Clinical Research Study Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!

Find a Clinical Research Study

171 - 180 of 199

MPS Biomarkers of Joint Disease

The purpose of this study is to establish connections between biomarkers (a measurable substance in your blood, urine, or saliva) and the stage and grade of bone and cartilage disease in MPS patients. 

Neurocognition in Hyperinsulinism

The purpose of this study is to understand how cognitive function changes over time in children with hyperinsulinism (HI) compared to children who are healthy volunteers. Participants will be asked to complete cognitive function tasks and questionnaires three times over the course of two years: at the start of the study, one year later, and one year after that. Each visit is approximately 2 hours. If you like, you can receive a summary of the results from the tasks. Compensation is provided for your time and effort. 

OT-58 for Homocystinuria

This research study is focused on patients who have Cystathionine beta synthase deficiency Homocystinuria (CBSDH). The purpose of this study is to test the safety and tolerability of an investigational drug called OT-58 (the study drug). An “investigational drug” is a drug that is being tested and is not approved by the U.S. Food and Drug Administration (FDA). Specifically, this study will measure how much OT-58 gets into the blood stream, how long it takes the body to get rid of it, and whether it reduces the amount of homocysteine in your blood. 

ML-004 for Adolescents and Adults With ASD

The purpose of this study is to test the safety of an investigational medicine called ML-004 and how it might affect communication, behavior, and other symptoms of autism spectrum disorder (ASD).  This medication is investigational because it has not been approved by the FDA for the treatment of symptoms associated with autism. 
You may qualify if you: 
  • Are 12 to 25 years old
  • Have an autism diagnosis
  • Have a designated care/study partner able to attend every visit and answer questions about the participant. This person does not need to be the participant's parent or guardian. This person should have significant contact with them and can support them for the duration of the study. 
  • Are able to swallow the study medication (tablet)

Approach Avoidance Model of Repetitive Behaviors

The goal of this research study is to learn about experiences with repetitive behaviors from autistic teens and their families. In order to learn about your experiences with repetitive behaviors, you will be invited to complete a set of online questionnaires about your (or your teen's) experiences. The goal of this study is to promote advocacy and transparency for autistic teens' lived experiences. A small subset of teens may also be asked to complete a brain MRI and additional behavioral assessments, if they are interested. Participating in the MRI and further behavioral assessments is voluntary and is not required to complete the online surveys.

Preventing Distracted Driving

The Center for Injury Research & Prevention is seeking teens age 16-19 and a parent to participate in a research study about distracted driving. Both teens and parents must be licensed drivers and use smartphones. The purpose of this research study is to figure out if a new smartphone app impacts distracted driving, and to learn parent and teen perspectives on the app. Participants will be asked to complete occasional surveys and use a smartphone app for up to 3 weeks. The entire study can be completed remotely, and no visits to CHOP are required. Families are compensated for their time in the study. 

ADHD ETA Driving Cohort Study

We are asking both parents and their child between ages 16-18 who recently received their learner’s permit to partner with us as we learn more about teen driving safety. We are looking for children both with and without an ADHD diagnosis to participate. First, parents will answer questions about themselves and their child. Then, both parents and their child will complete up to five surveys over the course of two to three years. The surveys will ask about your thoughts and experiences with driving, health, and other outcomes.

Drive Focus Study

We are asking teens with autism between the ages of 16-21 who have expressed interest in learning how to drive or have received their learner’s permit in the past 3 months, and their parent/primary caregiver to participate in an interview study. The purpose of this study is to inform the development of driver training technology for autistic individuals who are interested in learning to drive. Participants will be asked to complete one or two interviews where they are shown images of the app and/or asked to test it out on a study-provided tablet. Interviews will take approximately 60 minutes. Participants will receive compensation for participation.

ADHD ETA Naturalistic Driving Study

This study is open to teens ages 16-20 who are about to receive or recently received their driver’s license, and a parent. We are looking for teens both with and without an ADHD diagnosis. Participants must have access to a vehicle that the study team can install with data collection equipment and be residents of New Jersey or Pennsylvania. We are asking if families will partner with us as we learn more about the real-world driving behaviors of teen with and without ADHD. Families will receive compensation for their participation. 


The purpose of this study is to evaluate the effects, good or bad, of targeted therapies or immunotherapy (drugs that help the body's immune system fight cancer cells) in patients who have solid tumors with specific genetic alterations or with a high number of mutations. Patients will be assigned to cohorts (groups) based on having a specific type of genetic alteration in their tumor. The study includes cohorts for patients whose tumors have genetic alterations in the ROS1, NTRK, PIK3CA, BRAF, or RET genes or a high number of mutations in their tumor.