Clinical Research Finder

Children's Hospital of Philadelphia leads or participates in hundreds of clinical trials. Use this database to learn the purpose of these trials, find out who can participate and more.

Find a Clinical Research Study

21 - 30 of 154

EchoSense Doppler Sensor in Pediatric Patients

You are invited to participate in a voluntary research study of the EchoSense Doppler Technology at CHOP. The objective of this study is to evaluate the Lung Doppler Signals non-invasively in children with pulmonary hypertension. We will correlate these signals to the values typically obtained from a heart catheterization. Our target enrollment is 30 patients. There are no significant risks associated with participating, and the study should take approximately 20 minutes to complete. As stated above, this study is completely voluntary, and you have the right to withdrawl at any time, and If you refuse to participate, this will not impact with the medical care you will receive. IRB 15-012495

A Review of Thyroidectomies at Children’s Hospital of Philadelphia

The purpose of this study is to examine CHOP’s experience with patients ages 0 to 19 years old who have already undergone or will be undergoing total thyroidectomy (TTx) and/or completion thyroidectomy performed at the Thyroid Center at the Children’s Hospital of Philadelphia.

The study procedures are limited to review of patients medical records located at CHOP.

For more information, eligibility and/or participation please contact the study Research Coordinator at 267-426-3906 for more information, eligibility and/or participation. IRB 15-012519

Outcome Measures of Alexander Disease

A thorough review of outcome measures that assess disease progression has not been established for any of the subcategories of Alexander disease. These results will be crucial to our understanding of disease presentation and progression. Providing this information about the pathophysiology will allow for effective development of clinical trials to test therapies and the future use of neuroprotective agents in children. IRB 16-012649

Neuroscience Biorepository

CHOP is conducting a research study that will help make it possible to do future studies in children and family members both with and without problems with their brain and nervous system. This study involving collecting blood and other types of samples from participants along with medical information. These samples and the information will be stored in a “repository” for an indefinite amount of time. We’ll use these tools in the future to create and develop new research studies that may help us find answers to some of these difficult illnesses. IRB 16-012830

Vascular Overgrowth Study

We are conducting a research study on vascular birthmarks and overgrowth. The purpose of this study is to develop a better understanding of the cause of vascular overgrowth syndromes. We are collecting DNA in the forms of cells from skin biopsies, tissue specimens, blood samples, and/or buccal swabs. Individuals (any age) with vascular overgrowth syndromes can participate. What we learn from this study will help us to provide people with vascular overgrowth syndromes and their relatives more detailed and accurate information and hopefully will lead us to better treatments. IRB 16-012850

BMT CTN 1503 (STRIDE2): BMT for Severe Sickle Cell Disease

The purpose of this research study is to compare transplant (HCT/BMT) to standard of care treatment in young adults with SCD who have experienced complications. Once consented we would assess to see if you have a matched donor. Subjects who have a closely matched donor will undergo a bone marrow transplant. This is called the Donor Arm. Subjects who do not have a closely matched donor will receive the current standard of care for their disease. This is called the No Donor Arm. We will follow subjects in both arms for two years to evaluate outcomes over that time period. IRB 16-012854

Alternative Donor Transplant for Bone Marrow Failure (BMF) using CliniMACs Alpha Beta Depletion

The purpose of this research study is to test a new method of cell processing for stem cell transplants with an unrelated donor or partially matched related donor for patients with BMF who do not have a well matched related donor. The new method is called alpha/beta T cell and B cell depletion using a device called CliniMACs.  We want to see if this method can reduce some of the complications of the transplant and decrease the time it takes for the new stem cells to establish a new immune system. IRB 16-012881  

MEG Techniques for Low-Functioning Pediatric

The Lurie Family Foundations MEG Imaging Lab at CHOP are looking for Healthy Children for a study on how the brain works. We are looking for both male and female children between the ages of 8-12 years old. We will provide you with reimbursement for your time and parking will be at no cost. For more information please contact our study coordinator Leah Gaetz at 267-426-4914 or IRB 16-012890


Collect data and blood samples to make observations and determinations about rate and severity of graft-versus-host disease in HCT patients. IRB 16-012909

3D Outcomes of Bracing in AIS

Our team is trying to understand how wearing the Boston (TLSO) brace can affect three-dimensional (3D) changes in the spine and ribcage. We are looking to partner with families who have an adolescent who will be treated with a brace and is between the age of 10 and 16 years. Our study is observational, which means that your child will NOT be asked to make any changes to their daily life. If your child agrees to participate, he or she will be asked to wear a smart strap, a strap that replaces one of the regular straps on the brace. The smart strap will be free of charge and registers brace wear duration and strap tension via Bluetooth, therefore patients and families can track treatment information and see their prescription through a smartphone app. IRB 16-013059