Edward F. Attiyeh, MD

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Edward F. Attiyeh, MD, is an attending physician with the Cancer Center at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - Albert Einstein College of Medicine, Bronx, NY

Residency

Pediatrics - Yale-New Haven Children's Hospital, New Haven, MA

Fellowship

Pediatric Hematology/Oncology - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Hematology-Oncology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Titles and Academic Titles

Attending Physician

Adjunct Assistant Professor of Pediatrics (Oncology), Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2020

Ambros IM, Tonini GP, Pötschger U, Gross N, Mosseri V, Beiske K, Berbegall AP, Bénard J, Bown N, Caron H, Combaret V, Couturier J, Defferrari R, Delattre O, Jeison M, Kogner P, Lunec J, Marques B, Martinsson T, Mazzocco K, Noguera R, Schleiermacher G, Valent A, Van Roy N, Villamon E, Janousek D, Pribill I, Glogova E, Attiyeh EF, Hogarty MD, Monclair TF, Holmes K, Valteau-Couanet D, Castel V, Tweddle DA, Park JR, Cohn S, Ladenstein R, Beck-Popovic M, De Bernardi B, Michon J, Pearson ADJ, Ambros PF.: Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group. J Clin Oncol 38: 3685-3697, Nov 2020.

2018

Depuydt P, Boeva V, Hocking TD, Cannoodt R, Ambros IM, Ambros PF, Asgharzadeh S, Attiyeh EF, Combaret V, Defferrari R, Fischer M, Hero B, Hogarty MD, Irwin MS, Koster J, Kreissman S, Ladenstein R, Lapouble E, Laureys G, London WB, Mazzocco K, Nakagawara A, Noguera R, Ohira M, Park JR, Pötschger U, Theissen J, Tonini GP, Valteau-Couanet D, Varesio L, Versteeg R, Speleman F, Maris JM, Schleiermacher G, De Preter K.: Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. J Natl Cancer Inst 110: 1084-1093, Oct 2018.

2017

Liu Z, Lam N, Wang E, Virden RA, Pawel B, Attiyeh EF, Maris JM, Thiele CJ.: Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma. Oncogene 36: 97-109, Jan 2017.

Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R.: Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report. Blood 129: 3051-3058, Jun 2017.

Chang X, Zhao Y, Hou C, Glessner J, McDaniel L, Diamond MA, Thomas K, Li J, Wei Z, Liu Y, Guo Y, Mentch FD, Qiu H, Kim C, Evans P, Vaksman Z, Diskin SJ, Attiyeh EF, Sleiman P, Maris JM, Hakonarson H.: Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk. Nat Commun 8: 569, Sep 2017.

2015

Patel R R, Hodinka R L, Kajon A E, Klieger S, Oikonomopoulou Z, Petersen H, Rand E, Attiyeh E F, Fisher B T: A Case of Adenovirus Viremia in a Pediatric Liver Transplant Recipient With Neutropenia and Lymphopenia: Who and When Should We Treat? Journal of the Pediatric Infectious Diseases Society 4(1): e1-5, Mar 2015.

Mandriota Stefano J, Valentijn Linda J, Lesne Laurence, Betts David R, Marino Denis, Boudal-Khoshbeen Mary, London Wendy B, Rougemont Anne-Laure, Attiyeh Edward F, Maris John M, Hogarty Michael D, Koster Jan, Molenaar Jan J, Versteeg Rogier, Ansari Marc, Gumy-Pause Fabienne: Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget 6(21): 18558-76, Jul 2015.

Vujkovic Marijana, Attiyeh Edward F, Ries Rhonda E, Horn Michelle, Goodman Elizabeth K, Ding Yang, Kavcic Marko, Alonzo Todd A, Gerbing Robert B, Hirsch Betsy, Raimondi Susana, Gamis Alan S, Meshinchi Soheil, Aplenc Richard: Concordance of copy number alterations using a common analytic pipeline for genome-wide analysis of Illumina and Affymetrix genotyping data: a report from the Children's Oncology Group. Cancer genetics 208(7-8): 408-13, Jul-Aug 2015.

Eleveld Thomas F, Oldridge Derek A, Bernard Virginie, Koster Jan, Daage Leo Colmet, Diskin Sharon J, Schild Linda, Bentahar Nadia Bessoltane, Bellini Angela, Chicard Mathieu, Lapouble Eve, Combaret Valérie, Legoix-Né Patricia, Michon Jean, Pugh Trevor J, Hart Lori S, Rader JulieAnn, Attiyeh Edward F, Wei Jun S, Zhang Shile, Naranjo Arlene, Gastier-Foster Julie M, Hogarty Michael D, Asgharzadeh Shahab, Smith Malcolm A, Guidry Auvil Jaime M, Watkins Thomas B K, Zwijnenburg Danny A, Ebus Marli E, van Sluis Peter, Hakkert Anne, van Wezel Esther, van der Schoot C Ellen, Westerhout Ellen M, Schulte Johannes H, Tytgat Godelieve A, Dolman M Emmy M, Janoueix-Lerosey Isabelle, Gerhard Daniela S, Caron Huib N, Delattre Olivier, Khan Javed, Versteeg Rogier, Schleiermacher Gudrun, Molenaar Jan J, Maris John M: Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nature genetics 47(8): 864-71, Aug 2015.

Attiyeh Edward F, Maris John M, Lock Richard, Reynolds C Patrick, Kang Min H, Carol Hernan, Gorlick Richard, Kolb E Anders, Keir Stephen T, Wu Jianrong, Landesman Yosef, Shacham Sharon, Lyalin Dmitry, Kurmasheva Raushan T, Houghton Peter J, Smith Malcolm A: Pharmacodynamic and Genomic Markers Associated With Response to the XPO1/CRM1 Inhibitor Selinexor (KPT-330): A Report From the Pediatric Preclinical Testing Program. Pediatric blood & cancer Sep 2015.

Schnepp Robert W, Khurana Priya, Attiyeh Edward F, Raman Pichai, Chodosh Sara E, Oldridge Derek A, Gagliardi Maria E, Conkrite Karina L, Asgharzadeh Shahab, Seeger Robert C, Madison Blair B, Rustgi Anil K, Maris John M, Diskin Sharon J: A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer cell 28(5): 599-609, Nov 2015.

2013

Chand Damini, Yamazaki Yasuo, Ruuth Kristina, Schönherr Christina, Martinsson Tommy, Kogner Per, Attiyeh Edward F, Maris John, Morozova Olena, Marra Marco A, Ohira Miki, Nakagawara Akira, Sandström Per-Erik, Palmer Ruth H, Hallberg Bengt: Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma. Disease models & mechanisms 6(2): 373-82, Mar 2013.

Pugh Trevor J, Morozova Olena, Attiyeh Edward F, Asgharzadeh Shahab, Wei Jun S, Auclair Daniel, Carter Scott L, Cibulskis Kristian, Hanna Megan, Kiezun Adam, Kim Jaegil, Lawrence Michael S, Lichenstein Lee, McKenna Aaron, Pedamallu Chandra Sekhar, Ramos Alex H, Shefler Erica, Sivachenko Andrey, Sougnez Carrie, Stewart Chip, Ally Adrian, Birol Inanc, Chiu Readman, Corbett Richard D, Hirst Martin, Jackman Shaun D, Kamoh Baljit, Khodabakshi Alireza Hadj, Krzywinski Martin, Lo Allan, Moore Richard A, Mungall Karen L, Qian Jenny, Tam Angela, Thiessen Nina, Zhao Yongjun, Cole Kristina A, Diamond Maura, Diskin Sharon J, Mosse Yael P, Wood Andrew C, Ji Lingyun, Sposto Richard, Badgett Thomas, London Wendy B, Moyer Yvonne, Gastier-Foster Julie M, Smith Malcolm A, Auvil Jaime M Guidry, Gerhard Daniela S, Hogarty Michael D, Jones Steven J M, Lander Eric S, Gabriel Stacey B, Getz Gad, Seeger Robert C, Khan Javed, Marra Marco A, Meyerson Matthew, Maris John M: The genetic landscape of high-risk neuroblastoma. Nature genetics 45(3): 279-84, Mar 2013.

Rader Julieann, Russell Mike R, Hart Lori S, Nakazawa Michael S, Belcastro Lili T, Martinez Daniel, Li Yimei, Carpenter Erica L, Attiyeh Edward F, Diskin Sharon J, Kim Sunkyu, Parasuraman Sudha, Caponigro Giordano, Schnepp Robert W, Wood Andrew C, Pawel Bruce, Cole Kristina A, Maris John M: Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 19(22): 6173-82, Nov 2013.

2012

Dondeti Vijay R, Wubbenhorst Bradley, Lal Priti, Gordan John D, D'Andrea Kurt, Attiyeh Edward F, Simon M Celeste, Nathanson Katherine L: Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. Cancer research 72(1): 112-21, Jan 2012.

Gumy-Pause Fabienne, Pardo Bruno, Khoshbeen-Boudal Mary, Ansari Marc, Gayet-Ageron Angèle, Sappino André-Pascal, Attiyeh Edward F, Ozsahin Hulya: GSTP1 hypermethylation is associated with reduced protein expression, aggressive disease and prognosis in neuroblastoma. Genes, chromosomes & cancer 51(2): 174-85, Feb 2012.

Bosse Kristopher R, Diskin Sharon J, Cole Kristina A, Wood Andrew C, Schnepp Robert W, Norris Geoffrey, Nguyen Le B, Jagannathan Jayanti, Laquaglia Michael, Winter Cynthia, Diamond Maura, Hou Cuiping, Attiyeh Edward F, Mosse Yael P, Pineros Vanessa, Dizin Eva, Zhang Yongqiang, Asgharzadeh Shahab, Seeger Robert C, Capasso Mario, Pawel Bruce R, Devoto Marcella, Hakonarson Hakon, Rappaport Eric F, Irminger-Finger Irmgard, Maris John M: Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer research 72(8): 2068-78, Apr 2012.

Diskin Sharon J, Capasso Mario, Schnepp Robert W, Cole Kristina A, Attiyeh Edward F, Hou Cuiping, Diamond Maura, Carpenter Erica L, Winter Cynthia, Lee Hanna, Jagannathan Jayanti, Latorre Valeria, Iolascon Achille, Hakonarson Hakon, Devoto Marcella, Maris John M: Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nature genetics Sep 2012.

Schleiermacher G, Mosseri V, London W B, Maris J M, Brodeur G M, Attiyeh E, Haber M, Khan J, Nakagawara A, Speleman F, Noguera R, Tonini G P, Fischer M, Ambros I, Monclair T, Matthay K K, Ambros P, Cohn S L, Pearson A D J: Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project. British journal of cancer Sep 2012.

Dubois Steven G, Geier Ethan, Batra Vandana, Yee Sook Wah, Neuhaus John, Segal Mark, Martinez Daniel, Pawel Bruce, Yanik Greg, Naranjo Arlene, London Wendy B, Kreissman Susan, Baker David, Attiyeh Edward, Hogarty Michael D, Maris John M, Giacomini Kathleen, Matthay Katherine K: Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. International journal of molecular imaging 2012: 250834, 2012.

2011

Wang Kai, Diskin Sharon J, Zhang Haitao, Attiyeh Edward F, Winter Cynthia, Hou Cuiping, Schnepp Robert W, Diamond Maura, Bosse Kristopher, Mayes Patrick A, Glessner Joseph, Kim Cecilia, Frackelton Edward, Garris Maria, Wang Qun, Glaberson Wendy, Chiavacci Rosetta, Nguyen Le, Jagannathan Jayanti, Saeki Norihisa, Sasaki Hiroki, Grant Struan F A, Iolascon Achille, Mosse Yael P, Cole Kristina A, Li Hongzhe, Devoto Marcella, McGrady Patrick W, London Wendy B, Capasso Mario, Rahman Nazneen, Hakonarson Hakon, Maris John M: Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature 469(7329): 216-20, Jan 2011.

Cole Kristina A, Huggins Jonathan, Laquaglia Michael, Hulderman Chase E, Russell Mike R, Bosse Kristopher, Diskin Sharon J, Attiyeh Edward F, Sennett Rachel, Norris Geoffrey, Laudenslager Marci, Wood Andrew C, Mayes Patrick A, Jagannathan Jayanti, Winter Cynthia, Mosse Yael P, Maris John M: RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America 108(8): 3336-41, Feb 2011.

Nguyá»…n Lá»… B, Diskin Sharon J, Capasso Mario, Wang Kai, Diamond Maura A, Glessner Joseph, Kim Cecilia, Attiyeh Edward F, Mosse Yael P, Cole Kristina, Iolascon Achille, Devoto Marcella, Hakonarson Hakon, Li Hongzhe K, Maris John M: Phenotype Restricted Genome-Wide Association Study Using a Gene-Centric Approach Identifies Three Low-Risk Neuroblastoma Susceptibility Loci. PLoS genetics 7(3): e1002026, Mar 2011.

2009

Attiyeh EF, Diskin SJ, Attiyeh MA, Mossé YP, Hou C, Jackson EM, Kim C, Glessner J, Hakonarson H, Biegel JA, and Maris JM: Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy. Genome research 19(2): 276-83, Feb 2009.

Teachey DT, Greiner R, Seif A, Attiyeh EF, Bleesing J, Choi J, Manno C, Rappaport E, Schwabe D, Sheen C, Sullivan KE, Zhuang H, Wechsler DS, and Grupp SA: Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome. British Journal of Haematology 145(1): 101-6, Apr 2009.

Volchenboum SL, Li C, Li S, Attiyeh EF, Reynolds C P, Maris JM, Look AT, and George RE: Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis. Cancer research 69(10): 4143-9, May 2009.

Capasso M, Devoto M, Hou C, Asgharzadeh S, Glessner JT, Attiyeh EF, Mosse YP, Kim C, Diskin SJ, Cole KA, Bosse K, Diamond M, Laudenslager M, Winter C, Bradfield JP, Scott RH, Jagannathan J, Garris M, McConville C, London WB, Seeger RC, Grant SF, Li H, Rahman N, Rappaport E, Hakonarson H, Maris JM: Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nature genetics 41(6): 718-723, Jun 2009.

Diskin SJ, Hou C, Glessner JT, Attiyeh EF, Laudenslager M, Bosse K, Cole K, Mossé YP, Wood A, Lynch JE, Pecor K, Diamond M, Winter C, Wang K, Kim C, Geiger EA, McGrady PW, Blakemore AIF, London WB, Shaikh TH, Bradfield J, Grant SFA, Li H, Devoto M, Rappaport ER, Hakonarson H, and Maris John M: Copy number variation at 1q21.1 associated with neuroblastoma. Nature 459(7249): 987-91, Jun 2009.

Park JR, Villablanca JG, London WB, Gerbing RB, Haas-Kogan D, Adkins ES, Attiyeh EF, Maris JM, Seeger RC, Reynolds CP, Matthay KK: Outcome of high-risk stage 3 neuroblastoma with myeloablative therapy and 13-cis-retinoic acid: A report from the Children's Oncology Group. Pediatr Blood Cancer 52(1): 44-50, 2009.

2008

Cole KA,  Attiyeh EF,  Mosse YP,  Laquaglia MJ,  Diskin SJ,  Brodeur GM,  Maris JM: A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene. Mol Cancer Res 6(5): 735-42, 2008.

Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, Scott RH, Asgharzadeh S, Attiyeh EF, Diskin SJ, Laudenslager M, Winter C, Cole KA, Glessner JT, Kim C, Frackelton EC, Casalunovo T, Eckert AW, Capasso M, Rappaport EF, McConville C, London WB, Seeger RC, Rahman N, Devoto M, Grant SF, Li H, Hakonarson H: Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med 358(24): 2585-93, 2008.

Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, Laureys G, Speleman F, Kim C, Hou C, Hakonarson H, Torkamani A, Schork NJ, Brodeur GM, Tonini GP, Rappaport E, Devoto M, Maris JM: Identification of ALK as a major familial neuroblastoma predisposition gene. Nature 455(7215): 930-5, 2008.

Winter C, Pawel B, Seiser E, Zhao H, Raabe E, Wang Q, Judkins AR, Attiyeh EF, Maris JM: Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation status. Pediatr Blood Cancer 51(1): 10-6, 2008.

2007

George RE*, Attiyeh EF*, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM: Genome-Wide Analysis of Neuroblastomas using High-Density Single Nucleotide Polymorphism Arrays. Public Library of Science ONE 2: e255, Feb 2007 Notes: * These authors contributed equally.

Mosse YP, Diskin SJ, Wasserman N, Rinaldi K, Attiyeh EF, Cole K, Jagannathan J, Bhambhani K, Winter C, Maris JM: Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression. Genes, Chromosomes and Cancer 46(10): 936-49, Oct 2007.

2006

Wang Q, Diskin S, Rappaport E, Attiyeh EF, Mosse Y, Shue D, Seiser E, Jagannathan J, Shusterman S, Bansal M, Khazi D, Winter C, Okawa E, Grant G, Cnaan A, Zhao H, Cheung NK, Gerald W, London W, Matthay KK, Brodeur GM, Maris JM: Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Cancer Research 66(12): 6050-62, Jun 15 2006.

Yan AC, Chamlin SL, Liang MG, Hoffman B, Attiyeh EF, Chang B, and Honig PJ: Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. Pediatric Dermatology 23(4): 330-4, Jul-Aug 2006.

2005

Attiyeh EF, London WB, Mossé YP, Wang Q, Winter C, Khazi D, McGrady PW, Seeger RC, Look AT, Shimada H, Brodeur GM, Cohn SL, Matthay KK, and Maris JM, for the Children's Oncology Group.: Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma. New England Journal of Medicine 353(21): 2243-53, Nov 24 2005.

1998

Epstein CB, Attiyeh EF, Hobson DA, Silver AL, Broach JR, and Levine AJ: p53 Mutations Isolated in Yeast Based on Loss of Transcription Factor Activity: Similarities and Differences from p53 Mutations Detected in Human Tumors. Oncogene 16(16): 2115-22, Apr 23 1998.

Books

Chapters

2008

Attiyeh EF: Ewing Sarcoma. The 5-minute Pediatric Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkins, 2008.

Attiyeh EF: Rhabdomyosarcoma. The 5-minute Pediatric Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkins, 2008.

Attiyeh EF: Neuroblastoma. The 5-Minute Pediatric Consult. M. William Schwartz (eds.). Lippincott Williams & Wilkins, 2008.

Awards and Honors

2008, Advances in Neuroblastoma Research (ANR) Best Paper
2006-2009, ASCO Foundation Career Development Award
2005, ASCO Foundation Brigid Leventhal Merit Award
2005-2007, AACR-Pennsylvania Department of Health Fellowship in Basic Cancer Research
2005-2006, ASCO Foundation Young Investigator Award
2005, ASCO Foundation Fellowship Merit Award
2005-2007, Children's Neuroblastoma Cancer Foundation Award
2004-2008, William Guy Forbeck Research Foundation Scholar

Editorial and Academic Positions

Editorial Positions

2014-Present, Peer-reviewer, British Journal of Cancer
2013-present, Peer-reviewer, European Journal of Medical Genetics
2012-present, Peer-reviewer, Cancer Genetics
2012-present, Peer-reviewer, Cancer Research
2012-present, Peer-reviewer, Clinical Cancer Research
2011-present, Peer-reviewer, New England Journal of Medicine
2011-present, Peer-reviewer, American Journal of Pathology
2010-present, Peer-reviewer, Nucleic Acids Research
2010-present, Peer-reviewer, Briefings in Bioinformatics
2010-present, Peer-reviewer, Journal of Molecular Diagnostics
2009-present, Peer-reviewer, BMC Cancer
2008-present, Peer-reviewer, Journal of Pediatric Hematology/Oncology
2006-present, Peer-reviewer, Pediatric Blood and Cancer

Leadership and Memberships

Memberships in Professional Organizations

2006-present, Children's Oncology Group (COG)
2003-present, American Society of Clinical Oncology (ASCO)
2003-present, American Association for Cancer Research (AACR)
2002-present, American Society of Pediatric Hematology/Oncology (ASPHO)