Fran Balamuth, MD, PhD

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Fran Balamuth, MD, PhD, is an attending physician and the Director of Research in the Emergency Department, Co-Director of the Center for Sepsis Excellence, and a faculty member in the Center for Pediatric Clinical Effectiveness at Children’s Hospital of Philadelphia.

Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Fran Balamuth MD, PhD, MSCE is Associate Professor of Pediatrics at the University of Pennsylvania, and an attending physician in the emergency department at the Children’s Hospital of Philadelphia. Dr. Balamuth’s research interests focus on pediatric sepsis recognition using both epidemiologic and translational approaches, for which she has received both NIH and foundational funding. She is the co-PI of the PROMPT BOLUS trial, a multinational pragmatic trial which compares saline vs balanced fluids in pediatric sepsis, and will be the largest acute care pediatric trial in history. In addition, she co-leads the CHOP Pediatric Sepsis Program, which supports and promotes local clinical, research, educational, and quality improvement initiatives around sepsis. She is an internationally recognized sepsis leader, and has been invited to serve on the national steering committee for the Improving Pediatric Sepsis Outcomes quality collaborative through the US Children’s Hospital Association, and 2 international task forces focused on defining pediatric sepsis through the US Centers for Disease Control and Prevention and the Society of Critical Care Medicine.

Education and Training

Medical School

MD - Yale University School of Medicine, New Haven, CT

Residency

Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Postdoctoral Fellow - Yale University School of Medicine, New Haven, CT
Pediatric Emergency Medicine - Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Emergency Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

PhD in Immunobiology - Yale University School of Medicine, New Haven, CT
MSCE - University of Pennsylvania School of Medicine, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Director of Research, Division of Emergency Medicine

Co-Director, Pediatric Sepsis Program

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2022

Yehya N, Fitzgerald JC, Hayes K, et al. Temperature Trajectory Sub-phenotypes and the Immuno-Inflammatory Response in Pediatric Sepsis. Shock 2022;57:645-51.

Grant DS, Neville DN, Levas M, et al. Validation of Septic Knee Monoarthritis Prediction Rule in a Lyme Disease Endemic Area. Pediatr Emerg Care 2022;38:e881-e5.

Chiotos K, Fitzgerald JC, Hayes M, et al. Improving Vancomycin Stewardship in Critically Ill Children. Pediatrics 2022.

Balamuth F, Scott HF, Weiss SL, et al. Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Third International Consensus Definitions for Sepsis and Septic Shock Definitions in the Pediatric Emergency Department. JAMA Pediatr 2022.

Periasamy U, Chilutti M, Kaplan SL, Hickey CP, Hayes K, Pennington JW, Balamuth F, Fitzgerald JC, Weiss SL.: Prevalence of and Associations With Avascular Necrosis After Pediatric Sepsis: A Single-Center Retrospective Study. Pediatr Crit Care Med Jan 2022.

2021

Yehya N, Fitzgerald JC, Hayes K, Zhang D, Bush J, Koterba N, Chen F, Tuluc F, Teachey DT, Balamuth F, Lacey SF, Melenhorst JJ, Weiss SL.: Temperature Trajectory Sub-Phenotypes and The Immuno-Inflammatory Response In Pediatric Sepsis. Shock Dec 2021.

Fisher BT, Sharova A, Boge CLK, Gouma S, Kamrin A, Blumenstock J, Shuster S, Gianchetti L, Collins D, Akaho E, Weirick ME, McAllister CM, Bolton MJ, Arevalo CP, Goodwin EC, Anderson EM, Christensen SR, Balamuth F, John ARO, Li Y, Coffin S, Gerber JS, Hensley SE.: Evolution of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence among employees of a US academic children's hospital during coronavirus disease 2019 (COVID-19) pandemic. Infect Control Hosp Epidemiol Dec 2021.

Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrel A, Lambert MP, Sullivan KE, Wherry EJ, Teachey DT, Bassiri H, Behrens EM.: Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nat Commun 12: 7222, Dec 2021.

Weiss SL, Balamuth F, Long E, Thompson GC, Hayes KL, Katcoff H, Cook M, Tsemberis E, Hickey CP, Williams A, Williamson-Urquhart S, Borland ML, Dalziel SR, Gelbart B, Freedman SB, Babl FE, Huang J, Kuppermann N; Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Investigators of the PECARN, PERC, and PREDICT Networks.: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial. Trials 22: 776, Nov 2021.

Sundheim KM, Levas MN, Balamuth F, Thompson AD, Neville DN, Garro AC, Kharbanda AB, Monuteaux MC, Nigrovic LE.: Seasonality of Acute Lyme Disease in Children. Trop Med Infect Dis 6: 196, Nov 2021.

Toto RL, Vorel ES, Tay KE, Good GL, Berdinka JM, Peled A, Leary M, Chang TP, Weiss AK, Balamuth FB.: Augmented Reality in Pediatric Septic Shock Simulation: Randomized Controlled Feasibility Trial. JMIR Med Educ 7: e29899, Oct 2021.

Lantos PM, Balamuth F, Neville D, Garro AC, Levas MN, Bennett J, Thompson AD, Kharbanda AB, Branda JA, Nigrovic LE.: Two-Tier Lyme Disease Serology in Children with Previous Lyme Disease. Vector Borne Zoonotic Dis Oct 2021.

Cruz AT, Nigrovic LE, Xie J, Mahajan P, Thomson JE, Okada PJ, Uspal NG, Mistry RD, Garro A, Schnadower D, Kulik DM, Curtis SJ, Miller AS, Fleming AH, Lyons TW, Balamuth F, Arms JL, Louie J, Aronson PL, Thompson AD, Ishimine PT, Schmidt SM, Pruitt CM, Shah SS, Grether-Jones KL, Bradin SA, Freedman SB.: Predictors of Invasive Herpes Simplex Virus Infection in Young Infants. Pediatrics September 2021.

Neville DN, Alexander ME, Bennett JE, Balamuth F, Garro A, Levas MN, Thompson AD, Kharbanda AB, Lewander DP, Dart AH, Nigrovic LE; Pedi Lyme Net.: Electrocardiogram as a Lyme Disease Screening Test. J Pediatr Jul 2021.

Fitzgerald JC, Kelly NA, Hickey C, Balamuth F, Thomas NH, Hogan A, Stack NJ, Trimarchi T, Weiss SL.: Implementation of a Follow-Up System for Pediatric Sepsis Survivors in a Large Academic Pediatric Intensive Care Unit. Front Pediatr 9: 691692, Jun 2021.

Paul R, Niedner M, Brilli R, Macias C, Riggs R, Balamuth F, Depinet H, Larsen G, Huskins C, Scott H, Lucasiewicz G, Schaffer M, DeSouza HG, Silver P, Richardson T, Hueschen L, Campbell D, Wathen B, Auletta JJ; IPSO COLLABORATIVE INVESTIGATORS.: Metric Development for the Multicenter Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Pediatrics May 2021.

Grant DS, Neville DN, Levas M, Balamuth F, Garro AC, Bennett JE, Thompson AD, Kharbanda AB, Lyons TW, Nigrovic LE; for Pedi Lyme Net.: Validation of Septic Knee Monoarthritis Prediction Rule in a Lyme Disease Endemic Area. Pediatr Emerg Care May 2021.

Garro A, Avery RA, Cohn KA, Neville DN, Balamuth F, Levas MN, Bennett JE, Kharbanda AB, Monuteaux MC, Nigrovic LE; for Pedi Lyme Net.: Validation of the Rule of 7's for Identifying Children at Low-risk for Lyme Meningitis. Pediatr Infect Dis J 40: 306-309, Apr 2021.

Diorio C, Shraim R, Vella LA, Giles JR, Baxter AE, Oldridge DA, Canna SW, Henrickson SE, McNerney KO, Balamuth F, Burudpakdee C, Lee J, Leng T, Farrell A, Lambert MP, Sullivan KE, John Wherry E, Teachey DT, Bassiri H, Behrens EM.: Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction. medRxiv Apr 2021.

Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG.: Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function. Crit Care Explor 3: e0360, Mar 2021.

Larsen GY, Brilli R, Macias CG, Niedner M, Auletta JJ, Balamuth F, Campbell D, Depinet H, Frizzola M, Hueschen L, Lowerre T, Mack E, Paul R, Razzaqi F, Schafer M, Scott HF, Silver P, Wathen B, Lukasiewicz G, Stuart J, Riggs R, Richardson T, Ward L, Huskins WC; IMPROVING PEDIATRIC SEPSIS OUTCOMES COLLABORATIVE INVESTIGATORS.: Development of a Quality Improvement Learning Collaborative to Improve Pediatric Sepsis Outcomes. Pediatrics 147: e20201434, Jan 2021.

Wang ME, Neuman MI, Nigrovic LE, Pruitt CM, Desai S, DePorre AG, Sartori LF, Marble RD, Woll C, Leazer RC, Balamuth F, Rooholamini SN, Aronson PL; FEBRILE YOUNG INFANT RESEARCH COLLABORATIVE.: Characteristics of Afebrile Infants u880460 Days of Age With Invasive Bacterial Infections. Hosp Pediatr 11: 100-105, Jan 2021.

Lin CY, Xie J, Freedman SB, McKee R, Schnadower D, Tarr PI, Finkelstein Y, Desai NM, Lane RD, Bergmann KR, Kaplan RL, Hariharan S, Cruz AT, Cohen DM, Dixon A, Ramgopal S, Powell EC, Kilgar J, Michelson KA, Bitzan M, Yen K, Meckler GD, Plint AC, Balamuth F, Bradin S, Gouin S, Kam AJ, Meltzer J, Hunley TE, Avva U, Porter R, Fein DM, Louie JP, Tarr GAM; Pediatric Emergency Research Canada (PERC) and Pediatric Emergency Medicine Collaborative Research Committee (PEMCRC) STEC Study Group.: Predicting Adverse Outcomes for Shiga Toxin-Producing E. coli Infections in Emergency Departments. J Pediatr  Pediatr, May 2021.

2020

Fran Balamuth MD, PhD, Elizabeth R. Alpern MD MSCE, Mengyuan Kan PhD, Maya Shumyatcher BA, Katie Hayes BS2, Ebbing Lautenbach MD, MSCE, and Blanca E. Himes, PhD: Gene Expression Profiles in Children with Suspected Sepsis. Annals of Emergency Medicine  Page: doi: 10.1016, Jan 2020 Notes: epub ahead of print.

Nigrovic Lise E, Bennett Jonathan E, Balamuth Fran, Levas Michael N, Neville Desiree, Lyons Todd W, Branda John A, Maulden Alexandra B, Lewander David, Garro Aris: Diagnostic Performance of C6 Enzyme Immunoassay for Lyme Arthritis. Pediatrics 145(1): e20190593, Jan 2020.

Downes Kevin J, Fitzgerald Julie C, Schriver Emily, Boge Craig L K, Russo Michael E, Weiss Scott L, Balamuth Fran, Kubis Sherri E, Tolomeo Pam, Bilker Warren B, Han Jennifer H, Lautenbach Ebbing, Coffin Susan E, Gerber Jeffrey S: Implementation of a Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study. Journal of the Pediatric Infectious Diseases Society 9(1): 36-43, Feb 2020.

Sarah Fesnak, MD, Mary Kate Abbadessa MSN, RN, CPEN, Katie Hayes , Svetlana Ostapenko, MS.Jane Lavelle, MD, Joseph J. Zorc, MD, MSCE, Fran Balamuth, MD, PhD: Sepsis in complex patients in the Emergency Department: Time to recognition and therapy in pediatric patients with high-risk conditions Pediatric Emergency Care 36(2): 63-65, Feb 2020.

Weiss SL, Balamuth F, Chilutti M, Ramos MJ, McBride P, Kelly NA, Payton KJ, Fitzgerald JC, Pennington JW.: Identification of Pediatric Sepsis for Epidemiologic Surveillance Using Electronic Clinical Data. Pediatric Critical Care Medicine 21(2): 113-121, February 2020.

Lyons TW, Garro AC, Cruz AT, Freedman SB, Okada PJ, Mahajan P, Balamuth F, Thompson AD, Kulik DM, Uspal NG, Arms JL, Nigrovic LE; HERPES SIMPLEX VIRUS STUDY GROUP OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE (PEM CRC).: Performance of the Modified Boston and Philadelphia Criteria for Invasive Bacterial Infections. Pediatrics 145(4): 3538, April 2020.

Maulden Alexandra B, Garro Aris C, Balamuth Fran, Levas Michael N, Bennett Jonathan E, Neville Desiree N, Branda John A, Nigrovic Lise E: Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. Journal of the Pediatric Infectious Diseases Society 9(2): 128-133, Apr 2020.

McKee Ryan S, Schnadower David, Tarr Phillip I, Xie Jianling, Finkelstein Yaron, Desai Neil, Lane Roni D, Bergmann Kelly R, Kaplan Ron L, Hariharan Selena, Cruz Andrea T, Cohen Daniel M, Dixon Andrew, Ramgopal Sriram, Rominger Annie, Powell Elizabeth C, Kilgar Jennifer, Michelson Kenneth A, Beer Darcy, Bitzan Martin, Pruitt Christopher M, Yen Kenneth, Meckler Garth D, Plint Amy C, Bradin Stuart, Abramo Thomas J, Gouin Serge, Kam April J, Schuh Abigail, Balamuth Fran, Hunley Tracy E, Kanegaye John T, Jones Nicholas E, Avva Usha, Porter Robert, Fein Daniel M, Louie Jeffrey P, Freedman Stephen B: Predicting Hemolytic Uremic Syndrome and Renal Failure in Shiga Toxin-Producing Escherichia coli Infected Children. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 70(8): 1643-1651, Apr 2020.

Nigrovic Lise E, Lewander David P, Balamuth Fran, Neville Desiree N, Levas Michael N, Bennett Jonathan E, Garro Aris: The Lyme Disease Polymerase Chain Reaction Test Has Low Sensitivity. Vector borne and zoonotic diseases (Larchmont, N.Y.) 20(4): 310-313, Apr 2020.

Chaiyachati BH, Agawu A, Zorc JJ, Balamuth F.: Trends in Pediatric Emergency Department Utilization after Institution of COVID-19 Mandatory Social Distancing. Journal of Pediatrics online ahead of print, July 2020.

Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase JM, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell B, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, Odom John AR, Lambert MP, Liebling EJ, Paessler M, Petrosa W, Phillips CA, Reilly AF, Romberg N, Seif AE, Sesok-Pizzini D, Sullivan K, Vardaro J, Behrens EM, Teachey DT, Bassiri H.: Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. Journal of Clinical Investigation Page: doi: 10.1172, July 2020 Notes: epub ahead of print.

Ellie Souganidis, Mary Kate Abbadessa, Brandon Ku, Christian Minich, Jane Lavelle, Joseph Zorc, Fran Balamuth: Analysis of Missed Sepsis Patients in a Pediatric Emergency Department With a Vital Sign-Based Electronic Sepsis Alert. Pediatric Emergency Care Page: doi: 10.1097, July  2020 Notes: epub ahead of print.

Julie C Fitzgerald, Michelle E Ross, Neal J Thomas, Scott L Weiss, Fran Balamuth, Marianne Chilutti, Robert W Grundmeier, Amanda Hyre Anderson : Association of early hypotension in pediatric sepsis with development of new or persistent acute kidney injury. Pediatric Nephrology online ahead of print, July  2020.

Cruz AT, Lane RD, Balamuth F, Aronson PL, Ashby DW, Neuman MI, Souganidis ES, Alpern ER, Schlapbach LJ.: Updates on pediatric sepsis. J Am Coll Emerg Physicians Open 1: 981-993, Jul 2020.

Kenneth A Michelson, Mark I Neuman, Christopher M Pruitt, Sanyukta Desai, Marie E Wang, Adrienne G DePorre, Rianna C Leazer, Laura F Sartori, Richard D Marble, Sahar N Rooholamini, Christopher Woll, Fran Balamuth, Paul L Aronson, Febrile Young Infant Research Collaborative: Height of fever and invasive bacterial infection. Arch. Dis. Child Page: doi: 10.1136, August 2020 Notes: epub ahead of print.

Daniel J Corwin, Laura F Sartori, Kathleen Chiotos, Audrey R Odom John, Keri Cohn, Hamid Bassiri, Edward M Behrens, David T Teachey, Sarah E Henrickson, Caroline J Diorio, Joseph J Zorc, Fran Balamuth : Distinguishing Multisystem Inflammatory Syndrome in Children From Kawasaki Disease and Benign Inflammatory Illnesses in the SARS-CoV-2 Pandemic. Pediatric Emergency Care 36: doi: 10.1097, September 2020 Notes: epub ahead of print.

Halden F Scott, Richard J Brilli, Raina Paul, Charles G Macias, Matthew Niedner, Holly Depinet, Troy Richardson, Ruth Riggs, Heidi Gruhler, Gitte Y Larsen, W Charles Huskins, Fran Balamuth, Improving Pediatric Sepsis Outcomes (IPSO) Collaborative Investigators.: Evaluating Pediatric Sepsis Definitions Designed for Electronic Health Record Extraction and Multicenter Quality Improvement. Critical Care Medicine 48(10): e916-e926, October 2020.

Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT.: Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations. Blood Adv 4: 6051-6063, Dec 2020.

Nigrovic LE, Neville DN, Balamuth F, Levas MN, Bennett JE, Kharbanda AB, Thompson AD, Branda JA, Garro AC; Pedi Lyme Net Working Group.: Pediatric Lyme Disease Biobank, United States, 2015-2020. Emerg Infect Dis 26: 3099-3101, Dec 2020.

P Gala, R Scarfone, A Murray, and F Balamuth: Eliminating lumbar puncture for low-risk febrile infants: A quality improvement initiative. Pediatric Emergency Care in press 2020.

Yankova LC, Neuman MI, Wang ME, Woll C, DePorre AG, Desai S, Sartori LF, Nigrovic LE, Pruitt CM, Marble RD, Leazer RC, Rooholamini SN, Balamuth F, Aronson PL.: Febrile Infants u880460 Days Old With Positive Urinalysis Results and Invasive Bacterial Infections. Hosp Pediatr 10: 1120-1125, Dec 2020.

2019

Maulden Alexandra B, Garro Aris C, Balamuth Fran, Levas Michael N, Bennett Jonathan E, Neville Desiree N, Branda John A, Nigrovic Lise E: Two-Tier Lyme Disease Serology Test Results Can Vary According to the Specific First-Tier Test Used. Journal of the Pediatric Infectious Diseases Society Feb 2019.

Masino Aaron J, Harris Mary Catherine, Forsyth Daniel, Ostapenko Svetlana, Srinivasan Lakshmi, Bonafide Christopher P, Balamuth Fran, Schmatz Melissa, Grundmeier Robert W: Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data. PloS one 14(2): e0212665, February 2019.

Lindell Robert B, Nishisaki Akira, Weiss Scott L, Balamuth Fran, Traynor Danielle M, Chilutti Marianne R, Grundmeier Robert W, Fitzgerald Julie C: Comparison of Methods for Identification of Pediatric Severe Sepsis and Septic Shock in the Virtual Pediatric Systems Database. Critical care medicine 47(2): e129-e135, Feb 2019. PMCID: PMC6336511

Pruitt Christopher M, Neuman Mark I, Shah Samir S, Shabanova Veronika, Balamuth Fran, et al. Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections. The Journal of pediatrics 204: 177-182.e1, Jan 2019. PMCID: PMC6309646

Nigrovic LE, Neville DN, Balamuth F, Bennett JE, Levas MN, Garro AC: A minority of children diagnosed with Lyme disease recall a preceding tick bite.  Ticks and Tick-Borne Diseases 10(3): 694-696, April 2019.

Weiss SL, Balamuth F, Thurm CW, Downes K, Fitzgerald JC, Laskin BL : Major Adverse Kidney Events in Pediatric Sepsis. Clinical Journal of American Society of Nephrology 14(5): 664-672, April 2019.

Aronson Paul L, Cruz Andrea T, Freedman Stephen B, Balamuth Fran, Grether-Jones Kendra L, Lyons Todd W, Fleming Alesia H, Louie Jeffrey, Mistry Rakesh D, Garro Aris C, Shah Samir S, Nigrovic Lise E: Association of Herpes Simplex Virus Testing with Hospital Length of Stay for Infants u880460 Days of Age Undergoing Evaluation for Meningitis. Journal of hospital medicine 14(1): E1-E4, May 2019.

Nigrovic Lise E, Lipsett Susan C, Molins Claudia R, Wormser Gary P, Bennett Jonathan E, Garro Aris C, Levas Michael N, Balamuth Fran, Neville Desiree, Lingampalli Nithya, Robinson William H, Branda John A: Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. Diagnostic microbiology and infectious disease 94(2): 160-164, Jun 2019.

Aronson Paul L, Shabanova Veronika, Shapiro Eugene D, Wang Marie E, Nigrovic Lise E, Pruitt Christopher M, DePorre Adrienne G, Leazer Rianna C, Desai Sanyukta, Sartori Laura F, Marble Richard D, Rooholamini Sahar N, McCulloh Russell J, Woll Christopher, Balamuth Fran, Alpern Elizabeth R, Shah Samir S, Williams Derek J, Browning Whitney L, Shah Nipam, Neuman Mark I: A Prediction Model to Identify Febrile Infants u880460 Days at Low Risk of Invasive Bacterial Infection. Pediatrics 144(1): e20183604, Jul 2019.

Desai Sanyukta, Aronson Paul L, Shabanova Veronika, Neuman Mark I, Balamuth Frances, Pruitt Christopher M, DePorre Adrienne G, Nigrovic Lise E, Rooholamini Sahar N, Wang Marie E, Marble Richard D, Williams Derek J, Sartori Laura, Leazer Rianna C, Mitchell Christine, Shah Samir S: Parenteral Antibiotic Therapy Duration in Young Infants With Bacteremic Urinary Tract Infections. Pediatrics 144(3): e20183844, September 2019.

Raman Jenny, Johnson Tiffani J, Hayes Katie, Balamuth Fran: Racial Differences in Sepsis Recognition in the Emergency Department. Pediatrics 144(4): e20190348, Oct 2019.

Balamuth, Fran; Kittick, Marlena; McBride, Peter; Woodford, Ashley; Vestal, Nicole; Casper, Charlie; Metheney, Melissa; Smith, Katherine; Atkin, Natalie; Baren, Jill; Dean, J. Michael; Kuppermann, Nathan; Weiss, Scott: PRagMatic Pediatric Trial of Balanced versus nOrmaL Saline FLUid in Sepsis: the PRoMPT BOLUS Pilot Feasibility Study. Academic Emergency Medicine 26(12): 1346-1356, Dec 2019.

2018

P Gala, R Scarfone, A Murray, and F Balamuth: Eliminating lumbar puncture for low-risk febrile infants: A quality improvement initiative. Pediatric Emergency Care in press 2018.

Nigrovic Lise E, Lipsett Susan C, Molins Claudia R, Wormser Gary P, Bennett Jonathan E, Garro Aris C, Levas Michael N, Balamuth Fran, Neville Desiree, Lingampalli Nithya, Robinson William H, Branda John A: Higher C6 enzyme immunoassay index values correlate with a diagnosis of noncutaneous Lyme disease. Diagnostic microbiology and infectious disease Dec 2018.

Aronson Paul L, Wang Marie E, Shapiro Eugene D, Shah Samir S, DePorre Adrienne G, Balamuth Fran, et al. Risk Stratification of Febrile Infants u880460 Days Old Without Routine Lumbar Puncture. Pediatrics 142(6), Dec 2018. PMCID: PMC6317769

Fran Balamuth M.D. Ph.D. MSCE,1 Andrea T. Cruz M.D. M.P.H.,2 Stephen B. Freedman M.D. M.P.H.,3 Paul T. Ishimine M.D., et al.12 for the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC) HSV Study Group.  : Test Characteristics of cerebrospinal fluid Gram stain to identify bacterial meningitis in infants less than 60 days old. Pediatric Emergency Care 204: 177-182, November 2018.

Downes Kevin J, Fitzgerald Julie C, Schriver Emily, Boge Craig L K, Russo Michael E, Weiss Scott L, Balamuth Fran, Kubis Sherri E, Tolomeo Pam, Bilker Warren B, Han Jennifer H, Lautenbach Ebbing, Coffin Susan E, Gerber Jeffrey S: Implementation of a Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) II Study. Journal of the Pediatric Infectious Diseases Society Nov 2018.

Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin SS, Aronson PL for the Febrile Young Infant Research Collaborative: Factors associated with adverse outcomes among febrile young infants with invasive bacterial infections. Journal of Pediatrics 204:177-182.e1.: doi: 10.1016, October 2018.

Julie C. Fitzgerald, MD, PhD; Michelle E. Ross, PhD; Neal J. Thomas, MD, MSc; Scott L. Weiss, MD MSCE, Fran Balamuth, MD, PhD, MSCE and Amanda Hyre Anderson, PhD: Risk Factors and Inpatient Outcomes Associated with Acute Kidney Injury at Pediatric Severe Sepsis Presentation Pediatric Nephrology 4(7): doi: 10.1126, October 2018.

Christopher Wall, Mark Neuman, Christopher Pruitt, Marie Wang, Eugene Shapiro, Samir Shah, Russell McCulloh, Lise Nigrovic, Sanyukta Desai, Adrienne DePorre, Rianna Leazer, Richard Marble, Frances Balamuth, Elana Feldman, Laura Sartori, Whitney Browning, Paul Aronson: Epidemiology and Etiology of Invasive Bacterial Infection in Infants u880460 Days Old Treated in Emergency Departments. Journal of Pediatrics 200(2): 210-217, September 2018.

Garro A, Bennett J, Balamuth F, Levas MN, Neville D, Branda JC, Maulden AB, Lantos PM, Nigrovic LE for the Pedi Lyme Net. : Positive Two-tiered Lyme Disease Serology is Uncommon in Asymptomatic Children Living in Endemic Areas of the U.S. Pediatric Infectious Disease Journal Page: doi: 10.1097, July 2018 Notes: epub ahead of print.

Carrie Daymont, Fran Balamuth, Halden Scott, Patrick Brady, Chris Bonafide, Holly Depinet, and Elizabeth Alpern: Elevated heart rate and risk of revisit with admission in pediatric emergency patients. Pediatric Emergency Care Page: e-pub ahead of print, July 2018.

Aronson PL, Wang ME, Nigrovic LE, Shah SS, Desai S, Pruitt CM, Balamuth F, Sartori L, Marble RD, Rooholamini SN, Leazer RC, Woll C, DePorre AG, Neuman MI; for the Febrile Young Infant Research Collaborative. : Time to pathogen detection for non-ill vs. ill-appearing infants u880460 days old with bacteremia and meningitis. Hospital Pediatrics 8(7): 379-384, July 2018.

Nelson CE, Ostapenko S, Zorc JJ, Balamuth F.: Utilization of Antipyretics for Nonurgent Fever in a Pediatric Emergency Department. Clinical Pediatrics 57(6): 722-726, June 2018.

Nelson CE, Chen A, McAndrew L, Tay KY, Balamuth F.: Management of Skin and Soft-Tissue Infections Before and After Clinical Pathway Implementation. Clinical Pediatrics 57(6): 660-666, June 2018.

Signoff Jessica K, Fitzgerald Julie C, Teachey David T, Balamuth Fran, Weiss Scott L: Hypofibrinogenemia Is Associated With Poor Outcome and Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome in Pediatric Severe Sepsis. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 19(5): 397-405, May 2018.

Thomson Joanna, Sucharew Heidi, Cruz Andrea T, Nigrovic Lise E, Freedman Stephen B, Garro Aris C, Balamuth Fran, Mistry Rakesh D, Arms Joseph L, Ishimine Paul T, Kulik Dina M, Neuman Mark I, Shah Samir S: Cerebrospinal Fluid Reference Values for Young Infants Undergoing Lumbar Puncture. Pediatrics Page:  doi: 10.1542, February 2018 Notes: epub ahead of print.

Aronson Paul L, McCulloh Russell J, Tieder Joel S, Nigrovic Lise E, Leazer Rianna C, Alpern Elizabeth R, Feldman Elana A, Balamuth Fran, Browning Whitney L, Neuman Mark I: Application of the Rochester Criteria to Identify Febrile Infants With Bacteremia and Meningitis. Pediatric emergency care Page: doi: 10.1097, February 2018 Notes: epub ahead of print.

Andrea T. Cruz, MD, MPH, Stephen B. Freedman, MDCM, MSc, Dina M. Kulik, MD, Pamela J. Okada, MD, Alesia H. Fleming, MD, MPH, Fran Balamuth, MD, PhD, et al. Herpes Simplex Virus Infection in Infants u8804 60-days-old Undergoing Evaluation for Meningitis. Pediatrics 141(2): 1688, February 2018.

2017

Sarah Fesnak, MD, Mary Kate Abbadessa MSN, RN, CPEN, Katie Hayes , Svetlana Ostapenko, MS.Jane Lavelle, MD, Joseph J. Zorc, MD, MSCE, Fran Balamuth, MD, PhD: Sepsis in complex patients in the Emergency Department: Time to recognition and therapy in pediatric patients with high-risk conditions Pediatric Emergency Care in press 2017.

Nigrovic, Lise; Bennett, Jonathan; Balamuth, Fran; Levas, Michael; Chenard, Rachel; Maulden, Alexandra; Garro, Aris: Accuracy of Clinician Suspicion of Lyme Disease in the Emergency Department. Pediatrics 140(6): 1975, December 2017

Thomson J1, Cruz AT, Nigrovic LE, Freedman SB, Garro AC, Ishimine PT, Kulik DM, Uspal NG, Grether-Jones KL, Miller AS, Schnadower D, Shah SS, Aronson PL, Balamuth F; Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC) HSV Study Group.: Concomitant Bacterial Meningitis in Infants With Urinary Tract Infection. Pediatric Infectious Disease Journal 36(9): 908-910, September 2017.

Richard Scarfone MD, Ashlee Murray MD, Payal Gala, MD, Fran Balamuth MD, PhD, MSCE: Lumbar Puncture for all Febrile Infants 29-56 days old: A Retrospective Cohort Reassessment  Journal of Pediatrics 187: 200-205, August 2017.

Moonjoo Han, MD, Julie C. Fitzgerald, MD, PhD, Fran Balamuth, MD, PhD, MSCE Luke Keele, PhD, Elizabeth R. Alpern, MD, MSCE, Jane Lavelle, MD, Marianne Chilutti, MS, Robert W. Grundmeier, MD, Vinay M. Nadkarni, MD, MS, Neal J. Thomas, MD, MSc, Scott L. Weiss, MD, MSCE: Association of Delayed Antimicrobial Therapy with One-year Mortality in Pediatric Sepsis. Shock 48(1): 29-35, July 2017.

Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid fluid choice and clinical outcomes in pediatric sepsis: a match retrospective cohort study. Journal of Pediatrics 2017;182:304-310.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Journal of the Pediatric Infectious Diseases Society 2017;6:134-141.

Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL.  Association of delayed antimicrobial therapy with one-year mortality in pediatric sepsis. Shock. 2017 Jul;48(1):29-35. doi: 10.1097/SHK.0000000000000833.

Balamuth F, Alpern ER, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Zorc JJ. Improving recognition of pediatric severe sepsis in the emergency department: contributions of a vital sign based electronic alert and bedside clinician identification. Annals of Emergency Medicine Annals of Emerg Med. 2017 (17)30315-3.

Scott L. Weiss, MD, MSCE,1 Fran Balamuth, MD, PhD, MSCE2, Josey Hensley, RN3Julie C. Fitzgerald, MD, PhD,1 Jenny Bush, RNC,1 Vinay M. Nadkarni, MD, MS,1Neal J. Thomas, MD, MSc4, Mark Hall, MD,3 Jennifer Muszynski, MD3: The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children with Sepsis Die. Pediatric Critical Care Medicine Page: epub ahead of print, May 2017.

Todd W. Lyons MD, Andrea T. Cruz MD, MPH, Stephen B. Freedman MDCM, MSc, Mark I. Neuman MD, MPH, Fran Balamuth MD, PhD, Rakesh Mistry MD MS, et al. Interpretation of cerebrospinal fluid white blood cell counts in young infants with a traumatic lumbar puncture. Ann Emerg Med. 2017 May;69(5):622-631. doi: 10.1016/j.annemergmed.2016.10.008. Epub 2016 Dec 29.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Balamuth F, et al. American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock. Critical Care Medicine 45(6): 1061-1093, June 2017.

Feldman EA, McCulloh RJ, Myers AL, Aronson PL, Neuman MI, Bradford MC, Alpern ER, Balamuth F, Blackstone MM, Browning W, Hayes K, Korman R, Leazer R, Nigrovic LE, Marble R, Roben E, Williams D, Tieder JS.: Empiric antibiotic use and susceptibility in infants with bacterial infections: a multi center retrospective cohort study. Hospital Pediatrics July 2017.

2016

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infect Control Hosp Epidemiol 2016;37(4):483-5.

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Centkowski S, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis. Pediatric Critical Care Medicine 2016; 17(9):817-822.

Richard Scarfone MD, Ashlee Murray MD, Payal Gala, MD, Fran Balamuth MD, PhD, MSCE: Lumbar Puncture for all Febrile Infants 29-56 days old: A Retrospective Cohort Reassessment Journal of Pediatrics. J Pediatr. 2017 Aug;187:200-205.e1. doi: 10.1016/j.jpeds.2017.04.003. Epub 2017 May 16.

2015

Balamuth F, Zhang Z, Rappaport E, Hayes K, Mollen C, Sullivan KE. RNA Biosignatures in Adolescent Patients in a Pediatric Emergency Department With Pelvic Inflammatory Disease. Pediatr Emerg Care. 2015 Jul;31(7):465-72.

Aronson PL, Thurm C, Williams DJ, Nigrovic LE, Alpern ER, Tieder JS, Shah SS, McCulloh RJ, Balamuth F, Schondelmeyer AC, Alessandrini EA, Browning WL, Myers AL, Neuman MI. Febrile Young Infant Research Collaborative. Association of clinical practice guidelines with emergency department management of febrile infants ≤56 days of age. J Hosp Med. 2015 Jun;10(6):358-65.

Balamuth F, Alpern ER, Weiss SL, Grundmeier R, Chilutti M, Fitzgerald JC, Hayes K, Bilker W, Lautenbach E. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department. Academic Emergency Medicine 2015;22(11):1298-306.

Balamuth F, Weiss SL, Hall M, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Centkowski S, Baumer S, Weiser J, Hayes K, Shah SS, Alpern ER.  Identifying pediatric severe sepsis and septic shock:  accuracy of diagnosis codes. Journal of Pediatrics 2015;167(6):1295-1300.

2014

Balamuth F, Weiss SL, Neuman MI, Scott H, Brady PW, Paul R, Farris RW, McClead R, Hayes K, Gaieski D, Hall M, Shah SS, Alpern ER. Pediatric severe sepsis in U.S. children's hospitals. Pediatr Crit Care Med. 2014 Nov;15(9):798-805.

Weiss SL, Fitzgerald JC, Balamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Nadkarni VM, Thomas NJ. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med. 2014 Nov;42(11):2409-17.

Balamuth F, Weiss SL, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Hayes K, Gaieski D, Hall M, Shah SS, Alpern ER. Pediatric Severe Sepsis in US Children's Hospitals. Pediatric Critical Care Medicine. 2014;15(9):798-805.

2013

Mistry RD, Wedin T, Balamuth F, McGowan KL, Ellison AM, Nelson KA, McLoughlin RJ, Alpern ER. Emergency department epidemiology of pneumococcal bacteremia in children since the institution of widespread PCV7 vaccination. J Emerg Med. 2013 Dec;45(6):813-20.

2010

Balamuth F, Zhao H, Mollen C.: Toward improving the diagnosis and the treatment of adolescent pelvic inflammatory disease in emergency departments: results of a brief, educational intervention. Pediatric emergency care 26(2): 85-92, Feb 2010.

2007

Jackman RP, Balamuth F, Bottomly K.: CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets. Journal of immunology (Baltimore, Md. : 1950) 178(9): 5543-51, May 2007.

2004

Balamuth F, Brogdon JL, Bottomly K: CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. Journal of immunology (Baltimore, Md. : 1950) 172(10): 5887-92, May 2004.

2001

Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K: Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity 15(5): 729-38, Nov 2001.

1994

Sato AI, Balamuth FB, Ugen KE, Williams WV, Weiner DB: Identification of CD7 glycoprotein as an accessory molecule in HIV-1-mediated syncytium formation and cellfree infection. Journal of immunology (Baltimore, Md. : 1950) 152(10): 5142-52, May 1994.

Books

Chapters

2017

Anna Weiss and Fran Balamuth: Triage of the Acutely Ill Child. Nelson's Textbook of Pediatrics, 21st Edition. Robert C. Tasker (eds.). ELSEVIER, in press 2017.

2016

Balamuth F, Alpern ER.: Protocol-based, septic-shock care may reduce acute kidney injury. Journal of Pediatrics 172: 224-227, May 2016.

Balamuth F, Fitzgerald J, and Weiss S: Shock. Textbook of Pediatric Emergency Medicine. Fleischer and Ludwig (eds.). Lippincott, Williams, and Wilkins, Page: 55-68, 2016.

Fran Balamuth, Fred Henretig, and Elizabeth Alpern: Fever. Textbook of Pediatric Emergency Medicine. Fleischer and Ludwig (eds.). Lippincott, Williams, and Wilkins, Page: 176-186, 2016.

2013

Balamuth F and Alpern ER: Fever. Schwartz's Clinical Handbook of Pediatric, 5th Edition. Elizabeth R. Alpern (eds.). Lippincott Williams & Wilkins, 2013.

Balamuth F, Henretic F, and Nadel F: Caustic Ingestions. Step Up to Pediatrics. Shah S, Averson B, and Ronan J (eds.). Lippincott Williams and Wilkins, Page: 494- 495, 2013.

Balamuth F, Henretig F, and Nadel F: Lead Poisoning. Step Up to Pediatrics. Shah S, Averson B, Ronan J (eds.). Lippincott Williams and Wilkins, 2013.

Balamuth F, Henretig F, and Nadel F: Acetaminophen Poisoning. Step Up to Pediatrics. Shah S., Averson B, and Ronan J (eds.). Lippincott Williams and Wilkins, 2013.

Balamuth F, Henretig F, and Nadel F: Oral Hypoglycemic Poisoning. Step Up to Pediatrics. Shah S, Averson B, and Ronan J (eds.). Lippincott Williams and Wilkins, 2013.

Balamuth F, Henretig F, and Nadel F: Methemoglobinemia. Step Up to Pediatrics. Shah S, Averson B, Ronan J (eds.). Lippincott Williams and Wilkins, 2013.

Balamuth F, Henretig F, and Nadel F: Organophosphate Poisoning. Step Up to Pediatrics. Shah S, Averson B, Ronan J (eds.). Lippincott Williams and Wilkins, Page: 497-498, 2013.

Balamuth F, Henretig F, and Nadel F: Calcium Channel Blocker Poisoning. Step Up to Pediatrics. Shah S, Averson B, and Ronan J (eds.). Lippincott Williams and Wilkins, Page: 495-496, 2013.

Balamuth F, Henretig F, and Nadel F: Iron Poisoning. Step Up to Pediatrics. Shah S, Averson B, Ronan J (eds.). Lippincott Williams and Wilkins, Page: 496-497, 2013.

2012

Fran Balamuth and Cynthia Mollen: Heroin Intoxication. The 5 Minute Pediatric Clinical Consult. M. William Schwartz, MD (eds.). Wolters Kluwer, Lippincott William Wilkins, publisher, 2012.

Posters and Presentations

2019

Sarah Nutman, Katie Hayes, Fran Balamuth: Predictors of Invasive Testing and Treatment of Fever Without A Source in Children 57 Days to 36 Months in the Emergency Department. Pediatric Academic Societies Annual Meeting, Baltimore, MD, poster presentation April 2019.

Raina Paul, Charles Macias, M Neider, R Brilli, Ruth Riggs, Troy Richardson, Gloria Lukasiewicz, Fran Balamuth, Halden Scott, M Schafer, Holly Depinet, Jeffrey Auletta: Variable and Metric Development for the Improving Pediatric Sepsis Outcomes Collaborative Pediatric Academic Societies Annual Meeting, Baltimore, MD, poster presentation April 2019.

Halden Scott, Raina Paul, R Brilli, Charles Macias, M Niedner, Holly Depinet, Troy Richardson, Ruth Riggs, Heidi Gruhler, Fran Balamuth: Defining Pediatric Sepsis for Large-Scale Electronic Health Record Case Identification in Multicenter Quality Improvement. Pediatric Academic Societies Annual Meeting, Baltimore, MD, platform presentation April 2019.

Fran Balamuth, Nicole Vestal, Marlena Kittick, Peter McBride, Charlie Casper, Melissa Metheney, Jill Baren, Mike Dean, Nate Kuppermann, Ashley Woodford, Scott Weiss: Pragmatic Pediatric Trial of Balanced versus Normal Saline Fluid in Sepsis: PRoMPT BOLUS Pilot Feasibility Study. Pediatric Academic Societies Annual Meeting, Baltimore, MD, poster presentation April 2019.

Desiree Neville, Jonathan Bennett, Fran Balamuth, Aris Garro, David Lewander, Mark Alexander, Lise Nigrovic, M Levas: The clinical impact of an electrocardiogram in children undergoing evaluation for Lyme disease in the emergency department. Pediatric Academic Societies Annual Meeting, Baltimore, MD, poster presentation April 2019.

2018

Sanya Desai, Sahar Rooholomani, Marie Want, Lise Nigrovic, Mark Neuman, Fran Balamuth, Samir Shah, Lura Sartori, Derek Williams, Rianna Leader, Richard Marble, Christine Mitchell, Christ Pruitt, Adrienne DePorre, and Paul Aronson: Duration of Parenteral Antibiotic Therapy in Young Infants with Bacteremic Urinary Tract Infections. Platform Presentation at Pediatric Academic Societies Meeting. Toronto, CA May  2018.

Lise Nigrovic, Jonathan Bennett, Fran Balamuth, Michael Levas, Desiree Neville, Alexandra Maulden, Rachel Chenard, John Branda, and Aris Garro: C6 enzyme immunoassay for the initial management of children presenting to the emergency department with acute arthritis. Platform Presentation at the Pediatric Academic Societies Meeting. Toronto, CA May  2018.

Ellie Souganidis, Mary Kate Abbadessa, Christian Minich, Jane Lavelle, Joseph Zorc, Fran Balamuth: Analysis of Missed Sepsis Patients in an ED with an Electronic Sepsis Alert Session Title: Emergency Medicine - Sepsis Poster presentation at the Pediatric Academic Societies Meeting. Toronto, CA May  2018.

Christopher Woll, Mark Neuman, Chris Pruitt, Marie Wang, Eugene Shapiro, Samir Shah, Russel McCullough, Lise Nigrovic, Sanya Desai, Adrienne DePorre, Rianna Leader, Richard Marble, Fran Balamuth, Elana Feldman, Laura Sartori, Whitney Browning, and Paul Aronson: Epidemiology of Invasive Bacterial Infection in Infants u880460 Days Treated in Emergency Departments. Poster presentation at the Pediatric Academic Societies Meeting. Toronto, CA May  2018.

Chris Pruitt, Sarah Shin, Sanya Desai, Rianna Leazer, Marie Wang, Laura Sartori, Richard Marble, Veronika Shabanova, Christopher Toll, Sahar Rooholamini, Catherine Lumb, Fran Balamuth, and Paul Aronson: Factors Associated with Adverse Outcomes Among Infants u880460 Days Old with Invasive Bacterial Infections. Platform Presentation at Pediatric Academic Societies Meeting. Toronto, CA May  2018.

Aronson PL, Wang ME, Nigrovic LE, Shah SS, Desai S, Pruitt CM, Balamuth F, Sartori L, Marble RD, Rooholamini SN, Leazer RC, Woll C, DePorre AG, Neuman MI; for the Febrile Young Infant Research Collaborative: Time to Pathogen Detection for Infants u880460 Days Old with Invasive Bacterial Infections Session Title: Hospital Medicine: febrile neonate Poster presentation at the Pediatric Academic Societies Meeting. Toronto, CA May  2018.

Jenny Raman, Tiffani Johnson, Katie Hayes, Fran Balamuth:  Racial Differences in Pediatric Sepsis Alert Performance in a Children's Hospital Emergency Department. Platform Presentation at Pediatric Academic Societies Meeting. Toronto, CA May  2018.

2017

Sarah Fesnak, Katie Hayes, Marianne Chilutti, Joe Zorc, MaryKate Abbadessa, Jane Lavelle, Fran Balamuth: Sepsis in complex patients in the Emergency Department: Time to recognition and therapy in patients with high risk conditions. Poster Presentation at the Pediatric Academic Societies Annual Meeting, San Francisco, CA May  2017.

Phoebe Hollyer1,2, Nancy Kassam-Adams PhD3,4, Cynthia Mollen MD MSCE3,4, Fran Balamuth MD, PhD, MSCE3,4: Parental Opinions on the Timing of Informed Consent in Pediatric Sepsis Research Poster Presentation at the Pediatric Academic Societies Annual Meeting, San Francisco, CA May 2017.

Lise Nigrovic1, Jonathan Bennett3, Frances Balamuth2, Michael Levas5,Aris Garro4: Accuracy of clinician suspicion for identifying Lyme disease in children presenting to emergency departments in Lyme disease endemic areas. Poster presentation at the Pediatric Academic Societies Annual Meeting, San Francisco, CA May 2017.

Fran Balamuth, Elizabeth Alpern, Katie Hayes, Ebbing Lautenbach, Blanca Himes: Gene Expression Profiles Differentiate Bacterial vs Viral Source Pathogen in Children with Suspected Sepsis. Poster Presentation at the Pediatric Academic Societies Annual Meeting, San Francisco, CA May  2017.

Courtney Nelson, Svetlana Ostapenko, Joseph Zorc, and Fran Balamuth: Treatment of Non-Urgent Fever in a Pediatric Emergency Department. Poster Presentation at the Pediatric Academic Societies Annual Meeting, San Francisco, CA May  2017.

2016

Allison Ballantine, MD, MEd, Susan DiTaranto, RN, MHA, CPON ,Kathryn Roberts, RN, MSN, CNS, CCRN, CCNS, Frances Balamuth, MD, PhD, MSCE, Scott Weiss, MD, MSCE, Julie Fitzgerald, MD, PhD Sarah Hadley, RN, CPHQ, Christian Minich, BS, Valerie Rigby, RN, Ron Keren, MD, MPH: Improving Response to Suspected Sepsis: Results of a hospital-wide quality improvement initiative. Poster presentation at the American Academy of Pediatrics Annual Meeting.  San Francisco, CA October  2016.

Paul L. Aronson, MD,Russell J. McCulloh, MD, Joel S. Tieder, MD, MPH, Lise E. Nigrovic, MD, MPH,Rianna C. Leazer, MD, Elizabeth R. Alpern, MD, MSCE, Elana A. Feldman, BA,Fran Balamuth, MD, PhD, MSCE, Whitney L. Browning, MD, and Mark I. Neuman, MD, MPH, for the Febrile Young Infant Research Collaborative: Application of Rochester Criteria to Identify Young Infants with Invasive Bacterial Infection. Poster presentation at the Pediatric Academic Society Annual Meeting, Baltimore, MD May  2016.

Lyons T, Cruz A, Freedman S, Neuman M, Balamuth F, Aronson P, Thomson J, Pruitt C, Shah S, Nigrovic L, for the PEM-CRC HSV Study Group: Cerebrospinal fluid WBC correction in infants with traumatic lumbar punctures. Platform Presentation at the Pediatric Academic Societies Annual Meeting, Baltimore, MD May  2016.

Feldman E; McCulloh R; Meyers A; Aronson P; Neuman M; Bradford, M; Williams D; Alpern E; Balamuth F; Blackstone MM; Browning W; Hayes K; Korman R; Leazer R; Nigrovic L; Marble R; Roben, E; Tieder JS: Epidemiology and Antimicrobial Susceptibility in Infants with Bacterial Infections Across US Children's Hospitals  Poster presentation at the Pediatric Academic Society Annual Meeting, Baltimore, MD May  2016.

Cruz A, Freedman S, Kulik D, Fleming A, Thomson J, Schnadower D, Garro A, Pruitt C, Balamuth F, Aronson P, Uspal N, Lyons T, Ishimine P, Bradin S, Grether-Jones K, Miller A, Louie L, Shah S, Nigrovic L: HSV in infants <= 60 days presenting for emergency department evaluation. Platform Presentation at the Pediatric Academic Societies Annual Meeting, Baltimore, MD May  2016.

Courtney E Nelson, MD; Fran Balamuth, MD, PhD; Stephanie Ng, APN; Lisa McAndrew, MD; Khoon-Yen Tay, MD; Aaron Chen, MD: Management of Skin and Soft Tissue Infections Before and After Clinical Pathway Implementation. Poster Presentation at the Pediatric Academic Societies Annual Meeting, Baltimore, MD May  2016.

Moonjoo Han, MD, Julie C. Fitzgerald, MD, PhD, Fran Balamuth, MD, PhD, MSCE, Luke Keele, PhD, Elizabeth R. Alpern, MD, MSCE, Jane Lavelle, MD, Marianne Chilutti, MS,5 Robert Grundmeier, MD,5,6 Vinay M. Nadkarni, MD, MS,1 Neal J. Thomas, MD, MSc,7 Scott L. Weiss, MD, MSCE1: Effects of Delayed Antimicrobial Therapy on Long-term Mortality After Pediatric Sepsis Poster Presentation at the Society for Critical Care Medicine Annual Meeting, Orlando, FL February 2016.

Jessica Signoff, MD; Julie Fitzgerald, MD; David Teachey, MD; Fran Balamuth, MD; Scott L Weiss, MD MSCE: Hypofibrinogenemia is associated with poor outcome and secondary HLH in pediatric severe sepsis. Poster Presentation at Society for Critical Care Medicine Annual Meeting, Orlando, FL February 2016.

Invited Lectures

2021

Fran Balamuth, MD. “Improving Recognition of Pediatric Sepsis by Digital Support Systems", World Sepsis Congress, Virtual Conference. Apr, 2021.

Fran Balamuth, MD. "Sepsis Screening", Grand Rounds, Nationwide Children's Hospital, Columbus, OH (virtual presentation), Nov 2021

Fran Balamuth, MD. "Improving Pediatric Sepsis Recognition", Advocare Children's Hospital, Chicago, IL (virtual presentation), Sept 2021.

2020

Fran Balamuth, MD. "Definitions of Sepsis in Children and Adolescents". Society for Healthcare Epidemiology of America Decennial Conference. Atlanta, GA, Mar, 2020.

Fran Balamuth, MD. "Implementing an Electronic Sepsis Alert in a Community Pediatric Emergency Department", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "The Champage Tap: Time to Pop the Cork?", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Association between clinician suspicion and empiric antibiotics for children undergoing emergency department evaluation for potential Lyme disease", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Sexual Abuse Response Team (SART): A Decade in Review", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Characteristics of afebrile infants u880460 days of age with invasive bacterial infections", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Agreement Between Quality Improvement-based Suspected Sepsis and Surveillance-based Confirmed Sepsis in Children", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "The Impact of a National Multicenter QI Collaborative on Pediatric Sepsis Care", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Validation of a Prediction Rule for Serious Bacterial Infections (SBIs) in Febrile Infants u8804 60 Days in a Multicenter Network", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Prevalence of bacteremia and meningitis in febrile infants u8804 60 days with positive urinalyses in a multicenter network", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Prospective Validation of the Lyme Meningitis Rule of 7's for identifying children with Lyme Meningitis", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

Fran Balamuth, MD. "Early Recognition Of Pediatric Sepsis In Community Emergency Departments", Pediatric Academic Societies (PAS) 2020 Meeting, Philadelphia PA (Meeting cancelled due to COVID-19), May, 2020.

2019

Fran Balamuth, MD. The PROMPT BOLUS Trial," Co-lecture with Scott Weiss at the Pediatric Emergency Research, Canada Conference, Banff, Alberta, CA, Feb, 2019.

Fran Balamuth, MD. "Pro/Con Debate: Controversies in Pediatric Sepsis," Invited Science Session at Pediatric Academic Societies Annual Meeting, Baltimore, MD, Apr, 2019.

Fran Balamuth, MD. "Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Sepsis-3 Definitions in the Pediatric Emergency Department," Platform presentation at Pediatric Academic Societies Annual Meeting, Baltimore, MD, Aug, 2019

Fran Balamuth, MD. "pSOFA in the Emergency Department," Improving Pediatric Sepsis Outcomes Collaborative Conference.  Dallas, TX, Jun, 2019.

Fran Balamuth, MD. "Pediatric Sepsis Screening in the Community Setting". Hospital Association of Pennsylvania Sepsis Conference.  Lancaster, PA, Sept, 2019.

Fran Balamuth, MD. "Saline vs. LR for Sepsis Fluid Resuscitation" Improving Pediatric Sepsis Outcomes Collaborative Conference.  Dallas, TX, Dec, 2019.

Awards and Honors

2016, CHOP Resident Faculty Honor Roll

2014, Outstanding Research Poster, CHOP Research Poster Day

2012, Best Abstract, Patient Quality and Safety Day, Children's Hospital of Philadelphia

2005, Alpha Omega Alpha, Yale University School of Medicine

Editorial and Academic Positions

Editorial positions

2012-present, Peer Reviewer, Academic Emergency Medicine
2012-present, Peer Reviewer, Annals of Emergency Medicine
2009-Present, Peer Reviewer, Archives of Pediatrics and Adolescent Medicine
2009-Present, Peer Reviewer, Pediatric Emergency Care
2012-Present, Peer Reviewer, Annals of Emergency Medicine
2012-Present, Peer Reviewer, Academic Emergency Medicine

Academic positions

2015-present, Co-chair, research committee. Improving Sepsis Outcomes Quality Collaborative Executive Committee
2015-present, Improving Pediatric Sepsis Outcomes (IPSO) National Expert Advisory Committee
2015-present, Grant writing and Publications Committee for the Pediatric Emergency Care Applied Research Network (PECARN)
2012-present, Sepsis Governance Committee, Children's Hospital of Philadelphia
2011-present, Leader, Emergency Department sepsis working group, Children's Hospital of Philadelphia
2009-Present, Education Improvement Committee, Division of Emergency Medicine, Children's Hospital of Philadelphia
2009-Present, Research Committee, Division of Emergency Medicine, Children's Hospital of Philadelphia
2009-Present, Scientific Review Committee, Division of Emergency Medicine, Children's Hospital of Philadelphia
2011-Present, Leader, Emergency Department sepsis working group, Children's Hospital of Philadelphia
2012-Present, Member, Sepsis Governance Committee, Children's Hospital of Philadelphia
2012-Present, Steering Committee Member, American Academy of Pediatrics Septic Shock Collaborative
2014-Present, Member, Society of Critical Care Medicine International Septic Shock Guideline Committee
2015-present, Member, Grant writing and Publications Committee for the Pediatric Emergency Care Applied Research Network (PECARN)
2015-Present, Member, Improving Pediatric Sepsis Outcomes (IPSO) National Expert Advisory Committee

Leadership and Memberships

Memberships in Professional Organizations

National

CHOP Clinical Trials Research Affinity Group, Advisory committee member

2013-present, Shock Society

2012-present, American Academy of Pediatrics Septic Shock Collaborative

2012-present, Society of Critical Care Medicine

 - 2014-present, International Septic Shock Guideline Committee

2010-present, Society for Academic Emergency Medicine

2009-present, Pediatric Academic Societies

2009-present, American Academy of Pediatrics

 - 2012-present, Septic Shock Collaborative Steering Committee