Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

1 - 10 of 122

Progressive Degeneration in Pediatric MS

The purpose of this research study is to learn more about childhood demyelination, why demyelination occurs and to better understand how demyelination affects children and adolescents.  To do this, we need to ask detailed questions about a child's early life, environment, and physical activity. To understand how demyelination affects the brain we will obtain special pictures of the brain, called magnetic resonance images (MRI). We will carefully assess all children and adolescents, not only at the time of demyelination, but also once yearly for 2 additional years.

In childhood MS, we wish to learn about quality of life, diet, and physical activity. MRI pictures of the brain and analysis of blood samples will help us also to better understand disease activity. IRB 15-012130

Metabolic MRI: Pilot Testing

The purpose of this research study is to test and adapt new techniques for performing magnetic resonance imaging (MRI). MRI provides pictures of the inside of the body and information about chemicals the body makes. Here are some examples of what we hope to accomplish:

  1. Adapt MRI techniques used at other institutions for use on CHOP MRI scanners
  2. Increase the amount of information learned from each MRI image

The research sequences involve changing the settings of the magnetic resonance scanner. By research sequences we mean that they are not approved by the US Food and Drug Administration (FDA) for clinical use. The data we obtain will help the FDA evaluate whether or not they can eventually approve the sequences for clinical use.

We are seeking to enroll healthy volunteers, 18 years of age and above. Pregnant females excluded for safety purposes. IRB 15-012204

Inhaled Insulin Afrezza® in Pediatric Patients with Type 1 Diabetes

The purpose of this research study is to test an investigational drug Afrezza® (inhaled insulin) in children and adolescents with T1DM between 4 and 17 years of age. Afrezza® is a rapid acting inhaled insulin, which was approved by Food and Drug Administration (FDA) for the treatment of diabetes in adults. Multiple doses of inhaled insulin will be evaluated over an approximate 4-week period.

Who can participate? Males or females between 4 and 17 years old in good general health, diagnosed with Type 1 Diabetes Mellitus and using insulin daily for at least 1 year

Study procedures you can expect during the study:

  • Interviews about your health
  • Physical examination
  • Blood and urine samples collection for testing
  • Lung function test
  • Electrocardiogram
  • Afrezza® administration
  • Subject Diary

If interested: Please email or call 267-426-3909. IRB 15-012292

The Bladder Brain Connection - Why Are Some Children Wet?

We know very little about how the bladder to brain connections work in children. The most common thing we hear from children who are having urinary leakage is "I was not aware my bladder was full." Is this full bladder message getting lost? In this study we will measure brain wave activity non invasively after you have drank some Gatorade to get a full bladder and after you have voided. The total time needed for this study will be about 3 to 4 hours. IRB 15-012473

EchoSense Doppler Sensor in Pediatric Patients

You are invited to participate in a voluntary research study of the EchoSense Doppler Technology at CHOP. The objective of this study is to evaluate the Lung Doppler Signals non-invasively in children with pulmonary hypertension. We will correlate these signals to the values typically obtained from a heart catheterization. Our target enrollment is 30 patients. There are no significant risks associated with participating, and the study should take approximately 20 minutes to complete. As stated above, this study is completely voluntary, and you have the right to withdrawl at any time, and If you refuse to participate, this will not impact with the medical care you will receive. IRB 15-012495

A Review of Thyroidectomies at Children’s Hospital of Philadelphia

The purpose of this study is to examine CHOP’s experience with patients ages 0 to 19 years old who have already undergone or will be undergoing total thyroidectomy (TTx) and/or completion thyroidectomy performed at the Thyroid Center at the Children’s Hospital of Philadelphia.

The study procedures are limited to review of patients medical records located at CHOP.

For more information, eligibility and/or participation please contact the study Research Coordinator at 267-426-3906 for more information, eligibility and/or participation. IRB 15-012519

Social Skills Video Game Study

Children between the ages of 5 and 16 are invited to participate in a study that seeks to improve eye contact in children with Autism Spectrum Disorder (ASD).  Children with ASD and those who are typically developing are eligible.  Participation in this study involves up to 5 study visits to the Center for Autism Research.  Participants will play video games while their heart rate, brain activity, and eye movement are measured.  Participants will be asked to give feedback about the video games, and parents will be asked to complete questionnaires about their children. IRB 15-012594    

Outcome Measures of Alexander Disease

A thorough review of outcome measures that assess disease progression has not been established for any of the subcategories of Alexander disease. These results will be crucial to our understanding of disease presentation and progression. Providing this information about the pathophysiology will allow for effective development of clinical trials to test therapies and the future use of neuroprotective agents in children. IRB 16-012649

Vascular Overgrowth Study

We are conducting a research study on vascular birthmarks and overgrowth. The purpose of this study is to develop a better understanding of the cause of vascular overgrowth syndromes. We are collecting DNA in the forms of cells from skin biopsies, tissue specimens, blood samples, and/or buccal swabs. Individuals (any age) with vascular overgrowth syndromes can participate. What we learn from this study will help us to provide people with vascular overgrowth syndromes and their relatives more detailed and accurate information and hopefully will lead us to better treatments. IRB 16-012850

BMT CTN 1503 (STRIDE2): BMT for Severe Sickle Cell Disease

The purpose of this research study is to compare transplant (HCT/BMT) to standard of care treatment in young adults with SCD who have experienced complications. Once consented we would assess to see if you have a matched donor. Subjects who have a closely matched donor will undergo a bone marrow transplant. This is called the Donor Arm. Subjects who do not have a closely matched donor will receive the current standard of care for their disease. This is called the No Donor Arm. We will follow subjects in both arms for two years to evaluate outcomes over that time period. IRB 16-012854