Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

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Study of breathing during sleep in infants with micrognathia and healthy infants

This study seeks to understand why some babies born with a small jaw (micrognathia) have sleep apnea and/or trouble growing and others do not. By enrolling healthy babies, we hope to get a better understanding of how infants breathe during sleep and grow over the first months of life. This observational study involves two study visits that each include an overnight sleep study and some other non-invasive tests.

SPARK

Randomized controlled trial evaluating the efficacy and safety of nasal corticosteroids (NCS) vs placebo in children with mild to moderate obstructive sleep apnea (OSAS). Participants will be randomized to a 3-month course of nasal fluticasone or placebo.Both groups will undergo procedures at baseline and 3 months.

Gene Therapy Trial for Hemophilia B

This is a clinical trial study that uses an adeno-associated virus (AAV) to deliver a more potent form of the factor IX gene (Padua) to liver cells, where the factor IX protein is expressed and enters the body’s blood circulation. The Padua gene may produce more factor IX protein, which may be beneficial to your condition; however, there are also some risks associated with the study. To learn more about the benefits and risks related to this study, please contact Dr. Lindsey George at (267) 425-0132. In order to participate in this study, you must be male, 18 years or older, have hemophilia B with FIX levels less or equal to 2%, a history of bleeding that requires prophylaxis or on demand therapy, and no history of inhibitor to factor IX. This study requires a number of visits over the course of 12 months, and all costs related to participation in the study will either be covered or reimbursed, and participants will be compensated for their time.

Novel Imaging in Autosomal Recessive Polycystic Kidney Disease

In this study, we are developing new ultrasound and magnetic resonance imaging (MRI) methods to measure kidney and liver disease severity in autosomal recessive polycystic kidney disease (ARPKD). Participants in this study will include individuals with ARPKD, and a comparison group of healthy individuals without liver or kidney disease. Children and young adults up to 21 years old may take part in the study. Study procedures include an ultrasound and MRI scan of the abdomen (MRI is only done in participants able to lie still for up to an hour, generally at least 8 years old). Participants wtih ARPKD will also have a blood test and will be asked to complete 1 follow up visit per year for up to 3 years after baseline.

Visual Measures in Pediatric MS

The purpose of this research study is to determine methods that will better determine whether someone has MS and to develop ways to measure the disease. These tests will help doctors learn about vision and how the brain processes information from your eyes in people with MS and healthy people. You will be asked to spend the day at CHOP to complete vision testing and other study procedures. Please contact Amy Lavery (laverya@email.chop.edu; 267-425-2136) if you are interested!

Study of immune cell function in patient with HLH and XLP

The purpose of this study is to look at cellular and molecular defects of the immune system for people with the Familial form of Hemophagocytic Lymphohistiocytosis and X-linked Lymphoproliferative Disease. The study is focused to study how mutations in genes associated with these disorders affect the production and function of a particular subset of white blood cells: Cytotoxic-T Lymphocytes and Natural Killer cells, which are essential to fight against viral infections and tumor formation. By understanding the basic mechanisms of these disorders we hope to gain insight into how these defects can be bypassed or corrected and to develop new tests for rapid diagnostics. Study procedures include interviews, blood draws, and medical chart review

autismMatch

autismMatch is a community-based registry of people with ASD, their families, and typically-developing people who are interested in learning more about autism research. Once enrolled in autismMatch, families will receive periodic contact by email from the Center for Autism Research when new studies are starting for which they are eligible. Families can choose to follow up or ignore these contacts.


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