Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

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The Charisma Study

We are currently enrolling adolescents ages 15-21 of South Asian ancestry, African American ancestry, and European American or "White" ancestry. This study is looking to better understand ancestry related differences in risks for developing cardiovascular disease and type 2 diabetes. The study involves 2 visits to the CHOP Main Hospital in Philadelphia, and participants will be compensated for their efforts.

Nocturnal Blood Pressure in Children and Adolescents with Lupus

The purpose of this research study is to help us learn more about ways to detect early signs of heart and blood vessel disease in pediatric lupus. This information will guide strategies to prevent heart disease in children and adolescents with lupus. Participants will be asked to make 1-2 visits to CHOP to complete imaging tests of the heart and blood vessels and a fasting blood draw. Participants will also wear a blood pressure monitor for 24 hours at home.

Larsen Syndrome: Risk factors for Thoracic Insufficiency Syndrome

This research study is looking at risk factors for developing Thoracic Insufficiency in children with Larsen's Syndrome. We are looking for children ages 6-18 who have been diagnosed with Larsen's Syndrome. Participants will be asked to undergo a physical exam, X-Rays, an MRI, and a Pulmonary Function Test. If interested, please contact Nirupa Galagedera ( or 215-590-1943) or Carina Lott ( or 267-426-0287).

The Virtual Growing Child

The purpose of this study is to examine breathing in healthy children ages 6-13 so that we may better understand the changes in function due to growth and the increase in size of the body organs. Participants will be asked to undergo a physical exam, an MRI, and a Pulmonary Function Test. If interested, please contact Nirupa Galagedera: or 215-590-4358.

Bone Quality in Glomerular Disorders

Glomerular disease is a major cause of chronic kidney disease associated with substantial morbidity; children and adults with glomerular disease face many threats to bone health. The purpose of this research study is to understand more about bone strength in children, adolescents and adults with Glomerular disease. This and future research will help us develop treatment guidelines for this population in order to promote bone health and prevent fractures and osteoporosis later in life. We will be evaluating bone quality in 150 participants with Glomerular disease and 120 healthy participants. The study requires 2 visits for a total of 3 hours and that the participants be 5 to 55 years old. Compensation will be provided. If interested in participating contact the research coordinator at 267-648-3256.

The Bladder Brain Connection - Why Are Some Children Wet?

We know very little about how the bladder to brain connections work in children. The most common thing we hear from children who are having urinary leakage is "I was not aware my bladder was full". Is this full bladder message getting lost? In this study we will measure brain wave activity non invasively after you have drank some Gatorade to get a full bladder and after you have voided. The total time needed for this study will be about 3 to 4 hours.

Pedaitric Study of Acute Recurrent and Chronic Pancreatitis

The goals of this research study are to learn more about acute recurrent and chronic pancreatitis in order to better understand the disease in the hopes of enhancing future treatment options. If you and your child agree to participate you will each be asked to: • Meet with the study team at your annual check-up • Complete questionnaires about medical history, family history, and quality of life • Agree to a one-time blood or saliva sample collection All participants will be compensated for their time and effort. If you would be interested in participating, please contact study coordinator Lucia Sanchez by phone at 267-426-8411, or email at .

Gluten-free diet adherence in children with celiac disease

This study looks to assess how celiac disease affects the quality of life of patients between the ages of 13-18. We are looking to recruit 100 patients who are in their first year of diagnosis and their parents. If the above criteria apply to you, you may be eligible to take part in the study.

Humanized CART19 phase 2 trial

This is a phase 2 study to determine the efficacy of huCART19 in pediatric and young adult patients with CD19-expressing high-risk relapsed or refractory B-cell acute lymphoblastic leukemia. The targeted population is patients 1-29 years with CD19-expressing high-risk relapsed/refractory B-cell acute lymphoblastic leukemia (ALL), including patients who previously received a B cell-directed cell therapy.