Clinical Research Study Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!

Find a Clinical Research Study

181 - 189 of 189

MRI of ARPKD liver disease

The primary goal of this research study is to see if new types of magnetic resonance imaging (MRI) can be used to measure liver health in children with autosomal recessive polycystic kidney disease (ARPKD) compared to healthy controls.  Both children with ARPKD and healthy children, aged 6 years and above can participate.

Aneurysms in ARPKD

The primary goal of this research study is to learn if patients with autosomal recessive polycystic kidney disease (ARPKD) are at risk for brain aneurysms or cardiovascular abnormalities. Participants in this study will involve patients that have a clinical diagnosis of ARPKD. The study will also involve a comparison group of healthy individuals that have no history of kidney or cardiac conditions.

PriCARE for Young Parents Yr1

Researchers from General Pediatrics are conducting focus groups on Child Adult Relationship Enhancement in Pediatric Primary Care (PriCARE), a parenting group program that helps to improve children’s behaviors and strengthen the caregiver-child relationship. The researchers are conducting this study to adapt PriCARE for parents and their parenting supports.
Parents who were younger than 21 at the time of the birth of their child, who currently have at least one child between the ages of 2-6, or are a parenting support person of a parent with a child 2-6 years old, are eligible.

Pathways to ASD Diagnosis

The purpose of the study is to learn more about the experience of caregivers who have a child diagnosed with autism. We also want to better understand what is working well in healthcare in the US. This study is open to primary caregivers of a child (aged 3-17) who has been diagnosed with autism spectrum disorder in the last year. Participants must have immigrated to the US and identify as Hispanic or Latinx. Study staff will interview participants about their experiences as a caregiver of an autistic child. This one-time interview will last 60-90 minutes in Spanish or English.


Researchers at CHOP are recruiting patients diagnosed with either acute leukemia (myeloid, lymphoid), myelodysplastic syndromes, or aplastic anemia and treated with allogeneic hematopoietic cell transplantation (HCT) within the past 6-48 months.

Research has shown that adolescents and young adults who are treated with HCT are at increased risk for skeletal muscle loss. So, the purpose of this study is to investigate if a combination of exercise training and an exercise supplement can mitigate this effect. The
supplement is called nicotinamide riboside.

Participants will be randomly assigned to 1 of 4 groups:
  • Exercise + Supplement
  • Exercise + Placebo
  • No Exercise + Supplement
  • No Exercise + Placebo
The study will provide all the exercise equipment required to complete the exercise intervention, including remote sessions.

Body Surface Gastric Mapping in Patients with GI Symptoms

The purpose of this study is to learn more about a new device that measures stomach myoelectric (electricity produced by muscles) activity in children and young adults using body surface gastric mapping (BSGM). The BSGM device is FDA approved in adults but not children under 18. 

We are looking to partner with patients who have a confirmed diagnosis of a Motility Disorder and/or Functional Gastrointestinal Disorder (FGID) or patients who are having motility tests/procedures performed for clinical care. We are also looking for healthy controls without any history of inflammatory disease or pyloric disorders. All study participants must be 8 - 25 years of age and have a body mass index (BMI) of less than 35. 

Participation is completely voluntary, and subjects may withdraw at any time without affecting their care. Participants may receive compensation for their time.

MPS Biomarkers of Joint Disease

The purpose of this study is to establish connections between biomarkers (a measurable substance in your blood, urine, or saliva) and the stage and grade of bone and cartilage disease in MPS patients. 

Neurocognition in Hyperinsulinism

The purpose of this study is to understand how cognitive function changes over time in children with hyperinsulinism (HI) compared to children who are healthy volunteers. Participants will be asked to complete cognitive function tasks and questionnaires three times over the course of two years: at the start of the study, one year later, and one year after that. Each visit is approximately 2 hours. If you like, you can receive a summary of the results from the tasks. Compensation is provided for your time and effort. 

OT-58 for Homocystinuria

This research study is focused on patients who have Cystathionine beta synthase deficiency Homocystinuria (CBSDH). The purpose of this study is to test the safety and tolerability of an investigational drug called OT-58 (the study drug). An “investigational drug” is a drug that is being tested and is not approved by the U.S. Food and Drug Administration (FDA). Specifically, this study will measure how much OT-58 gets into the blood stream, how long it takes the body to get rid of it, and whether it reduces the amount of homocysteine in your blood.