Ilia Fishbein, MD, PhD

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Ilia Fishbein, MD, PhD is a principal investigator for the Cell and Gene Therapy Collaborative at Children's Hospital of Philadelphia. 

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

PhD - Hebrew University of Jerusalem (Pharmaceutical Science), Jerusalem, Israel 

Internship

Intern in Medicine, Central Hospital #6, Penza, Russia

Fellowship

Postdoctoral Fellow, Division of Cardiology, Children's Hospital of Philadelphia

Graduate Degree

MD - University of Saratov; Saratov, Russia

Titles and Academic Titles

Principal Investigator

Departments and Services

Research Interests

  • Gene and cell therapy of cardiovascular diseases
  • Role of macrophages in the pathogenesis of in-stent restenosis
  • Surface modification of biomaterials for improving biocompatibility of medical implants

Publications

Papers

2020

Inamdar Vaishali V, Fitzpatrick Emmett, Alferiev Ivan, Nagaswami Chandrasekaran, Spruce Lynn A, Fazelinia Hossein, Bratinov George, Seeholzer Steven H, Levy Robert J, Fishbein Ilia, Stachelek Stanley J: Stability and bioactivity of pepCD47 attachment on stainless steel surfaces. Acta biomaterialia 104: 231-240, Mar 2020 Notes: NIHMS ID 1583105.

Battig MR, Alferiev IS, Guerrero DT, Fishbein I, Pressly BB, Levy RJ, Chorny M: An Experimental Single-Platform Approach to Enhance Functionalization of Magnetically Targetable Cells. ACS Applied Bio Materials 2020 Notes: accepted; mt-2020-00466a.R1; DOI: 10.1021/acsabm.0c00466; NIHMS1597029.

2018

Battig Mark R, Fishbein Ilia, Levy Robert J, Alferiev Ivan S, Guerrero David, Chorny Michael: Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug delivery and translational research 8(4): 954-963, Aug 2018.

2017

Fishbein I, Guerrero DT, Alferiev IS, Foster JB, Minutolo NG, Chorny M, Monteys AM, Driesbaugh KH, Nagaswami C, Levy RJ: Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Ther 24(11): 717-726, Nov 2017.

2016

Fishbein I, WelchT ,Guerrero DT ,Alferiev IS ,Adamo RF , Chorny M, Gupte RK, Tang Y, Levy RJ: Paraffin Processing of Stented Arteries Using a Post-Fixation Dissolution of Metallic and Polymeric Stents. Cardiovascular Pathology. 2016 Aug 20;25(6):483-488. PMID: 27616613 (eds.). 25(6): 483-488, Aug 2016.

Slee JB, Alferiev IS, Nagaswami C, Weisel JW, Levy RJ, Fishbein I, Stachelek SJ: Enhanced biocompatibility of CD47-functionalized vascular stents. Biomaterials 87: 82-92, Feb 2016 Notes: joint senior author. PMCID: NIHMS762654

Adamo RF, Fishbein I, Zhang K, Wen J, Levy RJ, Alferiev IS, Chorny M.: Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries. Journal of Controlled Release 222: 169-175, Jan 2016 Notes: joint first author. PMCID: PMC4718792

2015

Alferiev IS, Iyer R, Croucher JL, Adamo RF, Zhang K, Mangino JL, Kolla V, Fishbein I, Brodeur GM, Levy RJ, Chorny M: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51(1): 22-29, May 2015.

Abstracts

2019

Guerrero DT, Alferiev IS, Nguyen F, Guan P, Kolla V, Soberman D, Fishbein I, Levy RJ, Brodeur GM, Chorny M: Nanocarriers with reversibly hydrophobized co-drugs for treating aggressive neuroblastoma. 2nd International Conference on Pharmaceutical Nanotechnology & Nanomedicine,New York, NY March 2019 Notes: poster presentation.

Inamdar VV, Fitzpatrick E, Alferiev I, Nagaswami C, Levy RJ, Fishbein I, Stachelek SJ: Enhanced Biocompatibility of Stents via CD47 Surface Functionalization. Society for Biomaterials 2019 Annual Meeting, April 3-6, Seattle, WA Apr 2019 Notes: podium presentation.

Alferiev IS, Guerrero DT, Nguen F, Guan P, Kolla V, Soberman D, Fishbein I, Levy RJ, Brodeur GM, Chorny M: Poloxamer-based polymeric prodrugs as an experimental therapy for aggressive solid tumors. Conference on Polymers in Life Sciences; Philadelphia, PA May 2019 Notes: poster presentation.

Guerrero DT, Alferiev IS, Nguen F, Guan P, Kolla V, Soberman D, Fishbein I, Levy RJ, Brodeur GM, Chorny M: Formulation and evaluation of biodegradable polymeric nanoparticles as injectable anticancer co-drug carriers. Conference on Polymers in Life Sciences, Philadelphia, PA May 2019 Notes: poster presentation.

Hooshdaran B, Pressly BB, Alferiev IS, Wilensky RL, Gorman RC, Smith JD, Hazen S, Levy RJ, Fishbein I: Stent-based gene therapy of restenosis with an oxidation-resistant apoA1 mutant. AHA Vascular Discovery Annual Meeting, 2019, May 14-16, Boston, MA May 2019 Notes: podium presentation.

Inamdar VV, Fitzpatrick E, Alferiev IS, Nagaswami C, Levy RJ, Fishbein I, Stachelek SJ: CD47 surface functionalization increases the biocompatibility of metal stents. AHA: Vascular Discovery Annual Meeting, 2019 May 14-16, Boston, MA May 2019 Notes: poster presentation.

Pressly BB, Guerrero DT, Alferiev IS, Hooshdaran B, Kuoch M, Chorny M, Fishbein I: Induction of a Prohealing Macrophage Phenotype with Stent-eluted Gene Vectors for the Prevention of Restenosis. AHA: Vascular Discovery Annual Meeting, 2019 May 14-16, Boston, MA May 2019 Notes: poster presentation.

Guerrero, D.T., Alferiev, I.S., Nguyen, F., Guan, P. Kolla, V., Soberman, D. Fishbein, I., Levy, R.J., Brodeur, G.M., Chorny, M.: In situ activatable co-drugs for nanoparticle-based therapy of aggressive neuroblastoma. BMES Annual Meeting, October 16-19, 2019; Philadelphia, PA Oct 2019.

Aghali (Elhashmi) A, Keeney S, Fitzpatrick E, Shukla H, Castillero E, Fishbein I, Ferrari G, Levy RJ.: Serotonin Related Gene Expression Patterns in Aortic Valve Interstitial Cells Are Altered by Proliferation and Serotonin Transporter Inhibition. AHA Scientific Sessions 2019; November 16-18, Philadelphia, PA Nov 2019 Notes: poster presentation.

Inamdar VV, Fitzpatrick E, Alferiev I, Nagasami C, Levy RJ, Fishbein I, Stachelek SJ.: Peptide CD47 functionalization of metal surfaces prevents inflammatory cell attachment, activation and promotes anti-inflammatory phenotype in macrophages. AHA Scientific Sessions 2019; November 16-18, Philadelphia, PA Nov 2019 Notes: poster presentation.

Pressly BB, Hooshdaran B, Alferiev IS, Zoltick P, Wilensky RL, Gorman R, Smith JD, Hazen SL, Levy R, Fishbein I.: The Incorporation Of Oxidation Resistant ApoA1-4WF In Adeno-Associated Viral And Lentiviral Gene Vectors With Robust Cholesterol Efflux In Vitro. AHA Scientific Sessions 2019; November 16-18, Philadelphia, PA Nov 2019 Notes: poster presentation.

2018

Guerrero DT, Alferiev IS, Nguen F, Guan P, Kolla V, Soberman D, Fishbein I, Levy RJ, Brodeur GM, Chorny M: Codrug-impregnated nanocarriers as an experimental therapy for aggressive neuroblastoma. International Conference on Pharma Research and Development; Philadelphia, PA Jun 2018 Notes: poster presentation.

Guerrero DT, Alferiev IS, Nguen F, Guan P, Kolla V, Soberman D, Fishbein I, Levy RJ, Brodeur GM, Chorny M: Mutual prodrugs for treating aggressive neuroblastoma with biodegradable nanocarriers. 256th American Chemical Society National Meeting: Nanoscience, Nanotechnology & Beyond; Boston, MA August 2018 Notes: poster presentation.

2017

Fishbein I, Welch TR, Reddy SRV, Guerrero DT, Alferiev IS, Chorny M, Levy RJ: A dissimilar time course of neointimal formation after deployment of metallic and polymeric stents in rats. AHA Scientific Sessions 2017; November 11-15, Anaheim, CA 136, Suppl 1: A16801, Nov 2017 Notes: poster presentation.

2016

Fishbein I, Alferiev IS, Adamo RF, Guerrero DT, Tang Y, Chorny M, Levy RJ.: Post-Deployment Modifications of Stent with Endothelial Cells. Molecular Therapy; 19-th Annual Meeting of the American Society of Gene and Cell Therapy; May 4-7, 2016; Washington, DC 24(S1), May 2016 Notes: poster presentation.

Chorny M, Battig M, Adamo RF, Fishbein I, Zhang K, Wen J, Levy RJ, Alferiev I: Accelerating endothelium recovery in injured arteries with magnetically guided cell delivery. J Clin Exp Cardiology 7(6 (Suppl)): 52, Jul 2016 Notes: podium presentation.

Fishbein I, Alferiev IS, Foster JB, Guerrero DT, Mas Monteys A, Chorny M, Levy RJ: A novel stent based gene delivery system for the prevention of restenosis. AHA Scientific Sessions 2016; November 12-16, New Orleans, LA 134 (Suppl 1): A19633, Nov 2016 Notes: poster presentation.

2015

IS Alferiev, R Iyer, JL Croucher, RF Adamo, K Zhang, JL Mangino, V Kolla, I Fishbein, GM Brodeur, RJ Levy, M Chorny: SN-38 prodrug-loaded nanoparticles for neuroblastoma therapy. International Conference on Significant Advances in Biomedical Engineering, Philadelphia, PA April 27-29 2015.

Awards and Honors

The Nagai Foundation Graduate Student Award, Controlled Release Society

Goldhaber Family Award for Academic Achievements, Hebrew University of Jerusalem

Innovation Award at Stokes Fellows Research Poster Day, Children's Hospital of Philadelphia

Editorial and Academic Positions

Voting Member, Scholarship Oversight Committee, Division of Cardiology, Children's Hospital of Philadelphia

Member, Clinical and Scientific Advisory Committee (CSAC) for the Pennsylvania Pediatric Device Consortium (PPDC)

Leadership and Memberships

National

American Society of Gene and Cell Therapy

American Heart Association

National Institute of Health, Vascular Cell and Molecular Biology Study Section (Ad hoc reviewer)

Local

Executive Board of the Clinical and Scientific Advisory Committee (CSAC) for the Pennsylvania Pediatric Medical Device Consortium (PPDC) (a voting member)