Steven Joffe
About Steven Joffe
Titles
Attending Physician
Art and Ilene Penn Professor of Medical Ethics and Health Policy, Perelman School of Medicine at the University of Pennsylvania
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2013, Fellow, The Hastings Center
2002, Award for Excellence in Human Research Protection, Health Improvement Institute
1992, Alpha Omega Alpha, University of California, San Francisco
1992, Academic Excellence Award (Co-Valedictorian), University of California, San Francisco
1988, Regents Scholar, University of California, San Francisco
1987, Phi Beta Kappa, Harvard College
1985-1988, John Harvard Scholar, Harvard College
Leadership and Memberships
Memberships in Professional Organizations
National
2015, National Institutes of Health Clinical Center, Board of Scientific Counselors, Ad Hoc Member for Review of the Department of Bioethics
2015-Present, Committee on Federal Research Regulations and Reporting Requirements, National Academy of Sciences (Member)
2015-Present, Board of Scientific Counselors, National Institutes of Health Clinical Center (Member)
2014-Present, Advisory and Executive Committees, Center for International Blood and Marrow Transplant Research (CIBMTR) (Member)
2014-Present, African HIV Data Safety and Monitoring Board, National Institute of Allergies and Infectious Diseases (NIAID), Division of AIDS (DAIDS) (Member)
2014-Present, American Society of Human Genetics (Member)
2013-Present, National Institute of Allergy and Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID) HIV Prevention Data and Safety Monitoring Board - Africa
2012-Present, American Pediatric Society
2011-Present, NHGRI Clinical Sequencing Exploratory Research (CSER) Consortium ELSI Group (Chair 2013-present)
2009-Present, Center for International Blood and Marrow Transplantation Research
- Health Policy Working Committee (Co-chair 2009-2014)
2008-Present, American Society for Blood and Marrow Transplantation
2007-Present, Society for Pediatric Research
2007-Present, U.S. Food and Drug Administration, Pediatric Ethics Subcommittee, Advisory Committee
2003-Present, Public Responsibility in Medicine and Research (PRIM&R) (Member)f
2003-Present Children's Oncology Group
- Bioethics Committee (Chair 2008-Present)
2001-Present American Society of Bioethics and Humanities
1999-Present American Society of Clinical Oncology (Member)
- Data Governance Oversight Committee, CancerLinQ (Member, 2014-2015)
Editorial and Academic Positions
Editorial positions
Academic committees
2015-Present, Member, Committee on Teaching-Part 2, Perelman School of Medicine
Education & training
Graduate Degree
MPH, Epidemiology - University of California, Berkeley, CA
Medical Degree
MD - University of California, San Francisco School of Medicine, San Francisco, CA
Residency
Pediatrics, University of California, San Francisco, CA
Fellowship
Clinical Fellow, Pediatric Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, MA
Publications
Publications
2015
Weiss EM, Joffe S. Promoting informed decision making for comparative effectiveness randomized trials. JAMA 2015 Sep;169(9):803-4.
Cho MK, Magnus D, Constantine M, Lee SS, Kelley M, Alessi S, Korngiebel D, James C, Kuwana E, Gallagher TH, Diekema D, Capron AM, Joffe S, Wilfond BS. Attitudes toward risk and informed consent for research on medical practices: A cross-sectional survey. Ann Intern Med. 2015 May 19;162(10):690-6.
Goldberg AJ, Maschke KJ, Joffe S, Botkin JR, Rothwell E, Murray TH, Anderson R, Deming N, Rosenthal BF, Rivera SM. IRB practices and policies regarding the secondary research use of biospecimens. BMC Med Ethics. 2015 May 8;16:32.
Guilcher GM, Fernandez CV, Joffe S. Are hybrid umbilical cord blood banks really the best of both worlds? J Med Ethics. 2015 Mar;41(3):272-5
Majhail NS, Mau LW, Chitphakdithai P, Payton T, Eckrich M, Joffe S, Lee SJ, LeMaistre CF, LeRademacher J, Loberiza F, Logan B, Parsons SK, Repaczki-Jones R, Robinett P, Rizzo JD, Murphy E, Denzen EM. National Survey of Hematopoietic Cell Transplant Center Personnel, Infrastructure and Models of Care Delivery. Biol Blood Marrow Transplant. 2015 Mar 31. [Epub ahead of print]
Amendola LM, Dorschner MO, Robertson PD, Salama JS, Hart R, Shirts BH, Murray ML, Tokita MJ, Gallego CJ, Kim DS, Bennett JT, Crosslin DR, Ranchalis J, Jones KL, Rosenthal EA, Jarvik ER, Itsara A, Turner EH, Herman DS, Schleit J, Burt A, Jamal SM, Abrudan JL, Johnson AD, Conlin LK, Dulik MC, Santani A, Metterville DR, Kelly M, Foreman AK, Lee K, Taylor KD, Guo X, Crooks K, Kiedrowski LA, Raffel LJ, Gordon O, Machini K, Desnick RJ, Biesecker LG, Lubitz SA, Mulchandani S, Cooper GM, Joffe S, Richards CS, Yang Y, Rotter JI, Rich SS, O'Donnell CJ, Berg JS, Spinner NB, Evans JP, Fullerton SM, Leppig KA, Bennett RL, Bird T, Sybert VP, Grady WM, Tabor HK, Kim JH, Bamshad MJ, Wilfond B, Motulsky AG, Scott CR, Pritchard CC, Walsh TD, Burke W, Raskind WH, Byers P, Hisama FM, Rehm H, Nickerson DA, Jarvik GP. Actionable exomic incidental findings in 6503 participants: challenges of variant classification. Genome Res. 2015 Mar;25(3):305-15.
2014
Wang B, Joffe S, Kesselheim AS. Chemotherapy parity laws: a remedy for high drug costs? JAMA Intern Med. 2014 Nov;174(11):1721-2.
Ballen KK, Joffe S, Brazauskas R, Wang Z, Aljurf MD, Akpek G, Dandoy C, Frangoul HA, Freytes CO, Khera N, Lazarus HM, LeMaistre CF, Mehta P, Parsons SK, Szwajcer D, Ustun C, Wood WA, Majhail NS: Hospital Length of Stay in the First 100 Days after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia in Remission: Comparison among Alternative Graft Sources. Biol Blood Marrow Transplant. 2014 Nov;20(11):1819-27.
Lamont EB, Schilsky RL, He Y, Muss H, Cohen HJ, Hurria A, Meilleur A, Kindler HL, Venook A, Lilenbaum R, Niell H, Goldberg RM, Joffe S, Alliance for Clinical Trials in Oncology. Generalizability of trial results to elderly medicare patients with advanced solid tumors (alliance 70802). J Natl Cancer Inst. 2014 Nov 27;107(1):336.
Henderson GE, Wolf SM, Kuczynski KJ, Joffe S, Sharp RR, Parsons DW, Knoppers BM, Yu JH, Appelbaum PS. The challenge of informed consent and return of results in translational genomics: empirical analysis and recommendations. J Law Med Ethics. 2014 Fall;42(3):344-55.
Gray SW, Martins Y, Feuerman L, Bernhardt BA, Biesecker BB, Christensen KD, Joffe S, Rini C, Veenstra D, McGuire AL. Social and behavioral research in genomic sequencing: Approaches from the Clinical Sequencing Exploratory Research Consortium Outcomes and Measures Working Group. Genet Med. 2014 Oct;16(10):727-35.
Rathi VK, Strait KM, Gross CP, Hrynaszkiewicz I, Joffe S, Krumholz HM,Dzara K, Ross JS. Predictors of Clinical Trial Data Sharing: An Exploratory Analysis of a Cross-Sectional Survey. Trials. 2014 Oct 2;15:384
Joffe S, Miller FG. The ethics of cancer clinical trials in low-resource settings. J Clin Oncol. 2014 Oct 1;32(28):3192-6.
Miller FG, Joffe S, Kesselheim AS. Evidence, errors, and ethics. Perspect Biol Med. 2014;57(3):299-307.
Paquette ET, Najita J, Morley DS, Joffe S. Child and parent understanding of clinical trials: The Semi-Structured Comprehension Interview. Am J Bioeth. 2014;6(2):23-32.
Holm IA, Savage SK, Green RC, Juengst E, McGuire A, Kornetsky S, Brewster SJ, Joffe S, Taylor P. Guidelines for Return of Research Results from Pediatric Genomic Studies: Deliberations of the Boston Children's Hospital Gene Partnership Informed Cohort Oversight Board. Genet Med. 2014 Jul;16(7):547-52.
Hwong AR, Qaragholi N, Carpenter D, Joffe S, Campbell EG, Lehmann LS. A systematic review of state and manufacturer physician payment disclosure websites: Implications for implementation of the Sunshine Act. J Law Med Ethics. 2014 Summer;42(2):208-19
Van Allen EM, Wagle N, Stojanov P, Perrin DL, Cibulskis K, Marlow S, Jane-Valbuena J, Friedrich DC, Kryukov G, Carter SL, McKenna A, Sivachenko A, Rosenberg M, Kiezun A, Voet D, Lawrence M, Lichtenstein LT, Gentry JG, Huang FW, Fostel J, Farlow D, Barbie D, Gandhi L, Lander ES, Gray SW, Joffe S, Janne P, Garber J, MacConaill L, Lindeman N, Rollins B, Kantoff P, Fisher SA, Gabriel S, Getz G, Garraway LA. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat Med. 2014 Jun;20(6):682-8.
Wood WA, Lee SJ, Brazauskas R, Wang Z, Aljurf MD, Ballen KK, Buchbinder DK, Dehn J, Freytes CO, Lazarus HM, Lemaistre CF, Mehta P, Szwajcer D, Joffe S, Majhail NS. Survival improvements in adolescents and young adults after myeloablative allogeneic transplantation for acute lymphoblastic leukemia. Biol Blood Marrow Transplant. 2014 Jun;20(6):829-36.
Joffe S, Wertheimer A. Determining minimal risk for comparative effectiveness research. IRB. 2014 May-Jun;36(3):16-8.
Amendola LM, Dorschner MO, Robertson PD, Salama JS, Hart R, Shirts BH, Murray ML, Tokita MJ, Gallego CJ, Kim DS, Bennett JT, Crosslin DR, Ranchalis J, Jones KL, Rosenthal EA, Jarvik ER, Itsara A, Turner EH, Herman DS, Schleit J, Burt A, Jamal SM, Abrudan JL, Johnson AD, Conlin LK, Dulik MC, Santani A, Metterville DR, Kelly M, Foreman AK, Lee K, Taylor KD, Guo X, Crooks K, Kiedrowski LA, Raffel LJ, Gordon O, Machini K, Desnick RJ, Biesecker LG, Lubitz SA, Mulchandani S, Cooper GM, Joffe S, Richards CS, Yang Y, Rotter JI, Rich SS, O'Donnell CJ, Berg JS, Spinner NB, Evans JP, Fullerton SM, Leppig KA, Bennett RL, Bird T, Sybert VP, Grady WM, Tabor HK, Kim JH, Bamshad MJ, Wilfond B, Motulsky AG, Scott CR, Pritchard CC, Walsh TD, Burke W, Raskind WH, Byers P, Hisama FM, Rehm H, Nickerson DA, Jarvik GP. Actionable exomic incidental findings in 6503 participants: challenges of variant classification. Genome Res. 2015 Mar;25(3):305-15.
DeCamp M, Joffe S, Fernandez CV, Faden RR, Unguru Y; Working Group on Chemotherapy Drug Shortages in Pediatric Oncology. Chemotherapy Drug Shortages in Pediatric Oncology: A Consensus Statement. Pediatrics. 2014 Mar;133(3):e716-24.
Clayton EW, McCullough LB, Biesecker LG, Joffe S, Ross LF, Wolf SM. Addressing the Ethical Challenges in Genetic Testing and Sequencing of Children. Am J Bioeth. 2014 Mar;14(3):3-9.
Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R. Alzheimer's Disease Cooperative Study Steering Committee; Solanezumab Study Group: Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23;370(4):311-21.
2013
Miller FG, Joffe S. Phase 1 Oncology Trials and Informed Consent. J Med Ethics. 2013 Dec;39(12):761-4.
Ramoni RB, McGuire AL, Robinson JO, Morley DS, Plon SE, Joffe S. Experiences and attitudes of genome investigators regarding return of individual genetic test results. Genet Med. 2013 Nov;15(11):882-7.
Denicoff AM, McCaskill-Stevens W, Grubbs SS, Bruinooge SS, Comis RL, Devine P, Dilts DM, Duff ME, Ford JG, Joffe S, Schapira L, Weinfurt KP, Michaels M, Raghavan D, Richmond ES, Zon R, Albrecht TL, Bookman MA, Dowlati A, Enos RA, Fouad MN, Good M, Hicks WJ, Loehrer PJ Sr, Lyss AP, Wolff SN, Wujcik DM, Meropol NJ. The National Cancer Institute-American Society of Clinical Oncology Cancer Trial Accrual Symposium: Summary and Recommendations. J Oncol Pract. 2013 Nov;9(6):267-76.
Majhail NS, Tao L, Bredeson C, Davies S, Dehn J, Gajewski JL, Hahn T, Jakubowski A, Joffe S, Lazarus HM, Parsons SK, Robien K, Lee SJ, Kuntz KM. Prevalence of hematopoietic cell transplant survivors in the United States. Biol Blood Marrow Transplant. 2013 Oct;19(10):1498-501.
Doody R, Raman R, Siemers E, Sethuraman G, Mohs R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas R, Aisen P. A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease. N Engl J Med. 2013 Jul 25;369(4):341-50.
McCarthy PL Jr, Hahn T, Hassebroek A, Bredeson C, Gajewski J, Hale G, Isola L, Lazarus HM, Lee SJ, Lemaistre CF, Loberiza F, Maziarz RT, Rizzo JD, Joffe S, Parsons S, Majhail NS. Trends in Use of and Survival After Autologous Hematopoietic Cell Transplantation in North America, 1995-2005: Significant Improvement in Survival for Lymphoma and Myeloma During a Period of Increasing Recipient Age. Biol Blood Marrow Transplant. 2013 Jul;19(7):1116-23.
Hahn T, McCarthy PL Jr, Hassebroek A, Bredeson C, Gajewski JL, Hale GA, Isola LM, Lazarus HM, Lee SJ, Lemaistre CF, Loberiza F, Maziarz RT, Rizzo JD, Joffe S, Parsons S, Majhail NS. Significant Improvement in Survival After Allogeneic Hematopoietic Cell Transplantation During a Period of Significantly Increased Use, Older Recipient Age, and Use of Unrelated Donors. J Clin Oncol. 2013 Jul 1;31(19):2437-49.
Reeve BB, Withycombe JS, Baker JN, Hooke MC, Lyons JC, Mowbray C, Wang J, Freyer DR, Joffe S, Sung L, Tomlinson D, Gold SH, Hinds PS. The First Step to Integrating the Child's Voice in Adverse Event Reporting in Oncology Trials: A Content Validation Study Among Pediatric Oncology Clinicians. Pediatr Blood Cancer. 2013 Jul;60(7):1231-6.
McGuire AL, Joffe S, Koenig BA, Biesecker BB, McCullough LB, Blumenthal-Barby JS, Caulfield T, Terry SF, Green RC. Point-counterpoint. Ethics and genomic incidental findings. Science. 2013 May 31;340(6136):1047-8.
Jimenez R, Zhang B, Joffe S, Nilsson M, Rivera L, Mutchler J, Lathan C, Paulk ME, Prigerson HG. Clinical Trial Participation Among Ethnic/Racial Minority and Majority Patients with Advanced Cancer: What Factors Most Influence Enrollment? J Palliat Med. 2013 Mar;16(3):256-62.
Unguru Y, Joffe S, Fernandez CV, Yu AL. Ethical Issues for Control-Arm Patients After Revelation of Benefits of Experimental Therapy: A Framework Modeled in Neuroblastoma. J Clin Oncol. 2013 Feb 10;31(5):641-6.
McGuire AL, Robinson JO, Ramoni RB, Morley DS, Joffe S, Plon SE. Returning Genetic Research Results: Study Type Matters. Per Med. 2013 Jan;10(1):27-34.
Editorials, Reviews, Chapters
Joffe S, Truog RD. Consent to Medical Care: The Importance of Fiduciary Context. Miller FG, Wertheimer A, editors. The Ethics of Consent: Theory and Practice. Oxford: Oxford University Press; page: 347-73, 2010.
Joffe S, Kesselheim JC, and Shurin SB. Ethical considerations in pediatric oncology. In: Pizzo, PA and Poplack, DG, editors. Principles and Practice of Pediatric Oncology. Philadelphia: Lippincott Williams & Wilkins; page: 1347-66, October 2010.
Joffe S, Truog RD. Equipoise and Randomization. In: Emanuel EJ, Grady C, Crouch RA, Lie RK, Miller FG, Wendler D, editors. Oxford Textbook of Research Ethics. Oxford, UK: Oxford University Press; p. 245-60, 2008.