Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

1 - 10 of 170

Infant Brain Imaging Study

This research study focuses on how the brain develops differently in infants with autism spectrum disorder (ASD) compared to typically developing children. The goal of the study is to identify very early brain features that may be characteristic of autism. This information may help improve methods of early detection and intervention for infants who may be at risk for this disorder.

We are seeking to enroll families who have infants 3 months old or younger and who have an older sibling who has autism or who is typically developing. Babies will come to CHOP at 3 and 24 months of age, as well as two other time points in between, to receive developmental evaluations and magnetic resonance imaging (MRI) scans. Parents will receive comprehensive evaluation reports at no cost and will be compensated for their family's time and travel. IRB 07-005689

The SCOUT Study

The SCOUT study will compare children with urinary tract infections treated with 5 days of antibiotics + five days of placebo (no active medication) versus those treated with 10 full days of antibiotic therapy. The standard-of-care to treat uncomplicated UTIs is a 10-day course of antibiotics. Preliminary data shows that shorter courses of antibiotics have been effective in treating urinary tract infections in adults. The SCOUT Study will determine if five days of antibiotics is as effective and safe in treating a UTI (as compared to 10 days of the standard treatment) in children. IRB 11-008186

Linguistic Markers of Autism Spectrum Disorder

The goal of this study is to learn more about the ways autism spectrum disorder (ASD) is expressed in a large sample of individuals with and without ASD.  Children ages of 6-17, without ASD, are eligible to  participate.  Participation involves 1 study visit that lasts approximately 2-3 and involves behavioral and cognitive testing.  Parents will be asked to complete questionnaires about their children. Families will be compensated for their time. IRB 13-010514

RTA-408 in Friedreich Ataxia

The Children’s Hospital of Philadelphia is recruiting patients with Friedreich’s ataxia (FA) in the United States for a Phase 2 clinical trial studying the safety and effects of RTA 408 in FA. This drug has potential antioxidant properties and we are looking to see how it affects the symptoms of FA. In order to participate, you must have genetic confirmation of FA, maintain stable exercise and medications throughout the study, and discontinue all antioxidant supplements. This is a double-blind placebo-control trial, so half of all subjects will receive study drug and half will receive placebo. Each subject's study participation would last 12 months and include 10 study visits to CHOP. IRB 14-011262

SA237 in NMO

This study will evaluate the efficacy and safety of SA237 compared with placebo in subjects with Neuromyelitis Optica (NMO) and NMO Spectrum Disorder (NMOSD). Males and females age 12-17 years diagnosed with NMO or NMOSD will be eligible to participate. Caregivers will also be asked to complete questionnaires about themselves and will be considered subjects. Procedures include biological specimen collection, radiologic screenings, and questionnaires. The PI for this study is Dr. Sarah Hopkins who can be contacted at 215-590-1719 or IRB 15-012095

Progressive Degeneration in Pediatric MS

The purpose of this research study is to learn more about childhood demyelination, why demyelination occurs and to better understand how demyelination affects children and adolescents.  To do this, we need to ask detailed questions about a child's early life, environment, and physical activity. To understand how demyelination affects the brain we will obtain special pictures of the brain, called magnetic resonance images (MRI). We will carefully assess all children and adolescents, not only at the time of demyelination, but also once yearly for 2 additional years.

In childhood MS, we wish to learn about quality of life, diet, and physical activity. MRI pictures of the brain and analysis of blood samples will help us also to better understand disease activity. IRB 15-012130

EchoSense Doppler Sensor in Pediatric Patients

You are invited to participate in a voluntary research study of the EchoSense Doppler Technology at CHOP. The objective of this study is to evaluate the Lung Doppler Signals non-invasively in children with pulmonary hypertension. We will correlate these signals to the values typically obtained from a heart catheterization. Our target enrollment is 30 patients. There are no significant risks associated with participating, and the study should take approximately 20 minutes to complete. As stated above, this study is completely voluntary, and you have the right to withdrawl at any time, and If you refuse to participate, this will not impact with the medical care you will receive. IRB 15-012495

Vascular Overgrowth Study

We are conducting a research study on vascular birthmarks and overgrowth. The purpose of this study is to develop a better understanding of the cause of vascular overgrowth syndromes. We are collecting DNA in the forms of cells from skin biopsies, tissue specimens, blood samples, and/or buccal swabs. Individuals (any age) with vascular overgrowth syndromes can participate. What we learn from this study will help us to provide people with vascular overgrowth syndromes and their relatives more detailed and accurate information and hopefully will lead us to better treatments. IRB 16-012850

MEG Techniques for Low-Functioning Pediatric

The Lurie Family Foundations MEG Imaging Lab at CHOP are looking for Healthy Children for a study on how the brain works. We are looking for both male and female children between the ages of 8-12 years old. We will provide you with reimbursement for your time and parking will be at no cost. For more information please contact our study coordinator Leah Gaetz at 267-426-4914 or IRB 16-012890

Teen Study of Concussion

Concussion is a highly prevalent condition in adolescence, but it remains a clinical diagnosis that largely relies on subjective patient symptom-report as there are currently no reliable objective biomarkers for diagnosis. This study will ask adolescents with and without a concussion to undergo neuroimaging and neuropsychological testing to better understand the biological basis of brain pathology and to assess the predictive value of the brain imaging biomarkers with respect to clinical outcomes in adolescents with concussion. IRB 16-013207