Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

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Literacy Focus Group

Parent involvement is critical in child language development, learning and literacy. Our team is looking for parents of children under the age of 5 years to conduct parent-only focus groups to learn more about how parents think their behavior influences these developments and what they think their role in their child’s learning is. We are also aiming to better understand parents' thoughts on reading, interacting with their children and how technology factors into language development. Focus groups will last about 30-45 minutes, and will be held either at CHOP or in a local community setting in Philadelphia. All participants will be compensated for their time and insights.

Metabolic MRI: Pilot Testing

The purpose of this research study is to test and adapt new techniques for performing magnetic resonance imaging (MRI). MRI provides pictures of the inside of the body and information about chemicals the body makes. Here are some examples of what we hope to accomplish:

1. Adapt MRI techniques used at other institutions for use on CHOP MRI scanners

2. Increase the amount of information learned from each MRI image

The research sequences involve changing the settings of the magnetic resonance scanner. By research sequences we mean that they are not approved by the US Food and Drug Administration (FDA) for clinical use. The data we obtain will help the FDA evaluate whether or not they can eventually approve the sequences for clinical use.

We are seeking to enroll healthy volunteers, 18 years of age and above. Pregnant females excluded for safety purposes.

Providing Unique Support for Health (PUSH)

The purpose of this study is to identify and engage young black or hispanic/latino men (male sex at birth, but gender identity male, transfemale, or gender nonconforming) (YBLMSM/transwomen) in Philadelphia, PA, Baltimore, MD and Washington, DC in HIV and substance use prevention using a new Mobile-enhanced Engagement intervention (app that reminds you to take your meds, reminds you of your medical appointments, etc.). There are three different parts to this study: 1) respondent driven sampling (RDS); 2) Randomized Control Trial (RCT): MEI vs Standard of Care for HIV+ youth; and 3) PrEP RCT: Pre Exposure Prophylaxis - Mobile-enhanced Engagement Intervention (PrEP-MEI) vs. Standard PrEP referral;. It is possible to participate in only the RDS, the RDS and the AIM 3 PrEP RCT, or the RDS and AIM 2 RCT studies.

The RDS study involves 2 study visits lasting up to 1 month of participation where participants will be asked to complete an optional rapid HIV test (oral or fingerstick) or viral load testing (blood draw), web-based survey (on past sexual and HIV experiences), recruit your peers to participate in the study, and complete a post-recruitment survey. YBLMSM/transwomen and cisgender females 15-24 years may participate in RDS, but the following study portions are only for YBLMSM/transwomen:

People who successfully complete the RDS portion of the study may be asked to participate in an additional study visit of an audio-recorded focus group or interview.

The RCT study involves 6 study visits (5 in person, 1 phone) and lasts 18 months. Participants will be assigned to one of two groups receiving different HIV supportive interventions: 1) HIV case management with a Mobile-enhanced Engagement Intervention (MEI), or 2) standard of care HIV case management where a case manager will remind you of medical appointments. If you are assigned to the first group (MEI), you will be asked to use the MEI mobile app or web-browser version of the app during the study period. Participants will be asked to complete a web-survey (on past sexual and HIV experiences), HIV Antibody and Viral load testing (blood draw), urine drug testing, and allow the researchers to access your medical charts for HIV and STI testing results. You may also be asked to participate in audio-recorded in-depth interviews.

The PrEP RCT study involves 5 study visits (5 in person, 1 phone) and lasts 18 months. Participants will be assigned to one of two groups receiving different PrEP and substance use supportive interventions: 1) PrEP case management with a Mobile-enhanced Engagement Intervention (MEI-PrEP), or 2) standard PrEP referrals to services. If you are assigned to the first group (MEI-PrEP), you will be asked to use the MEI-PrEP mobile app or web-browser version of the app during the study period. Participants will be asked to complete a web-survey (on past sexual and HIV experiences), HIV Antibody (blood draw or 2 rapid OraQuick tests in place of serologic 4th generation testing when 4th generation testing is not available) and Viral load testing (blood draw), urine drug testing, use the MEI-PrEP mobile app or web-browser version of the app, and allow the researchers to access your medical charts for HIV and STI testing results. You may also be asked to participate in audio-recorded in-depth interviews.

The Charisma Study

We are currently enrolling adolescents ages 15-21 of South Asian ancestry, African American ancestry, and European American or "White" ancestry. This study is looking to better understand ancestry related differences in risks for developing cardiovascular disease and type 2 diabetes. The study involves 2 visits to the CHOP Main Hospital in Philadelphia, and participants will be compensated for their efforts.

Autism Language Study

The Lurie Family Foundations MEG Imaging Lab at CHOP are looking for Healthy Children and those with an Autism Spectrum disorder for a study on how the brain works. We are looking for both male and female children between the ages of 8-12 years old. We will provide you with reimbursement for your time and parking will be at no cost. For more information please contact our study coordinator Leah Gaetz at 267-426-4914 or MEGSTUDIES@email.chop.edu.

Abatacept Registry

The purpose of this registry is to study the long-term effects and safety of Abatacept(Orencia) as used for the treatment of Juvenile Idiopathic Arthritis(JIA). JIA patients that are currently taking Abatacept may be eligible to participate in this study.

CP-SMC Pilot Study

The purpose of this study is to assess deficits in movement and coordination in children with cerebral palsy (CP) and without. Children with CP have trouble coordinating their muscles while moving. Few options exist to measure muscle control. This new test will measure muscle control in children with and without CP and help guide future treatment plans.

Apixaban v SOC Pediatric Anticoagulants

The purpose of this study is to determine whether an investigational drug is safe for children to take. This study aims to compare the investigational drug to other blood thinners commonly used to treat acquired or congenital heart disease.Children with congenital or acquired heart disease may be at risk for forming blood clots. When blood clots block blood flow in the brain, this is called a “stroke.” The investigational drug is a blood thinner. This study will help us to understand more about the use this investigational drug in children with heart disease. For more information, please visit www.bmsstudyconnect.com or contact the study coordinator, Abigail Waldron.

Multiparametric MRI of Kidney Tranplant

In this study, we are developing new magnetic resonance imaging (MRI) methods to determine if it is effective in diagnosing complication in kidney transplant patients.Participants in this study will involve patients that have had a kidney transplant and are scheduled for a kidney biopsy. The study will also involve a comparison group of healthy individuals that have no history of kidney conditions. Study procedures will include a review of medical history and medications, MRI scan of the abdomen and blood/ urine test.


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