Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

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Pedaitric Study of Acute Recurrent and Chronic Pancreatitis

The goals of this research study are to learn more about acute recurrent and chronic pancreatitis in order to better understand the disease in the hopes of enhancing future treatment options. If you and your child agree to participate you will each be asked to: • Meet with the study team at your annual check-up • Complete questionnaires about medical history, family history, and quality of life • Agree to a one-time blood or saliva sample collection All participants will be compensated for their time and effort. If you would be interested in participating, please contact study coordinator Lucia Sanchez by phone at 267-426-8411, or email at sanchezlc@email.chop.edu .

Gluten-free diet adherence in children with celiac disease

This study looks to assess how celiac disease affects the quality of life of patients between the ages of 13-18. We are looking to recruit 100 patients who are in their first year of diagnosis and their parents. If the above criteria apply to you, you may be eligible to take part in the study.

Humanized CART19 phase 2 trial

This is a phase 2 study to determine the efficacy of huCART19 in pediatric and young adult patients with CD19-expressing high-risk relapsed or refractory B-cell acute lymphoblastic leukemia. The targeted population is patients 1-29 years with CD19-expressing high-risk relapsed/refractory B-cell acute lymphoblastic leukemia (ALL), including patients who previously received a B cell-directed cell therapy.

A Phase 1 Trial of Temsirolimus in Combination with Etoposide and Cyclophosphanide in Children with Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma

CHOP, in collaboration with the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) consortium, is conducting a study for children and young adults between the ages of 1 and 21, with relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma. This clinical trial is adding the study drug, temsirolimus, to a standard relapse ALL chemotherapy regimen of etoposide and cyclophosphamide. For more information about this study, including specific eligibility criteria, please visit clinicaltrials.gov and search for "NCT01614197" or visit the TACL website at https://tacl.chla.usc.edu/Tacl/#!/Page/3. To hear more about this and other available trails or get any questions answered please contact our Cancer Intake Specialist by phone at 267-426-0762 or email Oncointake@email.chop.edu.

Dasiglucaon for the treatment fo children with congenital hyperinsulinism

This study is a 2 period open label study that will evaluate the safety and efficacy of dasiglucagon in children between the ages of 3 months and 12 years. Dasiglucagon will be administered as a subcutaneous infusion. To be eligible subjects are to be having at least 3 or more hypoglycemic events a week, and are to have undergone a pancreatectomy for hyperinsulinism or are being treated with a non surgical approach, because they were not eligible for pancreatic surgery.

Sleep Promotion for Children

Sleep is important for healthy development, but a large number of children are not getting enough sleep. We have designed a study that will test different sleep promoting strategies for children. We are seeking volunteers aged 9-12 years, who typically sleep for 6.0-8.5 hours per night. Eligible participants will wear a Fitbit, be provided with a sleep goal, and will receive messages to help them reach their sleep goal over an 11-week period. Participants will be compensated for their time and effort. To learn more please contact Nick Huffnagle by email: mobilesgrow@email.chop.edu

Shifting Perspectives: Enhancing outcomes in adolescent anorexia nervosa with cognitive remediation therapy

Researchers at CHOP are trying to improve outcome in the treatment of adolescents with anorexia nervosa. Eligible families will receive Family Based Treatment for anorexia nervosa. Some families will also receive Cognitive Remediation Therapy for either the adolescent with anorexia nervosa or the adolescent's parents. Both parents are required to participate. Families will be asked to complete a number of assessments over the course of 6 months of treatment.

Medical Cannabis Registry

The overall goal of this research is to look at current use of medical cannabis products being given to children and adults as standard of care. 1. The primary objective is to create a registry that will ask how and why children and adult patients currently use medical cannabis as standard of care, and any other medications they take to allow observational research regarding how useful and safe, and describe the overall landscape of medical cannabis consumption. 2. Optional: Obtain blood samples from enrolled pediatric patients (age 0 to less than 18 years of age). This is to describe the PK profile (or how bodies handle medical cannabis) of select medical cannabis products of drug disposition and response. 3. Optional: An additional component of this study is to provide educational feedback on what is learned from the study to families and care providers to provide evidenced based dosing guidance for these products to the pediatric community and their families. This educational program is optional for families that have participated in the research listed above.

Progressive degeneration in pediatric MS

The purpose of this research study is to learn more about childhood demyelination, why demyelination occurs and to better understand how demyelination affects children and adolescents. To do this, we need to ask detailed questions about a child's early life, environment, and physical activity. To understand how demyelination affects the brain we will obtain special pictures of the brain, called magnetic resonance images (MRI). We will carefully assess all children and adolescents, not only at the time of demyelination, but also once yearly for 2 additional years. In childhood MS, we wish to learn about quality of life, diet, and physical activity. MRI pictures of the brain and analysis of blood samples will help us also to better understand disease activity.

Phase II Mayo Clinic Stem Cell Trial for HLHS

The purpose of this research study is to find out if stem cells from umbilical cord blood (collected at birth) can strengthen the muscle of the right side of the heart for patients diagnosed with Hypolplastic Left Heart Syndrome who are scheduled to undergo the Stage II Glenn surgical procedure.


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