Clinical Research Study Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!

Find a Clinical Research Study

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CureGN Study

Cure Glomerulonephropathy Network (CureGN) is a multi-year study of 2,400 children and adults with four rare glomerular (kidney) diseases at over 50 centers in the US, Canada, and Italy. The purpose of CureGN is to create a patient research network to learn about four major causes of glomerular disease : 1. Minimal Change Disease (MCD) 2. Focal Segmental Glomerulosclerosis (FSGS) 3. Membranous Nephropathy (MN) 4. IgA Nephropathy (IgAN)

Mitochondrial Myopathy Rating Scale

The purpose of this research study is to 1) validate the use of surveys such as fatigue scales, Mitochondrial Disease scales, and quality of life scales, 2) validate clinical exams, such as muscle strength tests, and the 6 minute walk test, and 3) to define the natural history of the disease in the Mitochondrial Disease patient population.

Research Study for Individuals with Hyperinsulinism, Type 1 Diabetes Mellitus, and Healthy Children

Our team is working on a study to better understand neurological problems, including seizures and developmental delays, that occur in children with hyperinsulinism, including HI/HA syndrome, and type 1 diabetes mellitus. The study involves a one day visit to The Children’s Hospital of Philadelphia and The University of Pennsylvania for a specialized magnetic resonance imaging scan (MRI) of the brain, an electroencephalogram (EEG), blood draw, and completion of questionnaires to evaluate development and behavior. The entire study visit is expected to take about five hours. If you are interested in learning more, please contact us at HIResearch@email.chop.edu.

Sleep and Growth Study 2

The Children’s Hospital of Philadelphia is seeking healthy adolescents between the ages of 12-13, who are currently in the 7th grade, to participate in the Sleep and Growth Study 2. The purpose of this research is to learn more about the changes in sleep and body size in adolescents as they transition from middle to high school. Participants will be asked to visit CHOP so that we can measure their bone density. Following this visit, participants will wear a sleep tracker over a 2-week period and speak to a team member by phone on three occasions about the types of food eaten in the previous 24 hours. If you and your child agree to participate, the study will involve 3 visits over approximately 2 years. All participants are compensated for their time and effort. For more information and study details, please call 215-590-2383, ext. 1, or email s_grow@chop.edu

HM15136 for the Treatment of Congenital Hyperinsulinism Research Study

The purpose of this study is to look at the safety and tolerability (how well you will react) of the study drug (HM15136) and to determine if it is effective for the treatment of Congenital Hyperinsulinism (HI). HM15136 is an experimental drug which is not approved by the FDA for the treatment of HI. HM15136 is stable and has a long effect in the body, only requiring it to be given (by injection) once a week.  HM15136 is designed to act like glucagon, a hormone produced by the pancreas that helps the body maintain normal blood sugar levels by increasing the glucose produced in the liver and breaking down glycogen (a form of stored glucose) into the usable glucose form.

Participation lasts for up to 22 weeks and will involve up to 13 study visits. Study procedures include taking the study drug for 8 weeks, having electrocardiograms, wearing a continuous glucose monitor (CGM) and using a handheld glucose meter, having blood and urine tests, and completing an electronic diary.

The main risks of this study include: nausea, vomiting, diarrhea, abdominal pain, injection site reactions (swelling, itching, bleeding, or pain), loss of appetite, weight loss, high blood sugar. You may benefit if the study drug proves to be more effective than your current treatment plan in treating low blood sugar.

Driving After Concussion in Adolescents

Although we know a lot about returning to sports, exercise, and school after concussion, we know very little about returning to drive after a concussion.  Our Driving after Concussion study needs the help of both healthy and recently concussed teen partners in our research to understand how concussion affects driving behaviors in teens.

We are looking for healthy (have not had a concussion in the last year) and recently concussed teens who are 16.5-18 years old with a driver’s license and their own smartphone.

Our teen research partners may be asked to complete surveys about themselves and download smartphone applications that track symptoms associated with concussion and/or observe real-world driving behaviors. They may also be asked to come to CHOP's Driving Simulator Lab to complete a 3-hour session that includes surveys, clinical testing, and device testing along with a simulated driving assessment to observe driving behavior.

All teens who participate will be compensated for their time and effort.

EDIT-301: Phase 1/2 Sickle Cell Disease Gene Therapy Trial

Individuals with severe sickle cell disease, who are between 18 and 50 years old, may be able to participate. A number of screening tests will be done to determine if subjects can participate. These include review of your past medical history, physical exam, blood and urine tests, pregnancy test, heart ultrasound, electrocardiogram, pulmonary function test, kidney function test, questionnaires, and magnetic resonance imaging (MRI) of the heart and liver. If eligible, blood stem cells will be collected by apheresis. A gene in these stem cells will then be edited to help the stem cells make more fetal hemoglobin. Higher levels of fetal hemoglobin can improve red blood cell sickling. You will then be hospitalized and chemotherapy will be given to empty out the bone marrow. The stem cells, with the modified gene, will then be given back to you. You will be followed for side effects and to see if the modified gene helps you make healthy red blood cells.

Locomotor Learning- Infant MEG

The purpose of this study is to find out how the brain learns to move in infants with and without brain injury. Some infants with brain injury later have cerebral palsy (CP), a condition that makes it hard for infants to learn how to move and control their balance, and others do not. Three groups of infants will participate- infants who had a brain injury and are at high risk for CP, infants who had a brain injury and are not at high risk for CP, and infants who are typically developing.

Chemotherapy-induced Nausea and Vomiting Control

For patients (and parents of patients) that have been diagnosed with, pediatric acute lymphoblastic leukemia (ALL), nausea and vomiting are among the most bothersome symptoms during chemotherapy treatment. The overall goal of this study is to find the best strategies used by parents and patients for managing these symptoms when receiving maintenance therapy.

Emergence and Progression of AGT

The purpose of this research study is to test how people with cystic fibrosis process sugar and learn more about their risk of developing cystic fibrosis-related diabetes. We will also test the body's ability to make insulin in response to sugar. 


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