Yi Fan, MD, PhD
About Yi Fan, MD, PhD
Titles
Manager
Research Interests
Brain tumor; Angiogenesis; Tissue repar; Immunotherapy; Cancer stem cells; Proton radiation
Education & training
Medical Degree
MD - Shanghai University of Traditional Chinese Medicine, Pudong New Area, Shanghai
PhD - Pathology, Case Western Reserve University School of Medicine, Euclid Ave, Cleveland, OH
Publications
Selected Publications
2025
Ni H, Reitman ZJ, Zou W, Akhtar MN, Paul R, Huang M, Zhang D, Zheng H, Zhang R, Ma R, Ngo G, Zhang L, Diffenderfer ES, Motlagh SAO, Kim MM, Minn AJ, Dorsey JF, Foster JB, Metz J, Koumenis C, Kirsch DG*, Gong Y*, Fan Y*. : FLASH radiation stimulates proinflammatory macrophage polarization and sensitizes medulloblastoma to CAR-T cell immunotherapy. Nature Cancer Page: doi.org/10.1038/s43018-025-00905-6, Feb 2025 Notes: *, co-corresponding authors.
2024
Cleveland AH, Fan Y.: Reprogramming endothelial cells to empower cancer immunotherapy. Trends in Molecular Medcine 30(2): 126-135. Feb 2024 Notes: Peer reviewed opinion.
Zhao X, Williamson T, Gong Y*, Epstein J*, Fan Y*.: Immunomodulatory therapy for ischemic heart disease. Circulation 150(13): 1050-1058, Sept 2024 Notes: *Co-senior author. peer-reviewed opinion.
Yang F, Akhtar N, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y*, & Fan Y*.: An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science Advances 10(9): eadj4678, Mar 2024 Notes: *Co-senior authors.
Zhang D, Cleveland AH, Krimitza E, Han K, Yi C, Stout AL, Zou W, Dorsey JF, Gong Y*, Fan Y*.: Spatial analysis of tissue immunity and vascularity by light sheet fluorescence microscopy. Nature Protocols 19(4): 1053-1082, Apr 2024 Notes: *Co-senior authors.
2023
Yang F, Zhang D, Jiang H, Ye J, Zhang L, Winkler J, Gong Y, & Fan Y.: Small-molecule reversal of macrophage-mediated immunosuppression overcomes glioblastoma resistance to immunotherapy. Science Translational Medicine 15: eabq3558, Feb 2023.
Zhang D, Li A, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, Kahn M, Rhoades SD, Weljie AM, Amankulor N, Yoshor D, Ye J, Koumenis C, Gong Y, & Fan Y. : PHGDH-mediated endothelial metabolism drives glioblastoma resistance to CAR T cell immunotherapy. Cell Metabolism 35: 1-18, Feb 2023.
2022
Huang M, Yang F, Zhang D, Lin M, Duan H, EI-Mayta R, Zhang L, Qin L, Shewale S, Pei L, Mitchell M, Rader D, Fan Y*, Gong Y*.: : Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nature Cardiovascular Research 1(4): 372–388, Apr 2022 Notes: *Co-senior author.
2021
Ma W, Wang Y, Zhang R, Yang F, Zhang D, Huang M, Zhang L, Dorsey JF, Binder ZA, O’Rourke DM, Fraietta JA, Gong Y*, Fan Y*.: Targeting PAK4 to reprogram vascular microenvironment and improve CAR T immunotherapy for glioblastoma. Nature Cancer 2: 83–97, February 2021 Notes: *Co-corresponding authors.
Yang F, He Z, Duan H, Zhang D, Li J, Yang H, Dorsey JF, Zou W, Nabavizadeh SA, Bagley SJ, Abdullah K, Brem S, Zhang L, Xu X, Byrne KT, Vonderheide RH*, Gong Y*, & Fan Y*.: Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40. Nature Comm. 12(1): 3424, June 2021 Notes: *Co-corresponding authors.
2020
Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O’Rourke DM, Brem S, Koumenis C, Gong Y, and Fan Y. : Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Science Transl Medicine 12(532): eaay7522, Feb 2020.