Collect data and blood samples to make observations and determinations about rate and severity of graft-versus-host disease in HCT patients. 

Patients with no available curative treatment options with leukemia are eligible to participate in this study to test an experimental approach called gene transfer that involves B cells. This study will take the patients white blood cells - T cells - and change them to turn against the cancer.

This study will test whether supplemental oxygen therapy, a common post-discharge treatment for BPD, improves outcomes. Enrolled infants, between the ages of 34-44 weeks Post Menstrual Age, with moderate or severe BPD, will be randomly assigned to higher or lower oxygen saturation target ranges. The study intervention will begin in the hospital and will continue at home until 6 months Corrected Age.

The Children’s Brain Tumor Network Collection (CBTN) Protocol is a collaborative, multi-institutional biobanking research program dedicated to the study of childhood brain tumors. The ultimate goal of the CBTN is to improve outcomes for children with brain tumors by offering freely accessible samples and data to researchers around the world. The CBTN collects and stores specimens from pediatric patients that have abnormal cell growth in their central nervous system, such as brain and spinal cord tumors. Only specimens that are no longer needed for the care of the child are accepted. Samples can include tissue, blood, cerebrospinal fluid, and in very rare cases urine and stool. These specimens will be paired with clinical data that will be collected over time on the patient. These samples and data may be shared with researchers to find better outcomes and treatments and may be used in genetic testing. Samples may be used in growing a cell line, which is a small tumor that may be used in an animal model for research and clinical trials. Biological relatives also have an optional opportunity to participate by providing a blood or a saliva sample, or a cheek swab. Subjects and their families also have the option of receiving results back if they are found to be clinically significant to the care of the patient. Private health information will be protected by an electronic system that acts as a gatekeeper between CHOP and researchers and protects the information that can identify someone. There is no compensation for participation.  

The purpose of this study is to characterize the microbiome in children with Crohn’s disease who have perianal fistula and to compare it to other children with Crohn’s disease who do not have perianal disease. Studying the role of the microbiome in perianal fistula may help us to develop new therapies.

The purpose of this research study is to identify genes that are involved in the development of Inflammatory Bowel Disease (IBD) at a young age (less than 8 years of age). This is a case-control study of IBD patients which compares children with symptoms and/or diagnosis of IBD.

The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for. 

The purpose of this study is to compare the genes of African American children and adults who have inflammatory bowel disease (IBD) with the genes of those who do not have IBD. Genes are pieces of hereditary material found in human cells. How an individual's genes cause intestinal inflammation in IBD is still being tested and not much is known about the association between genes and IBD in individuals with African ancestry. We hope to understand which genes cause IBD and if certain genes can help doctors personalize treatment for patients with IBD. For more information please contact IBDResearch@email.chop.edu. 

The Harmony Valve study is for patients in need of pulmonary valve replacement. The HarmonyTM Valve is a transcatheter pulmonary valve specifically designed for patients in need of a pulmonary valve replacement who do not want to have to undergo surgery. Surgical placement of a new valve is the most common treatment for a nonworking pulmonary valve, however, there are many risks associated with open heart surgery and it is followed by months of recovery. A less invasive approach for treatment is now available by placement of a pulmonary valve by a transcatheter procedure. The HarmonyTM Valve has not been approved by the FDA yet for commercial use and is only available by participating in the study., Please contact Dr. Matthew Gillespie (gillespie@email.chop.edu) if you or your patient may be interested in participating in the trial of this device., 

The purpose of this research study is to test a new method of cell processing for stem cell transplants with an unrelated donor or partially matched related donor for patients with BMF who do not have a well matched related donor. The new method is called alpha/beta T cell and B cell depletion using a device called CliniMACs.  We want to see if this method can reduce some of the complications of the transplant and decrease the time it takes for the new stem cells to establish a new immune system.