PhD in Physiology - Peking University, Beijing, China
Dalhousie University, Department of Psychology, Halifax, Canada
University of Pennsylvania, Department of Neurology, Philadelphia, PA
University of Toronto, Department of Physiology, Toronto, Canada
Research Scientist
Research Assistant Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania
My research centers on the molecular basis of Friedreich’s Ataxia, it’s treatment options and the physiological roles of NMDA receptors in human pulmonary artery smooth muscle cells.
Dong YN, Mesaros C, Xu P, Mercado-Ayon E, Halawani S, Ngaba L, Warren N, Sleiman P, Rodden L, Schadt KA, Blair IA, Lynch DR (2022) Frataxin controls ketone body metabolism through regulation of OXCT1. PNAS Nexus, 3, pgac 142.
Rodden LN, Rummey C, Dong YN, Lagedrost S, Regner S, Brocht A, Bushara K, Delatycki MB, Gomez C, Mathews K, Murray S, Perlman S, Ravina B, Subramony SH, Wilmot G, Zesiewicz T, Bolotta A, Dommisy A, Jespersen C, Ji B, Soragni E, Gottesfeld J, Lynch DR (2022) A non-synonymous SNP in SIRT6 predicts neurological severity in Friedreich ataxia. Frontiers in Molecular Biosciences, 9:933788.
Rodden LN, Rummey C, Dong YN and Lynch DR (2022). Clinical evidence for variegated silence in Friedreich ataxia patients: Ceiling effect of GAA repeat length reveals a clinical homogeneous subgroup. Neurology Genetics, 8:1683.
Mercado-Ayon E, Warren N, Halawani S, Rodden L, Ngaba L, Dong YN, Chang JC, Fonck C, Mavilio F, Lynch DR, Lin H (2022) Cerebellar Pathology in an Inducible Mouse Model of Friedreich Ataxia. Frontiers in Neuroscience, 16: 819569.
Dong YN, Hsu FC, Koziol-White CJ, Stepanova V, Jude J, Gritsiuta A, Rue R, Mott R, Coulter DA, Panettieri RA Jr, Krymskaya VP, Takano H, Goncharova EA, Goncharov DA, Cines DB, Lynch DR (2021) Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells. Scientific Reports, 11:8205.
Johnson J, Mercado-Ayon E, Mercado-Ayon Y, Dong YN, Halawani S, Ngaba L, Lynch DR. (2021) Mitochondrial dysfunction in the development and progression of neurodegenerative diseases. Archives of Biochemistry and Biophysics, 702:108698.
Rodríguez-Pascau L, Britti E, Calap-Quintana P, Dong YN, Vergara C, Delaspre F, Medina-Carbonero M, Tamarit J, Pallardó FV, Gonzalez-Cabo P, Ros J, Lynch DR, Martinell M, Pizcueta P (2021) PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia. Neurobiology of Disease,148:105162.
Dong YN, McMillan E, Clark EM, Lin H, Lynch DR (2019) GRP75 overexpression rescues frataxin deficiency and mitochondrial phenotypes in Friedreich ataxia cellular models. Human Molecular Genetics, 28:1594-1607.
2022, Friedreich Ataxia Research Alliance CollaMap Competition (3rd place winner)