Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

1 - 10 of 139

Friedreich Ataxia Clinical Outcomes Measures

This is a multicenter natural history and clinical measure study. Our objectives are to advance clinical care, research and therapeutic approaches in FA through the development and validation of clinical outcome measures in FA, collection of quantitative serial clinical data on patients and expansion of our established research network. A secondary objective is to build a parallel DNA and RNA repository for use in large scale translational research including modifier gene studies. We wish to also enroll control subjects for a hearing test and sample collection to compare to data from FA patients.

IRB 01-002609

Infant Brain Imaging Study

This research study focuses on how the brain develops differently in infants with autism spectrum disorder (ASD) compared to typically developing children. The goal of the study is to identify very early brain features that may be characteristic of autism. This information may help improve methods of early detection and intervention for infants who may be at risk for this disorder.

We are seeking to enroll families who have infants 3 months old or younger and who have an older sibling who has autism or who is typically developing. Babies will come to CHOP at 3 and 24 months of age, as well as two other time points in between, to receive developmental evaluations and magnetic resonance imaging (MRI) scans. Parents will receive comprehensive evaluation reports at no cost and will be compensated for their family's time and travel. IRB 07-005689

Children’s Brain Tumor Tissue Consortium (CBTTC)

The Children’s Brain Tumor Tissue Consortium (CBTTC) is a collaborative multi-institutional cooperative research program dedicated to the study of childhood brain tumors. The ultimate goal of the CBTTC is to improve outcomes for children with brain tumors by supporting research on new prognostic biomarkers and therapies. In order to achieve this, the consortium links high quality tumor specimens with clinical and genomic data in a de-identified manner. This information is then available to be requested by investigators worldwide. The results of the research is then filtered back into the project, sharing results and increasing collaboration to ultimately achieve better outcomes. IRB 09-007316

Observational Study of the Progression of SMA

The purpose of this study is to collect data from routine standard of care visits of SMA patients at the Children's Hospital of Philadelphia Neuromuscular Clinic. This data will be used to characterize the baseline status of newly diagnosed SMA patients and to evalaute the long term progression of SMA. Eligibility includes clinical diagnosis of Spinal Muscular Atrophy, genetic diagnosis of SMN, informed consent and diagnosis of SMA before the age of 19. Study visits occur during regular standard of care clinic visits. Study procedures include neuromuscular testing, optional surveys/interviews and optional biological specimens.

Please contact Principal Investigator Zarazuela Zolkipli Cunningham, MBChB, MRCP at 215-590-1719 or Study Coordinator Nancy Videon, RN at 267-426-7163 for more information. IRB 10-007816

Bio Repository for Patients with Inflammatory Bowel Disease and Other Gastrointestinal Conditions

The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for. IRB 11-008158

The SCOUT Study

The SCOUT study will compare children with urinary tract infections treated with 5 days of antibiotics + five days of placebo (no active medication) versus those treated with 10 full days of antibiotic therapy. The standard-of-care to treat uncomplicated UTIs is a 10-day course of antibiotics. Preliminary data shows that shorter courses of antibiotics have been effective in treating urinary tract infections in adults. The SCOUT Study will determine if five days of antibiotics is as effective and safe in treating a UTI (as compared to 10 days of the standard treatment) in children. IRB 11-008186

Genesis AA

The purpose of this study is to compare the genes of African American children and adults who have inflammatory bowel disease (IBD) with the genes of those who do not have IBD. Genes are pieces of hereditary material found in human cells. How an individual’s genes cause intestinal inflammation in IBD is still being tested and not much is known about the association between genes and IBD in individuals with African ancestry. We hope to understand which genes cause IBD and if certain genes can help doctors personalize treatment for patients with IBD. For more information please contact IBDResearch@email.chop.edu. IRB 11-008363

Linguistic Markers of Autism Spectrum Disorder

The goal of this study is to learn more about the ways autism spectrum disorder (ASD) is expressed in a large sample of individuals with and without ASD.  Children ages of 6-17, without ASD, are eligible to  participate.  Participation involves 1 study visit that lasts approximately 2-3 and involves behavioral and cognitive testing.  Parents will be asked to complete questionnaires about their children. Families will be compensated for their time. IRB 13-010514

Immunogenetics of Very Early Onset Inflammatory Bowel Disease

The purpose of this research study is to identify genes that are involved in the development of Inflammatory Bowel Disease (IBD) at a young age (less than 8 years of age).  This is a case-control study of IBD patients which compares children with symptoms and/or diagnosis of IBD at <8 years of age with those not diagnosed until  ≥8 years of age, as well as with family members, and other children without a diagnosis of IBD. Samples are collected for testing, such as blood, stool, oral or rectal swabs, and/or tissue samples. IRB 14-010826

Immunogenetics of Very Early Onset Inflammatory Bowel Disease

The purpose of this research study is to identify genes that are involved in the development of Inflammatory Bowel Disease (IBD) at a young age (less than 8 years of age).  This is a case-control study of IBD patients which compares children with symptoms and/or diagnosis of IBD at <8 years of age with those not diagnosed until  ≥8 years of age, as well as with family members, and other children without a diagnosis of IBD. Samples are collected for testing, such as blood, stool, oral or rectal swabs, and/or tissue samples. IRB 14-010826


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