Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!
The purpose of this study is to test the safety and efficacy of the investigational drug called repotrectinib in children whose cancers have specific genetic changes (in the ALK, ROS1, or NTRK1-3 genes). This is the first study using this drug in children under 12 years of age. Repotrectinib is administered in capsule form or liquid suspension.
The goal of this study is to develop ultrasound techniques that assess blood supply to the intestines using an investigational contrast agent. Our hope is to contribute to early diagnosis and improved outcomes.
The purpose of this research study is to understand
the
impact of transplant on the quality of life of the entire family including
sibling donors, other siblings and parents.
Children at a higher risk for Cerebral Palsy or children diagnosed with Cerebral Palsy within the age range of 4-13 months (corrected age) are being recruited for an Early Detection study.
For 3-months, two programs will be offered that may help babies with cerebral palsy move and use their arms more like other children at an early age. If you decide to participate, your participation may mean:
6-week telehealth parent support program, (with one in-person visit) with our counselor to learn more about movement, how babies learn, and parenting tips specifically designed for your family.
Two to three total in-person visits to our lab space to complete assessments and answer questions about how your baby is growing
The purpose of the Phase 2 portion of this study is to evaluate the safety and efficacy of the study drug called palbociclib when given in combination with two other drugs (temozolomide and irinotecan) in patients with Ewing sarcoma and when given in combination with topotecan and cyclophosphamide in patients with neuroblastoma.
The goal of this HIE (Hypoxic Ischemic Encephalopathy) Study is to develop ultrasound techniques for detecting impaired blood supply to the brain using an investigational contrast agent. Our hope is to contribute to early diagnosis and improved outcomes.
The purpose of this study is to see if a new topical (applied to the skin) formulation of rapamycin, PTX-022, is safe and effective in treating participants with microcystic Lymphatic Malformations (mLM).
This study involves taking a study drug called Lutathera. The overall goal of this study is to see if Lutathera is safe in adolescent subjects with either a gastroenteropancreatic neuroendocrine tumor (GEP-NET), or a pheochromocytoma and/or paraganglioma (PPGL). This study will also look at the levels of radioactivity after Lutathera administration.
The Philadelphia Coalition for a Cure (PC4C) study is interested in collecting blood and saliva samples from you, as well as leftover tissue and cerebrospinal fluid from surgeries at CHOP. Our primary research interest is brain tumors, so we aim to collect these tumors, but are also able to collect any tissue deemed to be from an abnormal growth, or other type of cancer. In addition to collecting samples, we also ask patients if we may access their clinical data that is collected and stored at CHOP (ie, notes from provider visits, treatment information, lab results, etc).
We work with other adult hospitals in the Greater Philadelphia Area (Temple University, University of Pennsylvania, Thomas Jefferson University, Cooper Health System, and Crozer Keystone Health System) who contribute samples and data to the bank as well.
The purpose of collecting samples and clinical data is to provide these to researchers (both in and outside of CHOP) interested in studying cancer and developing treatments. In these efforts, we hope to accelerate the process of oncology research and discovery by making this a widely available resource.
This study operates under the Center for Data Driven Discovery in Biomedicine (D3b). To learn more, please visit our website: https://d3b.center. For information on PC4C specifically, you may visit our page on the D3b site: https://d3b.center/our-research/philadelphia-coalition-for-a-cure-pc4c/.
Are you interested learning about opportunities to participate in research? Sign up to receive information about new research studies at CHOP. It’s a great way to support the work of the Research Institute.