Gerd A. Blobel MD, PhD, holds the Frank E. Weise III Endowed Chair of Pediatrics at Children’s Hospital of Philadelphia and the Perelman School of Medicine. Dr. Blobel earned his MD degree from the University of Heidelberg, Germany, and a PhD degree from Rockefeller University in New York. His lab focuses on the genetic and epigenetic control of hematopoiesis and its disorders. Specifically, he studies how tissue-specific transcription factors govern the specification and maintenance of hematopoietic cell lineages. He also examines how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity, and how genetic regulatory elements are organized spatially within the nucleus. He has given numerous lectures at international conferences on hematopoiesis, transcription, and epigenetics. Dr. Blobel has been continually funded by the NIH since arriving at Penn and holds a MERIT award. He was elected to the ASCI (2004) and AAP (2008). Dr. Blobel is the co-director of the Epigenetics Program at the University of Pennsylvania.
MD - Ruprecht-Karls University, Heidelberg, Baden-Württemberg, Germany
Harvard Medical School (Hematology), Cambridge, MA
PhD in Molecular Oncology - Rockefeller University, New York, NY
Investigator
Frank E. Weise III Endowed Chair in Pediatric Hematology
Professor of Pediatrics
Higher order chromatin structure
Gene expression
Epigenetics
Globin genes
Sickle cell disease
Therapeutics
Luan J, Vermunt MW, Syrett CM, Coté A, Tome JM, Zhang H, Huang A, Luppino JM, Keller CA, Giardine BM, Zhang S, Dunagin MC, Zhang Z, Joyce EF, Lis JT, Raj A, Hardison RC, Blobel GA.: CTCF blocks antisense transcription initiation at divergent promoters. Nat Struct Mol Biol 2022.
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA.: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nat Genet 2022.
Zhang H, Lam J, Zhang D, Lan Y, Vermunt MW, Keller CA, Giardine B, Hardison RC, Blobel GA.: CTCF and transcription influence chromatin structure re-configuration after mitosis. Nat Commun 12: 5157, Aug 2021.
Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel GA.: Distinct properties and functions of CTCF revealed by a rapidly inducible degron system. Cell Rep 34: 108783, Feb 2021.
Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA.: ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol Cell 81: 239-254, Jan 2021.
Zhang D, Huang P, Sharma M, Keller CA, Giardine B, Zhang H, Gilgenast TG, Phillips-Cremins JE, Hardison RC, Blobel GA.: Alteration of genome folding via contact domain boundary insertion. Nat Genet 52: 1076-1087, Oct 2020.
Zhang Haoyue, Emerson Daniel J, Gilgenast Thomas G, Titus Katelyn R, Lan Yemin, Huang Peng, Zhang Di, Wang Hongxin, Keller Cheryl A, Giardine Belinda, Hardison Ross C, Phillips-Cremins Jennifer E, Blobel Gerd A: Chromatin structure dynamics during the mitosis-to-G1 phase transition. Nature 576(7785): 158-162, 12 2019.
Behera Vivek, Stonestrom Aaron J, Hamagami Nicole, Hsiung Chris C, Keller Cheryl A, Giardine Belinda, Sidoli Simone, Yuan Zuo-Fei, Bhanu Natarajan V, Werner Michael T, Wang Hongxin, Garcia Benjamin A, Hardison Ross C, Blobel Gerd A: Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription. Cell reports 27(2): 400-415.e5, Apr 2019.
Bartman CR, Hamagami N, Keller CA, Giardine B, Hardison RC, Blobel GA, Raj A: Transcriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation. Molecular Cell 2019.
Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, and Blobel GA: Domain-focused CRISPR-screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science 2018.
Zhang H, Blobel GA. Genome folding dynamics during the M-to-G1-phase transition. Curr Opin Genet Dev. 2023 Apr 24;80:102036. doi: 10.1016/j.gde.2023.102036. Epub ahead of print. PMID: 37099832.
Zhang Z, Baxter AE, Ren D, Qin K, Chen Z, Collins SM, Huang H, Komar CA, Bailer PF, Parker JB, Blobel GA, Kohli RM, Wherry EJ, Berger SL, Shi J. Efficient engineering of human and mouse primary cells using peptide-assisted genome editing. Nat Biotechnol. 2023 Apr 24. doi: 10.1038/s41587-023-01756-1. Epub ahead of print. PMID: 37095348.
Xiang G, He X, Giardine BM, Weaver KJ, Taylor DJ, McCoy RC, Jansen C, Keller CA, Wixom AQ, Cockburn A, Miller A, Qi Q, He Y, Li Y, Lichtenberg J, Heuston EF, Anderson SM, Luan J, Vermunt MW, Yue F, Sauria MEG, Schatz MC, Taylor J, Göttgens B, Hughes JR, Higgs DR, Weiss MJ, Cheng Y, Blobel GA, Bodine D, Zhang Y, Li Q, Mahony S, Hardison RC. Cross-species regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. bioRxiv [Preprint]. 2023 Apr 4:2023.04.02.535219. doi: 10.1101/2023.04.02.535219. PMID: 37066352; PMCID: PMC10103973.
Peslak SA, Demirci S, Chandra V, Ryu B, Bhardwaj SK, Jiang J, Rupon JW, Throm RE, Uchida N, Leonard A, Essawi K, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Ferrara F, Wielgosz M, Abdulmalik O, Hamagami N, Germino-Watnick P, Le A, Chu R, Hinds M, Weiss MJ, Tong W, Tisdale JF, Blobel GA. Forced enhancer-promoter rewiring to alter gene expression in animal models. Mol Ther Nucleic Acids. 2023 Jan 31;31:452-465. doi: 10.1016/j.omtn.2023.01.016. PMID: 36852088; PMCID: PMC9958407.
Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine BM, Abdulmalik O, Shi J, Hardison RC, Blobel GA. Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood. 2023 Mar 9:blood.2022019578. doi: 10.1182/blood.2022019578. Epub ahead of print. PMID: 36893455.
Vermunt MW, Luan J, Zhang Z, Thrasher AJ, Huang A, Saari MS, Khandros E, Beagrie RA, Zhang S, Vemulamada P, Brilleman M, Lee K, Yano JA, Giardine BM, Keller CA, Hardison RC, Blobel GA. Gene silencing dynamics are modulated by transiently active regulatory elements. Mol Cell. 2023 Mar 2;83(5):715-730.e6. doi: 10.1016/j.molcel.2023.02.006. PMID: 36868189.
Kaur G, Ren R, Hammel M, Horton JR, Yang J, Cao Y, He C, Lan F, Lan X, Blobel GA, Blumenthal RM, Zhang X, Cheng X. Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410-DNA interaction using small angle X-ray scattering. Nucleic Acids Res. 2023 Feb 28;51(4):1674-1686. doi: 10.1093/nar/gkac1274. PMID: 36660822; PMCID: PMC9976917.
Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallières M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA. Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Adv. 2022 Dec 13;6(23):5956-5968. doi: 10.1182/bloodadvances.2022007904. PMID: 35622975; PMCID: PMC9678958.
Adema V, Ma F, Kanagal-Shamanna R, Thongon N, Montalban-Bravo G, Yang H, Peslak SA, Wang F, Acha P, Sole F, Lockyer P, Cassari M, Maciejewski JP, Visconte V, Gañán-Gómez I, Song Y, Bueso-Ramos C, Pellegrini M, Tan TM, Bejar R, Carew JS, Halene S, Santini V, Al-Atrash G, Clise-Dwyer K, Garcia-Manero G, Blobel GA, Colla S. Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts. Blood Cancer Discov. 2022 Nov 2;3(6):554-567. doi: 10.1158/2643-3230.BCD-21-0220. PMID: 35926182; PMCID: PMC9894566.
Luan J, Vermunt MW, Syrett CM, Coté A, Tome JM, Zhang H, Huang A, Luppino JM, Keller CA, Giardine BM, Zhang S, Dunagin MC, Zhang Z, Joyce EF, Lis JT, Raj A, Hardison RC, Blobel GA. CTCF blocks antisense transcription initiation at divergent promoters. Nat Struct Mol Biol. 2022 Nov;29(11):1136-1144. doi: 10.1038/s41594-022-00855-y. Epub 2022 Nov 11. PMID: 36369346; PMCID: PMC10015438.
Feng R, Mayuranathan T, Huang P, Doerfler PA, Li Y, Yao Y, Zhang J, Palmer LE, Mayberry K, Christakopoulos GE, Xu P, Li C, Cheng Y, Blobel GA, Simon MC, Weiss MJ. Activation of γ-globin expression by hypoxia-inducible factor 1α. Nature. 2022 Oct;610(7933):783-790. doi: 10.1038/s41586-022-05312-w. Epub 2022 Oct 12. PMID: 36224385; PMCID: PMC9773321.
Ricketts MD, Emptage RP, Blobel GA, Marmorstein R. The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity. J Biol Chem. 2022 Oct;298(10):102451. doi: 10.1016/j.jbc.2022.102451. Epub 2022 Sep 3. PMID: 36063997; PMCID: PMC9520036.
Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA. HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nat Genet. 2022 Sep;54(9):1417-1426. doi: 10.1038/s41588-022-01152-6. Epub 2022 Aug 8. PMID: 35941187; PMCID: PMC9940634.
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Publisher Correction: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nat Genet. 2022 Jun;54(6):906. doi: 10.1038/s41588-022-01112-0. Erratum for: Nat Genet. 2022 Jun;54(6):874-884. PMID: 35650318.
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA. Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nat Genet. 2022 Jun;54(6):874-884. doi: 10.1038/s41588-022-01076-1. Epub 2022 May 26. Erratum in: Nat Genet. 2022 Jun 1;: PMID: 35618846; PMCID: PMC9203980.
Topfer SK, Feng R, Huang P, Ly LC, Martyn GE, Blobel GA, Weiss MJ, Quinlan KGR, Crossley M. Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression. Blood. 2022 Apr 7;139(14):2107-2118. doi: 10.1182/blood.2021014205. PMID: 35090172; PMCID: PMC8990374.
Dierickx P, Zhu K, Carpenter BJ, Jiang C, Vermunt MW, Xiao Y, Luongo TS, Yamamoto T, Martí-Pàmies Í, Mia S, Latimer M, Diwan A, Zhao J, Hauck AK, Krusen B, Nguyen HCB, Blobel GA, Kelly DP, Pei L, Baur JA, Young ME, Lazar MA. Circadian REV-ERBs repress E4bp4 to activate NAMPT-dependent NAD+ biosynthesis and sustain cardiac function. Nat Cardiovasc Res. 2022 Jan;1(1):45-58. doi: 10.1038/s44161-021-00001-9. Epub 2021 Dec 23. PMID: 35036997; PMCID: PMC8754391.
Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021 Dec;53(12):1723. doi: 10.1038/s41588-021-00980-2. Erratum for: Nat Genet. 2021 Oct;53(10):1480-1492. PMID: 34725478.
Blobel GA, Higgs DR, Mitchell JA, Notani D, Young RA. Testing the super-enhancer concept. Nat Rev Genet. 2021 Dec;22(12):749-755. doi: 10.1038/s41576-021-00398-w. Epub 2021 Sep 3. PMID: 34480110.
Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021 Oct;53(10):1480-1492. doi: 10.1038/s41588-021-00934-8. Epub 2021 Oct 5. Erratum in: Nat Genet. 2021 Nov 1;: PMID: 34611363; PMCID: PMC8500624.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. PMID: 34358447; PMCID: PMC8932643.
Zhang H, Lam J, Zhang D, Lan Y, Vermunt MW, Keller CA, Giardine B, Hardison RC, Blobel GA. CTCF and transcription influence chromatin structure re-configuration after mitosis. Nat Commun. 2021 Aug 27;12(1):5157. doi: 10.1038/s41467-021-25418-5. PMID: 34453048; PMCID: PMC8397779.
Keller CA, Wixom AQ, Heuston EF, Giardine B, Hsiung CC, Long MR, Miller A, Anderson SM, Cockburn A, Blobel GA, Bodine DM, Hardison RC. Effects of sheared chromatin length on ChIP-seq quality and sensitivity. G3 (Bethesda). 2021 Jun 17;11(6):jkab101. doi: 10.1093/g3journal/jkab101. PMID: 33788948; PMCID: PMC8495733.
Riedel SS, Lu C, Xie HM, Nestler K, Vermunt MW, Lenard A, Bennett L, Speck NA, Hanamura I, Lessard JA, Blobel GA, Garcia BA, Bernt KM. Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Mol Cell. 2021 Jun 3;81(11):2332-2348.e9. doi: 10.1016/j.molcel.2021.04.014. Epub 2021 May 10. PMID: 33974912; PMCID: PMC8380056.
Zhang D, Lam J, Blobel GA. Engineering three-dimensional genome folding. Nat Genet. 2021 May;53(5):602-611. doi: 10.1038/s41588-021-00860-9. Epub 2021 May 6. PMID: 33958782.
Khandros E, Blobel GA. Heterogeneity of fetal hemoglobin production in adult red blood cells. Curr Opin Hematol. 2021 May 1;28(3):164-170. doi: 10.1097/MOH.0000000000000640. PMID: 33631783; PMCID: PMC8211413.
Henrich IC, Jain K, Young R, Quick L, Lindsay JM, Park DH, Oliveira AM, Blobel GA, Chou MM. Ubiquitin-Specific Protease 6 Functions as a Tumor Suppressor in Ewing Sarcoma through Immune Activation. Cancer Res. 2021 Apr 15;81(8):2171-2183. doi: 10.1158/0008-5472.CAN-20-1458. Epub 2021 Feb 8. PMID: 33558334; PMCID: PMC8137534.
Gasser SM, Blobel GA. Editorial overview: Breaking open the mysteries of nuclear and chromatin organization. Curr Opin Genet Dev. 2021 Apr;67:iii-vii. doi: 10.1016/j.gde.2021.03.001. Epub 2021 Mar 17. PMID: 33744084.
Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel GA. Distinct properties and functions of CTCF revealed by a rapidly inducible degron system. Cell Rep. 2021 Feb 23;34(8):108783. doi: 10.1016/j.celrep.2021.108783. PMID: 33626344; PMCID: PMC7999233.
Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA. ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol Cell. 2021 Jan 21;81(2):239-254.e8. doi: 10.1016/j.molcel.2020.11.006. Epub 2020 Dec 9. PMID: 33301730; PMCID: PMC8556680.
5-25-16 Vanderbilt University. “Functions, mechanisms, and therapeutic potential of chromatin looping.”
2-21-16 Keystone Symposium on Enhancer Malfunction in Cancer. Session Chair, speaker: “A hyperactive transcriptional state marks genome reactivation during mitotic exit.”
1-20-16 Molecular Medicine Seminar speaker, University of Connecticut Health Center: “Functions, mechanisms, and therapeutic potential of chromatin looping."
1-11-16 Distinguished Seminar Speaker: Perelman School of Medicine at the University of Pennsylvania Epigenetics program, Philadelphia, PA “Mechanisms, functions and therapeutic potential of chromatin looping."
12-18-15 Danny Thomas Lecture. St. Jude Children's Hospital, Memphis TN. “’Editing’ genome architecture to treat hemoglobinopathies.”
12-14-15 Joint Seminar Series, Department and Cancer Biology’s and Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA “Propagating transcriptional patterns through mitosis.”
2-5-15 American Society of Hematology Annual Meeting Orlando, FL “A Hyperactive Transcriptional State Marks Genome Reactivation during Mitotic Exit.”
11-20-15 Pfizer, Cambridge, MA, “Editing genome architecture to treat hemoglobinopathies.”
11-18-15 The Children's Hospital of Philadelphia Grand Rounds “Editing genome architecture to treat disease.”
11-10-15 Distinguished Speaker Seminar Series. Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at University of Southern California “Propagating transcriptional patterns through mitosis.”
10-23-15 Pasteur Institute, Paris. “Propagating transcriptional patterns through mitosis.”
10-1-15 Blue Top Seminar Series, Harvard Medical School: “Propagating transcriptional patterns through mitosis.”
9-10-15 Transcription Imaging Consortium, HHMI Janelia Farm Research campus: “Influence of mitosis on transcriptional control.”
9-9-15 Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA: ”Editing" genome folding to alter gene expression.
6-29-15 Gordon Research Conference on Red Cells. Holderness, NH “Propagating transcriptional patterns through mitosis.”
6-28-15 Gordon Research Seminars. Holderness, NH “Developing a career as a scientist.”
6-11-15 Biogen Cambridge, MA. ”Editing” genome folding to alter gene expression.
5-26-15 The 80th Cold Spring Harbor Laboratory Symposium on Quantitative Biology on 21st Century Genetics: Genes at Work.” Editing genome folding to alter gene expression.
5-6-15 EMBO Conference on Chromatin and Epigenetics, Heidelberg, Germany: “Propagating transcription patterns through mitosis.”
3-6-15 Weatherall Institute of Molecular Medicine, Oxford, UK: “Functions, mechanisms and therapeutic potential of chromatin looping.”
1-22-15 Department of Biology, Johns Hopkins University, Baltimore, MD: “Functions, mechanisms and therapeutic potential of chromatin looping.”
1-21-15 Translational Research Conference Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD: “Functions, mechanisms and therapeutic potential of chromatin looping.”
12-6-14 American Society of Hematology Annual Meeting, New Orleans: “Mechanistic Insights into Forced Chromatin Looping Mediated Activation of Fetal Globin Gene Expression.”
11-6-14 Michigan State University, Lansing, MI: “Functions, mechanisms and therapeutic potential of chromatin looping.”
10-19-14 Transcription Imaging Consortium Meeting, HHMI, Janelia Farm "Reactivating the silent genome after mitosis."
9-24-14 New York Blood Center “Activation of fetal globin expression by forced chromatin looping."
9-19-14 Keynote speaker, Biochemistry and Molecular Biology retreat, Penn State University. “Functions, mechanisms and therapeutic potential of chromatin looping.”
9-5-14 The 19th Conference on Hemoglobin Switching, Oxford, UK. Session Chair. Speaker: “Activation of fetal globin expression by forced chromatin looping.”
8-21-14 Cold Spring Harbor Conference on The Dynamic Organization of Nuclear Function. Chris Hsiung presenter: “The chromatin accessibility landscape of the mitotic genome.”
6-22-14 FASEB conference on Technologies for Controlling Gene Expression, Nassau, Bahamas, Session Chair; Speaker: “Controlling long range chromatin interactions.”
4-10-14 University of Virginia, Charlottesville VA: "Function and regulation of higher order chromatin interactions."
4-4-14 Interurban Clinical Club, Philadelphia, PA “Reactivation of developmentally silenced globin genes by forced chromatin looping.”
3-9-14 Conference on Long-Range Genome Organization and Transcription Dynamics, HHMI Janelia Farm Research campus "Exploring long range chromatin loops."
2-24-14 Department of Biochemistry, University of Sydney: “Propagating Transcriptional Patterns Through Mitosis.”
2-19-14 Asian Conference of Transcription. Melbourne, Australia, Plenary speaker: “Reprogramming the β-globin locus by forced chromatin looping."
2-11-14 Distinguished Lecturer for the Leading Edge of Cell Biology Seminar Series at UT Southwestern, Dallas, TX. “Organization and function of chromatin loops.”
1-22-14 University of California Irvine: “Functions and mechanisms of long range chromatin interactions."
2015, The Children's Hospital of Philadelphia Mentor Award
2014, Stanley N. Cohen Biomedical Research Award
2013, Foerderer Innovation Grant Award
2010, MERIT award 2R37DK058044
2008, The Frank E. Weise III Endowed Chair in Hematology
2008, Foerderer Innovation Grant Award
2008, Pilot project grant, Abramson Cancer Center
2007, Pilot grant, Center for Molecular Studies in Digestive and Liver Diseases
2007, Pilot project grant, Abramson Cancer Center
2001, Pilot grant from the Institute of Human Gene Therapy
1998, American Society of Hematology (ASH) Scholar Award
1998, Cooley’s Anemia Foundation Junior Faculty Award
1997, Baldasare Award
1997, Florence R.C. Murray Award
1997, Florence R.C. Murray Award
1992, Training grant, German Research Foundation (DFG)
1986, M.D. degree conferred, summa cum laude
and Culture of the State of Baden-Württemberg, Germany
Blood
Cancer Research
Cell
Development
Developmental Cell
Epigenetics & Chromatin
Experimental Hematology
Genes and Development
Genome Research
International Journal of Biochemistry and Cell Biology
Journal of Biological Chemistry
Journal of Cell Biology
Journal of Clinical Investigation
Journal of Leukocyte Biology
Molecular Cell
Molecular and Cellular Biology
Nature Cell Biology
Nature Genetics
Nature Methods
Nature Structural and Molecular Biology
Nucleic Acids Research
Oncogene
PLoS Genetics
PLoS One
PNAS
Science
Science Translational Medicine
2014, NIH Think Tank 4D Nucleome
2013-2017, American Society of Hematology (ASH) Scientific Committee on Red Cell Biology
Graduate Group in Cell and Molecular Biology (GGR)
Graduate Group in Cancer Biology
Graduate Group in Pharmacological Sciences
Graduate Group in Immunology
Combined Degree Admissions/Advisory Committee
CAMB Admissions Committee
Cancer Biology Admissions Committee
Executive Board Member, Epigenetics Program
American Society of Hematology
American Society for Microbiology
American Society for Biochemistry and Molecular Biology
American Society for Clinical Investigation (ASCI)
Member, Association of American Physicians (AAP)