Subglottic Hemangiomas

What are subglottic hemangiomas?

Subglottic hemangiomas may form a large mass in the airway below the vocal cords, causing varying degrees of airway obstruction. They grow rapidly for at least 12 to 18 months followed by slow shrinking. Some hemangiomas require medical intervention because of their life-threatening nature in the airway.

Hemangiomas are the most common vascular malformation in infants and children. The malformation is composed of capillaries and other small vessels. They may occur anywhere on the body and most appear as solitary skin lesions without involvement if the airway.

Subglottic hemangiomas may form a large mass in the subglottic airway causing varying degrees of airway obstruction. They grow rapidly for at least 12 to 18 months followed by slow shrinking (called involution). However, not every subglottic hemangioma will shrink completely. Many require active intervention because of their life-threatening nature in the airway.

Signs and symptoms

Hemangiomas of the larynx or trachea are often seen in children who have multiple hemangiomas appearing in a particular dermatomal region (one of the four regions of the body associated with a particular spinal nerve). They may be associated with hemangiomas in other non-airway sites such as the skin of the scalp or back.

Symptoms include:

  • Croup-like cough
  • Noisy breathing when inhaling and exhaling
  • Difficulty breathing

Testing and diagnosis

subglottic hemangioma Endoscopic view of bilateral subglottic hemangiomas. To diagnosis a subglottic hemangioma, the child will first have a plain neck X-ray. The X-ray alone may show a mass in his airway. Flexible laryngoscopy in the office may also be enough to reveal that a hemangioma is causing the respiratory symptoms.

To confirm the diagnosis, the doctor will perform an endoscopy with microlaryngoscopy and bronchoscopy. This will help to determine the extent of the airway hemangioma and make sure that it has no extension into the tracheal airway. Once the airway is established, an MRI of the neck and brain is useful to ensure that the hemangioma has not extended into the neck or skull.


There are many potential treatments for subglottic hemangiomas which will depend on the severity of the child's case. A drug called propanolol is rapidly becoming the first line treatment for severe subglottic hemangiomas.

How propanolol works

Propanolol shows promise in rapid reduction of airway symptoms for children with subglottic hemangiomas. All patients must undergo a cardiac evaluation before beginning this therapy. Propanolol is a beta blocker that causes capillary vasoconstriction, decreased expression of vascular endothelial growth factors, and apoptosis (death) of capillary endothelial cells. This causes the hemangioma to shrink.

The most common side effect of propanolol is drowsiness and hypoglycemia. For this reason, the child is observed in the hospital when he starts taking the drug and for start of treatment and the dosage is gradually increased to therapeutic levels over several days. This treatment may be supplemented with steroids. Most patients will respond within one to two weeks, but some may not respond at all and require other treatments. At CHOP, these children are always followed closely by the vascular malformation team.

Other treatment options

Subglottic hemangiomas can be treated using steroids, tracheostomy, laser, intralesional steroid injections, microdebrider excision, and open surgical excision. These all come with some risk.

  • Lasers and microdebridement of the subglottic hemangioma carries the risk of scarring which may lead to subglottic stenosis.
  • Steroids may improve symptoms but put the child at risk of many side effects. Steroid use is only advised for short periods of time.
  • Open surgery is a very effective treatment, but is a major operation with some risks. It is usually reserved for cases that fail more conservative approaches.
  • Tracheostomy may be used to bypass the airway until the hemangioma shrinks, but comes with risk of mucous plugging, accidental dislodgement and other life-threatening risks. Furthermore, many hemangiomas may not shrink on their own, requiring further treatment.  

Watch as a surgeon removes a subglottic hemangioma, and see the airway before and after treatment.

The outcome for treatment with endoscopic, open surgery or propanolol is outstanding and most patients go on to live normal lives.