Bradfield J, Lappe JM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA, Kelly A, Zemel BS, Grant SFA : A Genome-wide Association Study Identifies Gender Specific Loci Influencing aBMD and BMC at Multiple Skeletal Sites in Children of European Descent. American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Atlanta, GA Sept 2016.

2015

Chesi A, Roy SM, Mitchell JA, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer K, Kelly A, Grant SFA, Zemel BS, McCormack SE: Skeletal maturation and genetically determined population ancestry in non-obese, pre-pubertal children. American Society for Bone and mineral Research (ASBMR) Annual Meeting, Seattle, WA Oct 2015 Notes: Oral presentation by collaborator.

Posters and Presentations

Poster Presentations

James PJ, Hipp A, Marx C, Kerr J, Mitchell J, Berrigan D, Glanz K, Laden L: GPS-based exposure to neighborhood walkability and objectively measured physical activity [poster presentation]. International Society for Behavioral Nutrition and Physical Activity (ISBNPA); 2016 Jun; Cape Town, South Africa.

Kerr, J, Ellis K, Godbole S, Marinac C, Mitchell J, Hipp A, James P, Berrigan D : Differences in Physical Activity Estimates by Wear Time, Body Placement and Data Processing of Accelerometers [poster Presentation]. American College of Sports Medicine (ACSM) Annual Meeting; 2016 Jun; Boston, MA.

Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SFA, Zemel BS. A Rare Variant Near EN1 Associates with Pediatric Bone Mass in Females but Not Males [poster presentation]. Endocrine Society (ENDO) Annual Meeting; 2016 Apr; Boston, MA.

Cousminer DL, Chesi A, Mitchell JA, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Voight BF, Oberfield SE, Shepherd JA, Kelly A, McCormack SE, Zemel BS, Grant SFA. Individual Variants and Genetic Risk Score for Age at Menarche Associate with Pediatric Bone Mineral Density [poster presentation]. Endocrine Society (ENDO) Annual Meeting; 2016 Apr; Boston, MA.

2015

Chesi A, Mitchell JA, Basile KJ, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SFA. Multiple GWAS-implicated adult height loci operate in the context of pediatric bone mineral density and content determination [poster presentation]. American Society for Bone and Mineral Research (ASBMR) Annual Meeting; 2015 Oct; Seattle, WA.

Moran K, Carlson J, James P, Mitchell J, Glanz K, Hipp A, Kerr J. Latent profile analysis of sleep, physical activity, and sedentary time and associations with health [poster presentation]. Transdisciplinary Research on Energetics and Cancer  (TREC) Scientific Meeting, Fred Hutchinson Cancer Research Center; 2015 Sep; Seattle, WA.

Roy SM, Spivack JG, Faith MS, Chesi A, Mitchell JA, Grant SFA, Zemel BS, McCormack S. Concordance between weight-for-length and BMI under age 2 years in a large, longitudinal, multi-ethnic cohort [poster presentation]. Endocrine Society (ENDO) Annual Meeting; 2015 Mar; San Diego, CA.

Chesi A, Kalkwarf HJ, Mentch FD, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Bradfield JP, Mahboubi S, Roy SM, Mitchell JA, Chiavacci RM, Kelly A, Hakonarson H, Zemel BS, Grant SFA, McCormack SE. Loci influencing skeletal age in children and adolescents identified through a trans-ethnic appraisal of both common and rare genetic variants [poster presentation]. Endocrine Society (ENDO) Annual Meeting; 2015 Mar; San Diego, CA.

2014

Mitchell JA, Chesi A, Elci O, McCormack S, Kalkwarf H, Lappe J, Gilsanz V, Oberfield S, Shepherd J, Kelly A, Zemel B, Grant SFA. Adult bone density loci and sex specific bone mass in childhood [poster presentation]. American Society for Bone and Mineral Research (ASBMR) Annual Meeting; 2014 Sep; Houston, TX.

Chesi A, Mitchell JA, Kalkwarf H, Bradfield J, Lappe J, McCormack S, Gilsanz V, Oberfield S, Hakonarson H, Shepherd J, Kelly A, Zemel B, Grant SFA: A trans-ethnic genome-wide association study identifies gender specific loci influencing pediatric BMD and BMC at the distal radius  Poster presentation at American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Houston, TX Sep 2014.

Mitchell JA, Chesi A, Elci O, McCormack S, Kalkwarf H, Lappe J, Gilsanz V, Oberfield S, Shepherd J, Kelly A, Zemel B, Grant SFA. Adult bone density loci and sex specific bone mass in childhood [poster presentation]. AAOS/CORR/ORS/CMH-UCD/SWHR, Musculoskeletal Sex Differences Throughout the Lifespan Research Symposium; 2014 Aug; Rosemont, IL.

Murray K, Kerr J, Wing D, Godbole S, Black M, Natarajan L, Hipp A, Glantz K, Mitchell J, Laden F, James P, Marshall S. The role of time outdoors in the relationship between objectively measured sleep and physical activity [poster presentation]. International Society for Behavioral Nutrition and Physical Activity (ISBNPA),; 2014 Jun;San Diego, CA.

Oral Presentations

2015

Chesi A, Roy SM, Mitchell JA, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer K, Kelly A, Grant SFA, Zemel BS, McCormack SE: Skeletal maturation and genetically determined population ancestry in non-obese, pre-pubertal children. American Society for Bone and mineral Research (ASBMR) Annual Meeting, Seattle, WA October 2015 Notes: Oral presentation by collaborator.

Lectures by Invitation

2016

Mitchell JA. Youth Physical Activity Promotion in Pediatric Primary Care [lecture]. CDC's Physical Activity and Public Health Research Course; 2016 Sep; Columbia, SC.

Mitchell JA. Physical activity and body composition in childhood: population and lab-based research direction. [lecture]. CTRC Exercise Symposium, University of Pennsylvania; 2016 May; Philadelphia, PA.

Mitchell JA. Field Methods for Studying Circadian Misalignment in Relation to Cancer Risk [lecture]. TREC Grantee Conference, National Cancer Institute; 2016 Mar; Rockville, MD.

Mitchell JA. Genetics of Pediatric Bone Density: Findings from the BMDCS [lecture]. AAIM-ASBMR John Haddad Young Investigators Meeting; 2016  Mar; Snowmass, CO.

2015

Mitchell JA. Skeletal benefits of physical activity in childhood may be greatest for males with lower bone mineral content (BMC) and density (BMD) [lecture]. American Society for Bone and Mineral Research (ASBMR) Annual Meeting, Pediatric Bone and Mineral Working Group; 2015 Oct; Seattle, WA.

Mitchell JA. Pediatric bone density is influenced by physical activity and genetic variation at known bone density loci [lecture]. American Society for Bone and Mineral Research (ASBMR) Annual Meeting; 2015 Oct; Seattle, WA.

Mitchell JA. TREC Inspired Sleep Research and K Award Funding. From TREC Trainee to Transdisciplinary Investigator: Perspectives of Population Scientists [lecture]. Fred Hutchinson Cancer Research Center; 2015 Sep; Seattle, WA.

Mitchell JA. Physical activity, sedentary behavior and childhood obesity: a quantile regression analysis [lecture]. The International Children's Accelerometry Database (ICAD) Collaborators, International Society for Behavioral Nutrition and Physical Activity; 2015 Jun; Edinburgh, Scotland.

Mitchell JA. The skeletal benefits of physical activity in childhood are dependent on genetic variation of known bone density loci [lecture]. Endocrine Society (ENDO) Annual Meeting 2015; 2015 Mar; San Diego, CA.

Mitchell JA. Multiple GWAS-implicated adult height loci operate in the context of pediatric bone mineral density and content determination [lecture]. Endocrine Society (ENDO) Annual Meeting, 2015, 2015 Mar; San Diego, CA.

Mitchell JA. The skeletal benefits of physical activity in childhood are dependent on genetic variation of known bone density loci [lecture]. Exercise Science and Health Meeting; 2015 Mar; Cold Spring Harbor, NY.

2014

Mitchell JA. Physical activity and childhood obesity: findings from the application of quantile regression [lecture]. Children's Hospital of Pittsburgh, Weight Management and Wellness Center; 2014 Nov; Pittsburgh, PA.

Mitchell JA. Race, BMI and Inflammatory Markers in Breast Cancer Tumor Samples [lecture]. TREC Scientific Meeting, Harvard University; 2014 Nov; Boston, MA.

Mitchell JA. Inflammation Markers, BMI & Breast Cancer: Cross-TREC Project [lecture]. CPHHD/TREC Joint Scientific Meeting 2014 May; Marina del Rey, Los Angeles, CA.

Awards and Honors

2016, John Haddad Young Investigator Award, AIM-ASMBR

2015, Young Investigator Travel Award, American Society for Bone and Mineral Research (ASBMR)

2015, NIH Mentored Research Scientist Development Award, K01 NHLBI

2014, Transdisciplinary Research on Energetics and Cancer (TREC) Travel Award, TREC Scientific Meeting, Harvard University

2014, American Association of Orthopaedic Surgeons (AAOS) Young Investigator Award: Musculoskeletal Sex Differences throughout the Lifespan Symposium

2013, Transdisciplinary Research on Energetics and Cancer (TREC) Travel Award,  Fred Hutchinson Cancer Research Center

2012, Transdisciplinary Research on Energetics and Cancer (TREC) Travel Award, TREC Scientific Meeting, Washington University in St Louis

2012, New Investigator Award: American Society of Preventive Oncology (ASPO)

2011-2014, NIH Ruth L. Kirschstein National Research Service Award, F32 NCI

2010, Michael L. Pollock Student Scholarship, American College of Sports Medicine

2007-2011, Graduate (Ph.D.) Student Award, University of South Carolina

Editorial and Academic Positions

Editorial Positions

Ad Hoc Reviewer

2015-present, New England Journal of Medicine
2015-present, Public Health Reports
2015-present, British Journal of Nutrition
2014-present, Lancet Diabetes and Endocrinology
2014-present, American Journal of Human Biology
2014-present, BMJ Open
2014-present, European Journal of Sports Science
2014-present, Journal of Clinical Endocrinology & Metabolism
2013-present, Preventive Medicine
2013-present, JAMA Pediatrics
2013-present, The Journal of Early Adolescence
2013-present, Nutrition, Metabolism & Cardiovascular Diseases
2013-present, Journal of Science and Medicine in Sports
2013-present, Human Biology
2013-present, International Journal of Epidemiology
2013-present, International Journal of Obesity
2013-present, Lancet
2013-present, Journal of Epidemiology & Community Health
2013-present, Sleep Medicine
2013-present, Nutrition Journal
2013-present, Annals of Human Biology
2012-present, Obesity
2012-present, Archives of Pediatric and Adolescent Medicine
2012-present, Journal of Physical Activity and Health
2012-present, Pediatric Obesity
2012-present, Medicine and Science in Sports and Exercise
2012-present, Pediatrics
2012-present, Twin Research and Human Genetics
2010-present, American Journal of Preventive Medicine
2010-present, BMC Public Health

Academic and Institutional Committees

2014-present, The Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania (associate member)

2014, Genetic Epi Journal Club, University of Pennsylvania (co-organizer)

2011-present, Transdisciplinary Research on Energetics and Cancer Center, University of Pennsylvania (trainee member)

Leadership and Memberships

Memberships in Professional Organizations

2015-present, Endocrine Society (Member)
2015-present, American Society for Bone and Mineral Research (ASBMR) (Member)
2008-2014, Obesity Society (Member)
2007-present, American College of Sports Medicine (ACSM) (Member)