Tatiana Karakasheva, PhD, is the Associate Director and a research associate with the Gastrointestinal Epithelium Modeling Program at Children's Hospital of Philadelphia.
Education and Training
Postdoctoral Fellow - University of Pennsylvania, Philadelphia, PA
PhD - Cell and Molecular Biology Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, PA
MS in Biochemistry with concentration in Molecular Biology - Pirogov Russian National Research Medical University (previously Russian State Medical University), Medicobiologic Faculty, Division of Biochemistry, Moscow, Russia
Cell and Gene Therapy Clinical Training Program - Children's Hospital of Philadelphia, Philadelphia, PA
Titles and Academic Titles
Research Associate II
Associate Director, Gastrointestinal Epithelium Modeling Program
Kelsen JR, Dawany N, Conrad MA, Karakasheva TA, Maurer K, Wei JM, Uman S, Dent MH, Behera R, Bryant LM, Ma X, Moreira L, Chatterji P, Shraim R, Merz A, Mizuno R, Simon LA, Muir AB, Giraudo C, Behrens EM, Whelan KA, Devoto M, Russo PA, Andres SF, Sullivan KE, Hamilton KE. Colonoids From Patients With Pediatric Inflammatory Bowel Disease Exhibit Decreased Growth Associated With Inflammation Severity and Durable Upregulation of Antigen Presentation Genes. Inflamm Bowel Dis. 2020
Karakasheva TA, Kijima T, Shimonosono M, Maekawa H, Sahu V, Gabre JT, Cruz-Acuña R, Giroux V, Sangwan V, Whelan KA, Natsugoe S, Yoon AJ, Philipone E, Klein-Szanto AJ, Ginsberg GG, Falk GW, Abrams JA, Que J, Basu D, Ferri L, Diehl JA, Bass AJ, Wang TC, Rustgi AK, Nakagawa H. Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids. Curr Protoc Stem Cell Biol. 2020
Nakagawa H, Kasagi Y, Karakasheva TA, Hara T, Aaron B, Shimonosono M, Kijima T, Giroux V, Bailey D, Wilkins B, Abrams JA, Falk GW, Aceves SS, Spergel JM, Hamilton KE, Whelan K, Muir AB. Modeling Epithelial Homeostasis and Reactive Epithelial Changes in Human and Murine Three‐Dimensional Esophageal Organoids. Curr Protoc Stem Cell Biol. 2020
Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto A, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Wileyto EP, Long Q, Dunagin M, Raj A, Diehl JA, Wong KK, Bass AJ, Frank DA, and Rustgi AK. IL-6 mediates cross-talk between tumor cells and cancer associated fibroblasts in the tumor microenvironment: applications in therapeutic intervention. Cancer Res. 2018.
Karakasheva TA*, Dominguez GA*, Hashimoto A*, Lin EW, Chiu C, Sasser K. Lee Jae W, Beatty GL, Gabrilovich DI, and Rustgi AK. CD38+ M-MDSC expansion characterizes a subset of advanced colorectal cancer patients. JCI Insight. 2018. *these authors contributed equally to this article.
Lin EW, Karakasheva TA, Lee DJ, Lee JS, Long Q, Bass AJ, Wong KK, Rustgi AK. Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries. PLoS Genetics. 2017.
Lin EW, Karakasheva TA, Hicks PD, Bass AJ, Rustgi AK. The tumor microenvironment in esophageal cancer. Oncogene. 2016.
Tétreault MP, Weinblatt D, Ciolino JD, Klein-Szanto AJ, Sackey BK, Twyman-Saint Victor C, Karakasheva T, Teal V, Katz JP. Esophageal Expression of Active IκB Kinase-β in Mice Up-Regulates Tumor Necrosis Factor and Granulocyte-Macrophage Colony-Stimulating Factor, Promoting Inflammation and Angiogenesis. Gastroenterology. 2016.
Karakasheva TA*, Waldron TJ*, Eruslanov E, Kim SB, Lee JS, O’Brien S, Hicks PD, Basu D, Singhal S, Malavasi F, Rustgi AK. CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer. Cancer Res. 2015. *these authors contributed equally to this article.
Posters and Presentations
3D organoids and personalized medicine. 19th Annual NIH Center for Molecular Studies in Digestive and Liver Diseases Symposium. Invited speaker.
Patient-derived organoids from diagnostic biopsies: a pathway to personalized medicine in esophageal cancer. Frontiers in Organoid Medicine inaugural meeting, Cincinnati, OH.
Colorectal cancer: pathogenesis, model systems and translational therapeutics: CD38 and colorectal cancer immunity. Invited speaker at Bristol Meyers-Squibb (the meeting was scheduled to be at the BMS New Brunswick campus in NJ, but had to do teleconference due to inclement weather).
CD38 biology and therapy in GI cancers. Invited speaker at Sanofi, Discovery Biology section, Cambridge, MA.
CD38high MDSCs promote tumorigenesis in a murine model of esophageal cancer. Think Tank on Advancing Esophageal Cancer Research meeting, Boston MA. Invited speaker.
IL-6 and RANTES mediate the cross-talk between tumor cells and CAFs in the esophageal tumor microenvironment. 5th Annual NCI Tumor Microenvironment Network Junior Investigators Meeting, Bethesda MD.
Awards and Honors
2016, 3rd place (best abstract prize), The NIH Center for Molecular Studies in Molecular and Liver Diseases 17th Annual Symposium, Philadelphia, PA
2015, AACR-Bristol-Myers Squibb Scholar-in-Training Award. AACR Annual Meeting, Philadelphia, PA
Graduated with honors, Pirogov Russian National Research Medical University
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