Children's Hospital of Philadelphia leads or participates in hundreds of clinical research studies and clinical trials. Many of the studies that are currently enrolling patients can be found in this database. Use this finder to learn more about the purpose of these studies and clinical trials, find out who can participate, and tell us you're interested in enrolling. You can also look for studies that offer remote participation from home!
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Parents and their child between 16 and 21 on the autism spectrum are both asked to partner with us for this study as we learn more about the decisions you make about transportation, including driving. We also hope to learn about how transportation influences quality of life and other outcomes. First, parents will answer questions about themselves and their child. Then, both parents and their child will complete up to surveys over the course of two years. The surveys will ask about your thoughts and experiences with transportation and driving, quality of life, relationships, and other outcomes.
Inflammatory Bowel Disease (IBD) can sometimes add stress to your life and that may affect your physical symptoms of pain and stool habits. In this study, we want to know if practicing mindfulness via an online Mindfulness-based stress reduction (MBSR) course taught by a trained teacher can help with your IBD. If you are a patient with IBD, who is between 12-19 years of age, you might be eligible to participate in an 8 week long MBSR group course online. You will answer a series of questionnaires and submit stool samples 3 times over the course of the study, and you will also participate in 1 focus group to discuss your experience in the study. You will be compensated for your participation.
The Craniofacial Pathologies biobank is a research study collecting and storing reamining surgical specimens from the cranium and face from diagnosed patients at CHOP with a congenital craniofacial anomaly. The main purpose of this longitudinal study is to help researchers discover the causes of craniofacial pathologies that may lead to new treatments.
Although we know a lot about returning to sports, exercise, and school after concussion, we know very little about returning to drive after a concussion. Our Driving after Concussion study needs the help of both healthy and recently concussed teen partners in our research to understand how concussion affects driving behaviors in teens.
We are looking for healthy (have not had a concussion in the last year) and recently concussed teens who are 16.5-18 years old with a driver’s license and their own smartphone.
Our teen research partners may be asked to complete surveys about themselves and download smartphone applications that track symptoms associated with concussion and/or observe real-world driving behaviors. They may also be asked to come to CHOP's Driving Simulator Lab to complete a 3-hour session that includes surveys, clinical testing, and device testing along with a simulated driving assessment to observe driving behavior.
All teens who participate will be compensated for their time and effort.
The purpose of this study is to create a biorepository, which is a collection of biological samples and the data associated with them, to support our ongoing and future studies on ultra-rare pediatric neurodegenerative disorders. These include disorders associated with mitochondrial and autophagic dysfunction such as TBCK, congenital disorders of autophagy, mitochondrial disorders, and cases of neurodegeneration without known genetic diagnoses. Ultra-rare disorders affect 1 in every 50,000 kids.
Using the biological samples we collect, we intend to derive cellular disease models to study these disorders at a molecular level and screen for therapeutic targets. We also intend to look for biomarkers that may inform outcome measures in future interventions and clinical trials. By looking at the cells in these biological samples, we hope to understand how they work, what is wrong with them, and how we could fix them. The overarching aim is to yield generalizable knowledge about these disorders and translate it into better diagnostic awareness and clinical care.
Researchers at CHOP are trying to improve outcomes in
the treatment of adolescents with anorexia nervosa. Eligible families will
receive Family Based Treatment for anorexia nervosa. Some adolescents with
anorexia nervosa will also receive Cognitive Remediation Therapy (a treatment
that increases flexible thinking). Both parents are required to participate and
any siblings living at home are asked to come to the first four treatment
sessions. Families will receive treatment for approximately 6 months and will
be asked to complete number of assessments during treatment and at two time
points after treatment ends.
The purpose of this research study is to look at whether or not a sleep questionnaire can be used on infants 3 to 24 months of age, with or at high-risk of having Cerebral Palsy. This questionnaire is currently being used on older children, so we will be looking at a younger age group.
This study aims to support families with buying, cooking, and eating fresh fruits and vegetables at home! The goal of this study is to learn how fruit and vegetable vouchers and virtual cooking classes and resources affect families' experiences with home cooking and food shopping, as well as caregiver mental health.
Inherited Metabolic Disorders (IMD) are single gene conditions that affect metabolic pathways. IMD are individually rare, but collectively common. Advances in diagnosis and management have greatly increased the life expectancy of patients with IMD. Gaps in our knowledge about adult neurocognitive outcomes and quality of life confounds the ability to obtain critical therapeutic supports, including social services and vocational rehabilitation. The lack of information also complicates our ability to provide anticipatory guidance to the families of younger patients about prognosis and how to optimize outcome. This study examines neurocognitive outcomes for adults with IMD with a focus on executive and adaptive function, domains necessary for managing life skills, using an entirely remote format.
Participants in this study will complete online surveys on their life skills, medical self-management skills, and quality of life. Thinking skills will be assessed through online questionnaires and a web-based collection of games that test executive function. Some participants will be asked to take part in an interview about their experience as an adult and the transition from pediatric to adult-centered healthcare.
The purpose of this study is to evaluate social interactions in adolescents and whether changes in information can influence social behaviors. This study will focus on behavioral assessments of social processing over time in adolescents. The information collected in this study is essential for developing clinical treatments focused on addressing social processes in adolescent anorexia nervosa (AN) and to improve our understanding of social processing in adolescent AN, informing both future research and clinical care.