Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

11 - 20 of 118

BMT CTN 1503 (STRIDE2): BMT for Severe Sickle Cell Disease

The purpose of this research study is to compare transplant (HCT/BMT) to standard of care treatment in young adults with SCD who have experienced complications. Once consented we would assess to see if you have a matched donor. Subjects who have a closely matched donor will undergo a bone marrow transplant. This is called the Donor Arm. Subjects who do not have a closely matched donor will receive the current standard of care for their disease. This is called the No Donor Arm. We will follow subjects in both arms for two years to evaluate outcomes over that time period. IRB 16-012854

MEG Techniques for Low-Functioning Pediatric

The Lurie Family Foundations MEG Imaging Lab at CHOP are looking for Healthy Children for a study on how the brain works. We are looking for both male and female children between the ages of 8-12 years old. We will provide you with reimbursement for your time and parking will be at no cost. For more information please contact our study coordinator Leah Gaetz at 267-426-4914 or gaetzl@email.chop.edu. IRB 16-012890

MAGIC

Collect data and blood samples to make observations and determinations about rate and severity of graft-versus-host disease in HCT patients. IRB 16-012909

3D Outcomes of Bracing in AIS

Our team is trying to understand how wearing the Boston (TLSO) brace can affect three-dimensional (3D) changes in the spine and ribcage. We are looking to partner with families who have an adolescent who will be treated with a brace and is between the age of 10 and 16 years. Our study is observational, which means that your child will NOT be asked to make any changes to their daily life. If your child agrees to participate, he or she will be asked to wear a smart strap, a strap that replaces one of the regular straps on the brace. The smart strap will be free of charge and registers brace wear duration and strap tension via Bluetooth, therefore patients and families can track treatment information and see their prescription through a smartphone app. IRB 16-013059

Teen Study of Concussion

Concussion is a highly prevalent condition in adolescence, but it remains a clinical diagnosis that largely relies on subjective patient symptom-report as there are currently no reliable objective biomarkers for diagnosis. This study will ask adolescents with and without a concussion to undergo neuroimaging and neuropsychological testing to better understand the biological basis of brain pathology and to assess the predictive value of the brain imaging biomarkers with respect to clinical outcomes in adolescents with concussion. IRB 16-013207 

Mito Myopathy Rating Scale

The purpose of this research study is to develop a new rating scale to be used in clinical trials (drug or intervention trials) in mitochondrial disease. The aim of the rating scale is to measure symptom changes over short periods of time to determine the efficacy of a drug or other intervention (eg exercise). IRB 16-013364

Promoting Unique Support for Health (PUSH)

The purpose of this study is to identify and engage young black or hispanic/latino men (male sex at birth, but gender identity male, transfemale, or gender nonconforming) in Philadelphia, PA, Baltimore, MD and Washington, DC in HIV and substance use prevention using a new Mobile-enhanced Engagement intervention (app that reminds you to take your meds, reminds you of your medical appointments, etc.). There are three different parts to this study: 1) respondent driven sampling (RDS);  2) Randomized Control Trial (RCT): MEI vs Standard of Care for HIV+ youth; and 3) PrEP RCT: Pre Exposure Prophylaxis - Mobile-enhanced Engagement Intervention (PrEP-MEI) vs. Standard PrEP referral;. It is possible to participate in only the RDS, the RDS and the AIM 3 PrEP RCT, or the RDS and AIM 2 RCT studies.

The RDS study involves 2 study visits lasting up to 1 month of participation where participants will be asked to complete a rapid oral HIV test, web-based survey (on past sexual and HIV experiences), recruit your peers to participate in the study, and complete a post-recruitment survey.

The RCT study involves 6 study visits (5 in person, 1 phone) and lasts 18 months. Participants will be assigned to one of two groups receiving different HIV supportive interventions: 1) HIV case management with a Mobile-enhanced Engagement Intervention (MEI), or 2) standard of care HIV case management where a case manager will remind you of medical appointments. If you are assigned to the first group (MEI), you will be asked to use the MEI mobile app or web-browser version of the app during the study period.  Participants will be asked to complete a web-survey (on past sexual and HIV experiences), HIV Antibody and Viral load testing (blood draw), urine drug testing, and allow the researchers to access your medical charts for HIV and STI testing results. You may also be asked to participate in audio-recorded in-depth interviews.

The PrEP RCT study involves 5 study visits (4 in person, 1 phone) and lasts 12 months. Participants will be assigned to one of two groups receiving different PrEP and substance use supportive interventions: 1) PrEP case management with a Mobile-enhanced Engagement Intervention (MEI-PrEP), or 2) standard PrEP referrals to services. If you are assigned to the first group (MEI-PrEP), you will be asked to use the MEI-PrEP mobile app or web-browser version of the app during the study period.  Participants will be asked to complete a web-survey (on past sexual and HIV experiences), HIV Antibody and Viral load testing (blood draw), urine drug testing, use the MEI-PrEP mobile app or web-browser version of the app, and allow the researchers to access your medical charts for HIV and STI testing results. You may also be asked to participate in audio-recorded in-depth interviews. IRB 16-013396

KTE-C19

Patients with no available curative treatment options with leukemia are eligible to participate in this study to test an experimental approach called gene transfer that involves B cells. This study will take the patients white blood cells - T cells - and change them to turn against the cancer. IRB 16-013488

Genetics of PHACE Syndrome

We are conducting a research study on the genetics of PHACE Syndrome. The purpose of this study is to develop a better understanding of the cause of PHACE Syndrome by collecting DNA in the forms of cells from skin biopsies, tissue specimens, blood samples, and/or buccal swabs. Individuals (any age) or family members of patients with PHACE Syndrome or a large segmental hemangioma can participate. What we learn from this study will help us to provide individuals with PHACE syndrome and their relatives more detailed and accurate information about the etiology of the disease. IRB 16-013503

Therapeutic use of Tadekinig alfa in NLRC4 mutation and XIAP deficiency

This is a clinical trial to study the use of Tadekinig alfa or placebo (medication) in the treatment of NLRC4 MAS mutation or XIAP deficiency. This study involves taking the medication every 48 hours for up to 26 weeks. Participants will also be required to attend up to 14 in-person study visits to review their disease state while they are taking the medication. Compensation for time and travel related to study visits may be provided to qualified participants. IRB 17-013986


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