Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

1 - 10 of 77

Study of breathing during sleep in infants with micrognathia and healthy infants

This study seeks to understand why some babies born with a small jaw (micrognathia) have sleep apnea and/or trouble growing and others do not. By enrolling healthy babies, we hope to get a better understanding of how infants breathe during sleep and grow over the first months of life. This observational study involves two study visits that each include an overnight sleep study and some other non-invasive tests.


Randomized controlled trial evaluating the efficacy and safety of nasal corticosteroids (NCS) vs placebo in children with mild to moderate obstructive sleep apnea (OSAS). Participants will be randomized to a 3-month course of nasal fluticasone or placebo.Both groups will undergo procedures at baseline and 3 months.

National Pediatric Cardiology Quality Improvement Collaborative

The purpose of this research study is to learn more about improving the treatment and outcomes for patients who have a diagnosis of a single ventricle, such as Hypoplastic Left Heart Syndrome (HLHS) or similar heart defects. You will be asked to fill out a questionnaire called the Ages and Stages Questionnaire about your child. It is used widely in pediatrics to check on babies’ development. We will ask you to fill this out about every three months during your child’s 15 months of life. Also, information will be collected about your child’s surgeries, clinic visits and hospital stays from diagnosis through the first year of life. The information may be used to help us understand an infant's response to surgery and medical treatment and may be used to improve care for children with single ventricles.

Study on Brain Responses During Simulated Driving

We want to study brain responses in individuals with autism spectrum disorders (ASD) during simulated driving. We will compare brain measures in adolescents and adults with and without ASD while driving. We are asking typically developing or ASD adolescents and adults ages 16 years and older to be in the study. If you are interested in being part of the study please contact Chelsea Ward at or 215-590-1244.


This study aims to prospectively explore the real life short and longer term outcomes of Vedolizumab in pediatric inflammatory bowel disease and to develop a prediction model for treatment success based on Vedolizumab trough levels and other clinical and laboratory markers. Children under 18 years of age that have been diagnosed with IBD and their physician is starting treatment with Vedolizumab may be eligible.

CTX and Idiopathic Bilateral Cataracts in Pediatric Patients

CTX is typically a highly progressive disease, with case reports of symptoms that first appear at any time from birth through adulthood and then worsen over time. Because idiopathic bilateral cataracts occur at an early age in many children with CTX, biomarker testing of these children presents an opportunity for diagnosing children with CTX. Eligible participants will be asked to give a small blood sample and urine sample, and may have genetic testing done to see if they have the gene for CTX. This study will take place on 1 visit for approximately 30 minutes.

LeukoSEQ: Whole Genome Sequencing in Leukodystrophies

Many patients with leukodystrophies wait years to have a genetic diagnosis or never achieve one at all. This study focuses on new tools to find specific problems in genes, whole genome sequencing. Genes are like the computer program of cells in the body, and if one gene does not work correctly, it can cause a problem with the cell and ultimately the whole body. In this study, a family with a newly identified leukodystrophy will submit blood samples and medical records for review to help doctors test new genetic technologies and help us understand how they may help in the leukodystrophies.

Somatosensory evoked potentials at different positions in children with cerebral palsy

Children between the ages of 4 and 7 years old, both with and without cerebral palsy, may be eligible for the study to help researchers learn if there is a difference in sensory processes. The study involves one visit that lasts approximately 25 minutes and includes a medical record review, a brief physical exam to measure body length, and low levels of electrical stimulation delivered to the ankle.

Optimizing vancomycin therapy in children

Vancomycin is a commonly administered antibiotic in critically ill children, but it can have unwanted side effects on the kidney (acute kidney injury). There are currently no effective methods to prevent development of acute kidney injury during vancomycin therapy. This study will collect blood and urine samples from children in the CHOP pediatric intensive care unit being prescribed vancomycin in an effort to describe how vancomycin behaves in the blood of critically ill children and to understand the relationship between new tests of kidney injury and function, called biomarkers, and the amount of vancomycin in the body. We hope this study will ultimately help improve the safety and efficacy of intravenous vancomycin administration in children by allowing us to develop an approach to provide personalized vancomycin dosing in critically ill children.

Melatonin, Sleep, and Mental Health

The purpose of this research study is to see if melatonin improves sleep and the sleep-wake patterns (also known as circadian rhythm) in children, teenagers, and young adults (ages 11-30) with at-risk symptoms. Melatonin is naturally produced in the brain and controls sleep-wake patterns. At-risk symptoms can be feeling like you do not want to do be around other people as much, difficulties with focus, and having beliefs that most people around you don’t have. At-risk symptoms can also be experiences like having jumbled up thoughts, your mind playing tricks on you, or seeing or hearing things that are not there. To see if melatonin changes sleep in youth with at-risk symptoms, we are giving some youth with at-risk symptoms a melatonin pill and some a placebo (a pill without any medication in it) for 6 months.