Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!
This study aims to collect data from patients seen at CHOP, CHOP's 3550 Market St. primary care location, Penn, or from the surrounding communities. If you choose to participate, we will take an optional blood, saliva, and/or stool sample, have you complete computer testing that measures things like your reaction time and your memory, have you complete questionnaires, and we will interview you and your parent or legal guardian to ask questions about your life experiences and perceptions, and past and current mental health.
The purpose of this study is to examine breathing in healthy children ages 6-18 so that we may better understand the changes in function due to growth and the increase in size of the body organs. Participants will be asked to undergo a physical exam, an MRI, and a Pulmonary Function Test. If interested, please contact Carina Lott: lottc@email.chop.edu or 267-426-0287.
Children (less than 10 years of age) are eligible if they have been diagnosed with either a medulloblastoma tumor or CNS embryonal tumors of the brain or spinal cord. The standard approach to the treatment of these brain tumors in young children may include surgery, radiation therapy to the brain and spinal cord and chemotherapy. Radiation therapy is the use of high energy x-rays to kill cancer cells. Chemotherapy means treatment with cancer killing drugs. This research study will compare two different treatment regimens to see which is better for treating children with this type of brain cancer.
CHOP and the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) consortium is conducting a study for children and young adults 21 years old or younger who have relapsed or refractory acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma. This study adds the study drug 'Ixazomib' to standard relapsed ALL chemotherapy drugs. For more information about this study, including specific eligibility criteria, please visit clinicaltrials.gov and search for "NCT03817320" or visit the TACL website at https://tacl.chla.usc.edu/Tacl/#!/Page/3. To hear more about this and other available trails or get any questions answered please contact our Cancer Intake Specialist by phone at 267-426-0762 or email Oncointake@email.chop.edu.
The goal of this study is to identify and measure anxiety symptoms in children and adolescents with food allergy. We are looking for families of children with IgE-mediated food allergies between 8 and 18 years of age to participate. The study procedures involve both the caregiver and child filling out online questionnaires on two separate occasions. If you are interested in participating, you can sign up immediately by clicking the link below: https://is.gd/FoodAllergyAnxiety If you have any questions, please contact the research coordinator, Leah Wilkey, by phone at 215-590-6198 or email at wilkeyl@email.chop.edu.
The mission of SPARK is to ignite research at an unprecedented scale to improve lives by advancing our understanding of autism. To join this national autism research cohort, individuals with a professional diagnosis of autism and their biological family members will be asked to share information about their medical and family history, as well as provide a DNA sample. Please contact the Center for Autism Research for more information at 1-866-570-6524 or autism@email.chop.edu.
This is a clinical trial for patients with neuroblastoma that has returned (relapsed) or has not responded to standard treatment. The patients will have a biopsy of their tumor that will be tested for genetic changes and then matched to available drugs. If the results from the testing show molecular features in the tumor that allow for study treatment, patients will be invited for further testing to see if they are eligible for new treatments. Experimental therapies are all taken orally and may consist of one drug or a combination of drugs
Patients will be followed in the facial nerve paralysis database and will be recruited for completion of a patient-facing survey. In addition, 2D and 3D photographs, which are clinical standards of care, will be taken for an evaluation of facial motion.
The purpose of this study is to learn how to monitor heart health in children and teens with lupus. This information will help us find ways to prevent early heart disease in children and teens with lupus. Participants will visit CHOP 3 times over 18 months. During the visits, participants will complete a fasting blood draw and imaging tests of the heart and blood vessels. Participants will also be asked to wear a blood pressure monitor for 24 hours at home after each visit.
The purpose of this study is to determine how what you eat and drink (your diet), antibiotics you take, and the bacteria that live in your gut (microbiome) contribute to developing kidney stones. Kidney stone disease, known as nephrolithiasis, is also influenced by products of metabolism (metabolites) that are found in your urine. These factors will be examined in participants at least 4 years of age. Each participant will completed three 24-hour dietary recalls and will provide one stool sample and up to two urine samples. The information from this study will help doctors find new metabolic pathways that can be used for treatment of kidney stones.
Are you interested learning about opportunities to participate in research? Sign up to receive information about new research studies at CHOP. It’s a great way to support the work of the Research Institute.