Clinical Research Study Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!

Find a Clinical Research Study

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The LiFFT Study

This study involves taking a study drug called lurbinectedin. The overall goal of this study is to see if different doses of the study drug are safe and effective at treating children and young adults with recurrent or relapsed solid tumors, including Ewing sarcoma. 


This is a study to measure the effectiveness of the medication voclosporin compared to placebo in adolescent patients with active lupus nephritis. Volcosporin is an outpatient, oral medication.

CAMEO: Pediatric Crohn's Disease Outcomes Study

This two-phase study is being conducted to determine the reasons why some children with newly diagnosed Crohn's disease heal their bowel inflammation after one type of therapy and why others do not. To do this, the study team will ask to collect blood, stool and biopsy (tissue) samples from participants newly diagnosed with Crohn's disease to measure their inflammation markers and evaluate their genes (DNA). To determine how much a participant's bowels have healed, we will also compare colonoscopy and MRE results that occur as part of the participant's standard clinical care. 


This research is studying a vaccine against Mpox (formerly known as monkeypox) that is FDA approved for adults but not yet approved for children. The goal of the study is to determine if the vaccine protects children just as well as it protects adults. The study is also looking at the safety of the vaccine. This study is open to healthy adolescents, ages 12-17. In addition, adolescents with certain immunodeficiency diseases or other conditions, that are well controlled, are eligible to participate. 


The purpose of this investigation is to evaluate the impact of non-persistent and persistent chemical exposures on autoimmunity, gene expression and the microbiome in children with and without Crohn’s disease. If these chemical exposures are associated with differences in the epigenome and microbiome that are known to predispose for Crohn’s disease, the proposed research could further support changes in dietary behaviors to limit exposure, and efforts to regulate manufacturing processes that unintentionally and intentionally add these chemicals to food.

Executive Function and Healthcare Transition in IMD

Inherited Metabolic Disorders (IMD) are single gene conditions that affect metabolic pathways. IMD are individually rare, but collectively common. Advances in diagnosis and management have greatly increased the life expectancy of patients with IMD. Gaps in our knowledge about adult neurocognitive outcomes and quality of life confounds the ability to obtain critical therapeutic supports, including social services and vocational rehabilitation. The lack of information also complicates our ability to provide anticipatory guidance to the families of younger patients about prognosis and how to optimize outcome. This study examines neurocognitive outcomes for adults with IMD with a focus on executive and adaptive function, domains necessary for managing life skills, using an entirely remote format.

Participants in this study will complete online surveys on their life skills, medical self-management skills, and quality of life. Thinking skills will be assessed through online questionnaires and a web-based collection of games that test executive function. Some participants will be asked to take part in an interview about their experience as an adult and the transition from pediatric to adult-centered healthcare. 

CrCEST MRI in Mitochondrial Disease

The Mitochondrial Medicine Program at the Children’s Hospital of Philadelphia is conducting a study focusing on non-invasive MRI procedures to measure biological activity within leg muscles of individuals, including both healthy volunteers and those with mitochondrial disease. This type of MRI is for research only, and it is not currently approved by the FDA. There is no direct benefit, but this research may contribute to future mitochondrial medicine. Your participation will last for approximately half a day during a visit at CHOP. We hope this research will contribute to the current knowledge of mitochondrial disease and improve diagnostic approaches. To learn more or inquire about this research study, please contact Sara Nguyen (

Early Driving among Adolescents with CHD

Getting a driver’s license is something that teens-including those with Congenital Heart Disease (CHD)-may look forward to. Although we know a lot about teenage driving and the programs in place to support learning this skill, we know very little about the early driving experiences of teenagers with CHD.

We are looking for teens with CHD who are 15 to 19 years old and have a learner’s permit or valid driver’s license, or interest in obtaining a learner’s permit or driver’s license and their parent/legal guardian. The study will be conducted remotely.

The electronic health record will be reviewed by a member of the study team, and teens and parents/legal guardians will be asked to complete demographic and health assessment surveys. Each teen and parent will participate in separate 45-minute video interviews to talk about what things support driving with a CHD and things that might make it harder to do. The video interview will take place on a video conferencing site using a computer or smartphone.

The total study participation time for each person (teen and parent/legal guardian) is 60 minutes. All teens and parents/legal guardians who participate will be compensated for their effort.

MEG Biomarkers in Autistic Adults

This study is being done to understand how the brain of autistic adolescents and adults process sound and language.  We hope the information gained from this study may lead to future therapies for language difficulties in autistic individuals.   

Designing the ThyTSQ for Teens and Parents

This study aims to design and optimize the Hypothyroidism Treatment Satisfaction Questionnaire (ThyTSQ) for measuring treatment satisfaction among teenage patients on thyroid hormone supplementation and parents of children of any age treated for hypothyroidism.